Genetic analysis of cyanobacterial development.

abstract：:The success of treatment of cancer patients depends on matching the most effective therapeutic regimen with the characteristics of the individual patient, balancing benefit against risk of adverse events. The primary challenge in achieving this goal is the heterogeneity of the disease, recognizing that breast, lung, c...

journal_title：Current opinion in genetics & development

authors： Potti A,Nevins JR

更新日期：2008-02-01 00:00:00

abstract：:Understanding the past is to understand the present. Mammalian life, with all its complexity comes from a humble beginning of a single fertilized egg cell. Achieving this requires an enormous diversification of cellular function, the majority of which is generated through a series of cellular decisions during embryoge...

journal_title：Current opinion in genetics & development

authors： Leung CY,Zernicka-Goetz M

更新日期：2015-10-01 00:00:00

abstract：:The processes by which the canonical protein synthesis machinery is modified by environmental stresses to allow healthy cells to respond to external conditions to maintain homeostasis, are frequently hijacked by tumour cells to enhance their survival. Two major stress response pathways that play a major role in this r...

journal_title：Current opinion in genetics & development

authors： Harvey RF,Willis AE

更新日期：2018-02-01 00:00:00

abstract：:The nuclear periphery has been implicated in gene regulation and it has been proposed that proximity to the nuclear lamina and inner nuclear membrane (INM) leads to gene repression. More recently, it appears that there is a correlation and interdependence between lamina associated domains (LADs), the epigenome and ove...

journal_title：Current opinion in genetics & development

authors： Luperchio TR,Wong X,Reddy KL

更新日期：2014-04-01 00:00:00

abstract：:The genomic perspective aids in integrating the analysis of single resistance (R-) genes into a higher order model of complex plant resistance systems. The majority of R-genes encode a class of proteins with nucleotide binding (NB) and leucine-rich repeat (LRR) domains. Several R-proteins act in multi-protein R-comple...

journal_title：Current opinion in genetics & development

authors： Friedman AR,Baker BJ

更新日期：2007-12-01 00:00:00

abstract：:Recent research has broadened significantly our understanding of how the somite, a specialized mesodermal structure found in vertebrate embryos, gives rise to the cartilage, muscle and tendon cell lineages. The specification of somite derivatives involves the action of patterning signals secreted from adjacent tissue ...

journal_title：Current opinion in genetics & development

authors： Brent AE,Tabin CJ

更新日期：2002-10-01 00:00:00

abstract：:Acquired resistance is a major limitation for the successful treatment of cancer patients. Although numerous efficacious cancer therapeutics have been developed in the past decades, resistance arises due to a variety of reasons including tumoral genetic alterations, or modulation of factors in the tumor environment. U...

journal_title：Current opinion in genetics & development

authors： Prahallad A,Jensen MR,Chapeau EA

更新日期：2019-02-01 00:00:00

abstract：:Following neurulation, neural crest cells emerge from the neural tube and undergo extensive migrations. At the onset of migration, multipotent stem cells exist within the neural crest population. Eventually, these assume one of a number of possible fates, ranging from neurons and glia of the peripheral nervous system ...

journal_title：Current opinion in genetics & development

authors： Bronner-Fraser M

更新日期：1993-08-01 00:00:00

abstract：:The maternal-to-zygotic transition (MZT) is a universal step in animal development characterized by two major events: activation of zygotic transcription and degradation of maternally provided mRNAs. How zygotic gene products instruct the degradation of maternal messages remains a long-standing question in biology. Mi...

journal_title：Current opinion in genetics & development

authors： Giraldez AJ

更新日期：2010-08-01 00:00:00

abstract：:Most of the knowledge we have on the molecular mechanisms of transcription factor mediated reprogramming comes from studies conducted in induced pluripotency. Recently however, a few studies investigated the mechanisms of cellular reprogramming in direct and indirect transdifferentiation, which allows us to explore wh...

