Nano-antioxidants: An emerging strategy for intervention against neurodegenerative conditions.


:Oxidative stress has for long been linked to the neuronal cell death in many neurodegenerative conditions. Conventional antioxidant therapies have been less effective in preventing neuronal damage caused by oxidative stress due to their inability to cross the blood brain barrier. Nanoparticle antioxidants constitute a new wave of antioxidant therapies for prevention and treatment of diseases involving oxidative stress. It is believed that nanoparticle antioxidants have strong and persistent interactions with biomolecules and would be more effective against free radical induced damage. Nanoantioxidants include inorganic nanoparticles possessing intrinsic antioxidant properties, nanoparticles functionalized with antioxidants or antioxidant enzymes to function as an antioxidant delivery system. Nanoparticles containing antioxidants have shown promise as high-performance therapeutic nanomedicine in attenuating oxidative stress with potential applications in treating and preventing neurodegenerative conditions. However, to realize the full potential of nanoantioxidants, negative aspects associated with the use of nanoparticles need to be overcome to validate their long term applications.


Neurochem Int


Sandhir R,Yadav A,Sunkaria A,Singhal N




Has Abstract


2015-10-01 00:00:00












  • The relation between respiratory inhibition and uptake of 1-methyl-isoquinoline (MIQ+) in mitochondria.

    abstract::The effect of 1-methyl-isoquinoline (MIQ+) on the respiratory inhibition and the uptake of MIQ+ were measured using mouse liver mitochondria. MIQ+ inhibited the electron transport of complex I but did not inhibit the respiration of mitochondria with succinate as a substrate. MIQ+ was taken up by mitochondria in an ene...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Aiuchi T,Matsunaga M,Syo M,Nakaya K

    更新日期:1996-03-01 00:00:00

  • Ketogenic diet is antiepileptogenic in pentylenetetrazole kindled mice and decrease levels of N-acylethanolamines in hippocampus.

    abstract::The ketogenic diet (KD) is used for the treatment of refractory epilepsy in children, however, the mechanism(s) remains largely unknown. Also, the antiepileptogenic potential in animal models of epilepsy has been poorly addressed. Activation of cannabinoid type-1 receptor (CB(1)-R) upon seizure activity may mediate ne...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Hansen SL,Nielsen AH,Knudsen KE,Artmann A,Petersen G,Kristiansen U,Hansen SH,Hansen HS

    更新日期:2009-03-01 00:00:00

  • Excess influx of Zn(2+) into dentate granule cells affects object recognition memory via attenuated LTP.

    abstract::The influx of extracellular Zn(2+) into dentate granule cells is nonessential for dentate gyrus long-term potentiation (LTP) and the physiological significance of extracellular Zn(2+) dynamics is unknown in the dentate gyrus. Excess increase in extracellular Zn(2+) in the hippocampal CA1, which is induced with excitat...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Suzuki M,Fujise Y,Tsuchiya Y,Tamano H,Takeda A

    更新日期:2015-08-01 00:00:00

  • 5-Hydroxytryptamine2B receptors stimulate Ca2+ increases in cultured astrocytes from three different brain regions.

    abstract::The expression of 5-hydroxytryptamine-2B (5-HT2B) receptor mRNA has recently been shown in cultured astrocytes. Here the expression of functional 5-HT2B receptors has been studied in cultured astrocytes from rat cerebral cortex, hippocampus, and brain stem. Fluo-3- and fura-2-based microspectrofluorometry was used for...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Sandén N,Thorlin T,Blomstrand F,Persson PA,Hansson E

    更新日期:2000-04-01 00:00:00

  • Cross-inhibition of angiotensin AT1 receptors supports the concept of receptor oligomerization.

    abstract::G protein-coupled receptors are cell surface receptors that mediate the effects of extracellular signals in the endocrine/paracrine and sensory systems. Experimental evidence is accumulating, which suggest that these receptors form dimers or higher order oligomers. The functional relevance of G protein-coupled recepto...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Karip E,Turu G,Süpeki K,Szidonya L,Hunyady L

    更新日期:2007-10-01 00:00:00

  • Nonlinear and mixed inhibitory effect of matrine on the cytotoxicity of oligomeric amyloid-β protein.

    abstract::The formation of amyloid β-protein (1-42) (Aβ42) oligomers and Aβ42 oligomer cytotoxicity are two defining characteristics of the etiology of Alzheimer's disease (AD). In this study, we found that matrine (Mat) could maintain or even enhance the cytotrophic effect of Aβ42 monomers by inhibiting their aggregation and b...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Yang B,Li H,Zhang T,Wang Z,Li H,Zhang Y

