Nonsynaptic communication in the central nervous system.

abstract：:Pregabalin is effective in treating many neuropathic pain conditions. However, the mechanisms of its analgesic effects remain poorly understood. The aim of the present study was to determine whether pregabalin suppresses facial mechanical hypersensitivity and evoked glutamate release in the medullary dorsal horn (MDH)...

journal_title：Neurochemistry international

authors： Kumar N,Cherkas PS,Varathan V,Miyamoto M,Chiang CY,Dostrovsky JO,Sessle BJ,Coderre TJ

更新日期：2013-05-01 00:00:00

abstract：:Neurodegenerative disorders are strongly associated with oxidative stress, which is induced by reactive oxygen species including hydrogen peroxide (H₂O₂). Epidemiological studies have suggested that coffee may be neuroprotective, but the molecular mechanisms underlying this effect have not been clarified. In this stud...

journal_title：Neurochemistry international

authors： Kim J,Lee S,Shim J,Kim HW,Kim J,Jang YJ,Yang H,Park J,Choi SH,Yoon JH,Lee KW,Lee HJ

更新日期：2012-04-01 00:00:00

abstract：:Essential omega-3 polyunsaturated fatty acids (omega3) are crucial to brain development and function, being relevant for behavioral performance. In the present study we examined the influence of dietary omega3 in the development of the glutamatergic system and on behavior parameters in rats. Female rats received isoca...

journal_title：Neurochemistry international

authors： Moreira JD,Knorr L,Ganzella M,Thomazi AP,de Souza CG,de Souza DG,Pitta CF,Mello e Souza T,Wofchuk S,Elisabetsky E,Vinadé L,Perry ML,Souza DO

更新日期：2010-05-01 00:00:00

abstract：:Spinal muscular atrophy (SMA), the leading genetic cause of infant mortality worldwide, is characterised by the homozygous loss of the survival motor neuron 1 (SMN1) gene. The consequent degeneration of spinal motor neurons and progressive atrophy of voluntary muscle groups results in paralysis and eventually prematur...

journal_title：Neurochemistry international

authors： Farrelly-Rosch A,Lau CL,Patil N,Turner BJ,Shabanpoor F

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Axonal injury is the correlate of disease progression in NMO and MS. Neurofilament (Nf) belongs to neuron specific intermediate filaments located in axons. Nf protein subunits are potential biomarkers in cerebrospinal fluid (CSF) for acute axonal injury. However, whether CSF NfH and NfL levels are elevated i...

journal_title：Neurochemistry international

authors： Wang H,Wang C,Qiu W,Lu Z,Hu X,Wang K

更新日期：2013-12-01 00:00:00

abstract：:A low density of brain IR2-imidazoline receptive sites has previously been linked to depression. In this study we evaluated brain IR2-binding sites in a rat model of depression, olfactory bulbectomy, and determined the effects of chronic imipramine treatment in vivo on these sites. Compared with sham-operated controls...

journal_title：Neurochemistry international

authors： Zhu H,Paul IA,McNamara M,Redmond A,Nowak G,Piletz JE

更新日期：1997-01-01 00:00:00

abstract：:D1 and D2 receptors are key mediators of dopaminergic signaling in the brain, and since the manifestations of pathologies related to dopamine are different in female and male patients, it is important to analyze if there are sex-related differences in dopaminergic markers. To contribute to the knowledge in this regard...

journal_title：Neurochemistry international

authors： Orendain-Jaime EN,Ortega-Ibarra JM,López-Pérez SJ

更新日期：2016-11-01 00:00:00

abstract：:Amiloride, a potassium sparing diuretic, inhibits adenosine A1 receptor-radioligand binding in calf and rat brain membranes in the low micromolar range. The drug interacted with the A1 receptor in a manner different from classical A1 ligands, but structure-activity relationship studies indicated that this inhibitory e...

journal_title：Neurochemistry international

authors： Garritsen A,Beukers MW,IJzerman AP,Cragoe EJ Jr,Soudijn W

更新日期：1992-02-01 00:00:00

abstract：:Taurine-like immunoreactivity (TLI) is found in the pigeon retina at high levels within cones, in select cells of the inner nuclear layer and in sublaminae of the inner plexiform layer. At the ultrastructural level a high density of immuno-gold particles in visualized in the ellipsoid, but not in the paraboloid area o...

journal_title：Neurochemistry international

authors： Ueck M,Hach A,Verdone-Smith C,Lake N

更新日期：1995-12-01 00:00:00

abstract：:The turnover of phospholipids was compared in peripheral nerves of Trembler dysmelinating mutant and control mice, after intraperitoneal and local injection of labeled ethanolamine. In the mutant sciatic nerve, neurochemical analysis showed that [(14)C]ethanolamine is incorporated into EGP (ethanolamine glycerophospho...

