当前位置： SCI文献检索 > NEUROCHEMISTRY INTERNATIONAL期刊下所有文献 > Bradykinin-induced phosphoinositide-dependent responses in protein kinase C down-regulated NCB-20 cells.

Bradykinin-induced phosphoinositide-dependent responses in protein kinase C down-regulated NCB-20 cells.

Abstract：

:Long-term (12 h) incubation of NCB-20 neuroblastoma x Chinese hamster brain cell hybrid cells with phorbol dibutylate caused a decrease in the enzyme activity of protein kinase C (PKC). Under these conditions, the formation of inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] and the mobilization of intracellular Ca(2+) triggered by bradykinin (BK), were significantly increased. The alterations in BK-triggered membrane currents in the PKC down-regulated cells were also observed: enhancement of outward currents and decreased inward currents. These results strongly suggested that down-regulation of PKC enhanced BK-induced phosphoinositide metabolism by relieving from the negative feedback control operating between the receptor and phospholipase C, and that the increased Ca(2+) responses due to accumulated Ins(1,4,5)P(3) lead to enhanced outward currents.

journal_name

Neurochem Int

journal_title

Neurochemistry international

authors

Okano Y,Higashida H,Tao F,Sakai T,Nozawa Y

doi

10.1016/0197-0186(91)90175-d

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

419-24

issue

3

eissn

0197-0186

issn

1872-9754

pii

0197-0186(91)90175-D

journal_volume

18

pub_type

杂志文章

相关文献

NEUROCHEMISTRY INTERNATIONAL文献大全
  • Selective stimulation of excitatory amino acid receptor subtypes and the survival of granule cells in culture: effect of quisqualate and AMPA.

    abstract：:Differentiating granule cells develop survival requirements in vitro which can be met by treatment with high K+ or excitatory amino acids. Promotion of cell survival by N-methyl-D-aspartate (NMDA) or kainate has already been established and here we report that treatment of the cells with alpha-amino-3-hydroxy-5-methyl...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(94)90067-1

    authors： Hack N,Balázs R

    更新日期：1994-09-01 00:00:00

  • Chronic citalopram treatment elevates serotonin synthesis in flinders sensitive and flinders resistant lines of rats, with no significant effect on Sprague-Dawley rats.

    abstract：:The influence of citalopram on regional 5-hydroxytryptamine (serotonin, 5-HT) synthesis, one of the most important presynaptic parameters of serotonergic neurotransmission, was studied. Sprague-Dawley (SPD) rats were used as the controls, and Flinders Resistant Line (FRL) rats were used as auxiliary controls, to hopef...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2009.01.005

    authors： Kanemaru K,Nishi K,Hasegawa S,Diksic M

    更新日期：2009-05-01 00:00:00

  • Modulation of choline acetyltransferase synthesis by okadaic acid, a phosphatase inhibitor, and KN-62, a CaM kinase inhibitor, in NS-20Y neuroblastoma.

    abstract：:Choline-O-acetyltransferase (ChAT) is the enzyme which catalyses the biosynthesis of the neurotransmitter acetylcholine in cholinergic neurons. Here we show that in mouse cholinergic NS-20Y neuroblastoma cells cultured in the presence of either okadaic acid (serine/threonine phosphatases 1 and 2A inhibitor) or KN-62 (...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/s0197-0186(00)00064-4

    authors： Pahud G,Bontron S,Eder-Colli L

    更新日期：2001-01-01 00:00:00

  • Dissociation between hippocampal neuronal loss, astroglial and microglial reactivity after pharmacologically induced reverse glutamate transport.

    abstract：:The inflammatory central nervous system response that involves activated microglia and reactive astrocytes may both heal and harm neurons, as inflammatory mediators lead to neuroprotection or excitation at one dose but to injury at a different concentration. To investigate these complex cellular interactions, L-trans-...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2006.06.008

    authors： de Yebra L,Malpesa Y,Ursu G,Pugliese M,Liévens JC,Kerkerian-Le Goff L,Mahy N