    更新日期:2020-07-01 00:00:00

  • Short-term effect of stress on tyrosine hydroxylase activity.

    abstract::The short-term influences of stress on the activities of tyrosine hydroxylase in vivo and in vitro were examined in mice. The in vivo tyrosine hydroxylase activity was estimated by the rate of dopa accumulation which was measured at 30 min after the injection of NSD-1015 (100 mg kg), an aromatic l-amino acid decarboxy...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Oka K,Ashiba G,Kiss B,Nagatsu T

    更新日期:1982-01-01 00:00:00

  • Effects of exogenous phospholipases on brain membrane phospholipid perturbation, (Na(+) + K(+))-ATPase activity and cellular swelling of brain slices.

    abstract::Rat brain membranes were incubated with bee venom phospholipase A(2) (PLA(2)) or phospholipase C (PLC) from Clostridium perfringens. PLA(2) caused a significant increase in free polyunsaturated fatty acids concomitant with membrane phospholipid degradation as monitored by HPLC and by gas chromatography. Equal concentr...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Chan PH,Chen S,Fishman RA

    更新日期:1987-01-01 00:00:00

  • Glutamate, GABA, glycine and taurine modulate serotonin synthesis and release in rostral and caudal rhombencephalic raphe cells in primary cultures.

    abstract::Control of serotonin release and synthesis by amino acid neurotransmitters was investigated in rat rostral and caudal rhombencephalic raphe cells in primary cultures respectively. Endogenous amounts of taurine, glycine, GABA and glutamate were measured in both types of cultures. These amino acids were spontaneously re...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Becquet D,Hery M,Francois-Bellan AM,Giraud P,Deprez P,Faudon M,Fache MP,Hery F

    更新日期:1993-09-01 00:00:00

  • Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products.

    abstract::The increasing incidence of autism suggests a major environmental influence. Epidemiology has implicated many candidates and genetics many susceptibility genes. Gene/environment interactions in autism were analysed using 206 autism susceptibility genes (ASG's) from the Autworks database to interrogate ∼1 million chemi...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审


    authors: Carter CJ,Blizard RA

    更新日期:2016-10-27 00:00:00

  • Potentiation by Ca2+ ionophores and inhibition by extracellular KCl of endothelin-induced phosphoinositide turnover in C6 glioma cells.

    abstract::Interactions between endothelin-1 (ET)-induced phosphoinositide (PI) hydrolysis and agents that increase Ca2+ influx (i.e. A23187 and ionomycin) or induce depolarization (i.e. KCl) were investigated using C6 glioma. A23187 dose-dependently potentiated ET (30 nM)- and ATP (100 microM)-induced [3H]inositol phosphate (IP...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Lin WW,Chuang DM

    更新日期:1992-09-01 00:00:00

  • PKCβ-dependent phosphorylation of the glycine transporter 1.

    abstract::The extracellular levels of the neurotransmitter glycine in the brain are tightly regulated by the glycine transporter 1 (GlyT1) and the clearance rate for glycine depends on its rate of transport and the levels of cell surface GlyT1. Over the years, it has been shown that PKC tightly regulates the activity of several...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Vargas-Medrano J,Castrejon-Tellez V,Plenge F,Ramirez I,Miranda M

    更新日期:2011-12-01 00:00:00

  • Modulation of choline acetyltransferase synthesis by okadaic acid, a phosphatase inhibitor, and KN-62, a CaM kinase inhibitor, in NS-20Y neuroblastoma.

    abstract::Choline-O-acetyltransferase (ChAT) is the enzyme which catalyses the biosynthesis of the neurotransmitter acetylcholine in cholinergic neurons. Here we show that in mouse cholinergic NS-20Y neuroblastoma cells cultured in the presence of either okadaic acid (serine/threonine phosphatases 1 and 2A inhibitor) or KN-62 (...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Pahud G,Bontron S,Eder-Colli L

    更新日期:2001-01-01 00:00:00

  • L-NAME prevents GM1 ganglioside-induced vasodilation in the rat brain.

    abstract::Monosialoganglioside (GM1) is a glycosphingolipid present in most cell membranes that displays antioxidant and neuroprotective properties. It has been recently described that GM1 induces vasodilation. However, the mechanisms underlying GM1-induced vasodilation were not evaluated to date. Therefore, in this study we in...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Furian AF,Oliveira MS,Magni DV,Souza MA,Bortoluzzi VT,Bueno LM,Royes LF,Mello CF

