Early steps in mammalian sex determination.

abstract：:Hepatocytes differentiate from the endoderm during embryonic development. Recent studies show, however, that hepatocytes can also be derived from rare cells that reside in the pancreas, bone marrow, and brain. Indeed, the latest discoveries indicate that embryonic hepatocytes normally arise by diversion of an endoderm...

journal_title：Current opinion in genetics & development

authors： Zaret KS

更新日期：2001-10-01 00:00:00

abstract：:Significant advances in the field of hepatocyte-specific gene expression have been made during the past year. Several new transcription factors have been cloned and partially characterized. Analyses of the promoter regions of several factors have also been initiated and Drosophila homologs for two of these factors hav...

journal_title：Current opinion in genetics & development

authors： Sladek FM,Darnell JE

更新日期：1992-04-01 00:00:00

abstract：:The regulation of synapse formation and plasticity in the developing and adult brain underlies a complex interplay of intrinsic genetic programs and extrinsic factors. Recent research identified microRNAs (miRNAs), a class of small non-coding RNAs, as a new functional layer in this regulatory network. Within only a fe...

journal_title：Current opinion in genetics & development

authors： Siegel G,Saba R,Schratt G

更新日期：2011-08-01 00:00:00

abstract：:Recent technological and computational advances in understanding the transcriptional and chromatin features of single cells have begun answering longstanding questions in the extent and impact of biological heterogeneity. Here, we outline the intrinsic and extrinsic mechanisms that underlie the transcriptional and fun...

journal_title：Current opinion in genetics & development

authors： Martinez-Jimenez CP,Odom DT

更新日期：2016-04-01 00:00:00

abstract：:The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 is built on a three-protein central oscillator that can be reconstituted in vitro, a redox-sensitive input for synchronization with the environment, and a bacterial two-component signal transduction pathway for global transcriptional regulation...

journal_title：Current opinion in genetics & development

authors： Dong G,Kim YI,Golden SS

更新日期：2010-12-01 00:00:00

abstract：:Current dogma holds that genes are the property of individual mammalian cells and partition between daughter cells during cell division. However, and rather unexpectedly, recent research has demonstrated horizontal cell-to-cell transfer of mitochondria and mitochondrial DNA in several mammalian cell culture systems. F...

journal_title：Current opinion in genetics & development

authors： Berridge MV,McConnell MJ,Grasso C,Bajzikova M,Kovarova J,Neuzil J

更新日期：2016-06-01 00:00:00

abstract：:Empowered by modern genotyping and large samples, population structure can be accurately described and quantified even when it only explains a fraction of a percent of total genetic variance. This is especially relevant and interesting for humans, where fine-scale population structure can both confound disease-mapping...

journal_title：Current opinion in genetics & development

authors： Novembre J,Peter BM

更新日期：2016-12-01 00:00:00

abstract：:The human genome is replete with interspersed repetitive sequences derived from the propagation of mobile DNA elements. Three families of human retrotransposons remain active today: LINE1, Alu, and SVA elements. Since 1988, de novo insertions at previously recognized disease loci have been shown to generate highly pen...

journal_title：Current opinion in genetics & development

authors： Babatz TD,Burns KH

更新日期：2013-06-01 00:00:00

abstract：:Recent reprogramming studies indicate that mammalian, somatic cells have the potential to achieve pluripotent states and undergo cell type switching. Such cellular traits are observed under natural conditions in animals that regenerate complex organs. A number of invertebrates display the amazing trait of whole body r...

journal_title：Current opinion in genetics & development

authors： Knapp D,Tanaka EM

更新日期：2012-10-01 00:00:00

abstract：:Recent developments in technology have made it possible to create high resolution genome-wide maps of histone marks, DNA binding proteins and physical interactions along genomic regions. Chromatin features are found together in different combinations, dividing the genome up into domains with distinct functional proper...

