New insights into molecular structure and function of ectonucleotidases in the nervous system.

abstract：:Structural analogues of ZAPA, Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid, an isothiouronium analogue of GABA, are potent GABAA agonists as seen in the isolated guinea-pig ileum and in the facilitation of [3H]diazepam binding to rat brain membranes. Compounds with guanidino or amidine groups replacing the amino func...

journal_title：Neurochemistry international

authors： Allan RD,Dickenson HW,Johnston GA,Kazlauskas R,Mewett KN

更新日期：1997-06-01 00:00:00

abstract：:Essential metals are crucial for the maintenance of cell homeostasis. Among the 23 elements that have known physiological functions in humans, 12 are metals, including iron (Fe) and manganese (Mn). Nevertheless, excessive exposure to these metals may lead to pathological conditions, including neurodegeneration. Simila...

journal_title：Neurochemistry international

authors： Farina M,Avila DS,da Rocha JB,Aschner M

更新日期：2013-04-01 00:00:00

abstract：:Increased concentrations of kynurenine pathway metabolites have been reported by several groups for disorders involving psychosis, including schizophrenia and bipolar disorder. To identify components of the pathway that may be relevant as biomarkers or may underlie the etiology of psychosis, it is essential to charact...

journal_title：Neurochemistry international

authors： Miller CL,Llenos IC,Cwik M,Walkup J,Weis S

更新日期：2008-05-01 00:00:00

abstract：:The effect of subcutaneous injections of saline (0.9% NaCl, 10-40 ?l/g b. wt) to 5- and 20-day old rats on the concentrations of tyrosine (Tyr) and tryptophan (Trp) in the serum and the brain and on the levels of biogenic amines and their metabolites in the developing brain at 6 h p.i. is described. At day 5 the conce...

journal_title：Neurochemistry international

authors： Huether G,Thoemke F,Sprotte U,Steinhaus U,Neuhoff V

更新日期：1985-01-01 00:00:00

abstract：:A purification procedure to obtain peroxisomes (microperoxisomes) from the brain of suckling rats is reported. A P2 fraction, (crude light mitochondria) frozen and thawed seven times, was subfractionated yielding a P4 fraction, 4-fold enriched in catalase activity with respect to the cytoplasmic extract S1. The P4 fra...

journal_title：Neurochemistry international

authors： Cimini AM,Moreno S,Giorgi M,Serafini B,Cerú MP

更新日期：1993-09-01 00:00:00

abstract：:Dopaminergic dysregulation in nucleus accumbens has been implicated in the origin of schizophrenia. Accumbal cholinergic interneurons exert powerful modulatory control of local dopamine function, through nicotinic receptors located on dopamine terminals. Fast-scan cyclic voltammetry in rat brain slices in vitro was us...

journal_title：Neurochemistry international

authors： Yavas E,Young AMJ

更新日期：2020-11-01 00:00:00

abstract：:RBFox proteins are well-known alternative splicing regulators. We have shown previously that during neuronal differentiation of P19 cells induced by all-trans retinoic acid and cell aggregation, RBFox1 shows markedly increased temporal expression. To find its key splicing regulation, we examined the effect of RBFox1 o...

journal_title：Neurochemistry international

authors： Alam S,Suzuki H,Tsukahara T

更新日期：2014-12-01 00:00:00

abstract：:The present study was designed to investigate the turnover rates of D1 dopamine receptors in the brain and retina of adult and aged rats. To this aim, we monitored the increase in the density of 3H-SCH 23390 binding sites after the administration of the irreversible antagonist N-ethoxycarbonyl-2-ethoxy-1,2 dihydroquin...

journal_title：Neurochemistry international

authors： Giorgi O,Pibiri MG,Dal Toso R,Toffano G,Biggio G

更新日期：1992-03-01 00:00:00

abstract：:GABA is catabolized in the mitochondrial matrix through the GABA shunt, encompassing transamination to succinic semialdehyde followed by oxidation to succinate by the concerted actions of GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH), respectively. Gamma-hydroxybutyrate (GHB) is a neurotra...

journal_title：Neurochemistry international

authors： Ravasz D,Kacso G,Fodor V,Horvath K,Adam-Vizi V,Chinopoulos C

更新日期：2017-10-01 00:00:00

abstract：:The system of GABA transporters in neural cells constitutes an efficient mechanism for terminating inhibitory GABAergic neurotransmission. As such these transporter are important therapeutical targets in epilepsy and potentially other neurological diseases related to the GABA system. In this study a number of analogs ...

