Abstract：
:The neocortex represents the brain structure that has been subjected to a major expansion in its relative size during the course of mammalian evolution. An exquisite coordination of appropriate growth of competent territories along multiple axes and their spatial patterning is required for regionalization of the cortical primordium and the formation of functional areas. The achievement of such a highly complex architecture relies on a precise orchestration of the proliferation of progenitors, onset of neurogenesis, spatio-temporal generation of distinct cell types and control of their migration. We will review recent work on alternative molecular mechanisms that, via the migration of signaling cells/structures, participate in coordinating growth and spatial patterning in the developing cerebral cortex. By integrating temporal and spatial parameters as well as absolute levels of signaling this novel strategy might represent a general mechanism for long-range patterning in large structures, in addition to the passive diffusion of morphogens.
journal_name
Curr Opin Genet Devjournal_title
Current opinion in genetics & developmentauthors
Borello U,Pierani Adoi
10.1016/j.gde.2010.05.003subject
Has Abstractpub_date
2010-08-01 00:00:00pages
408-15issue
4eissn
0959-437Xissn
1879-0380pii
S0959-437X(10)00083-3journal_volume
20pub_type
杂志文章,评审abstract：:The ability to reprogram cell lineage specification through the activity of master regulatory transcription factors has transformed disease modeling, drug screening, and cell therapy for regenerative medicine. Recent advances in the engineering of synthetic transcription factors to modulate endogenous gene expression ...
journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
pub_type： 杂志文章,评审
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
pub_type： 杂志文章,评审
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journal_title：Current opinion in genetics & development
pub_type： 杂志文章,评审
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journal_title：Current opinion in genetics & development
pub_type： 杂志文章,评审
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
pub_type： 杂志文章,评审
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
pub_type： 杂志文章,评审
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abstract：:The Selfish Operon Model postulates that the organization of bacterial genes into operons is beneficial to the constituent genes in that proximity allows horizontal cotransfer of all genes required for a selectable phenotype; eukaryotic operons formed for very different reasons. Horizontal transfer of selfish operons ...
journal_title：Current opinion in genetics & development
pub_type： 杂志文章,评审
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
pub_type： 杂志文章,评审
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journal_title：Current opinion in genetics & development
pub_type： 杂志文章,评审
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