Simple and rapid measurement of acetylcholine and choline by HPLC and enzymatic-electrochemical detection.

abstract：:Inositol 1,4,5-trisphosphate (IP(3)) receptors belong to the intracellular calcium channels that release calcium from the intracellular stores after binding IP(3). Three types of IP(3) receptors occurred in a tissue specific manner and different promoters direct their gene expression. Thus, understanding of the transc...

journal_title：Neurochemistry international

authors： Stefanik P,Macejova D,Mravec B,Brtko J,Krizanova O

更新日期：2005-06-01 00:00:00

abstract：:The possible influence of cholinergic and dopaminergic mechanisms on neurotensin-containing neurones was examined at two different levels; nucleus accumbens and striatum in the rat brain. The acute treatment with the anticholinergic drugs atropine and scopolamine increased neurotensin concentrations in the striatum an...

journal_title：Neurochemistry international

authors： Frey P,Lis M,Coward DM

更新日期：1988-01-01 00:00:00

abstract：:An intraocular injection of [(3)H]proline was used to label rabbit retinal ganglion cells including components subjected to axonal transport. Degradation of rapidly axonally transported labelled proteins was estimated in an in vitro system using homogenates of the nerve terminal regions. The energy requirements of thi...

journal_title：Neurochemistry international

authors： Gustavsson S,Karlsson JO

更新日期：1985-01-01 00:00:00

abstract：:The disposition of labelled [3H]GM1lactone, the inner ester of ganglioside GM1, was studied in the rat. After i.v. administration [3H]GM1lactone was quickly converted to its corresponding open form most likely by plasma esterases, and then displayed a pharmacokinetic profile identical to [3H]GM1. Following intramuscul...

journal_title：Neurochemistry international

authors： Bellato P,Milan F,Facchinetti E,Toffano G

更新日期：1992-04-01 00:00:00

abstract：:The Xenopus oocyte expression and recording system has allowed a detailed analysis of the physiology and pharmacology of neuronal ion channels including their sensitivity to ethanol. It is important however, to ascertain the effects of a particular drug on the channels inherently expressed by oocytes to ensure that dr...

journal_title：Neurochemistry international

authors： Clayton R,Woodward JJ

更新日期：2000-01-01 00:00:00

abstract：:The concentrations of gamma-glutamylglutamate, gamma-glutamylglutamine, gamma-glutamylcysteine, glutamate, aspartate, glutamine, cyst(e)ine and glutathione (including disulfides) were determined by HPLC analysis of both the tissue and the surrounding medium of incubated rat hippocampal slices. High potassium concentra...

journal_title：Neurochemistry international

authors： Li X,Orwar O,Revesjö C,Sandberg M

更新日期：1996-08-01 00:00:00

abstract：:Astroglial cells have a variety of roles in the central nervous system (CNS), providing a homeostasis for the proper functioning of neuronal cells. The classical view concerning the supportive role of astroglia towards associated neurons has to be extended. A great number of new evidences suggest that astrocytes inter...

journal_title：Neurochemistry international

authors： Struzyńska L

更新日期：2009-07-01 00:00:00

abstract：:The relationship between acidosis and the metabolism of glutamine and glutamate was studied in cultured astrocytes. Acidification of the incubation medium was associated with an increased formation of aspartate from glutamate and glutamine. The rise of the intracellular content of aspartate was accompanied by a signif...

journal_title：Neurochemistry international

authors： Yudkoff M,Daikhin Y,Nissim I,Nissim I

更新日期：2000-04-01 00:00:00

abstract：:Increased noradrenaline, induced by rapid eye movement (REM) sleep deprivation, stimulates Na-K ATPase activity in the rat brain. The brain contains neurons as well as glia and both possess Na-K ATPase, however, it was not known if REM sleep deprivation affects the enzyme in both types of cells identically. Rats were ...

journal_title：Neurochemistry international

authors： Baskey G,Singh A,Sharma R,Mallick BN

更新日期：2009-01-01 00:00:00

abstract：:Using immunohistochemical methods at the light and electron microscope level, the coexistence between a hypophysiotropic factor and an apparently unrelated neuropeptide was demonstrated in three distinct infundibular neuronal systems. The present results emphasize the importance of demonstrating peptide coexistences f...

journal_title：Neurochemistry international

authors： Tramu G,Beauvillain JC,Croix D,Pillez A,Garaud JC

更新日期：1984-01-01 00:00:00

abstract：:Diabetic neuropathic pain (DNP) plays a major role in decreased life quality of diabetes patients, however, the neural mechanisms underlying DNP remain unclear. Endomorphins are the endogenous ligands for mu-opioid receptor. There is increasing evidence implicating the involvement of spinal endomorphin-2 (EM2) in neur...

