Bisperoxovanadium complex promotes dopamine exocytosis in PC12 cells.

abstract：:The effect of GM(1) administration upon the time course of the postlesion changes of [(3)H]5hydroxytryptamine uptake in the partially denervated rat hippocampus has been studied 6, 21, 42 and 90 days after surgery. At 6 and 21 days after operation the postlesion decrease of [(3)H]5-hydroxytryptamine uptake was counter...

journal_title：Neurochemistry international

authors： Kiedrowski L,Gra Dkowska M,Oderfeld-Nowak B

更新日期：1987-01-01 00:00:00

abstract：:Bindings of glutamate receptor agonists and related modulators were investigated in 10 discrete tissues from gerbil brain using a biochemical technique. There appeared considerable discrepancies, in respect of intrahippocampal profiles, from reported data by autoradiography on rat brain. In the gerbil, an almost equiv...

journal_title：Neurochemistry international

authors： Kataoka K,Mitani A,Andou Y,Enomoto R,Ogita K,Yoneda Y

更新日期：1993-01-01 00:00:00

abstract：:It has been reported that mutations of gammaPKC cause hereditary spinocerebellar atrophy type 14 (SCA14). Our recent study has revealed that the SCA14 mutant gammaPKC is susceptible to aggregation and causes cell death. Among mutations/polymorphisms of gammaPKC, the R659S mutation was firstly segregated from families ...

journal_title：Neurochemistry international

authors： Mochizuki H,Seki T,Adachi N,Saito N,Mishima HK,Sakai N

更新日期：2006-12-01 00:00:00

abstract：:Synaptic degeneration is one of the earliest hallmarks of Alzheimer disease (AD) and results in loss of cognitive function. One of the causative agents for the synaptic degeneration is the amyloid β-peptide (Aβ), which is formed from its precursor protein by two sequential cleavages mediated by β- and γ-secretase. We ...

journal_title：Neurochemistry international

authors： Frykman S,Teranishi Y,Hur JY,Sandebring A,Yamamoto NG,Ancarcrona M,Nishimura T,Winblad B,Bogdanovic N,Schedin-Weiss S,Kihara T,Tjernberg LO

更新日期：2012-07-01 00:00:00

abstract：:Homozygous deletion or mutation in the survival motor neuron (SMN)1 gene causes proximal spinal muscular atrophy (SMA), whereas SMN2 acts as a modifying gene that can influence the severity of SMA. It has been suggested that restoration of the SMN protein level in neuronal cells may prevent cell loss and may be helpfu...

journal_title：Neurochemistry international

authors： Chang HC,Hung WC,Chuang YJ,Jong YJ

更新日期：2004-12-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder mostly affecting the aging population over sixty. Cardinal symptoms including, tremors, muscle rigidity, drooping posture, drooling, walking difficulty, and autonomic symptoms appear when a significant number of nigrostriatal dopaminergic ne...

journal_title：Neurochemistry international

authors： Sharma S,Moon CS,Khogali A,Haidous A,Chabenne A,Ojo C,Jelebinkov M,Kurdi Y,Ebadi M

更新日期：2013-09-01 00:00:00

abstract：:Deficiency of 5-methyltetrahydrofolate (5-MTHF) in cerebrospinal fluid (CSF) is associated with a number of neurometabolic conditions including mitochondrial electron transport chain defects. Whilst failure of the active transport of 5-methyltetrahydrofolate (5-MTHF) into the CSF compartment has been proposed as a pot...

journal_title：Neurochemistry international

authors： Aylett SB,Neergheen V,Hargreaves IP,Eaton S,Land JM,Rahman S,Heales SJ

更新日期：2013-12-01 00:00:00

abstract：:The effects of the GABA agonist, muscimol on [(3)H]flunitrazepam binding were examined in cerebellum and hippocampus regions proposed to contain different populations of benzodiazepine binding site subtypes. Quantitative analysis was made of the contribution of different components of [(3)H]flunitrazepam binding by ut...

journal_title：Neurochemistry international

authors： Mitchell R,Wilson L

更新日期：1984-01-01 00:00:00

abstract：:Neurons differentiated in vitro from embryonic stem cells (ESCs) have the potential to serve both as models of disease states and in drug discovery programs. In this study, we use sonic hedgehog (SHH) and fibroblast growth factor 8 (FGF-8) to enrich for forebrain and midbrain phenotypes from mouse ESCs. We then invest...

journal_title：Neurochemistry international

authors： Khaira SK,Nefzger CM,Beh SJ,Pouton CW,Haynes JM

更新日期：2011-09-01 00:00:00

abstract：:Five glutamate transporter genes have been identified; two of these (EAAT3 and EAAT4) are expressed in neurons and are predominantly confined to the membranes of cell bodies and dendrites. At an ultrastructural level, glutamate transporters have been shown to surround excitatory synapses in hippocampus and cerebellum ...

