Neuroprotection with the proteasome inhibitor MLN519 in focal ischemic brain injury: relation to nuclear factor kappaB (NF-kappaB), inflammatory gene expression, and leukocyte infiltration.

Abstract:

:The ubiquitin proteasome system (UPS) is a major cellular protein degradation pathway that involves the modulation of key proteins controlling inflammation, cell cycle regulation and gene expression. Modulation of the UPS with proteasome inhibitors has indicated efficacy in the treatment of several disease states including cancer and neuro-inflammatory disorders. In particular, a series of recent reports have evaluated the pre-clinical efficacy of the proteasome inhibitor MLN519 for the treatment of focal ischemic/reperfusion brain injury in rats. Evidence from these studies indicate that the neuroprotection provided by MLN519 is related to an anti-inflammatory effect linked to the modulation of nuclear factor kappaB (NF-kappaB) activity, attenuation of cytokine (TNF-alpha, IL-1beta, and IL-6) and cellular adhesion molecule (ICAM-1 and E-selectin) expression, and reduction of neutrophil and macrophage infiltration into the injured rat brain. It is the aim of this paper to review the experimental neuroprotection data reported using MLN519 with a focus on the molecular and cellular mechanisms of anti-inflammatory action.

journal_name

Neurochem Int

authors

Williams AJ,Dave JR,Tortella FC

doi

10.1016/j.neuint.2006.03.018

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

106-12

issue

2

eissn

0197-0186

issn

1872-9754

pii

S0197-0186(06)00160-4

journal_volume

49

pub_type

杂志文章,评审
  • Postmortem brain fatty acid profile of levodopa-treated Parkinson disease patients and parkinsonian monkeys.

    abstract::Fatty acids play a critical role in brain function but their specific role in the pathophysiology of Parkinson disease (PD) and levodopa-induced motor complications is still unknown. From a therapeutic standpoint, it is important to determine the relation between brain fatty acids and PD because the brain fatty acid c...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2005.12.002

    authors: Julien C,Berthiaume L,Hadj-Tahar A,Rajput AH,Bédard PJ,Di Paolo T,Julien P,Calon F

    更新日期:2006-04-01 00:00:00

  • Two-dimensional gel analysis of secreted proteins induced by interleukin-1 beta in rat astrocytes.

    abstract::Interleukin-1 beta (IL-1 beta) is a pro-inflammatory cytokine produced in the brain by endogenous microglial cells responding to injury. Levels of IL-1 beta are elevated in several neurodegenerative disorders, including Alzheimer's disease. IL-1 beta, which can act as a mitogen for astrocytes, also elicits the express...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/s0197-0186(01)00042-0

    authors: Chang JW,Young DA,Coleman PD,O'Banion MK

    更新日期:2001-11-01 00:00:00

  • Alternative splicing regulation of APP exon 7 by RBFox proteins.

    abstract::RBFox proteins are well-known alternative splicing regulators. We have shown previously that during neuronal differentiation of P19 cells induced by all-trans retinoic acid and cell aggregation, RBFox1 shows markedly increased temporal expression. To find its key splicing regulation, we examined the effect of RBFox1 o...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2014.08.001

    authors: Alam S,Suzuki H,Tsukahara T

    更新日期:2014-12-01 00:00:00

  • Glutamate transporter GLAST/EAAT1 directs cell surface expression of FXYD2/gamma subunit of Na, K-ATPase in human fetal astrocytes.

    abstract::Na+-dependent uptake of excitatory neurotransmitter glutamate in astrocytes increases cell energy demands primarily due to the elevated ATP consumption by glutamine synthetase and Na+, K+-ATPase. The major pool of GLAST/EAAT1, the only glutamate transporter subtype expressed by human fetal astrocytes in undifferentiat...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2006.12.015

    authors: Gegelashvili M,Rodriguez-Kern A,Sung L,Shimamoto K,Gegelashvili G

    更新日期:2007-06-01 00:00:00

  • Modification of GABA and calcium uptake by lipids in synaptosomes from normoxic and ischemic brain.

    abstract::The effects of membrane lipid disturbances induced by ischemia and exogenously added lipids on the uptake of GABA and Ca(2+) were investigated in gerbil brain synaptosomes. Ischemia was produced by bilateral ligation of common carotid arteries in Mongolian gerbil for 10 min. The level of the free fatty acids (FFA) inc...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(86)90101-4

    authors: Noremberg K,Strosznajder J

    更新日期:1986-01-01 00:00:00

  • Effects of lithium, alone or associated with pilocarpine, on muscarinic and dopaminergic receptors and on phosphoinositide metabolism in rat hippocampus and striatum.

