A personal view from a long-lasting collaborator on the research strategies of Marshall Nirenberg.

abstract：:Human induced pluripotent stem cells (hiPSCs) are considered as a powerful tool for drug and chemical screening and development of new in vitro testing strategies in the field of toxicology, including neurotoxicity evaluation. These cells are able to expand and efficiently differentiate into different types of neurona...

journal_title：Neurochemistry international

authors： Zagoura D,Canovas-Jorda D,Pistollato F,Bremer-Hoffmann S,Bal-Price A

更新日期：2017-06-01 00:00:00

abstract：:Streptozotocin (STZ) is a glucosamine-nitrosourea commonly used to induce long-lasting models of diabetes mellitus and Alzheimer's disease. Direct toxicity of STZ on the pancreas and kidneys has been well characterized, but the acute effect of this compound on brain tissue has received less attention. Herein, we inves...

journal_title：Neurochemistry international

authors： Rodrigues L,Wartchow KM,Suardi LZ,Federhen BC,Selistre NG,Gonçalves CA

更新日期：2019-09-01 00:00:00

abstract：:Long-term potentiation (LTP) is a well-established experimental model used to investigate the synaptic basis of learning and memory. LTP at mossy fibre - CA3 synapses in the hippocampus is unusual because it is normally N-methyl-d-aspartate (NMDA) receptor-independent. Instead it seems that the trigger for mossy fibre...

journal_title：Neurochemistry international

authors： Sherwood JL,Amici M,Dargan SL,Culley GR,Fitzjohn SM,Jane DE,Collingridge GL,Lodge D,Bortolotto ZA

更新日期：2012-09-01 00:00:00

abstract：:A simple, rapid and sensitive method for the detection of acetylcholine and choline in tissue extracts is reported. Acetylcholine and choline are first separated by HPLC then react in a mini-column with acetylcholinesterase and choline oxidase immobilized on Sepharose. The resulting H(2)O(2) produced by choline oxidas...

journal_title：Neurochemistry international

authors： Stadler H,Nesselhut T

更新日期：1986-01-01 00:00:00

abstract：:AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) excitotoxicity was examined in cultured neocortical neurons using the reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) to measure cell viability. Neurons were exposed to AMPA at different culture periods during development o...

journal_title：Neurochemistry international

authors： Jensen JB,Schousboe A,Pickering DS

更新日期：1998-05-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of (3S)-7-chloro-3-[2-((1R)-1-carboxyethoxy)-4-aminomethylphenyl]aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[c,d]indole-2-carboxylic acid hydrochloride (SM-31900), an antagonist with high selectivity and affinity for the NMDA receptor glycine-binding site, on the ...

journal_title：Neurochemistry international

authors： Ohtani K,Tanaka H,Ohno Y

更新日期：2003-04-01 00:00:00

abstract：:In this study, the role of exogenous fatty acids in the regulation of proteolipid protein (PLP) gene expression was investigated using the following model culture system: C6 glioma cells expressing the green-fluorescent protein (eGFP) driven by different segments of PLP promoter. Eicosapentanoic acid (EPA; 20:5 n-3), ...

journal_title：Neurochemistry international

authors： Salvati S,Natali F,Attorri L,Raggi C,Di Biase A,Sanchez M

更新日期：2004-04-01 00:00:00

abstract：:Neuroblastoma cells, cultivated on plastic dishes, in presence of 15 mM glucose resist very well to hypoxia. Cells incubated on plastic dishes, if left unshaken, showed a Pasteur effect at an oxygen concentration below 10%. Oxygen diffusion was the limiting factor in these plastic dishes since improved oxygen diffusio...

journal_title：Neurochemistry international

authors： Pauwels PJ,Opperdoes FR,Trouet A

更新日期：1984-01-01 00:00:00

abstract：:The developmental profile of cytosolic sialidase from the nerve ending and the nerve ending-free compartments of rat forebrain was studied from birth to 150 days. Soluble extracts containing the cytosol from nerve endings and nerve ending-free tissue were separately prepared; the recovery of cytosol in the two extract...

journal_title：Neurochemistry international

authors： Venerando B,Fiorilli A,Malesci A,Goi GC,Lombardo A,Preti A,Tettamanti G

更新日期：1983-01-01 00:00:00

abstract：:To characterise ketamine-induced sympathomimetic action, we examined the effects of ketamine on in vivo cardiac sympathetic nerve endings function. Using adult cats given anaesthesia with pentobarbital, dialysis probes were implanted in the left ventricular myocardium and dialysate noradrenaline (NA) concentrations we...

journal_title：Neurochemistry international

authors： Kitagawa H,Yamazaki T,Akiyama T,Mori H,Sunagawa K

更新日期：2003-02-01 00:00:00

abstract：:Using a consistent, reproducible and reliable cortical focal ischemia in rat (permanent unilateral occlusion of the left middle cerebral artery & the ipsilateral common carotid artery [MCAo + CCAo] with a 1 h temporary occlusion of the contralateral CCA), the levels of four major membrane fatty acids (palmitic, C16:0;...