journal_title：Current opinion in genetics & development

authors： Firas J,Polo JM

更新日期：2017-10-01 00:00:00

abstract：:Ras proteins activate a signaling cascade through direct binding of the serine/threonine kinase Raf. They also activate additional signaling pathways that are essential for full biological activity. Candidate effectors for these pathways include RalGDS and phosphatidyl inositol 3' kinase, as well as several other Ras ...

journal_title：Current opinion in genetics & development

authors： Katz ME,McCormick F

更新日期：1997-02-01 00:00:00

abstract：:The past few years have been significant advances in our understanding of eukaryotic genomes. In the field of parasitology, this is best exemplified by the application of genome mapping techniques to the study of genome structure and function in the protozoan parasite, Leishmania. Although much is known about the orga...

journal_title：Current opinion in genetics & development

authors： Ivens AC,Blackwell JM

更新日期：1996-12-01 00:00:00

abstract：:TGF-beta binding to the cell surface triggers activation of multiple signal transduction pathways that are connected in intricate ways with each other, and with other response networks involved in sensing cellular information input. Recent data indicate that changes in signal intensity and connectivity of these pathwa...

journal_title：Current opinion in genetics & development

authors： Wakefield LM,Roberts AB

更新日期：2002-02-01 00:00:00

abstract：:Plant genomes exhibit tremendous diversity in both their size and structure, with genome sizes across land plants ranging over two to three orders of magnitude and significant variation in structural organization was observed across species (EA Kellogg, JL Bennetzen, The evolution of nuclear genome structure in seed p...

journal_title：Current opinion in genetics & development

authors： Flowers JM,Purugganan MD

更新日期：2008-12-01 00:00:00

abstract：:Genomic information from ancient human remains is beginning to show its full potential for learning about human prehistory. We review the last few years' dramatic finds about European prehistory based on genomic data from humans that lived many millennia ago and relate it to modern-day patterns of genomic variation. T...

journal_title：Current opinion in genetics & development

authors： Günther T,Jakobsson M

更新日期：2016-12-01 00:00:00

abstract：:Radiotherapy is a form of cancer treatment that utilizes the ability of ionizing radiation to induce cell inactivation and cell death, generally via inflicting DNA double-strand breaks. However, different tumors and their normal surrounding tissues are not equally sensitive to radiation, posing a major challenge in th...

journal_title：Current opinion in genetics & development

authors： Metheetrairut C,Slack FJ

更新日期：2013-02-01 00:00:00

abstract：:Chromatin-based epigenetic inheritance cooperates with cis-acting DNA sequence information to propagate gene expression states and chromosome architecture across cell division cycles. Histone proteins and their modifications are central components of epigenetic systems but how, and to what extent, they are propagated ...

journal_title：Current opinion in genetics & development

authors： Gómez-Rodríguez M,Jansen LE

更新日期：2013-04-01 00:00:00

abstract：:Non-human primates (NHPs) have been proposed as good models for neurodevelopmental disorders due to close similarities to humans in terms of brain structure and cognitive function. The recent development of genome editing technologies has opened new avenues to generate and investigate genetically modified NHPs as mode...

journal_title：Current opinion in genetics & development

authors： Aida T,Feng G

更新日期：2020-12-01 00:00:00

abstract：:The induction of apoptosis of virus-infected cells is an important host defense mechanism against invading pathogens. Some viruses express anti-apoptotic proteins that efficiently block apoptosis induced by death receptors or in response to stress signaled through mitochondria. Viral interference with host cell apopto...

journal_title：Current opinion in genetics & development

authors： Tschopp J,Thome M,Hofmann K,Meinl E

更新日期：1998-02-01 00:00:00

abstract：:A rooted phylogenetic tree of the kinetoplastid protozoa has been constructed that, together with a comparative analysis of editing of several genes, leads to the surprising conclusion that extensive or pan-editing with multiple overlapping guide RNAs is more ancient than 5'-editing. The mechanism of editing is still ...