    abstract::The mechanism of action of lithium (Li) alone or with pilocarpine (Pilo), focusing on muscarinic and dopaminergic systems and also on phosphoinositide metabolism was studied. Li (3 mEq/kg) administered to rats once (1 d) or daily for 7 days (7 d), 24 h before Pilo (15 mg/kg), exacerbated cholinergic signs, leading to ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/s0197-0186(98)00028-x

    authors: Marinho MM,de Sousa FC,de Bruin VM,Vale MR,Viana GS

    更新日期:1998-10-01 00:00:00

  • Gliotoxin induces Mg2+ efflux from intact brain mitochondria.

    abstract::Gliotoxin (GT) is a hydrophobic fungal metabolite of the epipolythiodioxopiperazine group which reacts with membrane thiols. When added to a suspension of energized brain mitochondria, it induces matrix swelling of low amplitude, collapse of membrane potential (DeltaPsi), and efflux of endogenous cations such as Ca2+ ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2004.01.001

    authors: Salvi M,Bozac A,Toninello A

    更新日期:2004-10-01 00:00:00

  • Peripheral iron dextran induced degeneration of dopaminergic neurons in rat substantia nigra.

    abstract::Iron accumulation is considered to be involved in the pathogenesis of Parkinson's disease. To demonstrate the relationship between peripheral iron overload and dopaminergic neuron loss in rat substantia nigra (SN), in the present study we used fast cyclic voltammetry, tyrosine hydroxylase (TH) immunohistochemistry, Pe...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2007.03.006

    authors: Jiang H,Song N,Wang J,Ren LY,Xie JX

    更新日期:2007-07-01 00:00:00

  • Topographic associations between DNA fragmentation and Alzheimer's disease neuropathology in the hippocampus.

    abstract::To identify whether the process of apoptosis bears a topographic relationship to selected aspects of Alzheimer's disease (AD) pathology, we used an in situ nick translation method (TUNEL) to map DNA fragmentation in hippocampal sections immunostained for abnormally phosphorylated tau, which exists in the neurofibrilla...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/s0197-0186(96)00158-1

    authors: Sugaya K,Reeves M,McKinney M

    更新日期:1997-08-01 00:00:00

  • Peripheral oxytocin treatment modulates central dopamine transmission in the mouse limbic structures.

    abstract::The effects of subcutaneous (s.c.) oxytocin treatment have been investigated on various parameters of dopaminergic neurotransmission in basal forebrain structures (nucleus olfactorius posterior + nucleus accumbens + septum) of the mouse. Acute oxytocin treatment failed to influence dopamine utilization in the basal fo...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(86)90138-5

    authors: Kovács GL,Faludi M,Falkay G,Telegdy G

    更新日期:1986-01-01 00:00:00

  • An hypothesis for a vitamin A cycle in the pigment epithelium of bovine retina.

    abstract::Several metabolic transformations of vitamin A have now been found in the pigment epithelium of cattle retina, leading to the hypothesis that there may be a vitamin A cycle in these cells. A retinol binding protein of MW ? 17,000 in pigment epithelial cytosol has been identified independently in several laboratories. ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(80)90055-8

    authors: Berman ER,Segal N,Schneider A,Feeney L

    更新日期:1980-01-01 00:00:00

  • Resveratrol preconditioning modulates inflammatory response in the rat hippocampus following global cerebral ischemia.

    abstract::Considerable evidence has been accumulated to suggests that blocking the inflammatory reaction promotes neuroprotection and shows therapeutic potential for clinical treatment of ischemic brain injury. Consequently, anti-inflammatory therapies are being explored for prevention and treatment of these diseases. Induction...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2012.06.009

    authors: Simão F,Matté A,Pagnussat AS,Netto CA,Salbego CG

    更新日期:2012-10-01 00:00:00

  • Lipoprotein-associated lysolipids are differentially involved in high-density lipoprotein- and its oxidized form-induced neurite remodeling in PC12 cells.

    abstract::Oxidatively damaged proteins and lipid peroxidation products have been shown to accumulate in the brain of neurodegenerative diseases, such as Alzheimer's disease and multiple sclerosis, and oxidized lipoprotein is considered to be toxic and neurodegenerative. However, the role of lipoprotein and its oxidized form in ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2014.02.005

    authors: Sato K,Tobo M,Mogi C,Murata N,Kotake M,Kuwabara A,Im DS,Okajima F

    更新日期:2014-03-01 00:00:00

  • Molecular mechanism of biological action of the serotonergic neurotoxin 5,7-dihydroxytryptamine.

    abstract::5,7-Dihydroxytryptamine (5,7-DHT) is a selective serotonergic neurotoxin by virtue of its selective uptake into 5-hydroxytryptamine neurons and its ability to undergo autoxidation. The mechanism by which 5,7-DHT induces neurodegenerative effects remains enigmatic. The mechanism of autoxidation of 5,7-DHT, which has be...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(88)90165-9

    authors: Sinhababu AK,Borchardt RT

    更新日期:1988-01-01 00:00:00

  • Antidepressants attenuate the dexamethasone-induced decrease in viability and proliferation of human neuroblastoma SH-SY5Y cells: a involvement of extracellular regulated kinase (ERK1/2).

