Abstract:
:Multiple histone-modifying enzymes have been identified in the past several years. Much has been learned regarding the biochemistry of these enzymes and their effects on gene expression in cultured cells. However, the functions of these factors during development are still largely unknown. Recent genetic studies indicate that specific histone modifications and modifying enzymes play essential roles in both global and tissue-specific chromatin organization. In particular, these studies indicate that enzymes that control levels and patterns of histone acetylation and methylation are required for normal embryo patterning, organogenesis, and survival.
journal_name
Curr Opin Genet Devjournal_title
Current opinion in genetics & developmentauthors
Lin W,Dent SYdoi
10.1016/j.gde.2006.02.002subject
Has Abstractpub_date
2006-04-01 00:00:00pages
137-42issue
2eissn
0959-437Xissn
1879-0380pii
S0959-437X(06)00024-4journal_volume
16pub_type
杂志文章,评审abstract::The genetic study of rats and mice using natural variants, natural mutations, chemical or radiation induced mutations, engineered mutations and conditional engineered mutations has provided the tools for investigating the genetics of disease. The completion of the mouse genomic sequence and progress towards sequencing...
journal_title:Current opinion in genetics & development
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doi:10.1016/s0959-437x(03)00051-0
更新日期:2003-06-01 00:00:00
abstract::After fertilization, mouse embryos go through preimplantation development to give rise to blastocyst. Two key molecular events, zygotic genome activation (ZGA) and the first cell lineage specification, are essential for the process. Recent advances in low-input epigenomics profiling techniques allow the analysis of th...
journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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更新日期:1993-12-01 00:00:00
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journal_title:Current opinion in genetics & development
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更新日期:1996-06-01 00:00:00
abstract::The MCM2-7 complex, which may act as a replicative helicase during DNA synthesis, plays a central role in S-phase genome stability. MCM proteins are required for processive DNA replication and are a target of S-phase checkpoints. Loss of MCM function causes DNA damage and genome instability. MCM expression is upregula...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/j.gde.2003.11.002
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abstract::Genomic information from ancient human remains is beginning to show its full potential for learning about human prehistory. We review the last few years' dramatic finds about European prehistory based on genomic data from humans that lived many millennia ago and relate it to modern-day patterns of genomic variation. T...
journal_title:Current opinion in genetics & development
pub_type: 历史文章,杂志文章,评审
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journal_title:Current opinion in genetics & development
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更新日期:1994-04-01 00:00:00
abstract::Cornelia de Lange Syndrome (CdLS) is a rare multiple malformation disorder with characteristic facial features, growth and cognitive retardation, and many other abnormalities. CdLS individuals were recently shown to have heterozygous mutations in a previously uncharacterised gene, NIPBL, which encodes delangin, a homo...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/j.gde.2005.04.005
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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更新日期:2012-04-01 00:00:00
abstract::The vertebrate inner ear is a sensory organ of exquisite design and sensitivity. It responds to sound, gravity and movement, serving both auditory (hearing) and vestibular (balance) functions. Almost all cell types of the inner ear, including sensory hair cells, sensory neurons, secretory cells and supporting cells, d...
journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/j.gde.2003.08.002
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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更新日期:1998-10-01 00:00:00
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journal_title:Current opinion in genetics & development
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doi:10.1016/s0959-437x(99)00045-3
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abstract::Retrotransposable element insertions are 20 times more numerous per unit length of DNA in the large human genome compared to the small Drosophila genome. Whereas all Drosophila elements are subject to constant turnover (recent insertion and elimination by selection), this has not generally been the case for human retr...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/s0959-437x(02)00359-3
更新日期:2002-12-01 00:00:00
abstract::Premutation alleles (55-200 CGG repeats) of the fragile X mental retardation 1 gene (FMR1) are known to contribute to the fragile X phenotype through genetic instability and transmission of full mutation alleles (>200 repeats). There is now mounting evidence that the premutation alleles themselves contribute to clinic...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/s0959-437x(02)00299-x
更新日期:2002-06-01 00:00:00
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/j.gde.2006.04.017
更新日期:2006-06-01 00:00:00
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/s0959-437x(05)80059-0
更新日期:1994-04-01 00:00:00
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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更新日期:1999-02-01 00:00:00
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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更新日期:1992-04-01 00:00:00
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journal_title:Current opinion in genetics & development
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abstract::The induction of an appropriate cellular response to a stimulus often depends on the intricate interplay between multiple signaling pathways. Recent work utilizing Caenorhabditis elegans has enabled the identification of points of convergence between signaling pathways and permitted the elucidation of how multiple sig...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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abstract::Bladder cancer is the 5th commonest cancer and two major risk factors are smoking and occupational chemical exposure. There is also evidence of a genetic component to its aetiology. Candidate gene studies have mostly focused on genes involved in adduct metabolism and DNA repair, including a recent consortium-based met...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/j.gde.2010.01.002
更新日期:2010-06-01 00:00:00
abstract::The sequences of both of the human sex chromosomes and of a substantial part of the chimpanzee Y chromosome have now been determined, and most of the protein-coding genes have been identified. The X chromosome codes for more than 800 proteins but the Y chromosome for only approximately 60, illustrating their very diff...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/j.gde.2006.04.006
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abstract::Tumor blood vessels have multiple structural and functional abnormalities. They are unusually dynamic, and naturally undergo sprouting, proliferation, remodeling or regression. The vessels are irregularly shaped, tortuous, and lack the normal hierarchical arrangement of arterioles, capillaries and venules. Endothelial...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/j.gde.2004.12.005
更新日期:2005-02-01 00:00:00
abstract::To control changes in shape during development, the molecular regulatory networks have to interact with the mechanical, structural components of the individual cells, in particular the cytoskeleton and the cell wall. A widely accepted hypothesis proposes that molecular regulation interferes with wall synthesis and sti...
journal_title:Current opinion in genetics & development
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abstract::Engineering cancer-associated mutations into the mouse germline is an important tool for biological studies of growth control and tumorigenesis. Tractable models of many human cancers now exist in which the initiating genetic lesions have been elucidated and, in some instances, where the cooperating lesions are also k...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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更新日期:2003-02-01 00:00:00
abstract::Mutant onco-proteins play a direct, causal role in cancer and are therefore considered attractive drug targets. Clinical experience has supported this view, with some exceptions. However, clinical benefit has often been restricted by rapid emergence of drug-resistant clones through several distinct mechanisms. This pr...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/j.gde.2010.12.002
更新日期:2011-02-01 00:00:00
abstract::Recognition and pairing of homologous chromosomes are absolutely required for successful segregation during meiosis. We still have no model, however, that adequately explains the mechanism of these processes in a quantitative way. The fact that homologue pairing takes similar times across several orders of magnitude i...
journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
doi:10.1016/j.gde.2009.02.006
更新日期:2009-04-01 00:00:00