Rodent models of genetic disease.


:The genetic study of rats and mice using natural variants, natural mutations, chemical or radiation induced mutations, engineered mutations and conditional engineered mutations has provided the tools for investigating the genetics of disease. The completion of the mouse genomic sequence and progress towards sequencing the rat genome in the past year will enable the molecular identification of quantitative trait loci and induced mutations. Sequence-based single nucleotide polymorphism discovery and a greater understanding of the haplotype structure of inbred strains is revitalising quantitative trait locus mapping and there are now plans for an ambitious eight-way recombinant inbred cross and renewed interest in existing resources such as heterogeneous stocks. In the past year there have been refinements to ENU mutagenesis approaches including balancer chromosomes and a new gene-driven approach.


Curr Opin Genet Dev


Cox RD,Brown SD




Has Abstract


2003-06-01 00:00:00














  • The genetics of hereditary common cancers.

    abstract::Subsets of patients with common cancers belong to families in which the predisposition is inherited in a regular Mendelian fashion. Genes underlying these cancers are now recognized in colorectal cancer (APC, mismatch repair genes, LKB1) and in breast cancer (BRCA1, BRCA2) whereas, in prostate cancer, a locus in chrom...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: de la Chapelle A,Peltomäki P

    更新日期:1998-06-01 00:00:00

  • The retinoblastoma tumor suppressor protein.

    abstract::Loss of the retinoblastoma protein, pRb, appears to have a role in several human tumor types. Mice lacking pRb have been produced as models of human disease, but have a different spectrum of affected tissues. Recent work shows that the tumorigenic effects of pRb may be revealed only after additional genetic alteration...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Hinds PW

    更新日期:1995-02-01 00:00:00

  • Common predisposition alleles for moderately common cancers: bladder cancer.

    abstract::Bladder cancer is the 5th commonest cancer and two major risk factors are smoking and occupational chemical exposure. There is also evidence of a genetic component to its aetiology. Candidate gene studies have mostly focused on genes involved in adduct metabolism and DNA repair, including a recent consortium-based met...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Kiltie AE

    更新日期:2010-06-01 00:00:00

  • Stay hydrated: basolateral fluids shaping tissues.

    abstract::During development, embryos perform a mesmerizing choreography, which is crucial for the correct shaping, positioning and function of all organs. The cellular properties powering animal morphogenesis have been the focus of much attention. In contrast, much less consideration has been given to the invisible engine cons...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Schliffka MF,Maître JL

    更新日期:2019-08-01 00:00:00

  • How retrotransposons shape genome regulation.

    abstract::Retrotransposons are mutagenic units able to move within the genome. Despite many defenses deployed by the host to suppress potentially harmful activities of retrotransposons, these genetic units have found ways to meld with normal cellular functions through processes of exaptation and domestication. The same host mec...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Mita P,Boeke JD

    更新日期:2016-04-01 00:00:00

  • New insight into BRAF mutations in cancer.

    abstract::There has been much recent progress in our understanding of the role played by the RAS-RAF-MEK-ERK cascade in human cancer. RAS is an oncogene and this pathway is known to promote proliferation and malignant transformation. More recently, however, RAF has become the focus of attention, particularly in melanoma, where ...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Dhomen N,Marais R

    更新日期:2007-02-01 00:00:00

  • Epigenetic inheritance in Arabidopsis: selective silence.

    abstract::Eukaryotic organisms have the remarkable ability to inherit states of gene activity without altering the underlying DNA sequence. This epigenetic inheritance can persist over thousands of years, providing an alternative to genetic mutations as a substrate for natural selection. Epigenetic inheritance might be propagat...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Zilberman D,Henikoff S

    更新日期:2005-10-01 00:00:00

  • The fragile X premutation: into the phenotypic fold.

    abstract::Premutation alleles (55-200 CGG repeats) of the fragile X mental retardation 1 gene (FMR1) are known to contribute to the fragile X phenotype through genetic instability and transmission of full mutation alleles (>200 repeats). There is now mounting evidence that the premutation alleles themselves contribute to clinic...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Hagerman RJ,Hagerman PJ

    更新日期:2002-06-01 00:00:00

  • Polyploidy and genome restructuring: a variety of outcomes.

    abstract::Dramatic genome rearrangement has been observed after whole genome duplication (WGD) in some plant species, leading many to suggest that genome restructuring may be a common consequence of WGD. However, recent analyses of ancient WGDs in yeast and vertebrates have not shown any evidence for increased rearrangement aft...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Hufton AL,Panopoulou G

