Structural and dynamic perspectives on the promiscuous transport activity of P-glycoprotein.

abstract：:Choline acetyltransferase activity was detected in extensively washed membranes prepared from rat and guinea pig synaptosomes. When these preparations were treated with the non-ionic detergent Triton X-114 and heated to 37 degrees C to cause phase separation, a significant percentage was found to associate with the de...

journal_title：Neurochemistry international

authors： Docherty M,Bradford HF

更新日期：1988-01-01 00:00:00

abstract：:We showed that dextromethorphan (DM) provides neuroprotective/anticonvulsant effects and that DM and its major metabolite, dextrorphan, have a high-affinity for sigma(1) receptors, but a low affinity for sigma(2) receptors. In addition, we found that DM has a higher affinity than DX for sigma(1) sites, whereas DX has ...

journal_title：Neurochemistry international

authors： Shin EJ,Nah SY,Chae JS,Bing G,Shin SW,Yen TP,Baek IH,Kim WK,Maurice T,Nabeshima T,Kim HC

更新日期：2007-05-01 00:00:00

abstract：:Growing evidence suggests that α-lipoic acid (LA) has neuroprotective effects in various pathological conditions including brain ischemia and neurodegeneration. While anti-oxidative activity has been thought to play a central role in LA-mediated neuroprotection, the precise mechanism and the effect of LA enantiomers (...

journal_title：Neurochemistry international

authors： Yamada T,Hashida K,Takarada-Iemata M,Matsugo S,Hori O

更新日期：2011-12-01 00:00:00

abstract：:Vinpocetine (ethyl apovincaminate), a synthetic derivative of the Vinca minor alkaloid vincamine, is widely used for the treatment of cerebrovascular-related diseases. One of the proposed mechanisms underlying its action is to protect against the cytotoxic effects of glutamate overexposure. Glutamate excitotoxicity le...

journal_title：Neurochemistry international

authors： Tárnok K,Kiss E,Luiten PG,Nyakas C,Tihanyi K,Schlett K,Eisel UL

更新日期：2008-12-01 00:00:00

abstract：:Rat brain membranes were incubated with bee venom phospholipase A(2) (PLA(2)) or phospholipase C (PLC) from Clostridium perfringens. PLA(2) caused a significant increase in free polyunsaturated fatty acids concomitant with membrane phospholipid degradation as monitored by HPLC and by gas chromatography. Equal concentr...

journal_title：Neurochemistry international

authors： Chan PH,Chen S,Fishman RA

更新日期：1987-01-01 00:00:00

abstract：:Air pollution is an important contributor to the global burden of disease, particularly to respiratory and cardiovascular diseases. In recent years, evidence is accumulating that air pollution may adversely affect the nervous system as shown by human epidemiological studies and by animal models. Age appears to play a ...

journal_title：Neurochemistry international

authors： Costa LG,Cole TB,Dao K,Chang YC,Garrick JM

更新日期：2019-12-01 00:00:00

abstract：:Human glutamate dehydrogenase (GDH) gene was fused with a gene fragment encoding the nine amino acid (RKKRRQRRR) protein transduction domain of human immunodeficiency virus TAT protein in bacterial expression vector to produce genetic in-frame TAT-GDH fusion protein. The TAT-GDH protein can enter PC12 cells efficientl...

journal_title：Neurochemistry international

authors： Yoon HY,Lee SH,Cho SW,Lee JE,Yoon CS,Park J,Kim TU,Choi SY

更新日期：2002-07-01 00:00:00

abstract：:Repeated exposure to classical psychomotor stimulants, like amphetamine (AMPH), produces locomotor sensitization and accompanied structural plasticity of dendritic spines in the nucleus accumbens (NAcc). Following our previous report that repeated administration of methiopropamine (MPA), a structural analog to meth-AM...

journal_title：Neurochemistry international

authors： Cai WT,Yoon HS,Lee S,Kim JH

更新日期：2019-10-01 00:00:00

abstract：:Increased noradrenaline, induced by rapid eye movement (REM) sleep deprivation, stimulates Na-K ATPase activity in the rat brain. The brain contains neurons as well as glia and both possess Na-K ATPase, however, it was not known if REM sleep deprivation affects the enzyme in both types of cells identically. Rats were ...

journal_title：Neurochemistry international

authors： Baskey G,Singh A,Sharma R,Mallick BN

更新日期：2009-01-01 00:00:00

abstract：:Cytokines are a heterogenous group of polypeptide mediators that have been associated with activation of numerous functions, including the immune system and inflammatory responses. The cytokine families include, but are not limited to, interleukins (IL-I alpha, IL-I beta, ILIra and IL-2-IL-15), chemokines (IL-8/ NAP-I...