    更新日期：2006-12-01 00:00:00

  • Knockdown of glucose-6-phosphate dehydrogenase (G6PD) following cerebral ischemic reperfusion: the pros and cons.

    abstract：:NADPH derived from glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, has been implicated not only to promote reduced glutathione (GSH) but also enhance oxidative stress in specific cellular conditions. In this study, the effects of G6PD antisense oligodeoxynucleotides...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2012.05.003

    authors： Zhao G,Zhao Y,Wang X,Xu Y

    更新日期：2012-07-01 00:00:00

  • Dephosphorylation of purified brain tyrosine hydroxylase by rat striatal extracts.

    abstract：:Tyrosine hydroxylase (TH) was purified from bovine brain and enzymatically phosphorylated in vitro. Radioactively phosphorylated TH was dephosphorylated by rat tissue extracts. Of tissues examined, rat corpus striatal extracts were highest in specific activity in the TH dephosphorylating assay. Phosphorylated histone ...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(83)90016-5

    authors： Lazar MA,Raese JD,Barchas JD

    更新日期：1983-01-01 00:00:00

  • 7-Nitroindazole prevents dopamine depletion caused by low concentrations of MPP+ in rat striatal slices.

    abstract：:A significant loss of dopamine was found in rat striatal slices incubated with 1-methyl-4-phenylpyridinium ion (MPP+) at a concentration of 2 microM or higher. The addition of 7-nitroindazole, a specific inhibitor of neuronal nitric oxide synthase (nNOS), prevented this effect on dopamine when the concentration of MPP...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/s0197-0186(05)80006-3

    authors： Cutillas B,Espejo M,Ambrosio S

    更新日期：1998-07-01 00:00:00

  • Rapamycin decreases tau phosphorylation at Ser214 through regulation of cAMP-dependent kinase.

    abstract：:Preventing or reducing tau hyperphosphorylation is considered to be a therapeutic strategy in the treatment of Alzheimer's disease (AD). Rapamycin may be a potential therapeutic agent for AD, because the rapamycin-induced autophagy may enhance the clearance of the hyperphosphorylated tau. However, recent rodent studie...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2013.01.014

    authors： Liu Y,Su Y,Wang J,Sun S,Wang T,Qiao X,Run X,Li H,Liang Z

    更新日期：2013-03-01 00:00:00

  • BDNF downregulates 5-HT(2A) receptor protein levels in hippocampal cultures.

    abstract：:Both brain-derived neurotrophic factor (BDNF) and the serotonin receptor 2A (5-HT(2A)) have been related to depression pathology. Specific 5-HT(2A) receptor changes seen in BDNF conditional mutant mice suggest that BDNF regulates the 5-HT(2A) receptor level. Here we show a direct effect of BDNF on 5-HT(2A) receptor pr...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2009.06.013

    authors： Trajkovska V,Santini MA,Marcussen AB,Thomsen MS,Hansen HH,Mikkelsen JD,Arneberg L,Kokaia M,Knudsen GM,Aznar S

    更新日期：2009-12-01 00:00:00

  • Effects of ghrelin on the electrical activities of substantia nigra dopaminergic neurons treated with MPP.

    abstract：:Ghrelin, a 28 amino acid brain-gut peptide, has attracted increasing attention for its neuroprotective effect in Parkinson's disease (PD). In view of the pivotal role of excitability of dopaminergic neurons in substantia nigra pars compacta (SNc) in the function of nigrostriatal system, it is of great significance to ...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2020.104780

    authors： Chang X,Ma Z,Shi L,Xie J

    更新日期：2020-09-01 00:00:00

  • Unchanged glutamine synthetase activity and increased NMDA receptor density in epileptic human neocortex: implications for the pathophysiology of epilepsy.