    更新日期:2008-12-01 00:00:00

  • Lycopene protects against trimethyltin-induced neurotoxicity in primary cultured rat hippocampal neurons by inhibiting the mitochondrial apoptotic pathway.

    abstract::Lycopene is a potent free radicals scavenger with demonstrated protective efficacy in several experimental models of oxidative damage. Trimethyltin (TMT) is an organotin compound with neurotoxic effects on the hippocampus and other limbic structures and is used to model neurodegenerative diseases targeting these brain...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Qu M,Zhou Z,Chen C,Li M,Pei L,Chu F,Yang J,Wang Y,Li L,Liu C,Zhang L,Zhang G,Yu Z,Wang D

    更新日期:2011-12-01 00:00:00

  • Pharmacologic modeling of primary mitochondrial respiratory chain dysfunction in zebrafish.

    abstract::Mitochondrial respiratory chain (RC) disease is a heterogeneous and highly morbid group of energy deficiency disorders for which no proven effective therapies exist. Robust vertebrate animal models of primary RC dysfunction are needed to explore the effects of variation in RC disease subtypes, tissue-specific manifest...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Byrnes J,Ganetzky R,Lightfoot R,Tzeng M,Nakamaru-Ogiso E,Seiler C,Falk MJ

    更新日期:2018-07-01 00:00:00

  • Subtle BBB alterations in brain edema associated with acute liver failure.

    abstract::Vasogenic mechanism of brain edema in acute liver failure (ALF) remains poorly understood. Recent work demonstrates that matrix metalloproteinase-9 (MMP-9) contributes to the development of brain edema in experimental ALF (J Hepatol 44:1105, 2006). Importantly, MMP-9 blockage with specific monoclonal antibodies and/or...

    journal_title:Neurochemistry international

    pub_type: 评论,信件


    authors: Nguyen JH

    更新日期:2010-01-01 00:00:00

  • Ferrous ion activates the less active form of human adrenal tyrosine hydroxylase.

    abstract::The less active form of human tyrosine hydroxylase has been previously reported but its physiological role is unknown. We partially purified the less active form of tyrosine hydroxylase from human adrenals, and examined differences in the properties of the active and less active forms. We succeeded in activation of th...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Ishii A,Kiuchi K,Matsuyama M,Satake T,Nagatsu T

    更新日期:1990-01-01 00:00:00

  • Effects of typical (haloperidol) and atypical (risperidone) antipsychotic agents on protein expression in rat neural stem cells.

    abstract::Neural stem cells (NSCs) play a crucial role in the development and maturation of the central nervous system. Recently studies suggest that antipsychotic drugs regulate the activities of NSCs. However, the molecular mechanisms underlying antipsychotic-induced changes of the activity of NSCs, particularly protein expre...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Kashem MA,Ummehany R,Ukai W,Hashimoto E,Saito T,Mcgregor IS,Matsumoto I

    更新日期:2009-12-01 00:00:00

  • Matching kinetics of synaptic vesicle recycling and enhanced neurotransmitter influx by Ca2+ in brain plasma membrane vesicles.

    abstract::Using native plasma membrane vesicle suspensions from the rat cerebral cortex under conditions designed to alter intravesicular [Ca2+], we found that Ca2+ induced 47 +/- 5% more influx of [3H]GABA, [3H]D-aspartate and [3H]glycine at 37 degrees C with half-times 1.7 +/- 0.5, 1.3 +/- 0.4 and 1.3 +/- 0.4 min, respectivel...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Kovács I,Szárics E,Nyitrai G,Blandl T,Kardos J

    更新日期:1998-11-01 00:00:00

  • Clinical course of myelin oligodendrocyte glycoprotein 35-55 induced experimental autoimmune encephalomyelitis is aggravated by glia maturation factor.

    abstract::The role of glia maturation factor (GMF) in myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide-induced experimental autoimmune encephalomyelitis (EAE) was investigated using GMF-deficient (GMF-KO) mice. We demonstrate that GMF-KO mice were resistant to the MOG 35-55 peptide-induced EAE as compared to wild type (W...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Zaheer S,Wu Y,Yang X,Ahrens M,Sahu SK,Zaheer A

    更新日期:2012-02-01 00:00:00

  • Rac1 activity changes are associated with neuronal pathology and spatial memory long-term recovery after global cerebral ischemia.

    abstract::Excitotoxicity is the main event during neurological disorders producing drastic morphological and functional changes. Rac-GTPase is involved in cytoskeletal remodeling and survival. However, the role of Rac1 after cerebral ischemia has not been completely understood yet. In this study, we evaluated the activity of Ra...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Johanna GV,Fredy CA,David VC,Natalia MV,Angel CR,Patricia CG