journal_title：Neurochemistry international

authors： Ebadi M,Bashir RM,Heidrick ML,Hamada FM,Refaey HE,Hamed A,Helal G,Baxi MD,Cerutis DR,Lassi NK

更新日期：1997-04-01 00:00:00

abstract：:Platelet-activating factor (PAF), a biologically active lipid (1-O-alkyl-2-acetyl-sn-glycero-3-phosphoholine), is identified in different regions of brain, including hippocampus. Specific PAF-activated receptors (PAFRs) are expressed in corresponding brain areas. PAF has been proposed to be a retrograde messenger of l...

journal_title：Neurochemistry international

authors： Kondratskaya EL,Pankratov YV,Lalo UV,Chatterjee SS,Krishtal OA

更新日期：2004-02-01 00:00:00

abstract：:The amyloid precursor protein (APP) and presenilin-1 (PS-1) are not only of importance for the normal functioning of the various neurons, but also play central roles in the pathogenesis of Alzheimer's disease (AD). Through the use of immunohistochemical and Western blot techniques, the bidirectional axonal transport o...

journal_title：Neurochemistry international

authors： Papp H,Pakaski M,Kasa P

更新日期：2002-12-01 00:00:00

abstract：:Alteration in the lysosomal system (LS) may represent a central mechanism in neurodegeneration. 6-Hydroxydopamine (6-OHDA) induces oxidative stress and cell death in catecholaminergic cells. The LS and caspases participate in apoptosis, although the mechanism(s) that is involved is not completely understood. Here, we ...

journal_title：Neurochemistry international

authors： Lee DC,Womble TA,Mason CW,Jackson IM,Lamango NS,Severs WB,Palm DE

更新日期：2007-03-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor is a subtype of ionotropic glutamate receptor that is involved in synaptic mechanisms of learning and memory, and mediates excitotoxic neuronal injury. In this study, we tested the hypothesis that NMDA receptor subunit gene expression is altered in cortex and hippocampus of OKA...

journal_title：Neurochemistry international

authors： Kamat PK,Rai S,Swarnkar S,Shukla R,Nath C

更新日期：2014-10-01 00:00:00

abstract：:Excessive glucocorticoid levels in depressed patients have been associated with atrophic changes in some brain regions, but only few studies suggest that some antidepressants can interfere with deleterious effect of glucocorticoids on neuronal cells. The aim of the present study was to examine the effect of dexamethas...

journal_title：Neurochemistry international

authors： Leskiewicz M,Jantas D,Regulska M,Kaczanowska J,Basta-Kaim A,Budziszewska B,Kubera M,Lason W

更新日期：2013-11-01 00:00:00

abstract：:Choline-O-acetyltransferase (ChAT) is the enzyme which catalyses the biosynthesis of the neurotransmitter acetylcholine in cholinergic neurons. Here we show that in mouse cholinergic NS-20Y neuroblastoma cells cultured in the presence of either okadaic acid (serine/threonine phosphatases 1 and 2A inhibitor) or KN-62 (...

journal_title：Neurochemistry international

authors： Pahud G,Bontron S,Eder-Colli L

更新日期：2001-01-01 00:00:00

abstract：:Long term consequence of non-fatal overdose in people who use opioids are not well understood. The intermittent exposure to non-fatal overdose leads to a tauopathy that is often accompanied by abrogated neuroprotective response, abnormal amyloid processing and other pathologies. The scope and limitations of available ...

journal_title：Neurochemistry international

authors： Voronkov M,Cocchiaro B,Stock JB

更新日期：2020-12-10 00:00:00

abstract：:Recent studies have suggested that neurosteroids such as pregnenolone, progesterone (PG) and their derivatives, have a role in activating autophagy in addition to diverse other functions. In our previous studies, we demonstrated that cellular free Zn(2+) is involved in oxidative stress-induced autophagy and autophagic...

journal_title：Neurochemistry international

authors： Kim HN,Lee SJ,Koh JY

更新日期：2012-01-01 00:00:00

abstract：:Sprague-Dawley rats exposed to uncontrollable shock can be separated by a subsequent shock escape test into two groups: a "helpless" (LH) group which demonstrates a deficit in escape behavior, and a "nonlearned helpless" (NLH) group which shows no escape deficit and acquires the escape response as readily as naive con...

journal_title：Neurochemistry international

authors： Edwards E,Kornrich W,van Houtten P,Henn FA

更新日期：1992-07-01 00:00:00

abstract：:Long-term (12 h) incubation of NCB-20 neuroblastoma x Chinese hamster brain cell hybrid cells with phorbol dibutylate caused a decrease in the enzyme activity of protein kinase C (PKC). Under these conditions, the formation of inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] and the mobilization of intracellular Ca(2+) t...

