Nano-antioxidants: An emerging strategy for intervention against neurodegenerative conditions.

Abstract:

:Oxidative stress has for long been linked to the neuronal cell death in many neurodegenerative conditions. Conventional antioxidant therapies have been less effective in preventing neuronal damage caused by oxidative stress due to their inability to cross the blood brain barrier. Nanoparticle antioxidants constitute a new wave of antioxidant therapies for prevention and treatment of diseases involving oxidative stress. It is believed that nanoparticle antioxidants have strong and persistent interactions with biomolecules and would be more effective against free radical induced damage. Nanoantioxidants include inorganic nanoparticles possessing intrinsic antioxidant properties, nanoparticles functionalized with antioxidants or antioxidant enzymes to function as an antioxidant delivery system. Nanoparticles containing antioxidants have shown promise as high-performance therapeutic nanomedicine in attenuating oxidative stress with potential applications in treating and preventing neurodegenerative conditions. However, to realize the full potential of nanoantioxidants, negative aspects associated with the use of nanoparticles need to be overcome to validate their long term applications.

journal_name

Neurochem Int

authors

Sandhir R,Yadav A,Sunkaria A,Singhal N

doi

10.1016/j.neuint.2015.08.011

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

209-26

eissn

0197-0186

issn

1872-9754

pii

S0197-0186(15)30039-5

journal_volume

89

pub_type

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