    abstract::Excessive glucocorticoid levels in depressed patients have been associated with atrophic changes in some brain regions, but only few studies suggest that some antidepressants can interfere with deleterious effect of glucocorticoids on neuronal cells. The aim of the present study was to examine the effect of dexamethas...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2013.07.007

    authors: Leskiewicz M,Jantas D,Regulska M,Kaczanowska J,Basta-Kaim A,Budziszewska B,Kubera M,Lason W

    更新日期:2013-11-01 00:00:00

  • MicroRNAs in cancer: glioblastoma and glioblastoma cancer stem cells.

    abstract::MicroRNAs represent an abundant class of endogenously expressed 18-25 nucleotide non-coding RNA molecules that function to silence gene expression through a process of post-transcriptional modification. They exhibit varied and widespread functions during normal development and tissue homeostasis, and accordingly their...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuint.2014.06.002

    authors: Brower JV,Clark PA,Lyon W,Kuo JS

    更新日期:2014-11-01 00:00:00

  • The GABA(a) receptor complex in the developing chick optic tectum: Ontogeny of [(3)H]muscimol, [(3)H]flunitrazepam and [(35)S]TBPS binding sites.

    abstract::The developmental profiles of the neurotransmitter recognition site, labeled by [(3)H]muscimol, and of the two main modulatory sites, labeled by [(3)H]flunitrazepam and [ (35)S ]t- butylbicyclophosphorothionate , respectively, within the GABA(A) receptor complex, have been determined in chick tectal lobes between embr...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(87)90032-5

    authors: Batuecas A,Cubero A,Barat A,Ramírez G

    更新日期:1987-01-01 00:00:00

  • Tetrahydrocurcumin epigenetically mitigates mitochondrial dysfunction in brain vasculature during ischemic stroke.

    abstract::The objectives of this study are to identify the mechanism of mitochondrial dysfunction during cerebral ischemic/reperfusion (I/R) injury and the therapeutic potential of tetrahydrocurcumin (THC) to mitigate mitochondrial dysfunction in experimental stroke model. In our study, 8-10 weeks old male C57BL/6 wild-type mic...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2018.11.015

    authors: Mondal NK,Behera J,Kelly KE,George AK,Tyagi PK,Tyagi N

    更新日期:2019-01-01 00:00:00

  • Role of C-terminal region in the functional regulation of rat serotonin transporter (SERT).

    abstract::Previously, we revealed that the state of the actin cytoskeleton affects the uptake activity of the serotonin transporter (SERT). Recently, it was reported that the C-terminus of SERT interacts with MacMARCKS, a substrate of PKC that can bind to the actin cytoskeleton. To elucidate the importance of the C-terminal reg...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2004.08.008

    authors: Mochizuki H,Amano T,Seki T,Matsubayashi H,Mitsuhata C,Morita K,Kitayama S,Dohi T,Mishima HK,Sakai N

    更新日期:2005-01-01 00:00:00

  • Expression and localisation of brain-type organic cation transporter (BOCT/24p3R/LCN2R) in the normal rat hippocampus and after kainate-induced excitotoxicity.

    abstract::The iron siderophore binding protein lipocalin 2 (LCN2, also known as 24p3, NGAL and siderocalin) may be involved in iron homeostasis, but to date, little is known about expression of its putative receptor, brain-type organic cation transporter (BOCT, also known as BOCT1, 24p3R, NGALR and LCN2R), in the brain during n...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2015.04.009

    authors: Chia WJ,Tan FC,Ong WY,Dawe GS

    更新日期:2015-08-01 00:00:00

  • Ubiquitin dimers control the hydrolase activity of UCH-L3.

    abstract::Ubiquitin (Ub) carboxy terminal hydrolase (UCH)-L1 and UCH-L3 are two of the deubiquitinating enzymes expressed in the brain. Both gad mice, which lack UCH-L1 expression and Uchl3 knockout mice exhibit neurodegeneration, although at distinct areas. These phenotypes indicate the importance of UCH-L1 and UCH-L3 in the r...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2008.12.013

    authors: Setsuie R,Sakurai M,Sakaguchi Y,Wada K

    更新日期:2009-05-01 00:00:00

  • Inhibition of chick brain cholesterogenic enzymes by phenyl and phenolic derivatives of phenylalanine.

