Abstract:
:A number of principles have long guided research into serotonin neurochemistry and some of them are presently reconsidered with a slightly different outlook. An increasing amount of experimental data does not always support these older axioms and as more empirical observations are made, some of these may require modification. For example, increases in 5-HT produced by injections of l-tryptophan do not necessarily indicate that tryptophan hydroxylase is less than saturated with its substrate in vivo; injections of l-tryptophan increase 5-HT and its turnover but do not appear to increase its release; 5-HT release can apparently occur from the cytoplasm and need not involve exocytosis; presynaptic autoreceptors do not appear to modulate 5-HT release; and, 5-HIAA most accurately reflects monoamine oxidase activity, not release of 5-HT or activity of 5-HT neurons.
journal_name
Neurochem Intjournal_title
Neurochemistry internationalauthors
Kuhn DM,Wolf WA,Youdim MBdoi
10.1016/0197-0186(86)90157-9subject
Has Abstractpub_date
1986-01-01 00:00:00pages
141-54issue
2eissn
0197-0186issn
1872-9754pii
0197-0186(86)90157-9journal_volume
8pub_type
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