Alpha-synuclein and its neurotoxic fragment inhibit dopamine uptake into rat striatal synaptosomes. Relationship to nitric oxide.

abstract：:In recent years there has been a great deal of research within the stem cell field which has led to the definition and classification of a range of stem cells from a plethora of tissues and organs. Stem cells, by classification, are considered to be pluri- or multipotent and have both self-renewal and multi-differenti...

journal_title：Neurochemistry international

authors： Lindsay SL,Barnett SC

更新日期：2017-06-01 00:00:00

abstract：:Amiloride, a potassium sparing diuretic, inhibits adenosine A1 receptor-radioligand binding in calf and rat brain membranes in the low micromolar range. The drug interacted with the A1 receptor in a manner different from classical A1 ligands, but structure-activity relationship studies indicated that this inhibitory e...

journal_title：Neurochemistry international

authors： Garritsen A,Beukers MW,IJzerman AP,Cragoe EJ Jr,Soudijn W

更新日期：1992-02-01 00:00:00

abstract：:Nitrite therapy is more effective in cerebral ischemia when administered earlier. It would be beneficial during the hyperacute stages of stroke if the nitrite effect is demonstrated in intracerebral hemorrhage (ICH). When nitrite is injected intravenously 3h after ICH induction in rats, most doses of nitrite provided ...

journal_title：Neurochemistry international

authors： Jung KH,Chu K,Lee ST,Kim JM,Park DK,Kim M,Lee SK,Roh JK

更新日期：2011-08-01 00:00:00

abstract：:Neuronal cell death is often triggered by events that involve intracellular increases in Ca2+. Under resting conditions, the intracellular Ca2+ concentration is tightly controlled by a number of extrusion and sequestering mechanisms involving the plasma membrane, mitochondria, and ER. These mechanisms act to prevent a...

journal_title：Neurochemistry international

authors： D'Orsi B,Mateyka J,Prehn JHM

更新日期：2017-10-01 00:00:00

abstract：:The mechanisms of intracellular calcium store depletion and store-related Ca(2+) dysregulation in relation to apoptotic cell death in PC12 cells were investigated at physiological temperatures with a leak-resistant fluorescent indicator dye Fura-PE3/AM by a cooled CCD imaging analysis system. Electron microscopic obse...

journal_title：Neurochemistry international

authors： Yoshida I,Monji A,Tashiro K,Nakamura K,Inoue R,Kanba S

更新日期：2006-06-01 00:00:00

abstract：:Age-related neurodegenerative diseases are characterized by selective neuron loss, glial activation, inflammation and abnormalities in oxidative metabolism. Thiamine deficiency (TD) is a model of neurodegeneration induced by impairment of oxidative metabolism. TD produces a time-dependent, selective neuronal death in ...

journal_title：Neurochemistry international

authors： Ke ZJ,Gibson GE

更新日期：2004-07-01 00:00:00

abstract：:A possible modulatory role of kinases on voltage sensitive Na+ channels of presynaptic brain nerve endings was investigated by testing the effect of several kinase activators and inhibitors on the elevation of [Nai] induced by veratridine in mouse brain synaptosomes loaded with a selective Na+ indicator dye. Veratridi...

journal_title：Neurochemistry international

authors： Sitges M,Peña F,Chiu LM,Guarneros A

更新日期：1998-02-01 00:00:00

abstract：:Increased brain ammonia concentrations are a hallmark feature of several neurological disorders including congenital urea cycle disorders, Reye's syndrome and hepatic encephalopathy (HE) associated with liver failure. Over the last decade, increasing evidence suggests that hyperammonemia leads to alterations in the gl...

journal_title：Neurochemistry international

authors： Chan H,Butterworth RF

更新日期：2003-09-01 00:00:00

abstract：:Radial glial cells play a significant role in the repair of spinal cord injuries as they exert critical role in the neurogenesis and act as a scaffold for neuronal migration. Our previous study showed that mature astrocytes of spinal cord can undergo a de-differentiation process and further transform into pluripotenti...

journal_title：Neurochemistry international

authors： Yang H,Ling W,Vitale A,Olivera C,Min Y,You S

更新日期：2011-12-01 00:00:00

abstract：:Phosphodiesterase-5 (PDE5) inhibitors act by competing with the substrate, cGMP, for the catalytic site of the enzyme. Two commercialized PDE5 inhibitors, sildenafil and vardenafil, are being used to treat erectile dysfunction. These two compounds differ in the heterocyclic ring system used to mimic the purine ring of...

journal_title：Neurochemistry international

authors： Corbin JD,Beasley A,Blount MA,Francis SH

更新日期：2004-11-01 00:00:00

abstract：:Several studies have indicated a functional differentiation across the septotemporal axis of rat hippocampus. Our previous results have shown that the alpha 1 beta 2 gamma 2-GABAA receptor subtype dominates in dorsal hippocampus (DH), while the alpha 2 beta 1 gamma 2-subtype prevails in ventral hippocampus (VH). We th...

