An insight into the vision impairment following traumatic brain injury.

abstract：:The effects of the peroxovanadium complex potassium bisperoxo(1,10-phenanthroline)-oxovanadate (bpV[phen]) have been studied on dopamine (DA) exocytosis in PC12 cells. Bisperoxo(1,10-phenanthroline)-oxovanadate does not elicit dopamine secretion in PC12 cells. However, treatment of PC12 cells with 30 microM bpV[phen] ...

journal_title：Neurochemistry international

authors： Bieger S,Morinville A,Maysinger D

更新日期：2002-04-01 00:00:00

abstract：:The function of PMP70, one of the four ABC half-transporters of mammalian peroxisomes, encoded by ABCD3 gene, is still unclear. The finding that PMP70 over-expression partially corrected very long-chain fatty acid oxidation defects in fibroblasts of X-linked adrenoleukodystrophy patients, has unveiled its potential cl...

journal_title：Neurochemistry international

authors： Di Benedetto R,Denti MA,Salvati S,Sanchez M,Attorri L,David G,Di Biase A

更新日期：2008-05-01 00:00:00

abstract：:Inflammation which is an indispensable participant in tumor progression is intricately linked with redox modulation. The pro-inflammatory cytokine Tumor Necrosis Factor (TNFalpha) elevates reactive oxygen species (ROS) in glioblastoma multiforme (GBM). As both TNFalpha and oxidative stress independently play role in r...

journal_title：Neurochemistry international

authors： Ghosh S,Tewari R,Dixit D,Sen E

更新日期：2010-01-01 00:00:00

abstract：:Adenosine exerts two parallel modulatory roles in the CNS, acting as a homeostatic modulator and also as a neuromodulator at the synaptic level. We will present evidence to suggest that these two different modulatory roles are fulfilled by extracellular adenosine originated from different metabolic sources, and involv...

journal_title：Neurochemistry international

authors： Cunha RA

更新日期：2001-02-01 00:00:00

abstract：:The effects of the GABA agonist, muscimol on [(3)H]flunitrazepam binding were examined in cerebellum and hippocampus regions proposed to contain different populations of benzodiazepine binding site subtypes. Quantitative analysis was made of the contribution of different components of [(3)H]flunitrazepam binding by ut...

journal_title：Neurochemistry international

authors： Mitchell R,Wilson L

更新日期：1984-01-01 00:00:00

abstract：:Acetylcholinesterase release in the guinea-pig substantia nigra has been previously investigated 'on-line', using a sensitive chemiluminescent system. Since histological observations suggest that there is a difference in acetylcholinesterase distribution in the rat substantia nigra compared to that of the guinea-pig, ...

journal_title：Neurochemistry international

authors： Dally JJ,Schaefer M,Greenfield SA

更新日期：1996-12-01 00:00:00

abstract：:Arsenate is a toxic compound that has been connected with neuropathies and impaired cognitive functions. To test whether arsenate affects the viability and the GSH metabolism of brain astrocytes, we have used primary astrocyte cultures as model system. Incubation of astrocytes for 2h with arsenate in concentrations of...

journal_title：Neurochemistry international

authors： Meyer N,Koehler Y,Tulpule K,Dringen R

更新日期：2013-06-01 00:00:00

abstract：:AMPA receptors are fast ligand-gated members of glutamate receptors in neuronal and many types of non-neuronal cells. The heterotetramer complexes are assembled from four subunits (GluR1-4) in region-, development- and function-selective patterns. Each subunit contains three extracellular domains (a large amino termin...

journal_title：Neurochemistry international

authors： Szénási G,Vegh M,Szabo G,Kertesz S,Kapus G,Albert M,Greff Z,Ling I,Barkoczy J,Simig G,Spedding M,Harsing LG Jr

更新日期：2008-01-01 00:00:00

abstract：:The presence of corticotropin-releasing hormone (CRH) receptors has been previously demonstrated in corticotrophs from normal pituitaries using a method combining immunocytochemistry and liquid emulsion autoradiography. The aim of this study was to compare the characteristics of the 125I-Tyr0-hCRH binding in corticotr...

journal_title：Neurochemistry international

authors： Abs R,Smets G,Vauquelin G,Verhelst J,Mahler C,Verlooy J,Stevenaert A,Wouters L,Borgers M,Beckers A

更新日期：1997-03-01 00:00:00

abstract：:The amyloid precursor protein (APP) and presenilin-1 (PS-1) are not only of importance for the normal functioning of the various neurons, but also play central roles in the pathogenesis of Alzheimer's disease (AD). Through the use of immunohistochemical and Western blot techniques, the bidirectional axonal transport o...

