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Inhibition of evoked neurotransmitter release from rat hippocampus by a polypeptide toxin isolated from the marine snail Conus distans.

Abstract：

:The active fraction, isolated and partially purified from the crude venom of the marine snail Conus distans, with a molecular mass of about 25 kDa, inhibits neurotransmitter release in rat hippocampus. This toxin (distans Toxin) inhibits the electrically evoked tritium labelled noradrenaline release from rat hippocampal slices in a dose and time dependent manner. The neurotransmitter release is mainly regulated by N-type of voltage sensitive Ca(2+)-channels. The distans toxin behaves as a partial antagonist of calcium in the buffer, possibly by competing with calcium for this type of voltage sensitive Ca(2+)-channels.

journal_name

Neurochem Int

journal_title

Neurochemistry international

authors

Saxena VK,Partoens P,de Block J,Coen EP,Vauquelin G,De Potter WP

doi

10.1016/0197-0186(92)90127-d

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

69-74

issue

1

eissn

0197-0186

issn

1872-9754

journal_volume

20

pub_type

杂志文章

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