Ventral tegmental area/substantia nigra and prefrontal cortex rodent organotypic brain slices as an integrated model to study the cellular changes induced by oxygen/glucose deprivation and reperfusion: effect of neuroprotective agents.

abstract：:Lithium is well established as a treatment of manic-depressive illness. As for the mechanism of action of lithium, it is proposed that lithium has effects on intracellular calcium ion (Ca2+) movement. But there are few reports in which the effects of lithium on intracellular Ca2+ movement are observed in the mammalian...

journal_title：Neurochemistry international

authors： Okamoto Y,Kagaya A,Motohashi N,Yamawaki S

更新日期：1995-03-01 00:00:00

abstract：:We examined the intracellular delivery of Pep-1-cargo protein against transient ischemic damage in the hippocampal CA1 region in gerbils. For this study, we introduced green fluorescent protein (GFP) and constructed Pep-1-GFP protein. At 12h after Pep-1-GFP treatment, GFP fluorescence was shown in almost CA1 pyramidal...

journal_title：Neurochemistry international

authors： Cho JH,Hwang IK,Yoo KY,Kim SY,Kim DW,Kwon YG,Choi SY,Won MH

更新日期：2008-03-01 00:00:00

abstract：:The integrity of hippocampal G-protein mediated signalling following ibotenate induced lesion of the medial septum was examined. The lesion was confined histologically to the septum and induced a 23% reduction in hippocampal choline acetyltransferase (ChAT) activity and G-proteins levels and related enzyme activities ...

journal_title：Neurochemistry international

authors： McLaughlin M,Inglis FM,Ross BM,Breen KC,McCulloch J

更新日期：1999-07-01 00:00:00

abstract：:Our previous studies demonstrated that chronic social defeat (CSD) up-regulated expression of the serotonin transporter (SERT) and norepinephrine transporter (NET) in the brain, which was mediated by corticosteroid receptors. In the present study we first analyzed the alterations of corticosteroid receptors in differe...

journal_title：Neurochemistry international

authors： Zhang J,Fan Y,Raza MU,Zhan Y,Du XD,Patel PD,Zhu MY

更新日期：2017-09-01 00:00:00

abstract：:The effects of ?-amino-n-butyric acid (GABA), (+)bicuculline, isoguvacine and 3-(4-chlorophenyl)-4-aminobutyrate [(+/-)baclofen] on the K-induced release of [(3)H]acetylcholine (ACh) were studied in the superior cervical ganglia of the rat in vitro. GABA and isoguvacine inhibited [(3)H]ACh release and these inhibition...

journal_title：Neurochemistry international

authors： Farkas Z,Kása P,Balcar VJ,Joó F,Wolff JR

更新日期：1986-01-01 00:00:00

abstract：:Classical synaptic functions are important and suitable to relatively fast and discretely localized processes, but the nonclassical receptorial functions may be providing revolutionary possibilities for dealing at the cellular level with many of the more interesting and seemingly intractable features of neural and cer...

journal_title：Neurochemistry international

authors： Vizi ES,Kiss JP,Lendvai B

更新日期：2004-09-01 00:00:00

abstract：:Human atrial natriuretic peptide (Ser 99-Tyr 126) was rapidly degraded by both choroid plexus and hypothalamic membranes with a complex pattern of cleavage. The use of protease inhibitors allowed a preliminary characterization of the enzymes involved in the hydrolysis of the Ser-Phe and Phe-Arg bonds of iodine-labelle...

journal_title：Neurochemistry international

authors： Deschodt-Lanckman M,Vanneste Y,Michaux F

更新日期：1988-01-01 00:00:00

abstract：:Vinpocetine (ethyl apovincaminate), a synthetic derivative of the Vinca minor alkaloid vincamine, is widely used for the treatment of cerebrovascular-related diseases. One of the proposed mechanisms underlying its action is to protect against the cytotoxic effects of glutamate overexposure. Glutamate excitotoxicity le...

journal_title：Neurochemistry international

authors： Tárnok K,Kiss E,Luiten PG,Nyakas C,Tihanyi K,Schlett K,Eisel UL

更新日期：2008-12-01 00:00:00

abstract：:Agomelatine is a novel antidepressant with agonistic actions at melatonergic (MT1 and MT2 receptors) and antagonistic actions at 5HT-2C receptors. Venlafaxine, a serotonin norepinephrine reuptake inhibitor, is a widely prescribed drug in depression. The present study evaluated the low dose combinations of venlafaxine ...

journal_title：Neurochemistry international

authors： Thomas J,Khanam R,Vohora D

更新日期：2016-10-01 00:00:00

abstract：:In the present study we investigated the effects of a single injection of reserpine on dopamine receptor function in rat striatum. The measurement of adenylate cyclase activity indicated that cAMP formation induced by the selective D-1 agonist SKF 82526 was greatly increased 2 and 20 h after reserpine; in contrast, th...