journal_title：Neurochemistry international

authors： Otis TS,Brasnjo G,Dzubay JA,Pratap M

更新日期：2004-09-01 00:00:00

abstract：:The coenzyme functions of the B vitamins in intermediatry metabolism are well established; nevertheless, for none of them is it possible to determine precisely the connection between the biochemical lesions associated with deficiency and the neurological consequences. Although there is convincing evidence of a neurosp...

journal_title：Neurochemistry international

authors： Bender DA

更新日期：1984-01-01 00:00:00

abstract：:Neuroblastoma cells, cultivated on plastic dishes, in presence of 15 mM glucose resist very well to hypoxia. Cells incubated on plastic dishes, if left unshaken, showed a Pasteur effect at an oxygen concentration below 10%. Oxygen diffusion was the limiting factor in these plastic dishes since improved oxygen diffusio...

journal_title：Neurochemistry international

authors： Pauwels PJ,Opperdoes FR,Trouet A

更新日期：1984-01-01 00:00:00

abstract：:For elucidation of thyroid hormone-induced responsiveness of fish brain, various doses (0.012, 0.025, 0.05, 0.1, 0.25, 0.5, 1, 2 and 4 ?g/g) of triiodothyronine (T(3)) were injected in Singi fish, Heteropneustes fossilis (Bloch), for 3 consecutive days and the changes in cytosolic NADP-dependent malic enzyme (ME, EC 1...

journal_title：Neurochemistry international

authors： Srabani De AK,Ray DA,Medda AK

更新日期：1989-01-01 00:00:00

abstract：:Phosphine-borane complexes are novel cell-permeable drugs that protect neurons from axonal injury in vitro and in vivo. These drugs activate the extracellular signal-regulated kinases 1/2 (ERK1/2) cell survival pathway and are therefore neuroprotective, but do not scavenge superoxide. In order to understand the intera...

journal_title：Neurochemistry international

authors： Niemuth NJ,Thompson AF,Crowe ME,Lieven CJ,Levin LA

更新日期：2016-10-01 00:00:00

abstract：:The Xenopus oocyte expression and recording system has allowed a detailed analysis of the physiology and pharmacology of neuronal ion channels including their sensitivity to ethanol. It is important however, to ascertain the effects of a particular drug on the channels inherently expressed by oocytes to ensure that dr...

journal_title：Neurochemistry international

authors： Clayton R,Woodward JJ

更新日期：2000-01-01 00:00:00

abstract：:The effects of pretreatment of mice with some drugs which modify GABAergic neurotransmission on the convulsions and cerebellar cyclic nucelotide level changes induced by the subsequent intracerebroventricular administration of 4-isopropyl-2,6,7-trioxa-1-phosphabicyclo(2,2,2)octane-1-oxide (IPTBO) have been studied. Mu...

journal_title：Neurochemistry international

authors： Blenkinsop IS,Coult DB,Davies WE,Howells DJ

更新日期：1984-01-01 00:00:00

abstract：:25INBOMe ("25-I", "N-Bomb"), one of new psychoactive substances (NPSs), is being abused for recreational purpose. However, the liability for abuse or dependence has not been systematically studied yet. The objective of the present study was to evaluate rewarding and reinforcing effects of 25INBOMe using conditioned pl...

journal_title：Neurochemistry international

authors： Jeon SY,Kim YH,Kim SJ,Suh SK,Cha HJ

更新日期：2019-05-01 00:00:00

abstract：:Age is the leading risk factor for many of the most prevalent and devastating diseases including neurodegenerative diseases. A number of herbal medicines have been used for centuries to ameliorate the deleterious effects of ageing-related diseases and increase longevity. Oxidative stress is believed to play a role in ...

journal_title：Neurochemistry international

authors： Steele ML,Truong J,Govindaraghavan S,Ooi L,Sucher NJ,Münch G

更新日期：2013-04-01 00:00:00

abstract：:The disposition of labelled [3H]GM1lactone, the inner ester of ganglioside GM1, was studied in the rat. After i.v. administration [3H]GM1lactone was quickly converted to its corresponding open form most likely by plasma esterases, and then displayed a pharmacokinetic profile identical to [3H]GM1. Following intramuscul...

journal_title：Neurochemistry international

authors： Bellato P,Milan F,Facchinetti E,Toffano G

更新日期：1992-04-01 00:00:00

abstract：:The cholinergic nerve terminals of Torpedo electric organ are a rich source of a hydrophobic protein, the mediatophore, which endows artificial membranes with a calcium dependent mechanism that translocates acetylcholine. An antiserum raised against purified mediatophore permitted the identification of two different p...

journal_title：Neurochemistry international

authors： Morel N,Israel M,Synguelakis M,Le Gal la Salle G

更新日期：1989-01-01 00:00:00

abstract：:Alzheimer disease (AD) is the most common form of adult dementia. Its pathological hallmarks are synaptic degeneration, deposition of amyloid plaques and neurofibrillary tangles, leading to neuronal loss. A few hypotheses have been proposed to explain AD pathogenesis. The beta-amyloid (Abeta) and hyperphosphorylated t...

