Rodent models of genetic disease.

Abstract:

:The genetic study of rats and mice using natural variants, natural mutations, chemical or radiation induced mutations, engineered mutations and conditional engineered mutations has provided the tools for investigating the genetics of disease. The completion of the mouse genomic sequence and progress towards sequencing the rat genome in the past year will enable the molecular identification of quantitative trait loci and induced mutations. Sequence-based single nucleotide polymorphism discovery and a greater understanding of the haplotype structure of inbred strains is revitalising quantitative trait locus mapping and there are now plans for an ambitious eight-way recombinant inbred cross and renewed interest in existing resources such as heterogeneous stocks. In the past year there have been refinements to ENU mutagenesis approaches including balancer chromosomes and a new gene-driven approach.

journal_name

Curr Opin Genet Dev

authors

Cox RD,Brown SD

doi

10.1016/s0959-437x(03)00051-0

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

278-83

issue

3

eissn

0959-437X

issn

1879-0380

pii

S0959437X03000510

journal_volume

13

pub_type

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