journal_title：Neurochemistry international

authors： Sarup A,Larsson OM,Bolvig T,Frølund B,Krogsgaard-Larsen P,Schousboe A

更新日期：2003-09-01 00:00:00

abstract：:Interferon beta-1b (IFN beta-1b) (Betaseron) has been recently shown to alter the course of multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS) where migration of activated lymphocytes across the blood-brain barrier (BBB) is a critical step in the pathogenesis of this dis...

journal_title：Neurochemistry international

authors： Jiang H,Williams GJ,Dhib-Jalbut S

更新日期：1997-04-01 00:00:00

abstract：:TAR DNA-binding protein 43 (TDP-43) is a major pathological protein of ubiquitinated inclusions in motor neurons of sporadic amyotrophic lateral sclerosis (ALS). TDP-43 is ubiquitously expressed and the majority of TDP-43 is normally localized to the nucleus. In motor neurons of patients with ALS, TDP-43 is not locali...

journal_title：Neurochemistry international

authors： Hishizawa M,Yamashita H,Akizuki M,Urushitani M,Takahashi R

更新日期：2019-03-01 00:00:00

abstract：:Evidences have indicated a high degree of comorbidity of alcoholism and depression. N-acetylcysteine (NAC) has shown its clinical efficiency in the treatment of several psychiatric disorders and is identified as a multi-target acting drug. The ability of NAC to prevent alcohol abstinence-induced depression-like effect...

journal_title：Neurochemistry international

authors： Yawalkar R,Changotra H,Gupta GL

更新日期：2018-09-01 00:00:00

abstract：:The relative abilities of a series of local anesthetics in which either or both the ester oxygens had been replaced with sulfur or selenium to block axonal or synaptic preparations are compared with their abilities to displace (3)H-nicotine from lobster axon plasma membrane fragments. The relative affinities of a seri...

journal_title：Neurochemistry international

authors： Mautner HG,Jumblatt JE,Marquis JK

更新日期：1980-01-01 00:00:00

abstract：:The venom from the marine snail Conus pennaceus inhibits the binding of [3H]neuropeptide Y to calf brain membranes (Czerwiec et al., 1996a) and, in the present study, also to rat forebrain membranes. These membranes contain about 80% Y1- and 20% Y2-receptors. The inhibition by the venom was concentration-dependent wit...

journal_title：Neurochemistry international

authors： Diallo B,Vanderheyden PM,De Backer JP,Vauquelin G

更新日期：1998-01-01 00:00:00

abstract：:The changes in intracellar Ca(2+)-concentration, which occur during stimulation of vascular smooth muscle cells with excitatory agonists, are discussed. The effects of these agonists on the membrane potential of these cells are indirect, and mainly due to an activation of K(+)- and Cl(?)-channels by the release of cal...

journal_title：Neurochemistry international

authors： Casteels R,Droogmans G,Missiaen L

更新日期：1990-01-01 00:00:00

abstract：:The alternative routes of cleavage of the amyloid precursor protein (APP) result in the generation and secretion of both soluble APP and beta-amyloid, the latter being the main component of the amyloid deposits in the brains of individuals with Alzheimer's disease (AD). This study examined the question of whether acet...

journal_title：Neurochemistry international

authors： Pakaski M,Rakonczay Z,Kasa P

更新日期：2001-03-01 00:00:00

abstract：:This study aimed to elucidate locomotor activity changes in 6-hydroxydopamine (6-OHDA) induced Parkinson's disease (PD) and investigate the possible beneficial effects of melatonin on altered levels of locomotor activity, cyclooxygenase (COX), prostaglandin E2 (PGE2), nuclear factor kappa-B (NF-κB), nitrate/nitrite an...

journal_title：Neurochemistry international

authors： Yildirim FB,Ozsoy O,Tanriover G,Kaya Y,Ogut E,Gemici B,Dilmac S,Ozkan A,Agar A,Aslan M

更新日期：2014-12-01 00:00:00

abstract：:The immunostains of GD3, c-pathway polysialogangliosides and gangliotetraosylgangliosides belonging to the a- and b-pathways were analyzed in embryo optic lobe cells. Cells were cultured in serum free media with, and without, bovine brain ganglioside mixture (largely gangliotetraosylgangliosides). Control cells differ...

journal_title：Neurochemistry international

authors： Cossy-Isasi S,Panzetta P

更新日期：1994-04-01 00:00:00

abstract：:Sodium- and energy-dependent accumulation of [(3)H]l-glutamic acid (Glu) into rat cerebral cortical slices was inhibited by relatively high concentrations (40-100 ?M) of calmodulin antagonists, such as N-(6-aminohexyl)-1-naphthalenesulfonamide and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, in concentration-de...