    abstract：:We investigated whether alterations in glutamate metabolising glutamine synthetase activity occur in human epileptic neocortex, as shown previously for human epileptic hippocampus [Eid, T., Thomas, M.J., Spencer, D.D., Rundén-Pran, E., Lai, J.C.K., Malthankar, G.V., Kim, J.H., Danbolt, N.C., Ottersen, O.P., de Lanerol...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2005.06.001

    authors： Steffens M,Huppertz HJ,Zentner J,Chauzit E,Feuerstein TJ

    更新日期：2005-11-01 00:00:00

  • Aquaporin 4 antibody positive central nervous system autoimmunity and multiple sclerosis are characterized by a distinct profile of antibodies to herpes viruses.

    abstract：:Viral infections are implicated in the onset and promotion of autoimmunity in genetically predisposed individuals. In this study, immune response patterns to herpes viruses were compared in aquaporin 4 (AQP4) antibody positive central nervous system (CNS) autoimmunity and multiple sclerosis (MS). Serum samples of pati...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2010.08.003

    authors： Sellner J,Cepok S,Kalluri SR,Nestler A,Kleiter I,Kümpfel T,Linker R,Melms A,Menge T,Tumani H,Paul F,Hemmer B,Berthele A

    更新日期：2010-11-01 00:00:00

  • Adeno-associated virus mediated gene transfer into primary rat brain neuronal and glial cultures: enhancement with the pH-sensitive surfactant dodecyl 2-(1'-imidazolyl) propionate.

    abstract：:This study evaluated the effects of a novel, pH-sensitive surfactant, dodecyl 2-(1'-imidazolyl) propionate (DIP), on cationic lipid mediated transfection in primary rat brain neuronal and glial cultures. The cationic lipid complex DOTAP/DOPE (1, 2-dioleoyl-3-trimethylammonium propionate and dioleoyl phosphatidylethano...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/s0197-0186(00)00007-3

    authors： Wang S,Bui V,Hughes JA,King MA,Meyer EM

    更新日期：2000-07-01 00:00:00

  • Poloxamer 188 rescues MPTP-induced lysosomal membrane integrity impairment in cellular and mouse models of Parkinson's disease.

    abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Rupture of lysosome is a major cellular stress condition leading to cell death in PD. We have previously shown that environmenta...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2019.03.013

    authors： Dong H,Qin Y,Huang Y,Ji D,Wu F

    更新日期：2019-06-01 00:00:00

  • Evidence for a role for transglutaminase in Huntington's disease and the potential therapeutic implications.

    abstract：:Transglutaminase (TGase) activity is increased in affected regions of brains from patients with Huntington's disease (HD). TGase activity is particularly elevated in the nucleus compared with the cytoplasm from these brains. Gamma-glutaminyl-lysyl cross-links have been detected in nuclear inclusions in HD brain, indic...

    journal_title：Neurochemistry international

    pub_type： 杂志文章,评审

    doi：10.1016/s0197-0186(01)00060-2

    authors： Karpuj MV,Becher MW,Steinman L

    更新日期：2002-01-01 00:00:00

  • Activation of MAPK by potassium bisperoxo(1,10-phenanthroline)oxovanadate (V).

    abstract：:Potassium bisperoxo(1,10-phenantroline)oxovanadate (V) [bpV(phen)] is a potent protein tyrocine phosphatase inhibitor which mediates a variety of biological effects. The aim of these studies was to examine the role(s) of mitogen activated protein kinase (MAPK) pathways in PC12 cell proliferation and toxicity by bpV(ph...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/s0197-0186(99)00018-2

    authors： Cerovac Z,Ban J,Morinville A,Yaccato K,Shaver A,Maysinger D

    更新日期：1999-04-01 00:00:00

  • Melatonin biosynthesis in photoreceptor-enriched chick retinal cell cultures: role of cyclic AMP in the K(+)-evoked, Ca(2+)-dependent induction of serotonin N-acetyltransferase activity.

    abstract：:The roles of cyclic AMP and calcium in the regulation of serotonin N-acetyltransferase (NAT) activity were studied in low density monolayer cultures of chick retinal photoreceptors and neurons. Photoreceptor-enriched retinal cell cultures were prepared from embryonic day 6 retinas and cultured for 6 days. NAT activity...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(95)00035-7

    authors： Gan J,Alonso-Gómez AL,Avendano G,Johnson B,Iuvone PM

    更新日期：1995-08-01 00:00:00

  • Regulation of intracellular [Ca2+] and GABA release by presynaptic GABAB receptors in rat cerebrocortical synaptosomes.