journal_title：Neurochemistry international

authors： Niu L,Dai GH,He GL,Yang M,Hu HM,Liu ZK,Qian NS,Chen YL

更新日期：2017-09-01 00:00:00

abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), an inducer of parkinsonism, causes degeneration of nigro-striatal dopaminergic neurons by producing its neurotoxic metabolite, 1-methyl-4-phenylpiridium ion (MPP+), by monoamine oxidase B in glial cells. We used PC12 (rat pheochromocytoma cell line) as a model cell ...

journal_title：Neurochemistry international

authors： Itano Y,Kitamura Y,Nomura Y

更新日期：1994-11-01 00:00:00

abstract：:The immunostains of GD3, c-pathway polysialogangliosides and gangliotetraosylgangliosides belonging to the a- and b-pathways were analyzed in embryo optic lobe cells. Cells were cultured in serum free media with, and without, bovine brain ganglioside mixture (largely gangliotetraosylgangliosides). Control cells differ...

journal_title：Neurochemistry international

authors： Cossy-Isasi S,Panzetta P

更新日期：1994-04-01 00:00:00

abstract：:The ubiquitin proteasome system (UPS) is a major cellular protein degradation pathway that involves the modulation of key proteins controlling inflammation, cell cycle regulation and gene expression. Modulation of the UPS with proteasome inhibitors has indicated efficacy in the treatment of several disease states incl...

journal_title：Neurochemistry international

authors： Williams AJ,Dave JR,Tortella FC

更新日期：2006-07-01 00:00:00

abstract：:5,7-Dihydroxytryptamine (5,7-DHT) is a selective serotonergic neurotoxin by virtue of its selective uptake into 5-hydroxytryptamine neurons and its ability to undergo autoxidation. The mechanism by which 5,7-DHT induces neurodegenerative effects remains enigmatic. The mechanism of autoxidation of 5,7-DHT, which has be...

journal_title：Neurochemistry international

authors： Sinhababu AK,Borchardt RT

更新日期：1988-01-01 00:00:00

abstract：:The neonatal administration of 5,7-dihydroxytryptamine to rats (100 mg kg(?1) s.c. on the 1st and 2nd day after birth) resulted in marked reductions in serotoninergic presynaptic markers ([(3)H]-5-HT synaptosomal uptake, tryptophan hydroxylase activity and endogenous 5-HT content) in various forebrain areas, particula...

journal_title：Neurochemistry international

authors： Hamon M,Nelson DL,Mallat M,Bourgoin S

更新日期：1981-03-01 00:00:00

abstract：:The sensitivity of [(3)H]GABA and [(3)H]muscimol high-affinity binding sites to physiological (Krebs-Ringer's bicarbonate) and non-physiological (Tris-citrate) buffers was examined using synaptosomal membranes from bovine retinas. The maximum number of sites (B(max)) for [(3)H]GABA was present when the tissue was assa...

journal_title：Neurochemistry international

authors： Madtes P Jr,Bashir-Elahi R,Chader GJ

更新日期：1986-01-01 00:00:00

abstract：:The presence of corticotropin-releasing hormone (CRH) receptors has been previously demonstrated in corticotrophs from normal pituitaries using a method combining immunocytochemistry and liquid emulsion autoradiography. The aim of this study was to compare the characteristics of the 125I-Tyr0-hCRH binding in corticotr...

journal_title：Neurochemistry international

authors： Abs R,Smets G,Vauquelin G,Verhelst J,Mahler C,Verlooy J,Stevenaert A,Wouters L,Borgers M,Beckers A

更新日期：1997-03-01 00:00:00

abstract：:The agonist, [3H](-)[S]-1-(2-amino-2-carboxyethyl)-5-fluoro-pyrimidine-2,4-dione ([3H](S)F-Willardiine) binding to functional alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors of resealed plasma membrane vesicles and nerve endings freshly isolated from the rat cerebral cortex displayed two bind...

journal_title：Neurochemistry international

authors： Kovács I,Simon A,Szárics E,Barabás P,Héja L,Nyikos L,Kardos J

更新日期：2004-03-01 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease in which pathogenic T cells play an important role, and an experimental autoimmune encephalomyelitis (EAE) is used as an animal model of MS. Galectins are β-galactoside-binding lectins and involved in various physiological and pathological events. Among fifteen members ...

journal_title：Neurochemistry international

authors： Itabashi T,Arima Y,Kamimura D,Higuchi K,Bando Y,Takahashi-Iwanaga H,Murakami M,Watanabe M,Iwanaga T,Nio-Kobayashi J

更新日期：2018-09-01 00:00:00

abstract：:The aim of this study was to investigate the involvement of calmodulin in phospholipase D activation in SH-SY5Y cells. Cells prelabelled with [3H]-palmitic acid were incubated with calmodulin antagonists and/or other compounds. Phosphatidylethanol, a specific marker for phospholipase D activity, and phosphatidic acid ...

