The fight of viruses against apoptosis.

abstract：:Individual susceptibility to cancer in humans is determined by complex interactions between germline genetic variation and levels of exposure to environmental carcinogens or tumour promoters. Only a small fraction of cancer susceptibility is inherited in a Mendelian manner (high-penetrance familial cancer), and most t...

journal_title：Current opinion in genetics & development

authors： Mao JH,Balmain A

更新日期：2003-02-01 00:00:00

abstract：:Segmentation in Drosophila is a sequential process directed by at least 30 genes that encode various types of proteins, including: many transcription factors; a putative RNA-binding protein; a membrane-associated receptor kinase; several intracellular protein kinases; a number of secreted signaling molecules; and othe...

journal_title：Current opinion in genetics & development

authors： Kornberg TB,Tabata T

更新日期：1993-08-01 00:00:00

abstract：:Microarray technologies enable genome-scale expression measurements. Already proved to be of value for the functional analysis of individual genes and biological processes, the application of expression profiling to disease gene discovery is now growing in importance and practicality. ...

journal_title：Current opinion in genetics & development

authors： Meltzer PS

更新日期：2001-06-01 00:00:00

abstract：:Cancer remains one of the leading causes of death in the developed world and despite impressive advances in therapeutic modalities, only a small subset of patients are currently cured. The underlying genetic heterogeneity of cancers clearly plays a crucial role in determining both the clinical course of individual pat...

journal_title：Current opinion in genetics & development

authors： Pepper C,Norris K,Fegan C

更新日期：2020-02-01 00:00:00

abstract：:Loss of the retinoblastoma protein, pRb, appears to have a role in several human tumor types. Mice lacking pRb have been produced as models of human disease, but have a different spectrum of affected tissues. Recent work shows that the tumorigenic effects of pRb may be revealed only after additional genetic alteration...

journal_title：Current opinion in genetics & development

authors： Hinds PW

更新日期：1995-02-01 00:00:00

abstract：:The pituitary gland functions as a relay between the hypothalamus and peripheral target organs that regulate basic physiological functions, including growth, the stress response, reproduction, metabolism and lactation. The development of the pituitary gland has been studied extensively in mice, and has begun to be exp...

journal_title：Current opinion in genetics & development

authors： Zhu X,Lin CR,Prefontaine GG,Tollkuhn J,Rosenfeld MG

更新日期：2005-06-01 00:00:00

abstract：:Several advances have been made in our understanding of the control of the growth and patterning of embryonic limbs. Development of the vertebrate limb is dependent on reciprocal interactions between the ectoderm and mesoderm that regulate the structure and function of the apical ectodermal ridge. One key component of...

journal_title：Current opinion in genetics & development

authors： Dudley AT,Tabin CJ

更新日期：2000-08-01 00:00:00

abstract：:During development, embryos perform a mesmerizing choreography, which is crucial for the correct shaping, positioning and function of all organs. The cellular properties powering animal morphogenesis have been the focus of much attention. In contrast, much less consideration has been given to the invisible engine cons...

journal_title：Current opinion in genetics & development

authors： Schliffka MF,Maître JL

更新日期：2019-08-01 00:00:00

abstract：:Subsets of patients with common cancers belong to families in which the predisposition is inherited in a regular Mendelian fashion. Genes underlying these cancers are now recognized in colorectal cancer (APC, mismatch repair genes, LKB1) and in breast cancer (BRCA1, BRCA2) whereas, in prostate cancer, a locus in chrom...

journal_title：Current opinion in genetics & development

authors： de la Chapelle A,Peltomäki P

更新日期：1998-06-01 00:00:00

abstract：:The Prader-Willi and Angelman syndromes are now well established as the paradigm of genomic imprinting in human disease. Over the past year, much has been learnt about the mechanisms by which these syndromes arise and molecular diagnostics for the majority of patients are now available. Mouse models for aspects of the...