journal_title：Neurochemistry international

authors： Mahadik SP,Hungund BL,Gokhale VS,Ortiz A,Makar TK,Karpiak SE

更新日期：1993-08-01 00:00:00

abstract：:Fluorescence measurements and singlet singlet energy transfer experiments on endothelin-1 provide information on the conformation of this peptide in dilute aqueous solution. The tyrosine fluorescence quantum yield in the absence of transfer (in [Phe(21)]endothelin-1) is relatively large (?(tyr) = 0.39), indicating the...

journal_title：Neurochemistry international

authors： Pelton JT

更新日期：1991-01-01 00:00:00

abstract：:Depression is characterized by sadness, purposelessness, irritability, and impaired body functions. Depression causes severe symptoms for several weeks, and dysthymia, which may cause chronic, low-grade symptoms. Treatment of depression involves psychotherapy, medications, or phototherapy. Clinical and experimental ev...

journal_title：Neurochemistry international

authors： Shabbir F,Patel A,Mattison C,Bose S,Krishnamohan R,Sweeney E,Sandhu S,Nel W,Rais A,Sandhu R,Ngu N,Sharma S

更新日期：2013-02-01 00:00:00

abstract：:Intrauterine growth retardation induced by ligation of the uterine vessels in pregnant rats on the 5th day before delivery was associated with brain and body weights of hypotrophic offspring significantly lower than those of pair-aged control rats, even after 6 weeks of postnatal rearing under normal conditions. In vi...

journal_title：Neurochemistry international

authors： Chanez C,Flexor MA,Hamon M

更新日期：1985-01-01 00:00:00

abstract：:alpha(2)-Adrenoceptors are involved in various physiological functions, particularly in the cardiovascular system and the central nervous system. Different adrenoceptor subtypes (alpha(2A), alpha(2B) and alpha(2C)) have been recognised and the different subtypes may have role in activation of distinct physiological an...

journal_title：Neurochemistry international

authors： Gyires K,Zádori ZS,Török T,Mátyus P

更新日期：2009-12-01 00:00:00

abstract：:Focusing on development of novel drug candidates for the treatment of neurodegenerative diseases, we developed and synthesized a new compound, 2-(cyclohexylamino)-1-(4-cyclopentylpiperazin-1-yl)-2-methylpropan-1-one (amido-piperizine 1). The compound demonstrated robust neuroprotective properties after both glutamate ...

journal_title：Neurochemistry international

authors： Elbrønd-Bek H,Wellejus A,Kelly NM,Weidner MS,Jørgensen SH

更新日期：2011-11-01 00:00:00

abstract：:The venom from the marine snail Conus pennaceus inhibits the binding of [3H]neuropeptide Y to calf brain membranes (Czerwiec et al., 1996a) and, in the present study, also to rat forebrain membranes. These membranes contain about 80% Y1- and 20% Y2-receptors. The inhibition by the venom was concentration-dependent wit...

journal_title：Neurochemistry international

authors： Diallo B,Vanderheyden PM,De Backer JP,Vauquelin G

更新日期：1998-01-01 00:00:00

abstract：:Although ischemic preconditioning (IP) can provide powerful protection on brain against ischemic insult, it is rarely used in clinic to prevent the occurrence of ischemic stroke because of safety concerns. It is therefore necessary to seek the safer stimuli to initiate pharmacological preconditioning. Our previous wor...

journal_title：Neurochemistry international

authors： Wu X,Zhou C,Du F,Lu Y,Peng B,Chen L,Zhu L

更新日期：2013-01-01 00:00:00

abstract：:Carotenoids play a pivotal role in prevention of many degenerative diseases mediated by oxidative stress including neurodegenerative diseases like Alzheimer's Disease (AD). The involvement of retinoids in physiology, AD pathology and their therapeutic role in vitro and in vivo has been extensively studied. This review...

journal_title：Neurochemistry international

authors： Obulesu M,Dowlathabad MR,Bramhachari PV

更新日期：2011-10-01 00:00:00

abstract：:Brain cortex synaptoneurosomes actively incorporated [14C]arachidonic acid (AA) into lipids. Serotonin (5-HT), at a concentration range of 10 microM-1 mM, significantly stimulates the incorporation of AA mainly into phosphatidylinositol (PI) of brain cortex synaptoneurosomes. The stimulation rate of AA incorporation b...

journal_title：Neurochemistry international

authors： Strosznajder J,Samochocki M,Duran M

更新日期：1994-08-01 00:00:00

abstract：:Amyloid deposition within the brains of Alzheimer's Disease patients results in the activation of microglial cells and the induction of a local inflammatory response. The interaction of microglia or monocytes with beta-amyloid (A beta) fibrils elicits the activation a complex tyrosine kinase-based signal transduction ...