journal_title：Current opinion in genetics & development

authors： Simpson L,Maslov DA

更新日期：1994-12-01 00:00:00

abstract：:Eukaryotic messenger RNA utilization is a tightly controlled process. Control of translation is exerted at several levels, but the predominant step is ribosome binding, which is rate limiting for translation of most mRNAs. There appear to be several alternative modes by which ribosomes bind to the mRNA and initiate tr...

journal_title：Current opinion in genetics & development

authors： Sonenberg N

更新日期：1994-04-01 00:00:00

abstract：:Investigations on chromatin assembly in vitro implicate chromatin assembly factor 1 (CAF1) as a chaperone for histones H3/H4 and nucleosome assembly protein 1 (NAP1) as a chaperone for histones H2A/H2B. Deletion analysis of CAF1 in vivo suggests multiple redundant pathways for deposition of the histones. Histone depos...

journal_title：Current opinion in genetics & development

authors： Adams CR,Kamakaka RT

更新日期：1999-04-01 00:00:00

abstract：:Eukaryotic organisms have the remarkable ability to inherit states of gene activity without altering the underlying DNA sequence. This epigenetic inheritance can persist over thousands of years, providing an alternative to genetic mutations as a substrate for natural selection. Epigenetic inheritance might be propagat...

journal_title：Current opinion in genetics & development

authors： Zilberman D,Henikoff S

更新日期：2005-10-01 00:00:00

abstract：:The advent of gene targeting in the mouse has led to rapid advances in the identification of factors controlling gene expression that are essential for normal hematopoietic development. Recent work has also uncovered roles for some of these factors in leukemogenesis and in the global regulation of chromatin structure....

journal_title：Current opinion in genetics & development

authors： Engel I,Murre C

更新日期：1999-10-01 00:00:00

abstract：:The human genome is replete with interspersed repetitive sequences derived from the propagation of mobile DNA elements. Three families of human retrotransposons remain active today: LINE1, Alu, and SVA elements. Since 1988, de novo insertions at previously recognized disease loci have been shown to generate highly pen...

journal_title：Current opinion in genetics & development

authors： Babatz TD,Burns KH

更新日期：2013-06-01 00:00:00

abstract：:Over the past decade, many potential candidates for molecules involved in pattern formation in the vertebrate embryo have been identified. Manipulation of the expression of some of these factors has generated fascinating results that have allowed investigators to address their roles in embryogenesis. One such family c...

journal_title：Current opinion in genetics & development

authors： Dickinson ME,McMahon AP

更新日期：1992-08-01 00:00:00

abstract：:A plethora of post-transcriptional mechanisms are involved in essential steps in the pathway of genetic information expression in eukaryotes. These processes are specified by cis-acting signals on RNAs and are mediated by specific trans-acting factors, including RNA-binding proteins and small complementary RNAs. Recen...

journal_title：Current opinion in genetics & development

authors： Siomi H,Dreyfuss G

更新日期：1997-06-01 00:00:00

abstract：:Since the recognition of the uniqueness and coherence of the archaebacteria (sometimes called Archaea), our perception of their role in early evolution has been modified repeatedly. The deluge of sequence data and rapidly improving molecular systematic methods have combined with a better understanding of archaebacteri...

journal_title：Current opinion in genetics & development

authors： Keeling PJ,Charlebois RL,Doolittle WF

更新日期：1994-12-01 00:00:00

abstract：:Few mechanistic ideas from the pre-molecular era of biology have had as enduring an impact as the morphogen concept. In the classical view, cells in developing embryos obtain positional information by measuring morphogen concentrations and comparing them with fixed concentration thresholds; as a result, graded morphog...

journal_title：Current opinion in genetics & development

authors： Nahmad M,Lander AD

更新日期：2011-12-01 00:00:00

abstract：:Rapid progress in identifying the genes underlying autism spectrum disorder (ASD) has provided the substrate for a first wave of analyses into the underlying neurobiology. This review describes the consensus across these diverse analyses, highlighting two distinct sets of genes: 1) Genes that regulate chromatin and tr...

journal_title：Current opinion in genetics & development

authors： Sanders SJ

更新日期：2015-08-01 00:00:00