Genetics of Alzheimer's disease: new evidences for an old hypothesis?


:Alzheimer's disease (AD) is the prime cause of dementia and presents a strong genetic predisposition (60-80% of the attributable risk). In addition to APOE, a major recognized genetic determinant of AD, systematic, high-throughput genomic approaches have recently allowed the characterization of four new genetic determinants: CLU, CR1, PICALM and BIN1. Even if the complete picture of AD genetics is still not fully understood, the characterization of these new AD genetic determinants is probably going to strongly modify our perception of the pathophysiological process involved in AD. The new AD genetic landscape suggests that the common and late-onset forms of the disease are associated with a defect in peripheral Aβ peptide clearance, implying that the amyloid cascade hypothesis could be relevant not only in the AD monogenic forms.


Curr Opin Genet Dev


Lambert JC,Amouyel P




Has Abstract


2011-06-01 00:00:00














  • Hox gene evolution in nematodes: novelty conserved.

    abstract::The conserved homeobox (Hox) gene cluster is neither conserved nor clustered in the nematode Caenorhabditis elegans. Instead, C. elegans has a reduced and dispersed gene complement that is the result the loss of Hox genes in stages throughout its evolutionary history. The roles of Hox genes in patterning the nematode ...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Aboobaker A,Blaxter M

    更新日期:2003-12-01 00:00:00

  • Hepatocyte differentiation: from the endoderm and beyond.

    abstract::Hepatocytes differentiate from the endoderm during embryonic development. Recent studies show, however, that hepatocytes can also be derived from rare cells that reside in the pancreas, bone marrow, and brain. Indeed, the latest discoveries indicate that embryonic hepatocytes normally arise by diversion of an endoderm...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Zaret KS

    更新日期:2001-10-01 00:00:00

  • Combinatorial transcription factors.

    abstract::Combinatorial regulation of eukaryotic transcription is mediated by proteins that associate in a specific manner to form multiprotein DNA-bound complexes. Substantial progress has recently been made towards the understanding of the molecular determinants of the protein-protein and protein-DNA interactions that govern ...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Wolberger C

    更新日期:1998-10-01 00:00:00

  • Morphogenesis on the move: cell-to-cell trafficking of plant regulatory proteins.

    abstract::It has been shown recently that some plant transcription factors that regulate cell fate during development can traffic through plasmodesmata-the intercellular channels that connect plant cells. This phenomenon helps explain the non-autonomous effects of many developmental mutations in plants and defines a novel mecha...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Jackson D,Hake S

    更新日期:1997-08-01 00:00:00

  • Somatic variants in epilepsy - advancing gene discovery and disease mechanisms.

    abstract::In the past ten years, there has been increasing recognition that cells can acquire genetic variants during cortical development that can give rise to brain malformations as well as nonlesional focal epilepsy. These often brain tissue-specific, de novo variants can result in highly variable phenotypes based on the bur...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Heinzen EL

    更新日期:2020-12-01 00:00:00

  • The evolutionary history of Southern Africa.

    abstract::The genomic variability of Southern African groups is characterized by an exceptional degree of diversity, which is the result of long-term local evolutionary history, migrations and gene-flow. Over the last few years several investigations have identified and described signatures related to these processes, revealing...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Montinaro F,Capelli C

    更新日期:2018-12-01 00:00:00

  • Identical cells with different 3D genomes; cause and consequences?

    abstract::The mammalian genome is folded into topological domains, chromosomal units that probably serve to spatially accommodate enhancer-promoter interactions and control gene expression levels across cell populations. Longer-range contacts beyond topological domains are also formed, but only in subpopulations of cells. We pr...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Krijger PH,de Laat W

    更新日期:2013-04-01 00:00:00

  • Vertebrate craniofacial development: novel approaches and new dilemmas.

    abstract::Unexpected patterns of neuroblast, angioblast and myoblast movement and tissue organization have been defined using lineage tracing and transplantation methods. The most novel and enigmatic new data derive from analyses of genes in the Hox- and Pax-gene families. In addition to the characterization of expression patte...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Noden DM

    更新日期:1992-08-01 00:00:00

  • RNA toxicity and foci formation in microsatellite expansion diseases.

    abstract::More than 30 incurable neurological and neuromuscular diseases are caused by simple microsatellite expansions consisted of 3-6 nucleotides. These repeats can occur in non-coding regions and often result in a dominantly inherited disease phenotype that is characteristic of a toxic RNA gain-of-function. The expanded RNA...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Zhang N,Ashizawa T