journal_title：Neurochemistry international

authors： Sarantis K,Sotiriou E,Papatheodoropoulos C,Matsokis N,Angelatou F

更新日期：2008-05-01 00:00:00

abstract：:Although many studies have revealed alterations in neurotransmission during ischaemia, few works have been devoted to the neurochemical effects of mild hypoxia, a situation encountered during life in altitude or in several pathologies. In that context, the present work was undertaken to determine the in vivo mechanism...

journal_title：Neurochemistry international

authors： Orset C,Parrot S,Sauvinet V,Cottet-Emard JM,Bérod A,Pequignot JM,Denoroy L

更新日期：2005-06-01 00:00:00

abstract：:The effects of hypoxia on the metabolism of the central nervous system were investigated in rats submitted to a low oxygen atmosphere (8% O(2); 92% N(2)). [1-(13)C]glucose and [2-(13)C]acetate were used as substrates, this latter being preferentially metabolized by glial cells. After 1-h substrate infusion, the incorp...

journal_title：Neurochemistry international

authors： Chateil J,Biran M,Thiaudière E,Canioni P,Merle M

更新日期：2001-04-01 00:00:00

abstract：:Many studies indicate that chronic stress and excessive stress hormone can cause an inflammatory response. Thioredoxin-interacting protein (Txnip) as an endogenous thioredoxin inhibitor suppresses thioredoxin-produced antioxidant effects. Txnip was also found to interact with nucleotide-binding oligomerization domain-...

journal_title：Neurochemistry international

authors： Bharti V,Tan H,Zhou H,Wang JF

更新日期：2019-12-01 00:00:00

abstract：:Two puromycin-sensitive aminopeptidase isozymes (PSA-I and PSA-II) were isolated from chicken brain cytosol by ammonium sulfate fractionation followed by column chromatography on Cellex D and AH-Sepharose 4B and separated on Bio-Gel HTP. Each was purified to homogeneity on Sephadex G-200, Arg-Tyr-AH-Sepharose, Bio-Gel...

journal_title：Neurochemistry international

authors： Hui KS,Saito M,Hui M,Saito M,Lajtha A,Yamamoto K,Osawa T

更新日期：1993-05-01 00:00:00

abstract：:The neuromodulator adenosine, has been shown to have the highest density of central uptake sites in the nucleus tractus solitarius in the dorsal brain stem. The nucleus tractus solitarius is involved in the central regulation of reflex cardiovascular activity suggesting that adenosine may also be involved in central c...

journal_title：Neurochemistry international

authors： Lawrence AJ,Castillo-Meléndez M,Jarrott B

更新日期：1994-09-01 00:00:00

abstract：:TAR DNA-binding protein 43 (TDP-43) is a major pathological protein of ubiquitinated inclusions in motor neurons of sporadic amyotrophic lateral sclerosis (ALS). TDP-43 is ubiquitously expressed and the majority of TDP-43 is normally localized to the nucleus. In motor neurons of patients with ALS, TDP-43 is not locali...

journal_title：Neurochemistry international

authors： Hishizawa M,Yamashita H,Akizuki M,Urushitani M,Takahashi R

更新日期：2019-03-01 00:00:00

abstract：:Glial (GLT-1 and GLAST) and neuronal (EAAC1) high-affinity transporters mediate the sodium dependent glutamate reuptake in mammalian brain. Their dysfunction leads to neuronal damage by allowing glutamate to remain in the synaptic cleft for a longer duration. The purpose of the present study is to understand their con...

journal_title：Neurochemistry international

authors： Raghavendra Rao VL,Rao AM,Dogan A,Bowen KK,Hatcher J,Rothstein JD,Dempsey RJ

更新日期：2000-05-01 00:00:00

abstract：:Alzheimer's disease (AD) is a common neurodegenerative disorders, in which oxidative stress plays an important role. The present study investigated the effect of eicosapentaenoic acid-enriched phospholipids (EPA-enriched PL) from the sea cucumber Cucumaria frondosa on oxidative injury in PC12 cells induced by hydrogen...

journal_title：Neurochemistry international

authors： Wu FJ,Xue Y,Liu XF,Xue CH,Wang JF,Du L,Takahashi K,Wang YM

更新日期：2014-01-01 00:00:00

abstract：:Outer (OHC) and inner (IHC) hair cells in the organ of Corti of the mammalian cochlea process sound. OHC and their efferent synapse are part of a feedback system assumed to control and modulate information carried by afferent neurons passing from IHC to the brain. Underlying mechanisms are not well understood. This pa...