journal_title：Neurochemistry international

authors： Papp H,Pakaski M,Kasa P

更新日期：2002-12-01 00:00:00

abstract：:Human glutamate dehydrogenase (GDH) gene was fused with a gene fragment encoding the nine amino acid (RKKRRQRRR) protein transduction domain of human immunodeficiency virus TAT protein in bacterial expression vector to produce genetic in-frame TAT-GDH fusion protein. The TAT-GDH protein can enter PC12 cells efficientl...

journal_title：Neurochemistry international

authors： Yoon HY,Lee SH,Cho SW,Lee JE,Yoon CS,Park J,Kim TU,Choi SY

更新日期：2002-07-01 00:00:00

abstract：:Precise anatomical distribution of 5HT1 binding sites has been investigated in the nuclei raphe dorsalis, raphe centralis and locus caeruleus of the rat brain. An original pattern of distribution was observed in the raphe nuclei, closely correlated to the already known distribution of 5HT containing elements. This pat...

journal_title：Neurochemistry international

authors： Weissmann-Nanopoulos D,Mach E,Magre J,Demassey Y,Pujol JF

更新日期：1985-01-01 00:00:00

abstract：:Recent studies suggest that the behavioral effects of chronic antidepressant treatment are mediated by stimulation of hippocampal neuronal plasticity and neurogenesis. The present study was designed to examine the effects of 3,6'-disinapoyl sucrose (DISS), a bioactive component of Polygala tenuifolia Willd, on the exp...

journal_title：Neurochemistry international

authors： Hu Y,Liao HB,Dai-Hong G,Liu P,Wang YY,Rahman K

更新日期：2010-02-01 00:00:00

abstract：:A pre-requisite to understanding the physiological mechanisms of action of melatonin is the identification of the target sites where the hormone acts. The radioligand 2-[125I]iodo-melatonin has been used extensively to localize binding sites in both the brain and peripheral tissues. In general these binding sites have...

journal_title：Neurochemistry international

authors： Morgan PJ,Barrett P,Howell HE,Helliwell R

更新日期：1994-02-01 00:00:00

abstract：:The immunostains of GD3, c-pathway polysialogangliosides and gangliotetraosylgangliosides belonging to the a- and b-pathways were analyzed in embryo optic lobe cells. Cells were cultured in serum free media with, and without, bovine brain ganglioside mixture (largely gangliotetraosylgangliosides). Control cells differ...

journal_title：Neurochemistry international

authors： Cossy-Isasi S,Panzetta P

更新日期：1994-04-01 00:00:00

abstract：:A biochemical study of the endogenous levels of serotonin (5-HT), noradrenaline (NA) and the activity of choline acetyltransferase (CAT) was carried out in the intestinal tract of the rat. High levels of 5-HT and NA were detected in the caecum and the colon. These anatomical regions also presented the highest activity...

journal_title：Neurochemistry international

authors： Legay C,Faudon M,Ternaux JP

更新日期：1983-01-01 00:00:00

abstract：:Diabetic neuropathic pain (DNP) plays a major role in decreased life quality of diabetes patients, however, the neural mechanisms underlying DNP remain unclear. Endomorphins are the endogenous ligands for mu-opioid receptor. There is increasing evidence implicating the involvement of spinal endomorphin-2 (EM2) in neur...

journal_title：Neurochemistry international

authors： Niu L,Dai GH,He GL,Yang M,Hu HM,Liu ZK,Qian NS,Chen YL

更新日期：2017-09-01 00:00:00

abstract：:An endogenous modulator(s) of the dopamine receptor(s) in bovine and rat brain striatum was detected by demonstrating that water extracts of the striatum inhibited [(3)H]apomorphine binding. This modulator(s) was partially purified by methanol extraction and then successive ion exchange chromatographies on SP-Sephadex...

journal_title：Neurochemistry international

authors： Hirata A,Yamada I,Fujita N,Saito K,Nakahiro M,Yoshida H

更新日期：1986-01-01 00:00:00

abstract：:Esters of dimethylcarbamic acid are known to be poor substrates of acetylcholinesterase. They carbamylate the active catalytic site of the enzyme and the subsequent decarbamylation is a slow but measurable process. Similarly, acetylcholinesterase can be phosphonylated, and the dephosphonylation is extremely slow. Rapi...

journal_title：Neurochemistry international

authors： Dawson RM,Poretski M,Upsher CM

更新日期：1981-01-01 00:00:00

abstract：:Variants in the gene encoding the enzyme glutamic acid decarboxylase like 1 (GADL1) have been associated with response to lithium therapy. Both GADL1 and the related enzyme cysteine sulfinic acid decarboxylase (CSAD) have been proposed to be involved in the pyridoxal-5'-phosphate (PLP)-dependent biosynthesis of taurin...