journal_title：Neurochemistry international

authors： Liberini P,Nisoli E,Missale C,Memo M,Buonamici M,Rossi A,Spano PF

更新日期：1989-01-01 00:00:00

abstract：:Long-term potentiation (LTP), a model of activity-dependent synaptic plasticity and of certain forms of memory, comprises the persistent enhancement of excitatory neurotransmission that results from high-frequency activation. A presynaptic component of LTP is thought to be modulated by a retrograde messenger generated...

journal_title：Neurochemistry international

authors： Bazan NG,Packard MG,Teather L,Allan G

更新日期：1997-02-01 00:00:00

abstract：:We have previously reported that, unlike their rat counterparts, the survival of mouse cerebellar granule cells is independent of chronic stimulation whether owing to elevated K(+)-induced depolarization or NMDA (N-methyl-D-aspartate) receptor activation. One explanation could be that during the critical period mouse ...

journal_title：Neurochemistry international

authors： Mogensen HS,Jørgensen OS

更新日期：1996-11-01 00:00:00

abstract：:Diisopropyl phosphorofluoridate (DFP) produces Type I organophosphorus compound-induced delayed neurotoxicity (OPIDN) in adult female chickens. We have proposed that calcium/calmodulin protein kinase II (CaM kinase II) plays a role in the development of OPIDN by increasing the phosphorylation of cytoskeletal proteins....

journal_title：Neurochemistry international

authors： Abou-Donia MB,Viana ME,Gupta RP,Anderson JK

更新日期：1993-02-01 00:00:00

abstract：:Depression is characterized by sadness, purposelessness, irritability, and impaired body functions. Depression causes severe symptoms for several weeks, and dysthymia, which may cause chronic, low-grade symptoms. Treatment of depression involves psychotherapy, medications, or phototherapy. Clinical and experimental ev...

journal_title：Neurochemistry international

authors： Shabbir F,Patel A,Mattison C,Bose S,Krishnamohan R,Sweeney E,Sandhu S,Nel W,Rais A,Sandhu R,Ngu N,Sharma S

更新日期：2013-02-01 00:00:00

abstract：:The Mg(2+)-ATPase associated with highly purified cholinergic synaptic vesicles isolated from the Torpedo electric organ can be activated by millimolar concentrations of Ca(2+) only to a maximum of 46%. ATP is hydrolyzed in preference to other tri-nucleotides on Mg(2+)-activation but not on Ca(2+)-activation of the en...

journal_title：Neurochemistry international

authors： Stelzl H,Grondal EJ,Zimmermann H

更新日期：1987-01-01 00:00:00

abstract：:Adenosine exerts two parallel modulatory roles in the CNS, acting as a homeostatic modulator and also as a neuromodulator at the synaptic level. We will present evidence to suggest that these two different modulatory roles are fulfilled by extracellular adenosine originated from different metabolic sources, and involv...

journal_title：Neurochemistry international

authors： Cunha RA

更新日期：2001-02-01 00:00:00

abstract：:Arsenate is a toxic compound that has been connected with neuropathies and impaired cognitive functions. To test whether arsenate affects the viability and the GSH metabolism of brain astrocytes, we have used primary astrocyte cultures as model system. Incubation of astrocytes for 2h with arsenate in concentrations of...

journal_title：Neurochemistry international

authors： Meyer N,Koehler Y,Tulpule K,Dringen R

更新日期：2013-06-01 00:00:00

abstract：:This study aimed to examine the effects of Cacna1a mutation on the phenotype of Scn1a-associated epilepsy in rats. We used rats with an N1417H missense mutation in the Scn1a gene and others with an M251K mutation in the Cacna1a gene. Scn1a/Cacna1a double mutant rats were generated by mating both Scn1a and Cacna1a muta...

journal_title：Neurochemistry international

authors： Ohmori I,Kobayashi K,Ouchida M

更新日期：2020-12-01 00:00:00

abstract：:We examined the vesicular accumulation of the excitatory amino-acid (EAA) neurotransmitters, L-glutamate and L-aspartate, together with the non-metabolisable EAA analogue D-aspartate. Synaptosomes derived from whole brain were incubated in various concentrations of [3H]-amino acids under conditions to facilitate vesic...

journal_title：Neurochemistry international

authors： Fleck MW,Barrionuevo G,Palmer AM

更新日期：2001-09-01 00:00:00

abstract：:Minocycline is neuroprotective in animal models of a number of acute CNS injuries, neurodegenerative diseases and CNS infection. While anti-inflammatory and anti-apoptotic effects of Minocycline have been characterized, the molecular basis for the neuroprotective effects of Minocycline remains unclear. We report here ...

