microRNAs, the cell's Nepenthe: clearing the past during the maternal-to-zygotic transition and cellular reprogramming.

abstract：:TGFβ acts as a potent tumor suppressor and tumor promoter in a context dependent manner. Tumor suppressive functions include inhibition of cell proliferation, induction of apoptosis and regulation of autophagy. As tumors develop they switch their response to TGFβ and utilise this factor as a potent promoter of cell mo...

journal_title：Current opinion in genetics & development

authors： Inman GJ

更新日期：2011-02-01 00:00:00

abstract：:Multicellularity has evolved multiple times independently from a variety of ancestral unicellular lineages. Past research on multicellularity was focused more on explaining why it was repeatedly invented and less so on the molecular foundations associated with each transition. Several recent comparative functional ana...

journal_title：Current opinion in genetics & development

authors： Rokas A

更新日期：2008-12-01 00:00:00

abstract：:The definitive endoderm (DE) was first defined as the innermost germ layer found in all metazoan embryos. During development, it gives rise to a vast array of specialized epithelial cell types lining the respiratory and digestive systems, and contributes to associated organs such as thyroid, thymus, lungs, liver, and ...

journal_title：Current opinion in genetics & development

authors： Kraus MR,Grapin-Botton A

更新日期：2012-08-01 00:00:00

abstract：:Over the past decade, many potential candidates for molecules involved in pattern formation in the vertebrate embryo have been identified. Manipulation of the expression of some of these factors has generated fascinating results that have allowed investigators to address their roles in embryogenesis. One such family c...

journal_title：Current opinion in genetics & development

authors： Dickinson ME,McMahon AP

更新日期：1992-08-01 00:00:00

abstract：:Recent studies of beta-globin gene expression have concentrated on the analysis of factor binding and chromatin structure within the endogenous locus. These studies have more precisely defined the extent and nature of the active chromosomal domain and the elements that organize it. Surprisingly, the beta-globin locus ...

journal_title：Current opinion in genetics & development

authors： Bulger M,Sawado T,Schübeler D,Groudine M

更新日期：2002-04-01 00:00:00

abstract：:The current state of the gene regulatory network for endomesoderm specification in sea urchin embryos is reviewed. The network was experimentally defined, and is presented as a predictive map of cis-regulatory inputs and functional regulatory gene interconnections (updated versions of the network and most of the under...

journal_title：Current opinion in genetics & development

authors： Oliveri P,Davidson EH

更新日期：2004-08-01 00:00:00

abstract：:The combination of complete genome sequence information and estimates of mRNA abundances have begun to reveal causes of both silent and protein sequence evolution. Translational selection appears to explain patterns of synonymous codon usage in many prokaryotes as well as a number of eukaryotic model organisms (with t...

journal_title：Current opinion in genetics & development

authors： Akashi H

更新日期：2001-12-01 00:00:00

abstract：:Natural selection drives evolving populations up the fitness landscape, the projection from nucleotide sequence space to organismal reproductive success. While it has long been appreciated that topographic complexities on fitness landscapes can arise only as a consequence of epistatic interactions between mutations, e...

journal_title：Current opinion in genetics & development

authors： Weinreich DM,Lan Y,Wylie CS,Heckendorn RB

更新日期：2013-12-01 00:00:00

abstract：:Retrotransposons are mutagenic units able to move within the genome. Despite many defenses deployed by the host to suppress potentially harmful activities of retrotransposons, these genetic units have found ways to meld with normal cellular functions through processes of exaptation and domestication. The same host mec...

journal_title：Current opinion in genetics & development

authors： Mita P,Boeke JD

更新日期：2016-04-01 00:00:00

abstract：:Cardiovascular morphogenesis involves cell behavior and cell identity changes that are activated by mechanical forces associated with heart function. Recently, advances in in vivo imaging, methods to alter blood flow, and computational modelling have greatly advanced our understanding of how forces produced by heart c...