journal_title：Current opinion in genetics & development

authors： Nicholls RD

更新日期：1993-06-01 00:00:00

abstract：:The Caenorhabditis elegans hermaphrodite vulva is one of the best studied models for signal transduction and cell fate determination during organogenesis. Systematic forward genetic screens have identified a complex and highly interconnected signaling network formed by the conserved EGFR, NOTCH, and WNT signaling path...

journal_title：Current opinion in genetics & development

authors： Schmid T,Hajnal A

更新日期：2015-06-01 00:00:00

abstract：:The combination of complete genome sequence information and estimates of mRNA abundances have begun to reveal causes of both silent and protein sequence evolution. Translational selection appears to explain patterns of synonymous codon usage in many prokaryotes as well as a number of eukaryotic model organisms (with t...

journal_title：Current opinion in genetics & development

authors： Akashi H

更新日期：2001-12-01 00:00:00

abstract：:Numerous roles have been identified for extracellular signals such as Fibroblast Growth Factors (FGFs), Transforming Growth Factor-βs (TGFβs), Wingless-Int proteins (WNTs), and Sonic Hedgehog (SHH) in assigning fates to cells during development of the cerebrum. However, several fundamental questions remain largely une...

journal_title：Current opinion in genetics & development

authors： Hébert JM

更新日期：2013-08-01 00:00:00

abstract：:The current state of the gene regulatory network for endomesoderm specification in sea urchin embryos is reviewed. The network was experimentally defined, and is presented as a predictive map of cis-regulatory inputs and functional regulatory gene interconnections (updated versions of the network and most of the under...

journal_title：Current opinion in genetics & development

authors： Oliveri P,Davidson EH

更新日期：2004-08-01 00:00:00

abstract：:Kinase inhibitors have already established a foothold in the current armament for the treatment of malignancies. Indeed, the future of cancer therapy is likely to rely heavily on an ever-growing number of kinase inhibitors, either as single-agents or in combination with other targeted drugs or even chemotherapies. The...

journal_title：Current opinion in genetics & development

authors： Zhang C,Bollag G

更新日期：2010-02-01 00:00:00

abstract：:The ability to reprogram cell lineage specification through the activity of master regulatory transcription factors has transformed disease modeling, drug screening, and cell therapy for regenerative medicine. Recent advances in the engineering of synthetic transcription factors to modulate endogenous gene expression ...

journal_title：Current opinion in genetics & development

authors： Black JB,Gersbach CA

更新日期：2018-10-01 00:00:00

abstract：:A number of prokaryotic and eukaryotic genomes are currently being sequenced. Already, the nucleotide sequences of four yeast chromosomes and of 2.2 Mb from Caenorhabditis elegans have been reported. Human genomic sequences have also been used in comparative studies with both mouse and Fugu rubripes. ...

journal_title：Current opinion in genetics & development

authors： Jones SJ

更新日期：1995-06-01 00:00:00

abstract：:Although the protein product of the BRCA1 tumor suppressor gene has been implicated in a surprisingly diverse array of biological processes, the molecular mechanism by which BRCA1 loss promotes tumor formation remains unclear. Nonetheless, a pivotal advance has been achieved by recent studies that establish BRCA1 and ...

journal_title：Current opinion in genetics & development

authors： Baer R,Ludwig T

更新日期：2002-02-01 00:00:00

abstract：:Over the past decade, many potential candidates for molecules involved in pattern formation in the vertebrate embryo have been identified. Manipulation of the expression of some of these factors has generated fascinating results that have allowed investigators to address their roles in embryogenesis. One such family c...

journal_title：Current opinion in genetics & development

authors： Dickinson ME,McMahon AP

更新日期：1992-08-01 00:00:00

abstract：:Organogenesis depends upon a well-ordered series of inductive events involving coordination of molecular pathways that regulate the generation and patterning of specific cell types. Key questions in organogenesis involve the identification of the molecular mechanisms by which proteins interact to organize distinct pat...