journal_title：Neurochemistry international

authors： del Carmen Boyano-Adánez M,Gustavsson L

更新日期：2002-03-01 00:00:00

abstract：:Although many studies have revealed alterations in neurotransmission during ischaemia, few works have been devoted to the neurochemical effects of mild hypoxia, a situation encountered during life in altitude or in several pathologies. In that context, the present work was undertaken to determine the in vivo mechanism...

journal_title：Neurochemistry international

authors： Orset C,Parrot S,Sauvinet V,Cottet-Emard JM,Bérod A,Pequignot JM,Denoroy L

更新日期：2005-06-01 00:00:00

abstract：:The cardiovascular and pulmonary responses to vasoactive intestinal contractor (VIC) were compared with those of endothelin (ET)-1, ET-2, ET-3 and sarafotoxin 6b (S6b) and the mechanism by which ET-1 alters vascular resistance was investigated in the hindquarters vascular bed of the cat. In a manner similar to ET-1 an...

journal_title：Neurochemistry international

authors： Minkes RK,Kadowitz PJ

更新日期：1991-01-01 00:00:00

abstract：:Evidences have indicated a high degree of comorbidity of alcoholism and depression. N-acetylcysteine (NAC) has shown its clinical efficiency in the treatment of several psychiatric disorders and is identified as a multi-target acting drug. The ability of NAC to prevent alcohol abstinence-induced depression-like effect...

journal_title：Neurochemistry international

authors： Yawalkar R,Changotra H,Gupta GL

更新日期：2018-09-01 00:00:00

abstract：:Intoxication with inorganic arsenicals leads to neuropathies and impaired cognitive functions. However, little is known so far on the cellular targets that are involved in the adverse effects of arsenite to brain cells. To test whether arsenite may affect neural glucose and glutathione (GSH) metabolism, primary astroc...

journal_title：Neurochemistry international

authors： Tadepalle N,Koehler Y,Brandmann M,Meyer N,Dringen R

更新日期：2014-10-01 00:00:00

abstract：:We assessed the diagnostic accuracy of cerebrospinal fluid (CSF) neurofilament light chain (NFL) protein in the classification of patients with Alzheimer's disease (AD) and cognitively healthy control individuals (HCs) and patients with frontotemporal dementia (FTD) as comparisons. Particularly, we tested the performa...

journal_title：Neurochemistry international

authors： Lista S,Toschi N,Baldacci F,Zetterberg H,Blennow K,Kilimann I,Teipel SJ,Cavedo E,Dos Santos AM,Epelbaum S,Lamari F,Dubois B,Floris R,Garaci F,Hampel H,Alzheimer Precision Medicine Initiative (APMI).

更新日期：2017-09-01 00:00:00

abstract：:ATPase activities in CNS membranes were studied after administration of desipramine (DMI), a noradrenaline (NA) uptake inhibitor. In a previous paper we reported that Na+,K(+)-ATPase activity significantly increased 3 h after DMI administration (10 mg/kg) in hypothalamus and mesencephalus but not in cerebral cortex an...

journal_title：Neurochemistry international

authors： Viola MS,Rodríguez de Lores Arnaiz G,Enero MA

更新日期：1994-01-01 00:00:00

abstract：:The amyloid precursor protein (APP) and presenilin-1 (PS-1) are not only of importance for the normal functioning of the various neurons, but also play central roles in the pathogenesis of Alzheimer's disease (AD). Through the use of immunohistochemical and Western blot techniques, the bidirectional axonal transport o...

journal_title：Neurochemistry international

authors： Papp H,Pakaski M,Kasa P

更新日期：2002-12-01 00:00:00

abstract：:Growing evidence suggests that α-lipoic acid (LA) has neuroprotective effects in various pathological conditions including brain ischemia and neurodegeneration. While anti-oxidative activity has been thought to play a central role in LA-mediated neuroprotection, the precise mechanism and the effect of LA enantiomers (...

journal_title：Neurochemistry international

authors： Yamada T,Hashida K,Takarada-Iemata M,Matsugo S,Hori O

更新日期：2011-12-01 00:00:00

abstract：:The effects of pretreatment of mice with some drugs which modify GABAergic neurotransmission on the convulsions and cerebellar cyclic nucelotide level changes induced by the subsequent intracerebroventricular administration of 4-isopropyl-2,6,7-trioxa-1-phosphabicyclo(2,2,2)octane-1-oxide (IPTBO) have been studied. Mu...

journal_title：Neurochemistry international

authors： Blenkinsop IS,Coult DB,Davies WE,Howells DJ

更新日期：1984-01-01 00:00:00