    更新日期:2009-12-01 00:00:00

  • TGF-beta signaling: positive and negative effects on tumorigenesis.

    abstract::TGF-beta binding to the cell surface triggers activation of multiple signal transduction pathways that are connected in intricate ways with each other, and with other response networks involved in sensing cellular information input. Recent data indicate that changes in signal intensity and connectivity of these pathwa...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Wakefield LM,Roberts AB

    更新日期:2002-02-01 00:00:00

  • Somatic variants in epilepsy - advancing gene discovery and disease mechanisms.

    abstract::In the past ten years, there has been increasing recognition that cells can acquire genetic variants during cortical development that can give rise to brain malformations as well as nonlesional focal epilepsy. These often brain tissue-specific, de novo variants can result in highly variable phenotypes based on the bur...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Heinzen EL

    更新日期:2020-12-01 00:00:00

  • The role of yeast artificial chromosome clones in generating genome maps.

    abstract::The cloning of large DNAs as yeast artificial chromosomes (YACs) holds the promise of greatly expanding the scope of physical genomic mapping. Recent improvements in YAC clone libraries and their screening, as well as in the analysis of YAC-cloned DNA, are beginning to fulfill the potential of this system. ...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Burke DT

    更新日期:1991-06-01 00:00:00

  • Dysregulated translational control in brain disorders: from genes to behavior.

    abstract::Control of protein synthesis (mRNA translation) is essential for proper brain development and function. Perturbations to the mechanisms governing mRNA translation have repeatedly been shown to constitute a neurodegenerative, neuropsychiatric, and neurodevelopmental disorder risk factor. Developing effective therapeuti...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Wiebe S,Nagpal A,Sonenberg N

    更新日期:2020-12-01 00:00:00

  • Spatiotemporal mechanisms of morphogen gradient interpretation.

    abstract::Few mechanistic ideas from the pre-molecular era of biology have had as enduring an impact as the morphogen concept. In the classical view, cells in developing embryos obtain positional information by measuring morphogen concentrations and comparing them with fixed concentration thresholds; as a result, graded morphog...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Nahmad M,Lander AD

    更新日期:2011-12-01 00:00:00

  • Prion diseases.

    abstract::There have been remarkably rapid advances in the understanding of prion diseases over the past year. The controversial notion that the transmissible agent may be an abnormal isoform of a host-encoded protein, the prion protein, is now gaining wide acceptance. The conundrum of how a disease can both be inherited as an ...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Collinge J,Palmer MS

    更新日期:1992-06-01 00:00:00

  • Combinatorial complexity in chromatin structure and function: revisiting the histone code.

    abstract::Covalent modifications of histone proteins play key roles in transcription, DNA repair, recombination, and other such processes. Over a hundred histone modifications have been described, and a popular idea in the field is that the function of a single histone mark cannot be understood without understanding its combina...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Rando OJ

    更新日期:2012-04-01 00:00:00

  • Signal transduction from multiple Ras effectors.

    abstract::Ras proteins activate a signaling cascade through direct binding of the serine/threonine kinase Raf. They also activate additional signaling pathways that are essential for full biological activity. Candidate effectors for these pathways include RalGDS and phosphatidyl inositol 3' kinase, as well as several other Ras ...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Katz ME,McCormick F

    更新日期:1997-02-01 00:00:00

  • Genes mirror migrations and cultures in prehistoric Europe-a population genomic perspective.

    abstract::Genomic information from ancient human remains is beginning to show its full potential for learning about human prehistory. We review the last few years' dramatic finds about European prehistory based on genomic data from humans that lived many millennia ago and relate it to modern-day patterns of genomic variation. T...

    journal_title:Current opinion in genetics & development

    pub_type: 历史文章,杂志文章,评审


    authors: Günther T,Jakobsson M

    更新日期:2016-12-01 00:00:00

  • Comparative primate genomics: the year of the chimpanzee.

    abstract::This is the year of the chimpanzee genome. Chimpanzee chromosome 22 has been sequenced and soon will be followed by the whole genome, and thousands of chimpanzee cDNA sequences are available for comparative analysis. Not only does this genomic information allow us to identify human-specific changes in particular genes...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Ruvolo M