journal_title：Neurochemistry international

authors： Do Thi NA,Bourre JM,Koenig HL,Trouillet V,Dumont O,Piciotti M

更新日期：1990-01-01 00:00:00

abstract：:The venom from the marine snail Conus pennaceus inhibits the binding of [3H]neuropeptide Y to calf brain membranes (Czerwiec et al., 1996a) and, in the present study, also to rat forebrain membranes. These membranes contain about 80% Y1- and 20% Y2-receptors. The inhibition by the venom was concentration-dependent wit...

journal_title：Neurochemistry international

authors： Diallo B,Vanderheyden PM,De Backer JP,Vauquelin G

更新日期：1998-01-01 00:00:00

abstract：:A simple, rapid and sensitive method for the detection of acetylcholine and choline in tissue extracts is reported. Acetylcholine and choline are first separated by HPLC then react in a mini-column with acetylcholinesterase and choline oxidase immobilized on Sepharose. The resulting H(2)O(2) produced by choline oxidas...

journal_title：Neurochemistry international

authors： Stadler H,Nesselhut T

更新日期：1986-01-01 00:00:00

abstract：:Several metabolic transformations of vitamin A have now been found in the pigment epithelium of cattle retina, leading to the hypothesis that there may be a vitamin A cycle in these cells. A retinol binding protein of MW ? 17,000 in pigment epithelial cytosol has been identified independently in several laboratories. ...

journal_title：Neurochemistry international

authors： Berman ER,Segal N,Schneider A,Feeney L

更新日期：1980-01-01 00:00:00

abstract：:Much attention has been paid to the connection between periodontitis and Alzheimer's disease (AD). We previously showed that infection of P. gingivalis, one of major periodontal pathogen causing periodontitis, induced migration and inflammatory responses in murine microglia through gingipain-induced activation of prot...

journal_title：Neurochemistry international

authors： Nonaka S,Nakanishi H

更新日期：2020-11-01 00:00:00

abstract：:High levels of angiotensin converting enzyme (ACE) are found in the caudate-putamen (CPu), globus pallidus, entopeduncular nucleus and substantia nigra pars reticulata; these structures were connected by a continuous band of ACE. In order to investigate whether ACE was associated with dopaminergic projections from the...

journal_title：Neurochemistry international

authors： Chai SY,Christie MJ,Beart PM,Mendelsohn FA

更新日期：1987-01-01 00:00:00

abstract：:The present experiments investigated the effect of a neurotoxin purified from the venom of the spider Phoneutria nigriventer. This toxic component, P. nigriventer toxin 3-6 (PnTx3-6), abolished Ca(2+)-dependent glutamate release with an IC(50) of 74.4nM but did not alter Ca(2+)-independent secretion of glutamate when ...

journal_title：Neurochemistry international

authors： Vieira LB,Kushmerick C,Reis HJ,Diniz CR,Cordeiro MN,Prado MA,Kalapothakis E,Romano-Silva MA,Gomez MV

更新日期：2003-03-01 00:00:00

abstract：:Toluene is a commonly abused solvent found in many industrial and commercial products. The neurobiological effects of toluene remain unclear, but many of them, like those of ethanol, may be mediated by gamma-aminobutyric acid (GABA) and glutamate receptors. Chronic ethanol administration has been shown to alter levels...

journal_title：Neurochemistry international

authors： Williams JM,Stafford D,Steketee JD

更新日期：2005-01-01 00:00:00

abstract：:Tyrosine hydroxylase (TH) was purified from bovine brain and enzymatically phosphorylated in vitro. Radioactively phosphorylated TH was dephosphorylated by rat tissue extracts. Of tissues examined, rat corpus striatal extracts were highest in specific activity in the TH dephosphorylating assay. Phosphorylated histone ...

journal_title：Neurochemistry international

authors： Lazar MA,Raese JD,Barchas JD

更新日期：1983-01-01 00:00:00

abstract：:Long term consequence of non-fatal overdose in people who use opioids are not well understood. The intermittent exposure to non-fatal overdose leads to a tauopathy that is often accompanied by abrogated neuroprotective response, abnormal amyloid processing and other pathologies. The scope and limitations of available ...

journal_title：Neurochemistry international

authors： Voronkov M,Cocchiaro B,Stock JB

更新日期：2020-12-10 00:00:00

abstract：:Arsenate is a toxic compound that has been connected with neuropathies and impaired cognitive functions. To test whether arsenate affects the viability and the GSH metabolism of brain astrocytes, we have used primary astrocyte cultures as model system. Incubation of astrocytes for 2h with arsenate in concentrations of...