journal_title：Current opinion in genetics & development

authors： de Graaf CA,van Steensel B

更新日期：2013-04-01 00:00:00

abstract：:The impressive diversity of body plans, lifestyles and segmental specializations exhibited by crustaceans (barnacles, copepods, shrimps, crabs, lobsters and their kin) provides great material to address longstanding questions in evolutionary developmental biology. Recent advances in forward and reverse genetics and in...

journal_title：Current opinion in genetics & development

authors： Stamataki E,Pavlopoulos A

更新日期：2016-08-01 00:00:00

abstract：:Recent studies in invertebrates have provided important mechanistic insights into several general aspects of muscle development. Two new genes have been identified that are involved in muscle fusion in Drosophila and a novel maternal component was shown to be responsible for myogenic determination in an ascidian. In a...

journal_title：Current opinion in genetics & development

authors： Baylies MK,Michelson AM

更新日期：2001-08-01 00:00:00

abstract：:Although the protein product of the BRCA1 tumor suppressor gene has been implicated in a surprisingly diverse array of biological processes, the molecular mechanism by which BRCA1 loss promotes tumor formation remains unclear. Nonetheless, a pivotal advance has been achieved by recent studies that establish BRCA1 and ...

journal_title：Current opinion in genetics & development

authors： Baer R,Ludwig T

更新日期：2002-02-01 00:00:00

abstract：:There have been remarkably rapid advances in the understanding of prion diseases over the past year. The controversial notion that the transmissible agent may be an abnormal isoform of a host-encoded protein, the prion protein, is now gaining wide acceptance. The conundrum of how a disease can both be inherited as an ...

journal_title：Current opinion in genetics & development

authors： Collinge J,Palmer MS

更新日期：1992-06-01 00:00:00

abstract：:Identification of new genes involved in muscle disorders has dramatically changed the traditional clinical classification of the large and heterogeneous group of the muscular dystrophies. Results obtained in recent years by positional candidate cloning have demonstrated the role of the sarcolemma and of the nuclear en...

journal_title：Current opinion in genetics & development

authors： Toniolo D,Minetti C

更新日期：1999-06-01 00:00:00

abstract：:The Caenorhabditis elegans hermaphrodite vulva is one of the best studied models for signal transduction and cell fate determination during organogenesis. Systematic forward genetic screens have identified a complex and highly interconnected signaling network formed by the conserved EGFR, NOTCH, and WNT signaling path...

journal_title：Current opinion in genetics & development

authors： Schmid T,Hajnal A

更新日期：2015-06-01 00:00:00

abstract：:An epigenetic imprinting mechanism that is based on a gamete-specific methylation imprint restricts expression of a subset of mammalian genes to one parental chromosome. Recent results suggest that imprints may act only indirectly to induce monoallelic expression of coding genes. Instead, atypical non-coding RNAs appe...

journal_title：Current opinion in genetics & development

authors： Sleutels F,Barlow DP,Lyle R

更新日期：2000-04-01 00:00:00

abstract：:The nuclear periphery has been implicated in gene regulation and it has been proposed that proximity to the nuclear lamina and inner nuclear membrane (INM) leads to gene repression. More recently, it appears that there is a correlation and interdependence between lamina associated domains (LADs), the epigenome and ove...

journal_title：Current opinion in genetics & development

authors： Luperchio TR,Wong X,Reddy KL

更新日期：2014-04-01 00:00:00

abstract：:In the past ten years, there has been increasing recognition that cells can acquire genetic variants during cortical development that can give rise to brain malformations as well as nonlesional focal epilepsy. These often brain tissue-specific, de novo variants can result in highly variable phenotypes based on the bur...

journal_title：Current opinion in genetics & development

authors： Heinzen EL

更新日期：2020-12-01 00:00:00

abstract：:The emerging field of genomics examines the relationship between genetic and phenotypic variation by describing and analyzing patterns of natural variation on a genome-wide scale. In this endeavor, an important tool is the use of microarrays, which enable simultaneous screening of thousands of assays. Microarrays were...