journal_title：Neurochemistry international

authors： Winge I,Teigen K,Fossbakk A,Mahootchi E,Kleppe R,Sköldberg F,Kämpe O,Haavik J

更新日期：2015-11-01 00:00:00

abstract：:Excitotoxicity is the main event during neurological disorders producing drastic morphological and functional changes. Rac-GTPase is involved in cytoskeletal remodeling and survival. However, the role of Rac1 after cerebral ischemia has not been completely understood yet. In this study, we evaluated the activity of Ra...

journal_title：Neurochemistry international

authors： Johanna GV,Fredy CA,David VC,Natalia MV,Angel CR,Patricia CG

更新日期：2010-12-01 00:00:00

abstract：:Interactions between endothelin-1 (ET)-induced phosphoinositide (PI) hydrolysis and agents that increase Ca2+ influx (i.e. A23187 and ionomycin) or induce depolarization (i.e. KCl) were investigated using C6 glioma. A23187 dose-dependently potentiated ET (30 nM)- and ATP (100 microM)-induced [3H]inositol phosphate (IP...

journal_title：Neurochemistry international

authors： Lin WW,Chuang DM

更新日期：1992-09-01 00:00:00

abstract：:D1 dopamine receptors have been localized using a radioactive form of a new specific antagonist, [3H]SCH39166. This compound has been shown, in in vitro binding studies, to be highly selective for the D1 receptor subtype; more so than its predecessor, [3H]SCH23390. These ligand binds saturably, reversibly and with hig...

journal_title：Neurochemistry international

authors： Wamsley JK,Alburges ME,McQuade RD,Hunt M

更新日期：1992-03-01 00:00:00

abstract：:Pyrrolidinedithiocarbamate (PDTC) is a compound displaying antioxidant, pro-oxidant and metal chelator properties in different cell types. It has been described that PDTC may exert either anti-apoptotic or apoptotic activity. Moreover it is known that this agent regulates the activity of redox-sensitive transcription ...

journal_title：Neurochemistry international

authors： Porcile C,Stanzione S,Piccioli P,Bajetto A,Barbero S,Bisaglia M,Bonavia R,Florio T,Schettini G

更新日期：2003-07-01 00:00:00

abstract：:To identify whether the process of apoptosis bears a topographic relationship to selected aspects of Alzheimer's disease (AD) pathology, we used an in situ nick translation method (TUNEL) to map DNA fragmentation in hippocampal sections immunostained for abnormally phosphorylated tau, which exists in the neurofibrilla...

journal_title：Neurochemistry international

authors： Sugaya K,Reeves M,McKinney M

更新日期：1997-08-01 00:00:00

abstract：:Radial glial cells play a significant role in the repair of spinal cord injuries as they exert critical role in the neurogenesis and act as a scaffold for neuronal migration. Our previous study showed that mature astrocytes of spinal cord can undergo a de-differentiation process and further transform into pluripotenti...

journal_title：Neurochemistry international

authors： Yang H,Ling W,Vitale A,Olivera C,Min Y,You S

更新日期：2011-12-01 00:00:00

abstract：:Recent in vitro studies have revealed that benzodiazepines, opiates, barbiturates and ethanol might influence GABA binding to CNS membrane sites. Further studies of such interactions might be helpful for explaining both the mechanisms of action of these psychoactive agents and the tolerance/dependence that might resul...

journal_title：Neurochemistry international

authors： Defeudis FV

更新日期：1983-01-01 00:00:00

abstract：:MicroRNAs represent an abundant class of endogenously expressed 18-25 nucleotide non-coding RNA molecules that function to silence gene expression through a process of post-transcriptional modification. They exhibit varied and widespread functions during normal development and tissue homeostasis, and accordingly their...

journal_title：Neurochemistry international

authors： Brower JV,Clark PA,Lyon W,Kuo JS

更新日期：2014-11-01 00:00:00

abstract：:The system of GABA transporters in neural cells constitutes an efficient mechanism for terminating inhibitory GABAergic neurotransmission. As such these transporter are important therapeutical targets in epilepsy and potentially other neurological diseases related to the GABA system. In this study a number of analogs ...

journal_title：Neurochemistry international

authors： Sarup A,Larsson OM,Bolvig T,Frølund B,Krogsgaard-Larsen P,Schousboe A

更新日期：2003-09-01 00:00:00

abstract：:Aminoethylcysteine ketimine is a sulfur-containing cyclic compound produced by the enzymatic alpha-deamination of the parent aminoethylcysteine that has been detected in bovine brain and cerebellum. Aminoethylcysteine ketimine is known to dimerize spontaneously and easily lose one carboxyl group. This decarboxylated c...

journal_title：Neurochemistry international

authors： Matarese RM,Macone A,Crescentini G,Duprè S,Cavallini D

更新日期：1998-04-01 00:00:00