journal_title：Current opinion in genetics & development

authors： Bei M

更新日期：2009-10-01 00:00:00

abstract：:Cornelia de Lange Syndrome (CdLS) is a rare multiple malformation disorder with characteristic facial features, growth and cognitive retardation, and many other abnormalities. CdLS individuals were recently shown to have heterozygous mutations in a previously uncharacterised gene, NIPBL, which encodes delangin, a homo...

journal_title：Current opinion in genetics & development

authors： Strachan T

更新日期：2005-06-01 00:00:00

abstract：:Over the past twenty years, exciting developments in optical and molecular imaging approaches have allowed researchers to examine with unprecedented resolution the spatial organization of transcription sites in the nucleus. An attractive model that has developed from these studies is that active genes cluster to prefo...

journal_title：Current opinion in genetics & development

authors： Buckley MS,Lis JT

更新日期：2014-04-01 00:00:00

abstract：:Life-long neurogenesis is highly restricted to specialized niches in the adult mammalian brain and therefore the brain's capacity for spontaneous regeneration is extremely limited. However, recent work has demonstrated that under certain circumstances parenchymal astrocytes and NG2 glia can generate neuronal progeny. ...

journal_title：Current opinion in genetics & development

authors： Péron S,Berninger B

更新日期：2015-10-01 00:00:00

abstract：:Telomerase regulation and telomere shortening act as a strong tumor suppressor mechanism in human somatic cells. Point mutations in the promoter of telomerase reverse transcriptase (TERT) are the most frequent non-coding mutation in cancer. These TERT promoter mutations (TPMs) create de novo ETS factor binding sites u...

journal_title：Current opinion in genetics & development

authors： Lorbeer FK,Hockemeyer D

更新日期：2020-02-01 00:00:00

abstract：:Notch signaling has been implicated in a wide variety of processes from cell-fate decisions, tissue patterning and morphogenesis to human diseases and cancer. A model for Notch directly regulating gene expression has been proposed and at least two signaling pathways have been identified; however, the molecular mechani...

journal_title：Current opinion in genetics & development

authors： Weinmaster G

更新日期：1998-08-01 00:00:00

abstract：:In mammalian cells, four protein kinases form the PI3-kinase-related protein kinase (PIK) superfamily. These four enzymes-FRAP, DNA-PK, ATM, and ATR-are distinguished by their large size (all are >2500 amino acids), their common primary sequence relatedness through the carboxy-terminal protein kinase domain, and their...

journal_title：Current opinion in genetics & development

authors： Hoekstra MF

更新日期：1997-04-01 00:00:00

abstract：:Bioinformatics is now an essential tool in many aspects of human molecular genetics research. Methods for the prediction of gene structure are essential components in genomic sequencing projects and provide the key to deriving protein sequence and locating intron/exon junctions. Sequence comparison and database search...

journal_title：Current opinion in genetics & development

authors： Rawlings CJ,Searls DB

更新日期：1997-06-01 00:00:00

abstract：:The neocortex represents the brain structure that has been subjected to a major expansion in its relative size during the course of mammalian evolution. An exquisite coordination of appropriate growth of competent territories along multiple axes and their spatial patterning is required for regionalization of the corti...

journal_title：Current opinion in genetics & development

authors： Borello U,Pierani A

更新日期：2010-08-01 00:00:00

abstract：:In eukaryotic cells, transcription and DNA replication occur on DNA templates associated with chromatin proteins, most notably histone octamers. Protein factors that can assemble these units have been isolated from many sources. In particular, one factor from human cells is associated with ongoing DNA synthesis; other...

journal_title：Current opinion in genetics & development

authors： Kaufman PD,Botchan MR

更新日期：1994-04-01 00:00:00

abstract：:The genetic study of rats and mice using natural variants, natural mutations, chemical or radiation induced mutations, engineered mutations and conditional engineered mutations has provided the tools for investigating the genetics of disease. The completion of the mouse genomic sequence and progress towards sequencing...

journal_title：Current opinion in genetics & development

authors： Cox RD,Brown SD

更新日期：2003-06-01 00:00:00