    abstract：:In this study we determined the changes in the intracellular free Ca2+ concentration, associated with the inhibitory modulation of the exocytotic release of GABA by GABAB receptor activation in rat cerebrocortical synaptosomes. We observed that SK&F 97541 and (-)baclofen both act as agonists of the presynaptic GABAB r...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(95)00021-y

    authors： Santos AE,Carvalho CM,Macedo TA,Carvalho AP

    更新日期：1995-10-01 00:00:00

  • Posttranslational processing of proenkephalins and chromogranins/secretogranins.

    abstract：:Posttranslational processing of peptide-precursors is nowadays believed to play an important role in the functioning of neurons and endocrine cells. Both proenkephalins and chromogranins/secretogranins are considered as precursor molecules in these tissues, resulting in posttranslationally formed degradation products ...

    journal_title：Neurochemistry international

    pub_type： 杂志文章,评审

    doi：10.1016/0197-0186(93)90016-x

    authors： Dillen L,Miserez B,Claeys M,Aunis D,De Potter W

    更新日期：1993-04-01 00:00:00

  • High-affinity choline uptake and acetylcholine-metabolizing enzymes in CNS white matter. A quantitative study.

    abstract：:The presence of nicotinic and muscarinic receptors suggests the occurrence of cholinergic neurotransmission in white matter; however no quantitative information exists on acetylcholine formation and breakdown in white matter. We compared white structures of pig brain (fimbria, corpus callosum, pyramidal tracts, and oc...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2008.06.008

    authors： Hassel B,Solyga V,Lossius A

    更新日期：2008-12-01 00:00:00

  • TAT-mediated delivery of human glutamate dehydrogenase into PC12 cells.

    abstract：:Human glutamate dehydrogenase (GDH) gene was fused with a gene fragment encoding the nine amino acid (RKKRRQRRR) protein transduction domain of human immunodeficiency virus TAT protein in bacterial expression vector to produce genetic in-frame TAT-GDH fusion protein. The TAT-GDH protein can enter PC12 cells efficientl...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/s0197-0186(01)00138-3

    authors： Yoon HY,Lee SH,Cho SW,Lee JE,Yoon CS,Park J,Kim TU,Choi SY

    更新日期：2002-07-01 00:00:00

  • Systemic pregabalin attenuates facial hypersensitivity and noxious stimulus-evoked release of glutamate in medullary dorsal horn in a rodent model of trigeminal neuropathic pain.

    abstract：:Pregabalin is effective in treating many neuropathic pain conditions. However, the mechanisms of its analgesic effects remain poorly understood. The aim of the present study was to determine whether pregabalin suppresses facial mechanical hypersensitivity and evoked glutamate release in the medullary dorsal horn (MDH)...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2013.02.022

    authors： Kumar N,Cherkas PS,Varathan V,Miyamoto M,Chiang CY,Dostrovsky JO,Sessle BJ,Coderre TJ

    更新日期：2013-05-01 00:00:00

  • Cocaine-induced status epilepticus and death generate oxidative stress in prefrontal cortex and striatum of mice.

    abstract：:Oxidative stress (OS) has been related to cocaine's actions and also to numerous nervous system pathologies, including seizures. The purpose of this work was to determine the alterations in glutathione (GSH) content, nitrite/nitrate and MDA levels after cocaine-induced toxicity. Male Swiss mice were injected (i.p.) wi...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2009.10.001

    authors： Macêdo DS,Vasconcelos SM,Andrade-Neto M,Belchior LD,Honório Júnior JE,Gonçalves DO,Fonteles MM,Silva MI,Aguiar LM,Viana GS,de Sousa FC

    更新日期：2010-01-01 00:00:00

  • Iron/ascorbate-induced lipid peroxidation changes membrane fluidity and muscarinic cholinergic receptor binding in rat frontal cortex.