journal_title：Neurochemistry international

authors： Heilbronn E,Järlebark L,Lawoko G

更新日期：1995-10-01 00:00:00

abstract：:Classical synaptic functions are important and suitable to relatively fast and discretely localized processes, but the nonclassical receptorial functions may be providing revolutionary possibilities for dealing at the cellular level with many of the more interesting and seemingly intractable features of neural and cer...

journal_title：Neurochemistry international

authors： Vizi ES,Kiss JP,Lendvai B

更新日期：2004-09-01 00:00:00

abstract：:The effect of subcutaneous injections of saline (0.9% NaCl, 10-40 ?l/g b. wt) to 5- and 20-day old rats on the concentrations of tyrosine (Tyr) and tryptophan (Trp) in the serum and the brain and on the levels of biogenic amines and their metabolites in the developing brain at 6 h p.i. is described. At day 5 the conce...

journal_title：Neurochemistry international

authors： Huether G,Thoemke F,Sprotte U,Steinhaus U,Neuhoff V

更新日期：1985-01-01 00:00:00

abstract：:Carotenoids play a pivotal role in prevention of many degenerative diseases mediated by oxidative stress including neurodegenerative diseases like Alzheimer's Disease (AD). The involvement of retinoids in physiology, AD pathology and their therapeutic role in vitro and in vivo has been extensively studied. This review...

journal_title：Neurochemistry international

authors： Obulesu M,Dowlathabad MR,Bramhachari PV

更新日期：2011-10-01 00:00:00

abstract：:A decrease in the osmolarity of incubation medium is accompanied by calcium influx in neuronal presynaptic endings. We studied the influence of Ca2+ on exocytosis induced by hypotonic shock using the hydrophilic fluorescent dye acridine orange and the hydrophobic fluorescent dye FM2-10. It was shown using acridine ora...

journal_title：Neurochemistry international

authors： Waseem TV,Rakovich AA,Lavrukevich TV,Konev SV,Fedorovich SV

更新日期：2005-02-01 00:00:00

abstract：:Choline acetyltransferase activity was detected in extensively washed membranes prepared from rat and guinea pig synaptosomes. When these preparations were treated with the non-ionic detergent Triton X-114 and heated to 37 degrees C to cause phase separation, a significant percentage was found to associate with the de...

journal_title：Neurochemistry international

authors： Docherty M,Bradford HF

更新日期：1988-01-01 00:00:00

abstract：:Inositol 1,4,5-trisphosphate (IP(3)) receptors belong to the intracellular calcium channels that release calcium from the intracellular stores after binding IP(3). Three types of IP(3) receptors occurred in a tissue specific manner and different promoters direct their gene expression. Thus, understanding of the transc...

journal_title：Neurochemistry international

authors： Stefanik P,Macejova D,Mravec B,Brtko J,Krizanova O

更新日期：2005-06-01 00:00:00

abstract：:The release of [(3)H]GABA which is newly synthesized from [(3)H]l-glutamic acid (GLU) has been examined using striatal slices obtained from the rat brain. It was found that 8-10% of [(3)H]GLU transported was converted to [(3)H]GABA during the incubation of striatal slices in the presence of nipecotic acid (5 x 10(?5) ...

journal_title：Neurochemistry international

authors： Yoneda Y,Kanmori K,Takahashi M,Zuo PP,Paik IH,Kuriyama K

更新日期：1984-01-01 00:00:00

abstract：:The discovery of nonsynaptic communication in the 1960s and 1970s was an important milestone in investigating the function of the nervous system, and it revolutionized our view about information transmission between neurons. In addition, nonsynaptic communication has a practical importance not only within the nervous ...

journal_title：Neurochemistry international

authors： Selmeczy Z,Vizi ES,Csóka B,Pacher P,Haskó G

更新日期：2008-01-01 00:00:00

abstract：:The multidrug transporter P-glycoprotein (P-gp) is expressed in the blood-brain barrier endothelium where it effluxes a range of drug substrates, preventing their accumulation within the brain. P-gp has been studied extensively for 40 years because of its crucial role in the absorption, distribution, metabolism and el...

journal_title：Neurochemistry international

authors： Subramanian N,Condic-Jurkic K,O'Mara ML

更新日期：2016-09-01 00:00:00

abstract：:The Mg(2+)-ATPase associated with highly purified cholinergic synaptic vesicles isolated from the Torpedo electric organ can be activated by millimolar concentrations of Ca(2+) only to a maximum of 46%. ATP is hydrolyzed in preference to other tri-nucleotides on Mg(2+)-activation but not on Ca(2+)-activation of the en...

journal_title：Neurochemistry international

authors： Stelzl H,Grondal EJ,Zimmermann H

更新日期：1987-01-01 00:00:00