Retina regeneration in zebrafish.

abstract：:The digital reconstruction of the embryogenesis of model organisms from 3D+time data is revolutionizing practices in quantitative and integrative Developmental Biology. A manual and fully supervised image analysis of the massive complex data acquired with new microscopy technologies is no longer an option and automate...

journal_title：Current opinion in genetics & development

authors： Luengo-Oroz MA,Ledesma-Carbayo MJ,Peyriéras N,Santos A

更新日期：2011-10-01 00:00:00

abstract：:Asymmetric cell division during the process of sporulation in the bacterium Bacillus subtilis generates dissimilar progeny that exhibit distinct programs of gene transcription. Recent work reveals a partner switching mechanism that governs the activity of the sporulation regulatory protein sigma F and that may be resp...

journal_title：Current opinion in genetics & development

authors： Duncan L,Alper S,Losick R

更新日期：1994-10-01 00:00:00

abstract：:Recent studies of beta-globin gene expression have concentrated on the analysis of factor binding and chromatin structure within the endogenous locus. These studies have more precisely defined the extent and nature of the active chromosomal domain and the elements that organize it. Surprisingly, the beta-globin locus ...

journal_title：Current opinion in genetics & development

authors： Bulger M,Sawado T,Schübeler D,Groudine M

更新日期：2002-04-01 00:00:00

abstract：:The recent discovery of self-splicing introns in cyanobacteria has given renewed interest to the question of whether introns may have been present in the ancestor of all living things. The properties of introns in genes of bacteria and bacteriophages are discussed in the context of their possible origin and biological...

journal_title：Current opinion in genetics & development

authors： Shub DA

更新日期：1991-12-01 00:00:00

abstract：:All bovine chromosomes are now represented by a syntenic group, a linkage map and at least one in situ hybridization. Almost 1,000 loci are mapped, about 300 of which are coding sequences useful for comparative mapping and evolutionary inference. Economically important loci are beginning to appear on bovine linkage ma...

journal_title：Current opinion in genetics & development

authors： Womack JE,Kata SR

更新日期：1995-12-01 00:00:00

abstract：:Filamentous cyanobacteria, the only prokaryotes that form linear patterns of differentiated cells, can be genetically manipulated by the conjugative transfer of plasmids from Escherichia coli. It has become possible to determine the cellular localization of genetic transcription, including transcription of development...

journal_title：Current opinion in genetics & development

authors： Wolk CP

更新日期：1991-10-01 00:00:00

abstract：:Recent advances in cell reprogramming via employing different sets of factors, which allows generation of various cell types that are beyond the downstream developmental lineages from the starting cell type, provide significant opportunities to study fundamental biology and hold enormous promise in regenerative medici...

journal_title：Current opinion in genetics & development

authors： Yu C,Liu K,Tang S,Ding S

更新日期：2014-10-01 00:00:00

abstract：:The pattern of expression of homeodomain proteins often exceeds their apparent domain of activity. Tissue-specific proteins that modulate the in vivo activity of homeodomain proteins have been proposed to account for this functional restriction. The first identified example of such an accessory protein is DCoH, which ...

journal_title：Current opinion in genetics & development

authors： Hansen LP,Crabtree GR

更新日期：1993-04-01 00:00:00

abstract：:Imprinting occurs in the endosperm of flowering plants. Endosperm, produced by fertilization of the central cell in the female gametophyte, is essential for embryo and seed development. Several imprinted genes play an important role in endosperm development. The mechanism of gene imprinting involves DNA methylation an...

journal_title：Current opinion in genetics & development

authors： Huh JH,Bauer MJ,Hsieh TF,Fischer R

更新日期：2007-12-01 00:00:00

abstract：:The success of treatment of cancer patients depends on matching the most effective therapeutic regimen with the characteristics of the individual patient, balancing benefit against risk of adverse events. The primary challenge in achieving this goal is the heterogeneity of the disease, recognizing that breast, lung, c...