    abstract：:Lipid peroxidation (LP) is a complex process which involves the formation of lipid free radicals and leads to oxidative damage. LP has also been implicated in several neurodegenerative diseases as well as aging. In the present study, we evaluated the effects of the induction of LP in vitro on muscarinic cholinergic (M...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(93)90133-p

    authors： Ghosh C,Dick RM,Ali SF

    更新日期：1993-11-01 00:00:00

  • Reversible and irreversible acetylcholinesterase inhibitors cause changes in neuronal amyloid precursor protein processing and protein kinase C level in vitro.

    abstract：:The alternative routes of cleavage of the amyloid precursor protein (APP) result in the generation and secretion of both soluble APP and beta-amyloid, the latter being the main component of the amyloid deposits in the brains of individuals with Alzheimer's disease (AD). This study examined the question of whether acet...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/s0197-0186(00)00091-7

    authors： Pakaski M,Rakonczay Z,Kasa P

    更新日期：2001-03-01 00:00:00

  • Monocyte-mediated regulation of genes by the amyloid and prion peptides in SH-SY5Y neuroblastoma cells.

    abstract：:Alzheimer's disease as well as prion-related encephalopathies are neurodegenerative disorders of the central nervous system, which cause mental deterioration and progressive dementia. Both pathologies appear to be primarily associated with the pathological accumulation and deposit of β-amyloid or prion peptides in the...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2011.01.019

    authors： Morte B,Martínez T,Zambrano A,Pascual A

    更新日期：2011-05-01 00:00:00

  • Sildenafil treatment of vascular dementia in aged rats.

    abstract：BACKGROUND:and purpose: In this study, we employed a multiple microinfarction (MMI) based vascular dementia (VaD) model in aged rats and tested the therapeutic effects of Sildenafil, a phosphodiesterase type 5 inhibitor, on cognitive decline, white matter damage, autophagy and inflammatory response associated with VaD....

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2018.12.015

    authors： Venkat P,Chopp M,Zacharek A,Cui C,Landschoot-Ward J,Qian Y,Chen Z,Chen J

    更新日期：2019-07-01 00:00:00

  • Dopamine transporters are involved in the onset of hypoxia-induced dopamine efflux in striatum as revealed by in vivo microdialysis.

    abstract：:Although many studies have revealed alterations in neurotransmission during ischaemia, few works have been devoted to the neurochemical effects of mild hypoxia, a situation encountered during life in altitude or in several pathologies. In that context, the present work was undertaken to determine the in vivo mechanism...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/j.neuint.2005.02.005

    authors： Orset C,Parrot S,Sauvinet V,Cottet-Emard JM,Bérod A,Pequignot JM,Denoroy L

    更新日期：2005-06-01 00:00:00

  • Long-term changes in noradrenaline (NA) and dopamine (DA) contents of rat cerebellum following neonatal X-irradiation.

    abstract：:The effects of neonatal X-irradiation on cerebellar cathecholamine levels in rats were studied at different postnatal intervals. Since synaptogenesis in the cerebellar cortex is basically a postnatal phenomenon, changes in noradrenaline (NA) and dopamine (DA) levels induced by X-rays on the cerebella (CE) of adult rat...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(89)90081-8

    authors： Dopico AM,Zieher LM,Mayo J,Altschüller N,López JJ,Jaim-Etcheverry G

    更新日期：1989-01-01 00:00:00

  • Long lasting effects of intrauterine growth retardation on basal and 5-HT-stimulated Na(+)/K(+)-ATPase in the brain of developing rats.

    abstract：:Intrauterine growth retardation induced by ligation of the uterine vessels in pregnant rats on the 5th day before delivery was associated with brain and body weights of hypotrophic offspring significantly lower than those of pair-aged control rats, even after 6 weeks of postnatal rearing under normal conditions. In vi...

    journal_title：Neurochemistry international

    pub_type： 杂志文章

    doi：10.1016/0197-0186(85)90121-4

    authors： Chanez C,Flexor MA,Hamon M

    更新日期：1985-01-01 00:00:00