journal_title：Neurochemistry international

authors： Bojarski L,Herms J,Kuznicki J

更新日期：2008-03-01 00:00:00

abstract：:The phenylglycines 3-hydroxyphenylglycine, 4-carboxy-3-hydroxy-phenylglycine (4C3HPG), 4-carboxyphenylglycine (4CPG) and alpha-methyl-4-carboxyphenylglycine (MCPG) were evaluated as putative selective antagonists of metabotropic glutamate receptors on single neurones of the ventrobasal thalamus of rats, with a view to...

journal_title：Neurochemistry international

authors： Salt TE,Eaton SA

更新日期：1994-05-01 00:00:00

abstract：:Açai (Euterpe oleracea Mart.), a highly consumed fruit in Amazon, is from a common palm with remarkable antioxidant properties. Because oxidative stress and seizures are intimately linked, this study investigated the potential neuroprotective and anticonvulsant effects of commercial clarified açai juice (EO). EO did n...

journal_title：Neurochemistry international

authors： Souza-Monteiro JR,Hamoy M,Santana-Coelho D,Arrifano GP,Paraense RS,Costa-Malaquias A,Mendonça JR,da Silva RF,Monteiro WS,Rogez H,de Oliveira DL,do Nascimento JL,Crespo-López ME

更新日期：2015-11-01 00:00:00

abstract：:Although the cerebral cortical dopamine D(1) receptor is considered to play a role in normal and abnormal brain function, little information is available on its characteristics in human brain. We compared dopamine-stimulated adenylyl cyclase (AC) activity in homogenates of cerebral cortex (frontal, temporal, parietal,...

journal_title：Neurochemistry international

authors： Tong J,Ross BM,Sherwin AL,Kish SJ

更新日期：2001-08-01 00:00:00

abstract：:One- and two-dimensional electrophoresis patterns and distribution of major cytoskeletal proteins were studied in primary astrocytes with either flat-epitheloid or stellate appearance. No major differences in the electrophoretic patterns of actin, tubulin, glial fibrillary acidic protein (GFAP) and vimentin were detec...

journal_title：Neurochemistry international

authors： Ciesielski-Treska J,Ulrich G,Mensch C,Aunis D

更新日期：1984-01-01 00:00:00

abstract：:Ischemic neuronal injury is associated with several life- and vision-threatening diseases. Neuroprotection is essential in the treatment of these diseases. Here, we identified and characterized a novel peptide, FK18, from basic fibroblast growth factor (bFGF). We further assessed the neuroprotective effects of this pe...

journal_title：Neurochemistry international

authors： Xiong S,Xu Y,Ma M,Wang H,Wei F,Gu Q,Xu X

更新日期：2017-09-01 00:00:00

abstract：:Cytokines are a heterogenous group of polypeptide mediators that have been associated with activation of numerous functions, including the immune system and inflammatory responses. The cytokine families include, but are not limited to, interleukins (IL-I alpha, IL-I beta, ILIra and IL-2-IL-15), chemokines (IL-8/ NAP-I...

journal_title：Neurochemistry international

authors： Ebadi M,Bashir RM,Heidrick ML,Hamada FM,Refaey HE,Hamed A,Helal G,Baxi MD,Cerutis DR,Lassi NK

更新日期：1997-04-01 00:00:00

abstract：:Recently, a new experimental model of epilepsy was introduced by the authors [Neurochem. Int. 40 (2002) 413]. This model combines pentylenetetrazole (PTZ)-kindling in senescence-accelerated mice P8 (SAMP8), a genetic model of aging. Since imbalance of glutamate and GABA is a major cause of seizures, the study of glial...

journal_title：Neurochemistry international

authors： Kondziella D,Hammer J,Sletvold O,Sonnewald U

更新日期：2003-12-01 00:00:00

abstract：:Recent data indicate that BMY 7378 demonstrates high affinity, selectivity and low intrinsic activity at hippocampal 5-HT(1A) receptors, suggesting that BMY 7378 may represent the first selective 5-HT(1A) functional antagonist. The present study examined the agonist and antagonist properties of BMY 7378 at spinal cord...

journal_title：Neurochemistry international

authors： Zemlan FP,Zieleniewski-Murphy A,Maureen Murphy R,Behbehani MM

更新日期：1990-01-01 00:00:00

abstract：:Amyotrophic Lateral Sclerosis is a devastating neurological disease that is inevitably fatal after 3-5years duration. Treatment options are minimal and as such new therapeutic modalities are required. In this review, we discuss the role of the myostatin pathway as a modulator of skeletal muscle mass and therapeutic ap...

journal_title：Neurochemistry international

authors： Walsh FS,Rutkowski JL

更新日期：2012-11-01 00:00:00