    更新日期:2017-06-01 00:00:00

  • Inter-chromosomal gene regulation in the mammalian cell nucleus.

    abstract::Cellular phenotypes can critically rely on mono-allelic gene expression. Recent studies suggest that in mammalian cells inter-chromosomal DNA interactions may mediate the decision which allele to activate and which to silence. Here, these findings are discussed in the context of knowledge on gene competition, chromati...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: de Laat W,Grosveld F

    更新日期:2007-10-01 00:00:00

  • TERT promoter mutations and telomeres during tumorigenesis.

    abstract::Telomerase regulation and telomere shortening act as a strong tumor suppressor mechanism in human somatic cells. Point mutations in the promoter of telomerase reverse transcriptase (TERT) are the most frequent non-coding mutation in cancer. These TERT promoter mutations (TPMs) create de novo ETS factor binding sites u...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Lorbeer FK,Hockemeyer D

    更新日期:2020-02-01 00:00:00

  • First glimpses of the neurobiology of autism spectrum disorder.

    abstract::Rapid progress in identifying the genes underlying autism spectrum disorder (ASD) has provided the substrate for a first wave of analyses into the underlying neurobiology. This review describes the consensus across these diverse analyses, highlighting two distinct sets of genes: 1) Genes that regulate chromatin and tr...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Sanders SJ

    更新日期:2015-08-01 00:00:00

  • Chromatin proteins involved in the initiation of DNA replication.

    abstract::Eukaryotic DNA replication is regulated at least in part by the assembly of initiation proteins onto origins of replication. The origin recognition complex (ORC) is bound to origins throughout most of the cell cycle. Other initiation proteins, such as Cdc6 and the MCM/P1 proteins, are assembled onto ORC-containing chr...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Rowles A,Blow JJ

    更新日期:1997-04-01 00:00:00

  • Post-transcriptional control of stress responses in cancer.

    abstract::The processes by which the canonical protein synthesis machinery is modified by environmental stresses to allow healthy cells to respond to external conditions to maintain homeostasis, are frequently hijacked by tumour cells to enhance their survival. Two major stress response pathways that play a major role in this r...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Harvey RF,Willis AE

    更新日期:2018-02-01 00:00:00

  • Prion diseases.

    abstract::There have been remarkably rapid advances in the understanding of prion diseases over the past year. The controversial notion that the transmissible agent may be an abnormal isoform of a host-encoded protein, the prion protein, is now gaining wide acceptance. The conundrum of how a disease can both be inherited as an ...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Collinge J,Palmer MS

    更新日期:1992-06-01 00:00:00

  • Deciphering mechanisms of response and resistance in large-scale mouse cancer screens.

    abstract::Acquired resistance is a major limitation for the successful treatment of cancer patients. Although numerous efficacious cancer therapeutics have been developed in the past decades, resistance arises due to a variety of reasons including tumoral genetic alterations, or modulation of factors in the tumor environment. U...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Prahallad A,Jensen MR,Chapeau EA

    更新日期:2019-02-01 00:00:00

  • Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression.

    abstract::Cell proliferation is dependent upon the activation of receptor tyrosine kinases and integrins by soluble growth factors and extracellular matrix proteins, respectively. It is now apparent that concerted, rather than individual, signaling by these receptors is the critical feature responsible for cell-cycle progressio...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Assoian RK,Schwartz MA

    更新日期:2001-02-01 00:00:00

  • The evolution of animal microRNA function.

    abstract::MicroRNAs (miRNAs) are a large class of small RNAs that function as negative gene regulators in eukaryotes. They regulate diverse biological processes, and bioinformatics data indicate that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. ...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Niwa R,Slack FJ

    更新日期:2007-04-01 00:00:00

  • Gene regulatory network controlling embryonic specification in the sea urchin.

    abstract::The current state of the gene regulatory network for endomesoderm specification in sea urchin embryos is reviewed. The network was experimentally defined, and is presented as a predictive map of cis-regulatory inputs and functional regulatory gene interconnections (updated versions of the network and most of the under...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Oliveri P,Davidson EH

    更新日期:2004-08-01 00:00:00

  • Only scratching the cell surface: extracellular signals in cerebrum development.