journal_title：Neurochemistry international

authors： Yoneda Y,Ogita K,Yamada K,Kouda T,Ohgaki T,Uchida S,Meguri H

更新日期：1989-01-01 00:00:00

abstract：:The disposition of labelled [3H]GM1lactone, the inner ester of ganglioside GM1, was studied in the rat. After i.v. administration [3H]GM1lactone was quickly converted to its corresponding open form most likely by plasma esterases, and then displayed a pharmacokinetic profile identical to [3H]GM1. Following intramuscul...

journal_title：Neurochemistry international

authors： Bellato P,Milan F,Facchinetti E,Toffano G

更新日期：1992-04-01 00:00:00

abstract：:Na+-dependent uptake of excitatory neurotransmitter glutamate in astrocytes increases cell energy demands primarily due to the elevated ATP consumption by glutamine synthetase and Na+, K+-ATPase. The major pool of GLAST/EAAT1, the only glutamate transporter subtype expressed by human fetal astrocytes in undifferentiat...

journal_title：Neurochemistry international

authors： Gegelashvili M,Rodriguez-Kern A,Sung L,Shimamoto K,Gegelashvili G

更新日期：2007-06-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor is a subtype of ionotropic glutamate receptor that is involved in synaptic mechanisms of learning and memory, and mediates excitotoxic neuronal injury. In this study, we tested the hypothesis that NMDA receptor subunit gene expression is altered in cortex and hippocampus of OKA...

journal_title：Neurochemistry international

authors： Kamat PK,Rai S,Swarnkar S,Shukla R,Nath C

更新日期：2014-10-01 00:00:00

abstract：:The influx of extracellular Zn(2+) into dentate granule cells is nonessential for dentate gyrus long-term potentiation (LTP) and the physiological significance of extracellular Zn(2+) dynamics is unknown in the dentate gyrus. Excess increase in extracellular Zn(2+) in the hippocampal CA1, which is induced with excitat...

journal_title：Neurochemistry international

authors： Suzuki M,Fujise Y,Tsuchiya Y,Tamano H,Takeda A

更新日期：2015-08-01 00:00:00

abstract：:The effect of different dietary fats with varying degrees of unsaturation and essential fatty acid composition, which are commonly consumed in India, on the activity of some important membrane-bound enzymes was assessed in different brain regions of rat. Four groups of male CFY weanling rats were fed nutritionally ade...

journal_title：Neurochemistry international

authors： Srinivasarao P,Narayanareddy K,Vajreswari A,Rupalatha M,Prakash PS,Rao P

更新日期：1997-12-01 00:00:00

abstract：:Rapid eye movement sleep deprivation is associated with an increase in Na-K ATPase activity. In order to understand the possible biochemical mechanism of this increase, the kinetics of Na-K ATPase was studied. Although the enzyme activity increased after the deprivation, the catalytic efficiency of the enzyme remained...

journal_title：Neurochemistry international

authors： Adya HV,Mallick BN

更新日期：2000-03-01 00:00:00

abstract：:Cholinergic neuroblastoma NS20Y cells were differentiated by the chicken gizzard extract. They were first inoculated into a glass culture bottle and the aggregated cells which grew in the suspension culture were collected. The aggregated cells (round and immature neuroblastoma cells) were seeded on a polyornithinecoat...

journal_title：Neurochemistry international

authors： Miki N,Higashida H,Hayashi Y,Akiyama M,Kuo CH

更新日期：1982-01-01 00:00:00

abstract：:Acetylcholinesterase (AChE) hydrolyses acetylcholine to choline and acetate, playing an important role in terminating the neurotransmission in brain and muscle. Recently, the non-neuronal functions of AChE have been proposed in different tissues, in which there are various factors to regulate the expression of AChE. I...

journal_title：Neurochemistry international

authors： Wu Q,Bai P,Xia Y,Lai QWS,Guo MSS,Dai K,Zheng Z,Ling CSJ,Dong TTX,Pi R,Tsim KWK

更新日期：2020-12-01 00:00:00

abstract：:Human glutamate dehydrogenase (GDH) gene was fused with a gene fragment encoding the nine amino acid (RKKRRQRRR) protein transduction domain of human immunodeficiency virus TAT protein in bacterial expression vector to produce genetic in-frame TAT-GDH fusion protein. The TAT-GDH protein can enter PC12 cells efficientl...

journal_title：Neurochemistry international

authors： Yoon HY,Lee SH,Cho SW,Lee JE,Yoon CS,Park J,Kim TU,Choi SY

更新日期：2002-07-01 00:00:00

abstract：:A novel copper-containing protein has been isolated in electrophoretically homogeneous state from bovine brain extracts. Some physico-chemical properties of the protein are determined (molecular weight, copper content, isoelectric point, amino acid composition, optical and EPR spectra), and they are compared with thos...

journal_title：Neurochemistry international

authors： Mikaelyan MV,Nalbandyan RM

更新日期：1988-01-01 00:00:00