journal_title：Neurochemistry international

authors： Okano Y,Higashida H,Tao F,Sakai T,Nozawa Y

更新日期：1991-01-01 00:00:00

abstract：:Ubiquitin (Ub) carboxy terminal hydrolase (UCH)-L1 and UCH-L3 are two of the deubiquitinating enzymes expressed in the brain. Both gad mice, which lack UCH-L1 expression and Uchl3 knockout mice exhibit neurodegeneration, although at distinct areas. These phenotypes indicate the importance of UCH-L1 and UCH-L3 in the r...

journal_title：Neurochemistry international

authors： Setsuie R,Sakurai M,Sakaguchi Y,Wada K

更新日期：2009-05-01 00:00:00

abstract：:L-serine-O-sulphate is a member of a group of amino acids collectively called gliotoxins and is a substrate for the high affinity sodium-dependent glutamate transporters. Previous studies have shown that it is toxic to primary cultures of astrocytes but the mode of toxicity is unknown. The current study demonstrates t...

journal_title：Neurochemistry international

authors： Brennan L,Alves PM,Hewage C,Malthouse JP,McBean GJ

更新日期：2006-06-01 00:00:00

abstract：:MicroRNAs represent an abundant class of endogenously expressed 18-25 nucleotide non-coding RNA molecules that function to silence gene expression through a process of post-transcriptional modification. They exhibit varied and widespread functions during normal development and tissue homeostasis, and accordingly their...

journal_title：Neurochemistry international

authors： Brower JV,Clark PA,Lyon W,Kuo JS

更新日期：2014-11-01 00:00:00

abstract：:Esters of dimethylcarbamic acid are known to be poor substrates of acetylcholinesterase. They carbamylate the active catalytic site of the enzyme and the subsequent decarbamylation is a slow but measurable process. Similarly, acetylcholinesterase can be phosphonylated, and the dephosphonylation is extremely slow. Rapi...

journal_title：Neurochemistry international

authors： Dawson RM,Poretski M,Upsher CM

更新日期：1981-01-01 00:00:00

abstract：:We demonstrate the feasibility and usefulness of the histoblot immunostaining of cryosections of whole hemispheres of healthy and Alzheimer diseased (AD) human brains by localizing a neuron-specific marker, the anti-neuronal nuclei (NeuN) antigen. As expected, cortical NeuN-immunopositive regions were generally thinne...

journal_title：Neurochemistry international

authors： Beliczai Z,Varszegi S,Gulyas B,Halldin C,Kasa P,Gulya K

更新日期：2008-12-01 00:00:00

abstract：:Pregabalin is effective in treating many neuropathic pain conditions. However, the mechanisms of its analgesic effects remain poorly understood. The aim of the present study was to determine whether pregabalin suppresses facial mechanical hypersensitivity and evoked glutamate release in the medullary dorsal horn (MDH)...

journal_title：Neurochemistry international

authors： Kumar N,Cherkas PS,Varathan V,Miyamoto M,Chiang CY,Dostrovsky JO,Sessle BJ,Coderre TJ

更新日期：2013-05-01 00:00:00

abstract：:SN1, a system N amino acid transporter specific for astrocytes, is mainly responsible for export of newly synthesized L-glutamine from the cells. Astrocytic retention of L-glutamine which plays a critical role in ammonia-induced astrocytic swelling resulting in brain edema, could be tentatively attributed to the impai...

journal_title：Neurochemistry international

authors： Dąbrowska K,Albrecht J,Zielińska M

更新日期：2018-09-01 00:00:00

abstract：:Acetylcholinesterase release in the guinea-pig substantia nigra has been previously investigated 'on-line', using a sensitive chemiluminescent system. Since histological observations suggest that there is a difference in acetylcholinesterase distribution in the rat substantia nigra compared to that of the guinea-pig, ...

journal_title：Neurochemistry international

authors： Dally JJ,Schaefer M,Greenfield SA

更新日期：1996-12-01 00:00:00

abstract：:Previously we demonstrated that p53 mediates dopaminergic neurotoxicity via inducing mitochondrial burdens and proapoptotsis. However, little is known about the role of p53 in the excitotoxicity induced by psychostimulant, such as cocaine. Cocaine-induced kindling (convulsive) behaviors significantly increased p53 exp...

journal_title：Neurochemistry international

authors： Mai HN,Sharma N,Jeong JH,Shin EJ,Pham DT,Trinh QD,Lee YJ,Jang CG,Nah SY,Bing G,Kim HC

更新日期：2019-03-01 00:00:00

abstract：:A number of principles have long guided research into serotonin neurochemistry and some of them are presently reconsidered with a slightly different outlook. An increasing amount of experimental data does not always support these older axioms and as more empirical observations are made, some of these may require modif...

journal_title：Neurochemistry international

authors： Kuhn DM,Wolf WA,Youdim MB

更新日期：1986-01-01 00:00:00