Recent advances in the study of fine-scale population structure in humans.


:Empowered by modern genotyping and large samples, population structure can be accurately described and quantified even when it only explains a fraction of a percent of total genetic variance. This is especially relevant and interesting for humans, where fine-scale population structure can both confound disease-mapping studies and reveal the history of migration and divergence that shaped our species' diversity. Here we review notable recent advances in the detection, use, and understanding of population structure. Our work addresses multiple areas where substantial progress is being made: improved statistics and models for better capturing differentiation, admixture, and the spatial distribution of variation; computational speed-ups that allow methods to scale to modern data; and advances in haplotypic modeling that have wide ranging consequences for the analysis of population structure. We conclude by outlining four important open challenges: the limitations of discrete population models, uncertainty in individual origins, the incorporation of both fine-scale structure and ancient DNA in parametric models, and the development of efficient computational tools, particularly for haplotype-based methods.


Curr Opin Genet Dev


Novembre J,Peter BM




Has Abstract


2016-12-01 00:00:00












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    journal_title:Current opinion in genetics & development

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    authors: Rakyan VK,Beck S

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    abstract::Organismal fitness depends on adaptation to complex niches where chemical compounds and pathogens are omnipresent. These stresses can lead to the fixation of alleles in both xenobiotic responses and proliferative signaling pathways that promote survival in these niches. However, both xenobiotic responses and prolifera...

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    authors: Zdraljevic S,Andersen EC

    更新日期:2017-12-01 00:00:00

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    authors: Engel I,Murre C

    更新日期:1999-10-01 00:00:00

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    authors: Martin AR,Teferra S,Möller M,Hoal EG,Daly MJ

    更新日期:2018-12-01 00:00:00

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    abstract::Whole-transcriptome analyses have established that the plant circadian clock regulates virtually every plant biological process and most prominently hormonal and stress response pathways. Systems biology efforts have successfully modeled the plant central clock machinery and an iterative process of model refinement an...

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    authors: McClung CR,Gutiérrez RA

    更新日期:2010-12-01 00:00:00

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    abstract::The Selfish Operon Model postulates that the organization of bacterial genes into operons is beneficial to the constituent genes in that proximity allows horizontal cotransfer of all genes required for a selectable phenotype; eukaryotic operons formed for very different reasons. Horizontal transfer of selfish operons ...

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    pub_type: 杂志文章,评审


    authors: Lawrence J

    更新日期:1999-12-01 00:00:00

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    abstract::It has been shown recently that some plant transcription factors that regulate cell fate during development can traffic through plasmodesmata-the intercellular channels that connect plant cells. This phenomenon helps explain the non-autonomous effects of many developmental mutations in plants and defines a novel mecha...

    journal_title:Current opinion in genetics & development

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    authors: Jackson D,Hake S

    更新日期:1997-08-01 00:00:00

  • The transition from transcriptional initiation to elongation.

    abstract::Transcription is the first step in gene expression, and its regulation underlies multicellular development and the response to environmental changes. Most studies of transcriptional regulation have focused on the recruitment of RNA polymerase to promoters. However, recent work has shown that, for many promoters, post-...

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    authors: Wade JT,Struhl K

    更新日期:2008-04-01 00:00:00

  • Nuclear organization in the 3D space of the nucleus - cause or consequence?

    abstract::Recent evidence suggests that dynamic three-dimensional genomic interactions in the nucleus exert critical roles in regulated gene expression. Here, we review a series of recent paradigm-shifting experiments that highlight the existence of specific gene networks within the self-organizing space of the nucleus. These g...

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    authors: Nunez E,Fu XD,Rosenfeld MG

    更新日期:2009-10-01 00:00:00

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    abstract::In their development, plants precisely control the patterns of cell size, cell shape and cell division, the position of differentiation of cell types, and the position and number of organs. In the past year, progress has been made in understanding four of these five levels of control of plant pattern formation, includ...

    journal_title:Current opinion in genetics & development

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    authors: Meyerowitz EM

    更新日期:1994-08-01 00:00:00

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    abstract::The induction of an appropriate cellular response to a stimulus often depends on the intricate interplay between multiple signaling pathways. Recent work utilizing Caenorhabditis elegans has enabled the identification of points of convergence between signaling pathways and permitted the elucidation of how multiple sig...

    journal_title:Current opinion in genetics & development

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    authors: Hanna-Rose W,Han M

    更新日期:2000-10-01 00:00:00

  • Transcriptional factor interaction: a central step in DELLA function.

    abstract::Gibberellins (GAs) affect several growth and developmental responses during the plant life cycle. Components essential for GA perception and GA signaling have been identified in rice and Arabidopsis and are conserved among vascular plants but not in Physcomitrella patens. The recent observation that DELLAs bind in nuc...

    journal_title:Current opinion in genetics & development

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    authors: Davière JM,de Lucas M,Prat S

    更新日期:2008-08-01 00:00:00

  • TGF-beta signaling: positive and negative effects on tumorigenesis.

    abstract::TGF-beta binding to the cell surface triggers activation of multiple signal transduction pathways that are connected in intricate ways with each other, and with other response networks involved in sensing cellular information input. Recent data indicate that changes in signal intensity and connectivity of these pathwa...

    journal_title:Current opinion in genetics & development

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    authors: Wakefield LM,Roberts AB

    更新日期:2002-02-01 00:00:00

  • Functions of the BRCA1 and BRCA2 genes.

    abstract::Mutations in the BRCA1 and BRCA2 genes confer a high risk of breast cancer development. Both genes encode very large proteins of unknown function but recent results suggest that they may have roles in transcriptional regulation and DNA repair. These advances offer the prospect of understanding not only the normal cell...

