Abstract:
:Gastrointestinal peptides and hormones are known to penetrate through the utero-placental barrier and regulate fetal development. In the present study, we tested permeation of maternal brain-derived neurotrophic factor (BDNF) to fetuses, using BDNF-gene deficient mice and exogenous BDNF administration. At embryonic day 13.5 (E13.5)-14.5, BDNF protein concentrations in the fetal brain of BDNF homozygous null mutant (bdnf (-/-)) were comparable to the levels seen in wild-type fetuses. After E17.5, BDNF protein levels in bdnf (-/-) fetal brain were still detectable but its levels were significantly decreased below those in wild-type brain. When recombinant BDNF protein was injected into pregnant wild-type mice carrying E14.5 embryos, BDNF protein levels in fetal brain were elevated dose-dependently. These findings suggest that maternal BDNF reaches the fetal brain through utero-placental barrier and might contribute to its development.
journal_name
Neurochem Intjournal_title
Neurochemistry internationalauthors
Kodomari I,Wada E,Nakamura S,Wada Kdoi
10.1016/j.neuint.2008.11.005subject
Has Abstractpub_date
2009-02-01 00:00:00pages
95-8issue
2eissn
0197-0186issn
1872-9754pii
S0197-0186(08)00206-4journal_volume
54pub_type
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