journal_title：Current opinion in genetics & development

authors： Duchemin AL,Vignes H,Vermot J,Chow R

更新日期：2019-08-01 00:00:00

abstract：:Modelling human colon cancer has long been the ambition of researchers and oncologists with the aim to better replicate disease progression and treatment response. Advances in our understanding of genetics, stem cell biology, tumour microenvironment and immunology have prepared the groundwork for recent major advances...

journal_title：Current opinion in genetics & development

authors： Lannagan TR,Jackstadt R,Leedham SJ,Sansom OJ

更新日期：2021-01-07 00:00:00

abstract：:The past decade has seen a huge jump in the resolution and scale at which we can interrogate the three-dimensional properties of the genome. This revealed different types of chromatin structures including topologically associating domains, partitioning genes and their enhancers into interacting domains. While the visu...

journal_title：Current opinion in genetics & development

authors： Cavalheiro GR,Pollex T,Furlong EE

更新日期：2021-01-23 00:00:00

abstract：:The neocortex represents the brain structure that has been subjected to a major expansion in its relative size during the course of mammalian evolution. An exquisite coordination of appropriate growth of competent territories along multiple axes and their spatial patterning is required for regionalization of the corti...

journal_title：Current opinion in genetics & development

authors： Borello U,Pierani A

更新日期：2010-08-01 00:00:00

abstract：:During the past year, significant advances have been made in understanding the functions of the oncoproteins, E6 and E7, of human papillomaviruses that are associated with malignant genital tumors. In addition, important new information is now available on the responses of both the keratinocyte and of the individual f...

journal_title：Current opinion in genetics & development

authors： Gissmann L

更新日期：1992-02-01 00:00:00

abstract：:There have been remarkably rapid advances in the understanding of prion diseases over the past year. The controversial notion that the transmissible agent may be an abnormal isoform of a host-encoded protein, the prion protein, is now gaining wide acceptance. The conundrum of how a disease can both be inherited as an ...

journal_title：Current opinion in genetics & development

authors： Collinge J,Palmer MS

更新日期：1992-06-01 00:00:00

abstract：:Considerable progress has been made in unraveling the mechanistic features of RNA editing processes in a number of genetic systems. Recent highlights include the identification of the catalytic subunit of the mammalian apolipoprotein B mRNA editing enzyme as a zinc-dependent cytidine deaminase that binds to RNA, the d...

journal_title：Current opinion in genetics & development

authors： Benne R

更新日期：1996-04-01 00:00:00

abstract：:Since the cloning of the Y-located testis-determining factor, sex determining region Y (SRY), several other genes have been implicated in the process of mammalian sex determination. Mutations of an SRY-related gene, SRY-related high-mobility group box 9 (SOX9), result in autosomal sex reversal and campomelic dysplasia...

journal_title：Current opinion in genetics & development

authors： Ramkissoon Y,Goodfellow P

更新日期：1996-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a large class of small RNAs that function as negative gene regulators in eukaryotes. They regulate diverse biological processes, and bioinformatics data indicate that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. ...

journal_title：Current opinion in genetics & development

authors： Niwa R,Slack FJ

更新日期：2007-04-01 00:00:00

abstract：:Eukaryotic organisms have the remarkable ability to inherit states of gene activity without altering the underlying DNA sequence. This epigenetic inheritance can persist over thousands of years, providing an alternative to genetic mutations as a substrate for natural selection. Epigenetic inheritance might be propagat...

journal_title：Current opinion in genetics & development

authors： Zilberman D,Henikoff S

更新日期：2005-10-01 00:00:00

abstract：:The recent flood of information concerning Saccharomyces cerevisiae replication origins and the proteins that interact with them contrasts alarmingly to the trickle of progress in our understanding of metazoan origins. In mammalian cells, origins are complex and heterogeneous, and appear to be selected by features of ...