journal_title：Neurochemistry international

authors： Combs CK,Bates P,Karlo JC,Landreth GE

更新日期：2001-11-01 00:00:00

abstract：:Maple syrup urine disease (MSUD) is an inherited neurometabolic disorder biochemically characterized by the accumulation of the branched-chain alpha-keto acids (BCKA) alpha-ketoisocaproic (KIC), alpha-keto-beta-methylvaleric (KMV) and alpha-ketoisovaleric (KIV) and their respective branched-chain alpha-amino acids in ...

journal_title：Neurochemistry international

authors： Funchal C,Latini A,Jacques-Silva MC,Dos Santos AQ,Buzin L,Gottfried C,Wajner M,Pessoa-Pureur R

更新日期：2006-12-01 00:00:00

abstract：:The disposition of labelled [3H]GM1lactone, the inner ester of ganglioside GM1, was studied in the rat. After i.v. administration [3H]GM1lactone was quickly converted to its corresponding open form most likely by plasma esterases, and then displayed a pharmacokinetic profile identical to [3H]GM1. Following intramuscul...

journal_title：Neurochemistry international

authors： Bellato P,Milan F,Facchinetti E,Toffano G

更新日期：1992-04-01 00:00:00

abstract：:Synaptic like microvesicles (SLMV) form a pleiomorphic population of vesicles present in neuroendocrine cells of the pituitary and the adrenal medulla. Their composition and biogenesis is very similar to small synaptic vesicles (SSV) present in nerve terminals. Membrane proteins of SSV involved in fusion (synaptotagmi...

journal_title：Neurochemistry international

authors： Llona I

更新日期：1995-09-01 00:00:00

abstract：:The evolving role of mitochondria as a target for different death-inducing noxae prompted us to investigate trimethyltin (TMT)-dependent effects on mitochondrial functionality. For this purpose, we used a homogeneous cell culture model represented by undifferentiated PC12 cells. Mitochondria isolated from PC12 cells t...

journal_title：Neurochemistry international

authors： Misiti F,Orsini F,Clementi ME,Lattanzi W,Giardina B,Michetti F

更新日期：2008-05-01 00:00:00

abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), an inducer of parkinsonism, causes degeneration of nigro-striatal dopaminergic neurons by producing its neurotoxic metabolite, 1-methyl-4-phenylpiridium ion (MPP+), by monoamine oxidase B in glial cells. We used PC12 (rat pheochromocytoma cell line) as a model cell ...

journal_title：Neurochemistry international

authors： Itano Y,Kitamura Y,Nomura Y

更新日期：1994-11-01 00:00:00

abstract：:Oxidative stress (OS) has been related to cocaine's actions and also to numerous nervous system pathologies, including seizures. The purpose of this work was to determine the alterations in glutathione (GSH) content, nitrite/nitrate and MDA levels after cocaine-induced toxicity. Male Swiss mice were injected (i.p.) wi...

journal_title：Neurochemistry international

authors： Macêdo DS,Vasconcelos SM,Andrade-Neto M,Belchior LD,Honório Júnior JE,Gonçalves DO,Fonteles MM,Silva MI,Aguiar LM,Viana GS,de Sousa FC

更新日期：2010-01-01 00:00:00

abstract：:The present experiments investigated the effect of a neurotoxin purified from the venom of the spider Phoneutria nigriventer. This toxic component, P. nigriventer toxin 3-6 (PnTx3-6), abolished Ca(2+)-dependent glutamate release with an IC(50) of 74.4nM but did not alter Ca(2+)-independent secretion of glutamate when ...

journal_title：Neurochemistry international

authors： Vieira LB,Kushmerick C,Reis HJ,Diniz CR,Cordeiro MN,Prado MA,Kalapothakis E,Romano-Silva MA,Gomez MV

更新日期：2003-03-01 00:00:00

abstract：:Aquaporin-4 (AQP4) is a key molecule for maintaining water and ion homeostasis associated with neuronal activity in the central nervous system, but the roles of AQP4 in adult neurogenesis remain largely unexplored. Based on preliminary evidences over the past years, AQP4 appears to emerge as an important player regula...

journal_title：Neurochemistry international

authors： Zheng GQ,Li Y,Gu Y,Chen XM,Zhou Y,Zhao SZ,Shen J

更新日期：2010-04-01 00:00:00

abstract：:Nucleotides can be released as signaling substances in the nervous system from both neural and glial cells. Their function is terminated by ecto-nucleotidases and sequential extracellular metabolism to the nucleoside. Recently considerable progress has been made in unraveling the molecular structure of an ecto-ATPase ...

journal_title：Neurochemistry international

authors： Zimmermann H,Braun N,Kegel B,Heine P

更新日期：1998-05-01 00:00:00