journal_title：Current opinion in genetics & development

authors： Gilad Y,Borevitz J

更新日期：2006-12-01 00:00:00

abstract：:Cohesin defines the topology of chromosomes in mitosis and meiosis by holding sister chromatids together; more recently a role for cohesin in chromatin organisation and gene expression in interphase has emerged. ...

journal_title：Current opinion in genetics & development

authors： Seitan VC,Merkenschlager M

更新日期：2012-04-01 00:00:00

abstract：:The recent identification of Wnt-7a as a signalling molecule in dorsal/ventral patterning means that we now have a known signal for control of each of the three limb axes. Fibroblast growth factors can allow proximal/distal patterning and Sonic hedgehog gene expression signals anterior/posterior patterning. Networks o...

journal_title：Current opinion in genetics & development

authors： Tickle C

更新日期：1995-08-01 00:00:00

abstract：:Logical models provide insight about key control elements of biological networks. Based solely on the logical structure, we can determine state transition diagrams that give the allowed possible transitions in a coarse grained phase space. Attracting pathways and stable nodes in the state transition diagram correspond...

journal_title：Current opinion in genetics & development

authors： Glass L,Siegelmann HT

更新日期：2010-12-01 00:00:00

abstract：:The transcription factor TFIIH is a versatile, multi-functional protein complex with multiple engagements. Apart from its role in basal transcription, TFIIH is intimately implicated in DNA repair and (probably) in cell cycle control (both of which are required to prevent carcinogenesis) as well as having possible role...

journal_title：Current opinion in genetics & development

authors： Hoeijmakers JH,Egly JM,Vermeulen W

更新日期：1996-02-01 00:00:00

abstract：:Cell proliferation is dependent upon the activation of receptor tyrosine kinases and integrins by soluble growth factors and extracellular matrix proteins, respectively. It is now apparent that concerted, rather than individual, signaling by these receptors is the critical feature responsible for cell-cycle progressio...

journal_title：Current opinion in genetics & development

authors： Assoian RK,Schwartz MA

更新日期：2001-02-01 00:00:00

abstract：:Compartmentalized distribution of functional components is a hallmark of the eukaryotic nucleus. Technological advances in recent years have provided unprecedented insights into the role of chromatin organization and interactions of various structural-functional components toward gene regulation. SATB1, the global chr...

journal_title：Current opinion in genetics & development

authors： Galande S,Purbey PK,Notani D,Kumar PP

更新日期：2007-10-01 00:00:00

abstract：:Microarray technologies enable genome-scale expression measurements. Already proved to be of value for the functional analysis of individual genes and biological processes, the application of expression profiling to disease gene discovery is now growing in importance and practicality. ...

journal_title：Current opinion in genetics & development

authors： Meltzer PS

更新日期：2001-06-01 00:00:00

abstract：:Unlike mammals, zebrafish are able to regenerate a damaged retina. Key to this regenerative response are Müller glia that respond to retinal injury by undergoing a reprogramming event that allows them to divide and generate a retinal progenitor that is multipotent and responsible for regenerating all major retinal neu...

journal_title：Current opinion in genetics & development

authors： Wan J,Goldman D

更新日期：2016-10-01 00:00:00

abstract：:More than 30 incurable neurological and neuromuscular diseases are caused by simple microsatellite expansions consisted of 3-6 nucleotides. These repeats can occur in non-coding regions and often result in a dominantly inherited disease phenotype that is characteristic of a toxic RNA gain-of-function. The expanded RNA...

journal_title：Current opinion in genetics & development

authors： Zhang N,Ashizawa T

更新日期：2017-06-01 00:00:00

abstract：:Loss of cardiomyocytes from cardiovascular disease is irreversible and current therapeutic strategies do not redress the loss of myocardium after injury. The discovery that endogenous fibroblasts in the heart can be reprogrammed to cardiomyocyte-like cells after myocardial infarction and heart function is improved sub...

journal_title：Current opinion in genetics & development

authors： Srivastava D,Berry EC

更新日期：2013-10-01 00:00:00