journal_title：Neurochemistry international

authors： Meyer N,Koehler Y,Tulpule K,Dringen R

更新日期：2013-06-01 00:00:00

abstract：:Choline acetyltransferase activity was detected in extensively washed membranes prepared from rat and guinea pig synaptosomes. When these preparations were treated with the non-ionic detergent Triton X-114 and heated to 37 degrees C to cause phase separation, a significant percentage was found to associate with the de...

journal_title：Neurochemistry international

authors： Docherty M,Bradford HF

更新日期：1988-01-01 00:00:00

abstract：:In the past few years, several studies have demonstrated in the rat subcommissural organ the presence of nerve endings and modified ependymocytes showing an uptake of [(3)H]GABA. The present work was performed to demonstrate in this cerebral zone the possibility of a GABA synthesis by the immunohistochemical localizat...

journal_title：Neurochemistry international

authors： Weissmann-Nanopoulos D,Belin MF,Didier M,Aguera M,Partisani M,Maitre M,Pujol JF

更新日期：1983-01-01 00:00:00

abstract：:The molecular mechanism responsible for hyperphosphorylated tau accumulation in dendrites of Alzheimer's disease (AD) neurons has not been fully clarified. Recently, we reported that tau mRNA is distributed into dendrites, and that translation and phosphorylation of tau protein are immediately enhanced in response to ...

journal_title：Neurochemistry international

authors： Tanaka T,Ohashi S,Takashima A,Kobayashi S

更新日期：2020-10-01 00:00:00

abstract：:Immunohistochemical study on growth inhibitory factor (GIF) in rat brain has revealed that a glial cell layer on the surface of cerebral cortex and the cells surrounding Purkinje cells has been reported. In addition, neurons in gray matter were weakly immunostained for GIF. In situ hybridization using digoxigenin-labe...

journal_title：Neurochemistry international

authors： Anezaki T,Ishiguro H,Hozumi I,Inuzuka T,Hiraiwa M,Kobayashi H,Yuguchi T,Wanaka A,Uda Y,Miyatake T

更新日期：1995-07-01 00:00:00

abstract：:The mobilization of inositol triphosphate ip3 by N-methyl D-aspartate (NMDA) and kainate, two excitatory amino acid EAA receptor agonists, was studied in cultured chick retina cells as a function of culture differentiation. Kainate (EC50 = 30 microM) stimulated from 6 to 9-fold the production of [3H]ip3 between E8C3 (...

journal_title：Neurochemistry international

authors： Reis RA,Kubrusly RC,de Mello MC,de Mello FG

更新日期：1995-04-01 00:00:00

abstract：:An endogenous modulator(s) of the dopamine receptor(s) in bovine and rat brain striatum was detected by demonstrating that water extracts of the striatum inhibited [(3)H]apomorphine binding. This modulator(s) was partially purified by methanol extraction and then successive ion exchange chromatographies on SP-Sephadex...

journal_title：Neurochemistry international

authors： Hirata A,Yamada I,Fujita N,Saito K,Nakahiro M,Yoshida H

更新日期：1986-01-01 00:00:00

abstract：:The extracellular levels of the neurotransmitter glycine in the brain are tightly regulated by the glycine transporter 1 (GlyT1) and the clearance rate for glycine depends on its rate of transport and the levels of cell surface GlyT1. Over the years, it has been shown that PKC tightly regulates the activity of several...

journal_title：Neurochemistry international

authors： Vargas-Medrano J,Castrejon-Tellez V,Plenge F,Ramirez I,Miranda M

更新日期：2011-12-01 00:00:00

abstract：:The Alzheimer's disease amyloid protein precursor (APP) gene is part of a multi-gene super-family from which sixteen homologous amyloid precursor-like proteins (APLP) and APP species homologues have been isolated and characterised. Comparison of exon structure (including the uncharacterised APL-1 gene), construction o...

journal_title：Neurochemistry international

authors： Coulson EJ,Paliga K,Beyreuther K,Masters CL

更新日期：2000-03-01 00:00:00

abstract：:Neutrophil granulocytes (or polymorphonuclear cells, PMNs) have long been considered as crude killing machines, particularly trained to attack bacterial or fungal pathogens in wounds or infected tissues. That perspective has fundamentally changed over the last decades, as PMNs have been shown to exert a livery exchang...

journal_title：Neurochemistry international

authors： Strecker JK,Schmidt A,Schäbitz WR,Minnerup J

更新日期：2017-07-01 00:00:00

abstract：:Adenosine is a neuromodulator that can control brain damage through activation of A(1), A(2A) and A(3) receptors, which are located in both neurons and other brain cells. We took advantage of cultured neurons to investigate the role of neuronal adenosine receptors in the control of neurotoxicity caused by kainate and ...

journal_title：Neurochemistry international

authors： Rebola N,Rodrigues RJ,Oliveira CR,Cunha RA

更新日期：2005-10-01 00:00:00