    更新日期:2010-12-01 00:00:00

  • Adenosine and dopamine receptor antagonist binding in the rat ventral and dorsal striatum: lack of changes after a neonatal bilateral lesion of the ventral hippocampus.

    abstract::There is experimental evidence from radioligand binding experiments for the existence of strong antagonistic interactions between different subtypes of adenosine and dopamine receptors in the striatum, mainly between adenosine A1 and dopamine D1 and between adenosine A2A and dopamine D2 receptors. These interactions s...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Lillrank SM,Lipska BK,Weinberger DR,Fredholm BB,Fuxe K,Ferré S

    更新日期:1999-03-01 00:00:00

  • Effect of hypercholesterolemia and of oxidative stress on the nitric oxide-cGMP pathway.

    abstract::Soluble guanylyl cyclase (sGC) is a key enzyme of the NO-cGMP pathway which is believed to mediate vasoprotective actions. In cardiovascular diseases such as hypercholesterolemia and atherosclerosis, these important functions of the vascular endothelium are strongly impaired. One of the major reasons for this so-calle...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审


    authors: Francois M,Kojda G

    更新日期:2004-11-01 00:00:00

  • Retinal protein kinase C.

    abstract::The protein kinase C (PKC) family of serine/threonine kinase isoenzymes are universally expressed in vertebrate tissues where they control vital cellular functioning. PKC comprises twelve currently identified mammalian isoenzymes, described in three distinct groups according to their need for different effector stimul...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审


    authors: Wood JP,McCord RJ,Osborne NN

    更新日期:1997-02-01 00:00:00

  • Glutamate-responsive translation of dendritic GSK3β mRNA triggers a cycle for amplification of reactivated preexisting GSK3β that is indispensable for tau hyperphosphorylation.

    abstract::The molecular mechanism responsible for hyperphosphorylated tau accumulation in dendrites of Alzheimer's disease (AD) neurons has not been fully clarified. Recently, we reported that tau mRNA is distributed into dendrites, and that translation and phosphorylation of tau protein are immediately enhanced in response to ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Tanaka T,Ohashi S,Takashima A,Kobayashi S

    更新日期:2020-10-01 00:00:00

  • Activation of liver x receptors prevents the spinal LTP induced by skin/muscle retraction in the thigh via SIRT1/NF-Κb pathway.

    abstract::It has been reported that skin/muscle incision and retraction (SMIR) in the thigh, produces mechanical allodynia in the hind paw, far from the site of incision/retraction. The mechanical allodynia lasts about 22 days, indicating chronic post-operative pain develops. The precise mechanisms, however, are largely unclear...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Zhong X,Wang W,Mao Z,Gao F,Guo R,Wei X,Liu X,Wei X

    更新日期:2019-09-01 00:00:00

  • Glutamate transporter GLAST/EAAT1 directs cell surface expression of FXYD2/gamma subunit of Na, K-ATPase in human fetal astrocytes.

    abstract::Na+-dependent uptake of excitatory neurotransmitter glutamate in astrocytes increases cell energy demands primarily due to the elevated ATP consumption by glutamine synthetase and Na+, K+-ATPase. The major pool of GLAST/EAAT1, the only glutamate transporter subtype expressed by human fetal astrocytes in undifferentiat...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Gegelashvili M,Rodriguez-Kern A,Sung L,Shimamoto K,Gegelashvili G

    更新日期:2007-06-01 00:00:00

  • In vitro mitochondrial failure and oxidative stress mimic biochemical features of Alzheimer disease.

    abstract::Primary cortical neurons exposed to the mitochondrial toxin NaN3 (0.1-3 mM) were submitted to oxidative stress with H2O2 (30-150 μM), to mimic conditions observed in neurodegenerative disorders. The effects of such treatment on a series of parameters useful in characterizing neuronal damage were investigated: (i) the ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Selvatici R,Marani L,Marino S,Siniscalchi A

    更新日期:2013-08-01 00:00:00

  • An hypothesis for a vitamin A cycle in the pigment epithelium of bovine retina.

    abstract::Several metabolic transformations of vitamin A have now been found in the pigment epithelium of cattle retina, leading to the hypothesis that there may be a vitamin A cycle in these cells. A retinol binding protein of MW ? 17,000 in pigment epithelial cytosol has been identified independently in several laboratories. ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Berman ER,Segal N,Schneider A,Feeney L

    更新日期:1980-01-01 00:00:00