    更新日期:2004-12-01 00:00:00

  • The evolution of plant genomes: scaling up from a population perspective.

    abstract::Plant genomes exhibit tremendous diversity in both their size and structure, with genome sizes across land plants ranging over two to three orders of magnitude and significant variation in structural organization was observed across species (EA Kellogg, JL Bennetzen, The evolution of nuclear genome structure in seed p...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Flowers JM,Purugganan MD

    更新日期:2008-12-01 00:00:00

  • Cdks and the Drosophila cell cycle.

    abstract::Cyclin-dependent kinases play essential roles in driving the cell cycle. Much progress has been made in Drosophila over the past year in identifying the specific requirements for individual cyclins in particular cell cycle events. These studies encompass many aspects of the cell cycle, from the addition of a G1 phase ...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Follette PJ,O'Farrell PH

    更新日期:1997-02-01 00:00:00

  • Control of muscle development by dueling HATs and HDACs.

    abstract::Skeletal muscle cells have provided an especially auspicious system in which to dissect the roles of chromatin structure in the control of cell growth, differentiation, and development. The MyoD and MEF2 families of transcription factors act cooperatively to regulate the expression of skeletal muscle-specific genes. R...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: McKinsey TA,Zhang CL,Olson EN

    更新日期:2001-10-01 00:00:00

  • Routes to induced pluripotent stem cells.

    abstract::The generation of induced pluripotent stem cells (iPSCs) with Oct4, Sox2, Klf4, c-Myc has been described as 'direct' reprogramming in contrast to reprogramming via nuclear transfer. Interestingly, recent studies have suggested that the conversion process itself includes transient up-regulation and down-regulation of h...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Ruetz T,Kaji K

    更新日期:2014-10-01 00:00:00

  • The antiquity of group I introns.

    abstract::The recent discovery of self-splicing introns in cyanobacteria has given renewed interest to the question of whether introns may have been present in the ancestor of all living things. The properties of introns in genes of bacteria and bacteriophages are discussed in the context of their possible origin and biological...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Shub DA

    更新日期:1991-12-01 00:00:00

  • Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family.

    abstract::In mammalian cells, four protein kinases form the PI3-kinase-related protein kinase (PIK) superfamily. These four enzymes-FRAP, DNA-PK, ATM, and ATR-are distinguished by their large size (all are >2500 amino acids), their common primary sequence relatedness through the carboxy-terminal protein kinase domain, and their...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Hoekstra MF

    更新日期:1997-04-01 00:00:00

  • Chromatin organization: form to function.

    abstract::Recent developments in technology have made it possible to create high resolution genome-wide maps of histone marks, DNA binding proteins and physical interactions along genomic regions. Chromatin features are found together in different combinations, dividing the genome up into domains with distinct functional proper...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: de Graaf CA,van Steensel B

    更新日期:2013-04-01 00:00:00

  • Neutral theory of molecular evolution.

    abstract::DNA sequence data are generally interpreted as favouring Kimura's neutral theory but not without dissent and often with a great deal of controversy with respect to molecular clocks, DNA polymorphism, adaptive evolution, and gene genealogy. Although the theory serves as a guiding principle, many issues concerning mutat...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Takahata N

    更新日期:1996-12-01 00:00:00

  • Chemical approaches to cell reprogramming.

    abstract::Recent advances in cell reprogramming via employing different sets of factors, which allows generation of various cell types that are beyond the downstream developmental lineages from the starting cell type, provide significant opportunities to study fundamental biology and hold enormous promise in regenerative medici...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Yu C,Liu K,Tang S,Ding S

    更新日期:2014-10-01 00:00:00

  • Barrett's metaplasia as a paradigm for understanding the development of cancer.

    abstract::The conversion of one cell type to another is defined as metaplasia (or sometimes it is referred to as transdifferentiation or cellular reprogramming). Metaplasia is important clinically and may predispose to the development of cancer. Barrett's metaplasia is one such example and is the focus of the present review. Ba...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Burke ZD,Tosh D

    更新日期:2012-10-01 00:00:00

  • Baculoviruses: high-level expression in insect cells.

    abstract::Baculoviruses continue to serve as workhorse vectors for the high-level expression of eukaryotic genes in insect cells; however, numerous researchers are also finding novel uses for these vectors by taking advantage of the unique nature of the viruses and their host cells. Concurrently, the technology involved in cons...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Miller LK

    更新日期:1993-02-01 00:00:00