    abstract::Phenylalanine and its phenyl metabolites produced a clear inhibition of chick brain mevalonate 5-pyrophosphate decarboxylase, while mevalonate kinase and mevalonate 5-phosphate kinase were not significantly affected. Phenolic derivatives produced a similar or higher inhibition than that found in the presence of phenyl...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(91)90182-d

    authors: Castillo M,Iglesias J,Zafra MF,Garcia-Peregrin E

    更新日期:1991-01-01 00:00:00

  • Depolarization-induced changes of free intracellular Ca(2+) concentration and of [(3)H]dopamine release in undifferentiated and differentiated PC12 cells.

    abstract::The rat pheochromocytoma cell line PC12 undergoes morphological differentiation into neurone-like cells when exposed to nerve growth factor (NGF). We found that in PC12 cells the enzymatic activity of choline-acetyltransferase and of tyrosine hydroxylase changed very little during NGF exposure, while tyrosine hydroxyl...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(90)90142-g

    authors: Reber BF,Porzig H,Becker C,Reuter H

    更新日期:1990-01-01 00:00:00

  • 1-methylnicotinamide (MNA) in prevention of diabetes-associated brain disorders.

    abstract::The present study has been designed to establish the potential benefits from 1-methylnicotinamide (MNA) treatment on brain disorders associated with type 1 diabetes. All experiments were carried out after 6 weeks of streptozotocin-induced diabetes (60 mg/kg of body weight, i.p.) in male Wistar rats treated for 5 weeks...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2009.10.004

    authors: Kuchmerovska T,Shymanskyy I,Chlopicki S,Klimenko A

    更新日期:2010-01-01 00:00:00

  • A personal view from a long-lasting collaborator on the research strategies of Marshall Nirenberg.

    abstract::In this review, I summarized transition in Dr. Marshall Nirenberg's research interests during 1970s, from a view of a long-lasting collaborator. Nirenberg switched his research filed to neurobiology after his success in deciphering genetic code and being honored with the Nobel Prize in Physiology or Medicine in 1968. ...

    journal_title:Neurochemistry international

    pub_type: 传,历史文章,杂志文章

    doi:10.1016/j.neuint.2012.02.030

    authors: Higashida H

    更新日期:2012-11-01 00:00:00

  • Partial purification of ?-glycerotoxin, a presynaptic neurotoxin from the venom glands of the polychaete annelid glycera convoluta.

    abstract::The venom secreted from glands appended to the jaws of Glycera convoluta, a Polychaete Annelid, increases the spontaneous quantal release of transmitter from nerve terminals. The component that is biologically active on vertebrate cholinergic nerve terminals has recently been shown to be a high molecular weight protei...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/0197-0186(85)90009-9

    authors: Bon C,Saliou B,Thieffry M,Manaranche R

    更新日期:1985-01-01 00:00:00

  • Glutaminase activity in GLS1 Het mouse brain compared to putative pharmacological inhibition by ebselen using ex vivo MRS.

    abstract::Glutaminase mediates the recycling of neurotransmitter glutamate, supporting most excitatory neurotransmission in the mammalian central nervous system. A constitutive heterozygous reduction in GLS1 engenders in mice a model of schizophrenia resilience and associated increases in Gln, reductions in Glu and activity-dep...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2019.104508

    authors: Kosten L,Chowdhury GMI,Mingote S,Staelens S,Rothman DL,Behar KL,Rayport S

    更新日期:2019-10-01 00:00:00

  • Astrocytes and the delivery of glucose from plasma to neurons.

    abstract::Conventional kinetic models of brain glucose uptake and metabolism that visualize brain glucose as being in a single pool in equilibrium with plasma, are unable to account for some recently described experimental findings. These include microdialysis demonstrations of a brain extracellular fluid glucose concentration ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/0197-0186(95)00094-1

    authors: Forsyth RJ

    更新日期:1996-03-01 00:00:00

  • Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain.

    abstract::Monocarboxylate transporter (MCT1) levels in brains of adult Long-Evans rats on a high-fat (ketogenic) diet were investigated using light and electron microscopic immunocytochemical methods. Rats given the ketogenic diet (91% fat and 9% protein) for up to 6 weeks had increased levels of the monocarboxylate transporter...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/s0197-0186(00)00102-9

    authors: Leino RL,Gerhart DZ,Duelli R,Enerson BE,Drewes LR

    更新日期:2001-05-01 00:00:00

  • Distinct regulation of insulin receptor substrate-1 and -2 by 90-kDa heat-shock protein in adrenal chromaffin cells.

    abstract::Multiple signaling pathways via insulin receptor substrate-1 and -2 play crucial roles in health, diseases, and therapeutics (i.e., longevity, tumorigenesis, and neuroprotection). The 90-kDa heat-shock protein (Hsp90) is an emerging target molecule of therapeutics, Hsp90 inhibitors being promising against various dise...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2009.08.013

    authors: Yoshikawa N,Nemoto T,Satoh S,Maruta T,Yanagita T,Chosa E,Wada A

    更新日期:2010-01-01 00:00:00