journal_title：Current opinion in genetics & development

authors： Potti A,Nevins JR

更新日期：2008-02-01 00:00:00

abstract：:The increasing availability of large-scale autosomal genetic variation data sampled from world-wide geographic areas, coupled with advances in the statistical methodology to analyse these data, is showcasing the power of DNA as a major tool to gain insights into the demographic history of humans and other organisms. H...

journal_title：Current opinion in genetics & development

authors： Wangkumhang P,Hellenthal G

更新日期：2018-12-01 00:00:00

abstract：:Over four decades ago, the first oscillations in metabolism in yeast cells were reported. Since then, multiple forms of oscillatory behavior have been observed in yeast grown under a variety of continuous culturing environments. The remarkable synchrony of cells undergoing such oscillations has made them ideal subject...

journal_title：Current opinion in genetics & development

authors： Laxman S,Tu BP

更新日期：2010-12-01 00:00:00

abstract：:Loss of cardiomyocytes from cardiovascular disease is irreversible and current therapeutic strategies do not redress the loss of myocardium after injury. The discovery that endogenous fibroblasts in the heart can be reprogrammed to cardiomyocyte-like cells after myocardial infarction and heart function is improved sub...

journal_title：Current opinion in genetics & development

authors： Srivastava D,Berry EC

更新日期：2013-10-01 00:00:00

abstract：:Significant advances in the field of hepatocyte-specific gene expression have been made during the past year. Several new transcription factors have been cloned and partially characterized. Analyses of the promoter regions of several factors have also been initiated and Drosophila homologs for two of these factors hav...

journal_title：Current opinion in genetics & development

authors： Sladek FM,Darnell JE

更新日期：1992-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a large class of small RNAs that function as negative gene regulators in eukaryotes. They regulate diverse biological processes, and bioinformatics data indicate that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. ...

journal_title：Current opinion in genetics & development

authors： Niwa R,Slack FJ

更新日期：2007-04-01 00:00:00

abstract：:The advent of gene targeting in the mouse has led to rapid advances in the identification of factors controlling gene expression that are essential for normal hematopoietic development. Recent work has also uncovered roles for some of these factors in leukemogenesis and in the global regulation of chromatin structure....

journal_title：Current opinion in genetics & development

authors： Engel I,Murre C

更新日期：1999-10-01 00:00:00

abstract：:The mammalian genome is folded into topological domains, chromosomal units that probably serve to spatially accommodate enhancer-promoter interactions and control gene expression levels across cell populations. Longer-range contacts beyond topological domains are also formed, but only in subpopulations of cells. We pr...

journal_title：Current opinion in genetics & development

authors： Krijger PH,de Laat W

更新日期：2013-04-01 00:00:00

abstract：:Trait exaggeration, well known to naturalists and evolutionary biologists, has recently become a prominent research subject in the modern field of Evolutionary Developmental Biology. A large number of traits that can be considered as cases of exaggeration exist in nature. Yet, the field has almost exclusively focused ...

journal_title：Current opinion in genetics & development

authors： Toubiana W,Khila A

更新日期：2016-08-01 00:00:00

abstract：:Non-human primates (NHPs) have been proposed as good models for neurodevelopmental disorders due to close similarities to humans in terms of brain structure and cognitive function. The recent development of genome editing technologies has opened new avenues to generate and investigate genetically modified NHPs as mode...

journal_title：Current opinion in genetics & development

authors： Aida T,Feng G

更新日期：2020-12-01 00:00:00

abstract：:Type 1 diabetes is the most common autoimmune disorder in childhood, characterized by the development of autoimmunity through unknown environmental insults in genetically susceptible individuals. There are now over 50 regions of the genome that harbor type 1 diabetes susceptibility genes, with much of the genetic risk...