journal_title：Current opinion in genetics & development

authors： Gilbert DM

更新日期：1998-04-01 00:00:00

abstract：:Genetic conflicts arise when the evolutionary interests of two genetic elements are not aligned. Conflicts between genomes (e.g. pathogen versus host) or within the same genome (e.g. internal parasitic DNA sequences versus the rest of the host genome) can both foster 'molecular arms races', in which genes on both side...

journal_title：Current opinion in genetics & development

authors： Daugherty MD,Zanders SE

更新日期：2019-10-01 00:00:00

abstract：:The genomic variability of Southern African groups is characterized by an exceptional degree of diversity, which is the result of long-term local evolutionary history, migrations and gene-flow. Over the last few years several investigations have identified and described signatures related to these processes, revealing...

journal_title：Current opinion in genetics & development

authors： Montinaro F,Capelli C

更新日期：2018-12-01 00:00:00

abstract：:Cyclin-dependent kinases play essential roles in driving the cell cycle. Much progress has been made in Drosophila over the past year in identifying the specific requirements for individual cyclins in particular cell cycle events. These studies encompass many aspects of the cell cycle, from the addition of a G1 phase ...

journal_title：Current opinion in genetics & development

authors： Follette PJ,O'Farrell PH

更新日期：1997-02-01 00:00:00

abstract：:The advent of methods for mapping the location of specific proteins across genomes is substantially enlightening our understanding of gene regulation. One recent discovery is that Pol II is concentrated at the 5' end of thousands of genes in mammalian and Drosophila cells. Before this, much research had focused on und...

journal_title：Current opinion in genetics & development

authors： Li J,Gilmour DS

更新日期：2011-04-01 00:00:00

abstract：:The mammalian genome is folded into topological domains, chromosomal units that probably serve to spatially accommodate enhancer-promoter interactions and control gene expression levels across cell populations. Longer-range contacts beyond topological domains are also formed, but only in subpopulations of cells. We pr...

journal_title：Current opinion in genetics & development

authors： Krijger PH,de Laat W

更新日期：2013-04-01 00:00:00

abstract：:A number of prokaryotic and eukaryotic genomes are currently being sequenced. Already, the nucleotide sequences of four yeast chromosomes and of 2.2 Mb from Caenorhabditis elegans have been reported. Human genomic sequences have also been used in comparative studies with both mouse and Fugu rubripes. ...

journal_title：Current opinion in genetics & development

authors： Jones SJ

更新日期：1995-06-01 00:00:00

abstract：:Genome instability is a feature of nearly all cancers and can be exploited for therapy. In addition, a growing number of genome maintenance genes have been associated with developmental disorders. Efforts to understand the role of genome instability in these processes will be greatly facilitated by a more comprehensiv...

journal_title：Current opinion in genetics & development

authors： Balmus G,McIntyre RE

更新日期：2014-02-01 00:00:00

abstract：:The genetic study of rats and mice using natural variants, natural mutations, chemical or radiation induced mutations, engineered mutations and conditional engineered mutations has provided the tools for investigating the genetics of disease. The completion of the mouse genomic sequence and progress towards sequencing...

journal_title：Current opinion in genetics & development

authors： Cox RD,Brown SD

更新日期：2003-06-01 00:00:00

abstract：:Eukaryotic genomes encode genetic information in their linear sequence, but appropriate expression of their genes requires chromosomes to fold into complex three-dimensional structures. Fueled by a growing collection of sequencing and imaging-based technologies, studies have uncovered a hierarchy of DNA interactions, ...

journal_title：Current opinion in genetics & development

authors： Luppino JM,Joyce EF

更新日期：2020-04-01 00:00:00

abstract：:During development, embryos perform a mesmerizing choreography, which is crucial for the correct shaping, positioning and function of all organs. The cellular properties powering animal morphogenesis have been the focus of much attention. In contrast, much less consideration has been given to the invisible engine cons...

journal_title：Current opinion in genetics & development

authors： Schliffka MF,Maître JL

更新日期：2019-08-01 00:00:00