    abstract::Numerous roles have been identified for extracellular signals such as Fibroblast Growth Factors (FGFs), Transforming Growth Factor-βs (TGFβs), Wingless-Int proteins (WNTs), and Sonic Hedgehog (SHH) in assigning fates to cells during development of the cerebrum. However, several fundamental questions remain largely une...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Hébert JM

    更新日期:2013-08-01 00:00:00

  • Chromatin remodeling in development and differentiation.

    abstract::During development and differentiation, early inductive processes that influence cell fate at a later stage leave marks at distinct gene loci that are maintained through several rounds of mitosis. The structure of chromatin is part of this epigenetic memory that restricts or permits differential expression of genes in...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Müller C,Leutz A

    更新日期:2001-04-01 00:00:00

  • Genetic screens in mice for genome integrity maintenance and cancer predisposition.

    abstract::Genome instability is a feature of nearly all cancers and can be exploited for therapy. In addition, a growing number of genome maintenance genes have been associated with developmental disorders. Efforts to understand the role of genome instability in these processes will be greatly facilitated by a more comprehensiv...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Balmus G,McIntyre RE

    更新日期:2014-02-01 00:00:00

  • Selfish operons: the evolutionary impact of gene clustering in prokaryotes and eukaryotes.

    abstract::The Selfish Operon Model postulates that the organization of bacterial genes into operons is beneficial to the constituent genes in that proximity allows horizontal cotransfer of all genes required for a selectable phenotype; eukaryotic operons formed for very different reasons. Horizontal transfer of selfish operons ...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Lawrence J

    更新日期:1999-12-01 00:00:00

  • Phylogeny and natural history of the primate lentiviruses, SIV and HIV.

    abstract::Studies of primate lentivirus phylogeny over the past decade have established a minimum of five related, but genetically distinct, groups of simian immunodeficiency virus (SIV), each originating from a different African primate species. The hypothesis that HIV-2 (and SIVmac) arose by cross-species transmission from so...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Hirsch VM,Dapolito G,Goeken R,Campbell BJ

    更新日期:1995-12-01 00:00:00

  • The mechanisms shaping the single-cell transcriptional landscape.

    abstract::Recent technological and computational advances in understanding the transcriptional and chromatin features of single cells have begun answering longstanding questions in the extent and impact of biological heterogeneity. Here, we outline the intrinsic and extrinsic mechanisms that underlie the transcriptional and fun...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Martinez-Jimenez CP,Odom DT

    更新日期:2016-04-01 00:00:00

  • Regeneration and reprogramming.

    abstract::Recent reprogramming studies indicate that mammalian, somatic cells have the potential to achieve pluripotent states and undergo cell type switching. Such cellular traits are observed under natural conditions in animals that regenerate complex organs. A number of invertebrates display the amazing trait of whole body r...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Knapp D,Tanaka EM

    更新日期:2012-10-01 00:00:00

  • Genes that drive invasion and migration in Drosophila.

    abstract::Successful cell migration depends on the careful regulation of the timing of movement, the guidance of motile cells, and cytoskeletal and adhesive changes within the cells. This review focuses on genes that act cell-autonomously to promote these aspects of cell migration in Drosophila. We discuss recent advances in un...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Starz-Gaiano M,Montell DJ

    更新日期:2004-02-01 00:00:00

  • Genetic analysis and gene expression of human immunodeficiency virus.

    abstract::Ten years after the initial description of acquired immune deficiency syndrome, its causative agent, the human immunodeficiency virus, remains the subject of intense scientific interest. Recent research has focused on the detailed analysis of the molecular principles governing gene expression and virion formation and ...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Kräusslich HG

    更新日期:1992-02-01 00:00:00

  • Epilepsy genetics--past, present, and future.

    abstract::Human epilepsy is a common and heterogeneous condition in which genetics play an important etiological role. We begin by reviewing the past history of epilepsy genetics, a field that has traditionally included studies of pedigrees with epilepsy caused by defects in ion channels and neurotransmitters. We highlight impo...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Poduri A,Lowenstein D

    更新日期:2011-06-01 00:00:00

  • Choose your fate: artery, vein or lymphatic vessel?

    abstract::The specification of cell fate is integral to embryonic development. Recent research has identified several molecules that are involved in the development of the embryonic vasculature. Their combined actions are required for the specification and development of the arteries, veins and lymphatic vessels; vascular netwo...

    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Harvey NL,Oliver G

    更新日期:2004-10-01 00:00:00