journal_title：Current opinion in genetics & development

authors： Robertson CC,Rich SS

更新日期：2018-06-01 00:00:00

abstract：:The dystrophin-glycoprotein complex (DGC) is a multisubunit complex that connects the cytoskeleton of a muscle fiber to its surrounding extracellular matrix. Mutations in the DGC disrupt the complex and lead to muscular dystrophy. There are a few naturally occurring animal models of DGC-associated muscular dystrophy (...

journal_title：Current opinion in genetics & development

authors： Durbeej M,Campbell KP

更新日期：2002-06-01 00:00:00

abstract：:Identification of new genes involved in muscle disorders has dramatically changed the traditional clinical classification of the large and heterogeneous group of the muscular dystrophies. Results obtained in recent years by positional candidate cloning have demonstrated the role of the sarcolemma and of the nuclear en...

journal_title：Current opinion in genetics & development

authors： Toniolo D,Minetti C

更新日期：1999-06-01 00:00:00

abstract：:Gibberellins (GAs) affect several growth and developmental responses during the plant life cycle. Components essential for GA perception and GA signaling have been identified in rice and Arabidopsis and are conserved among vascular plants but not in Physcomitrella patens. The recent observation that DELLAs bind in nuc...

journal_title：Current opinion in genetics & development

authors： Davière JM,de Lucas M,Prat S

更新日期：2008-08-01 00:00:00

abstract：:The current state of the gene regulatory network for endomesoderm specification in sea urchin embryos is reviewed. The network was experimentally defined, and is presented as a predictive map of cis-regulatory inputs and functional regulatory gene interconnections (updated versions of the network and most of the under...

journal_title：Current opinion in genetics & development

authors： Oliveri P,Davidson EH

更新日期：2004-08-01 00:00:00

abstract：:The definitive endoderm (DE) was first defined as the innermost germ layer found in all metazoan embryos. During development, it gives rise to a vast array of specialized epithelial cell types lining the respiratory and digestive systems, and contributes to associated organs such as thyroid, thymus, lungs, liver, and ...

journal_title：Current opinion in genetics & development

authors： Kraus MR,Grapin-Botton A

更新日期：2012-08-01 00:00:00

abstract：:The discovery of hundreds of plant micro RNAs (miRNAs) has triggered much speculation about their potential roles in plant development. The search for plant genes involved in miRNA processing has revealed common factors such as DICER, and new molecules, including HEN1. Progress is also being made toward identifying mi...

journal_title：Current opinion in genetics & development

authors： Hunter C,Poethig RS

更新日期：2003-08-01 00:00:00

abstract：:Cell-cell and starvation signals are funneled through the phosphorelay to initiate sporulation by activating the transcription regulator SpoOA. Activation of SpoOA leads to synthesis of the transcription factors sigmaF and sigmaE. Substantial advances have been made in our understanding of the signal circuitry of the ...

journal_title：Current opinion in genetics & development

authors： Piggot PJ

更新日期：1996-10-01 00:00:00

abstract：:To understand organ morphogenetic mechanisms, it is essential to clarify how spatiotemporally-regulated molecular/cellular dynamics causes physical tissue deformation. In the case of vertebrate limb development, while some of the genes and oriented cell behaviors underlying morphogenesis have been revealed, tissue def...

journal_title：Current opinion in genetics & development

authors： Suzuki T,Morishita Y

更新日期：2017-08-01 00:00:00

abstract：:The advent of methods for mapping the location of specific proteins across genomes is substantially enlightening our understanding of gene regulation. One recent discovery is that Pol II is concentrated at the 5' end of thousands of genes in mammalian and Drosophila cells. Before this, much research had focused on und...

journal_title：Current opinion in genetics & development

authors： Li J,Gilmour DS

更新日期：2011-04-01 00:00:00

abstract：:Microarray technologies enable genome-scale expression measurements. Already proved to be of value for the functional analysis of individual genes and biological processes, the application of expression profiling to disease gene discovery is now growing in importance and practicality. ...

journal_title：Current opinion in genetics & development

authors： Meltzer PS

更新日期：2001-06-01 00:00:00