journal_title：Neurochemistry international

authors： Mishra MK,Ghosh D,Duseja R,Basu A

更新日期：2009-06-01 00:00:00

abstract：:Using immunohistochemical methods at the light and electron microscope level, the coexistence between a hypophysiotropic factor and an apparently unrelated neuropeptide was demonstrated in three distinct infundibular neuronal systems. The present results emphasize the importance of demonstrating peptide coexistences f...

journal_title：Neurochemistry international

authors： Tramu G,Beauvillain JC,Croix D,Pillez A,Garaud JC

更新日期：1984-01-01 00:00:00

abstract：:Diabetic neuropathy (DN) is a common form of peripheral neuropathy, yet the mechanisms responsible for chronic pain in this disease are poorly understood. The up-regulation of the expression and function of voltage-gated sodium channel Nav1.7 has been implicated in DN, however, the exact mechanism is unclear. In the p...

journal_title：Neurochemistry international

authors： Huang Y,Zang Y,Zhou L,Gui W,Liu X,Zhong Y

更新日期：2014-09-01 00:00:00

abstract：:Poly(ADP-ribose)polymerase-1 (PARP-1) overactivation is a key event in neurodegeneration but the underlying molecular mechanisms wait to be unequivocally identified. Energy failure, transcriptional derangement and deadly nucleus-mitochondria cross-talk have been proposed as mechanisms responsible for PARP-1 neurotoxic...

journal_title：Neurochemistry international

authors： Fossati S,Cipriani G,Moroni F,Chiarugi A

更新日期：2007-01-01 00:00:00

abstract：:The present study confirmed our previous assumption on the crucial role of central alpha2B-like adrenoceptor subtype in gastric mucosal defense. It was found that beside clonidine, rilmenidine, an alpha2/imidazoline receptor agonist and ST-91, an alpha2B-adrenoceptor preferring agonist inhibited the mucosal lesions in...

journal_title：Neurochemistry international

authors： Gyires K,Zádori ZS,Shujaa N,Minorics R,Falkay G,Mátyus P

更新日期：2007-10-01 00:00:00

abstract：:Acetylcholine is an excitatory neurotransmitter in the central nervous system of insects and the nicotinic acetylcholine receptor (nAChR) is a target for neonicotinoid insecticides. Functional insect nAChRs are difficult to express in host cells, and hence difficult to study. In mammals, acetylcholine and nicotine evo...

journal_title：Neurochemistry international

authors： Pyakurel P,Shin M,Venton BJ

更新日期：2018-03-01 00:00:00

abstract：:An intraocular injection of [(3)H]proline was used to label rabbit retinal ganglion cells including components subjected to axonal transport. Degradation of rapidly axonally transported labelled proteins was estimated in an in vitro system using homogenates of the nerve terminal regions. The energy requirements of thi...

journal_title：Neurochemistry international

authors： Gustavsson S,Karlsson JO

更新日期：1985-01-01 00:00:00

abstract：:The active fraction, isolated and partially purified from the crude venom of the marine snail Conus distans, with a molecular mass of about 25 kDa, inhibits neurotransmitter release in rat hippocampus. This toxin (distans Toxin) inhibits the electrically evoked tritium labelled noradrenaline release from rat hippocamp...

journal_title：Neurochemistry international

authors： Saxena VK,Partoens P,de Block J,Coen EP,Vauquelin G,De Potter WP

更新日期：1992-01-01 00:00:00

abstract：:Although microvascular cell death is a well established hallmark of diabetic retinopathy, which is a major cause of vision loss, much remains to be learned about the functional changes that precede the onset of morphological damage to retinal blood vessels. Early alterations of function are of interest since they may ...

journal_title：Neurochemistry international

authors： Nakaizumi A,Zhang T,Puro DG

更新日期：2012-11-01 00:00:00

abstract：:Microglia, the primary resident immune cells of the central nervous system (CNS), responds rapidly to pathogens and injury by secreting immune mediators including nitric oxide (NO). The reaction of NO with the anti-oxidant glutathione forms S-nitrosoglutathione (GSNO), the major pool of biologic NO in the body. GSNO i...

journal_title：Neurochemistry international

authors： Rossi-George A,Guo CJ

更新日期：2016-10-01 00:00:00

abstract：:Glucose is the preferred energy substrate for the adult brain. However, during periods of fasting and consumption of a high fat, low carbohydrate (ketogenic) diet, ketone bodies become major brain fuels. The present study was conducted to investigate how the ketogenic diet influences neuronal-glial interactions in ami...

journal_title：Neurochemistry international

authors： Melø TM,Nehlig A,Sonnewald U

更新日期：2006-05-01 00:00:00