Abstract:
:Evolutionary studies suggest that the limbs of vertebrates and the appendages of arthropods do not share a common origin. However, recent genetic studies show new similarities in their developmental programmes. These similarities might be caused by the independent recruitment of homologous genes for similar functions or by the conservation of an ancestral proximal-distal development programme. This basic programme might have arisen in an ancestral outgrowth and been independently co-opted in vertebrate and arthropod appendages. It has subsequently diverged in both phyla to fine-pattern the limb and to control phylum-specific cellular events. We suggest that although vertebrate limbs and arthropod appendages are not strictly homologous structures they retain remnants of a common ancestral developmental programme.
journal_name
Curr Opin Genet Devjournal_title
Current opinion in genetics & developmentauthors
Pueyo JI,Couso JPdoi
10.1016/j.gde.2005.06.007subject
Has Abstractpub_date
2005-08-01 00:00:00pages
439-46issue
4eissn
0959-437Xissn
1879-0380pii
S0959-437X(05)00103-6journal_volume
15pub_type
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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journal_title:Current opinion in genetics & development
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abstract::Recent evidence suggests that dynamic three-dimensional genomic interactions in the nucleus exert critical roles in regulated gene expression. Here, we review a series of recent paradigm-shifting experiments that highlight the existence of specific gene networks within the self-organizing space of the nucleus. These g...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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abstract::The advent of gene targeting in the mouse has led to rapid advances in the identification of factors controlling gene expression that are essential for normal hematopoietic development. Recent work has also uncovered roles for some of these factors in leukemogenesis and in the global regulation of chromatin structure....
journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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abstract::Studies of primate lentivirus phylogeny over the past decade have established a minimum of five related, but genetically distinct, groups of simian immunodeficiency virus (SIV), each originating from a different African primate species. The hypothesis that HIV-2 (and SIVmac) arose by cross-species transmission from so...
journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/j.gde.2010.08.010
更新日期:2010-12-01 00:00:00
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/j.gde.2010.09.002
更新日期:2010-12-01 00:00:00
abstract::Rapid progress in identifying the genes underlying autism spectrum disorder (ASD) has provided the substrate for a first wave of analyses into the underlying neurobiology. This review describes the consensus across these diverse analyses, highlighting two distinct sets of genes: 1) Genes that regulate chromatin and tr...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/j.gde.2015.10.002
更新日期:2015-08-01 00:00:00
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/s0959-437x(96)80054-2
更新日期:1996-04-01 00:00:00
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/j.gde.2018.09.002
更新日期:2018-08-01 00:00:00
abstract::In the Drosophila eye, photoreceptor clusters are arranged with mirror-image symmetry about the dorso-ventral midline. Recent work indicates critical rôles for Wingless and JAK/STAT signalling in setting up long-range gradients of positional information that determine this symmetry. Furthermore, important functions ha...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/S0959-437X(99)80067-7
更新日期:1999-08-01 00:00:00
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/j.gde.2013.10.010
更新日期:2014-02-01 00:00:00
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/j.gde.2010.05.003
更新日期:2010-08-01 00:00:00
abstract::The ciliated protozoa undergo an extensive genome reorganization during the course of forming a transcriptionally active macronucleus. The process includes numerous chromosome fragmentation and DNA breakage and rejoining events. Recent work indicates that transposable elements play a role in the process. ...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/s0959-437x(05)80306-5
更新日期:1991-10-01 00:00:00
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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abstract::Telomerase regulation and telomere shortening act as a strong tumor suppressor mechanism in human somatic cells. Point mutations in the promoter of telomerase reverse transcriptase (TERT) are the most frequent non-coding mutation in cancer. These TERT promoter mutations (TPMs) create de novo ETS factor binding sites u...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/j.gde.2017.08.010
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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abstract::Subsets of patients with common cancers belong to families in which the predisposition is inherited in a regular Mendelian fashion. Genes underlying these cancers are now recognized in colorectal cancer (APC, mismatch repair genes, LKB1) and in breast cancer (BRCA1, BRCA2) whereas, in prostate cancer, a locus in chrom...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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abstract::To control changes in shape during development, the molecular regulatory networks have to interact with the mechanical, structural components of the individual cells, in particular the cytoskeleton and the cell wall. A widely accepted hypothesis proposes that molecular regulation interferes with wall synthesis and sti...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/j.gde.2018.04.001
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abstract::A plethora of post-transcriptional mechanisms are involved in essential steps in the pathway of genetic information expression in eukaryotes. These processes are specified by cis-acting signals on RNAs and are mediated by specific trans-acting factors, including RNA-binding proteins and small complementary RNAs. Recen...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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更新日期:1997-06-01 00:00:00
abstract::The cloning of large DNAs as yeast artificial chromosomes (YACs) holds the promise of greatly expanding the scope of physical genomic mapping. Recent improvements in YAC clone libraries and their screening, as well as in the analysis of YAC-cloned DNA, are beginning to fulfill the potential of this system. ...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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更新日期:1991-06-01 00:00:00
abstract::Flowers are central to sexual reproduction in plants. The study of floral development proved tremendously successful in obtaining key insight into processes, such as fate determination, pattern formation, and growth regulation. Recent advances relate to the complex mechanisms underlying the crosstalk between phytohorm...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/j.gde.2015.01.001
更新日期:2015-06-01 00:00:00