    journal_title:Current opinion in genetics & development

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    authors: Bertwistle D,Ashworth A

    更新日期:1998-02-01 00:00:00

  • How genetic modifiers influence the phenotype of spinal muscular atrophy and suggest future therapeutic approaches.

    abstract::Both complex disorders and monogenetic diseases are often modulated in their phenotype by further genetic, epigenetic or extrinsic factors. This gives rise to extensive phenotypic variability and potentially protection from disease manifestations, known as incomplete penetrance. Approaches including whole transcriptom...

    journal_title:Current opinion in genetics & development

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    authors: Wirth B,Garbes L,Riessland M

    更新日期:2013-06-01 00:00:00

  • Point mutations as a source of de novo genetic disease.

    abstract::Family-based next generation sequencing (NGS) has recently pointed to an important role for de novo germline point mutations in both rare and common genetic disorders associated with reduced fitness. In this review we highlight the impact of the mutational target size on the frequency of diseases caused by these de no...

    journal_title:Current opinion in genetics & development

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    authors: de Ligt J,Veltman JA,Vissers LE

    更新日期:2013-06-01 00:00:00

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    abstract::Several advances have been made in our understanding of the control of the growth and patterning of embryonic limbs. Development of the vertebrate limb is dependent on reciprocal interactions between the ectoderm and mesoderm that regulate the structure and function of the apical ectodermal ridge. One key component of...

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    authors: Dudley AT,Tabin CJ

    更新日期:2000-08-01 00:00:00

  • Invertebrate myogenesis: looking back to the future of muscle development.

    abstract::Recent studies in invertebrates have provided important mechanistic insights into several general aspects of muscle development. Two new genes have been identified that are involved in muscle fusion in Drosophila and a novel maternal component was shown to be responsible for myogenic determination in an ascidian. In a...

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    authors: Baylies MK,Michelson AM

    更新日期:2001-08-01 00:00:00

  • Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation.

    abstract::Cornelia de Lange Syndrome (CdLS) is a rare multiple malformation disorder with characteristic facial features, growth and cognitive retardation, and many other abnormalities. CdLS individuals were recently shown to have heterozygous mutations in a previously uncharacterised gene, NIPBL, which encodes delangin, a homo...

    journal_title:Current opinion in genetics & development

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    authors: Strachan T

    更新日期:2005-06-01 00:00:00

  • Genetics of type 1 diabetes.

    abstract::Type 1 diabetes is the most common autoimmune disorder in childhood, characterized by the development of autoimmunity through unknown environmental insults in genetically susceptible individuals. There are now over 50 regions of the genome that harbor type 1 diabetes susceptibility genes, with much of the genetic risk...

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    authors: Robertson CC,Rich SS

    更新日期:2018-06-01 00:00:00

  • Micromechanics of root development in soil.

    abstract::Our understanding of how roots develop in soil may be at the eve of significant transformations. The formidable expansion of imaging technologies enables live observations of the rhizosphere micro-pore architecture at unprecedented resolution. Granular matter physics provides ways to understand the microscopic fluctua...

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    authors: Dupuy LX,Mimault M,Patko D,Ladmiral V,Ameduri B,MacDonald MP,Ptashnyk M

    更新日期:2018-08-01 00:00:00

  • Clinical utility of telomere length measurements in cancer.

    abstract::Cancer remains one of the leading causes of death in the developed world and despite impressive advances in therapeutic modalities, only a small subset of patients are currently cured. The underlying genetic heterogeneity of cancers clearly plays a crucial role in determining both the clinical course of individual pat...

    journal_title:Current opinion in genetics & development

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    authors: Pepper C,Norris K,Fegan C

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  • Long non-coding RNAs and enhancers.

    abstract::Long non-coding RNAs (ncRNAs) are emerging as important regulatory factors in mammalian genomics. A number of reports within the last 2 years have identified thousands of actively expressed long ncRNA transcripts with distinct properties. The long ncRNAs show differential expression patterns and regulation in a wide v...

    journal_title:Current opinion in genetics & development

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    authors: Ørom UA,Shiekhattar R

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  • The genetics of Parkinson's disease.

    abstract::The effort to map the entire human genome has led recently to the important milestone publication in late 1999 of the complete sequence of chromosome 22. This has been facilitated by increasingly sophisticated tools for genetic analysis and the ensuing wealth of detailed genetic information. The quest for genetic fact...

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    authors: de Silva HR,Khan NL,Wood NW

    更新日期:2000-06-01 00:00:00

  • The making of a maggot: patterning the Drosophila embryonic epidermis.

    abstract::Cell fates are instructed by signals emitted from specialized cell populations called organizers. The study of epidermal patterning in Drosophila is contributing novel insights concerning the establishment and action of such organizers. Juxtaposed rows of cells express either the wingless or hedgehog signaling molecul...

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    authors: DiNardo S,Heemskerk J,Dougan S,O'Farrell PH

    更新日期:1994-08-01 00:00:00

  • Novel gene families involved in neural pathfinding.

    abstract::Recent studies have uncovered a bifunctional role of the diffusible axon guidance molecules netrin-1 and UNC-6 in that they attract some axons and steer others away simultaneously. Homology screens have extended the semaphorin and collapsin family to include at least 20 members, in both secreted and membrane-bound for...

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    authors: Müller BK,Bonhoeffer F,Drescher U

    更新日期:1996-08-01 00:00:00

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    abstract::The definitive endoderm (DE) was first defined as the innermost germ layer found in all metazoan embryos. During development, it gives rise to a vast array of specialized epithelial cell types lining the respiratory and digestive systems, and contributes to associated organs such as thyroid, thymus, lungs, liver, and ...

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