Abstract:
:The definitive endoderm (DE) was first defined as the innermost germ layer found in all metazoan embryos. During development, it gives rise to a vast array of specialized epithelial cell types lining the respiratory and digestive systems, and contributes to associated organs such as thyroid, thymus, lungs, liver, and pancreas. In the adult, the DE provides a protective barrier against the environment and assumes many essential functions including digestion, nutrient absorption, and glucose homeostasis. Since general endoderm formation and patterning have been reviewed recently in a comprehensive manner [1], we will only provide a brief summary of how extracellular signals and downstream transcription factors control endoderm patterning. We will then focus on emerging work addressing the chromatin remodeling events occurring during endoderm organ specification and discuss how these molecular tools can be used to engineer endodermal organs in vitro.
journal_name
Curr Opin Genet Devjournal_title
Current opinion in genetics & developmentauthors
Kraus MR,Grapin-Botton Adoi
10.1016/j.gde.2012.05.002subject
Has Abstractpub_date
2012-08-01 00:00:00pages
347-53issue
4eissn
0959-437Xissn
1879-0380pii
S0959-437X(12)00064-0journal_volume
22pub_type
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