Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression.

abstract：:The conversion of one cell type to another is defined as metaplasia (or sometimes it is referred to as transdifferentiation or cellular reprogramming). Metaplasia is important clinically and may predispose to the development of cancer. Barrett's metaplasia is one such example and is the focus of the present review. Ba...

journal_title：Current opinion in genetics & development

authors： Burke ZD,Tosh D

更新日期：2012-10-01 00:00:00

abstract：:In the Drosophila eye, photoreceptor clusters are arranged with mirror-image symmetry about the dorso-ventral midline. Recent work indicates critical rôles for Wingless and JAK/STAT signalling in setting up long-range gradients of positional information that determine this symmetry. Furthermore, important functions ha...

journal_title：Current opinion in genetics & development

authors： Strutt H,Strutt D

更新日期：1999-08-01 00:00:00

abstract：:Population data suggest that many parasitic protozoa (e.g. Trypanosoma, Leishmania, Entamoeba and Giardia) reproduce clonally, but this hypothesis has been highly controversial for Plasmodium falciparum. Although reproduction is predominantly clonal in the enteric bacteria Escherichia coli and Salmonella, the level of...

journal_title：Current opinion in genetics & development

authors： Hartl DL

更新日期：1992-12-01 00:00:00

abstract：:Cardiovascular morphogenesis involves cell behavior and cell identity changes that are activated by mechanical forces associated with heart function. Recently, advances in in vivo imaging, methods to alter blood flow, and computational modelling have greatly advanced our understanding of how forces produced by heart c...

journal_title：Current opinion in genetics & development

authors： Duchemin AL,Vignes H,Vermot J,Chow R

更新日期：2019-08-01 00:00:00

abstract：:The induction of apoptosis of virus-infected cells is an important host defense mechanism against invading pathogens. Some viruses express anti-apoptotic proteins that efficiently block apoptosis induced by death receptors or in response to stress signaled through mitochondria. Viral interference with host cell apopto...

journal_title：Current opinion in genetics & development

authors： Tschopp J,Thome M,Hofmann K,Meinl E

更新日期：1998-02-01 00:00:00

abstract：:Recent research has broadened significantly our understanding of how the somite, a specialized mesodermal structure found in vertebrate embryos, gives rise to the cartilage, muscle and tendon cell lineages. The specification of somite derivatives involves the action of patterning signals secreted from adjacent tissue ...

journal_title：Current opinion in genetics & development

authors： Brent AE,Tabin CJ

更新日期：2002-10-01 00:00:00

abstract：:Trait exaggeration, well known to naturalists and evolutionary biologists, has recently become a prominent research subject in the modern field of Evolutionary Developmental Biology. A large number of traits that can be considered as cases of exaggeration exist in nature. Yet, the field has almost exclusively focused ...

journal_title：Current opinion in genetics & development

authors： Toubiana W,Khila A

更新日期：2016-08-01 00:00:00

abstract：:Atherosclerosis is the major cause of cardiovascular disease. Hypercholesterolaemia, hypertension and cigarette smoking are the common risk factors for atherosclerosis. These risk factors unite behind a convergence of mechanism, involving oxidation and inflammation in the artery wall that, with time, gives rise to cha...

journal_title：Current opinion in genetics & development

authors： Scott J

更新日期：2004-06-01 00:00:00

abstract：:Chromatin-based epigenetic inheritance cooperates with cis-acting DNA sequence information to propagate gene expression states and chromosome architecture across cell division cycles. Histone proteins and their modifications are central components of epigenetic systems but how, and to what extent, they are propagated ...

journal_title：Current opinion in genetics & development

authors： Gómez-Rodríguez M,Jansen LE

更新日期：2013-04-01 00:00:00

abstract：:Ras proteins play a critical role in controlling normal cellular growth and, when activated by mutation, in causing malignant transformation. Regulation of p21ras is achieved by GTPase activating proteins, which control the rate of hydrolysis of GTP to GDP, and also by GDP dissociation stimulators, which catalyze the ...

journal_title：Current opinion in genetics & development

authors： Downward J

更新日期：1992-02-01 00:00:00

abstract：:Logical models provide insight about key control elements of biological networks. Based solely on the logical structure, we can determine state transition diagrams that give the allowed possible transitions in a coarse grained phase space. Attracting pathways and stable nodes in the state transition diagram correspond...

journal_title：Current opinion in genetics & development

authors： Glass L,Siegelmann HT

更新日期：2010-12-01 00:00:00

abstract：:Investigations on chromatin assembly in vitro implicate chromatin assembly factor 1 (CAF1) as a chaperone for histones H3/H4 and nucleosome assembly protein 1 (NAP1) as a chaperone for histones H2A/H2B. Deletion analysis of CAF1 in vivo suggests multiple redundant pathways for deposition of the histones. Histone depos...

journal_title：Current opinion in genetics & development

authors： Adams CR,Kamakaka RT

更新日期：1999-04-01 00:00:00

abstract：:More than 30 incurable neurological and neuromuscular diseases are caused by simple microsatellite expansions consisted of 3-6 nucleotides. These repeats can occur in non-coding regions and often result in a dominantly inherited disease phenotype that is characteristic of a toxic RNA gain-of-function. The expanded RNA...

journal_title：Current opinion in genetics & development

authors： Zhang N,Ashizawa T

更新日期：2017-06-01 00:00:00

abstract：:The regulation of synapse formation and plasticity in the developing and adult brain underlies a complex interplay of intrinsic genetic programs and extrinsic factors. Recent research identified microRNAs (miRNAs), a class of small non-coding RNAs, as a new functional layer in this regulatory network. Within only a fe...

journal_title：Current opinion in genetics & development

authors： Siegel G,Saba R,Schratt G

更新日期：2011-08-01 00:00:00

abstract：:The induction of an appropriate cellular response to a stimulus often depends on the intricate interplay between multiple signaling pathways. Recent work utilizing Caenorhabditis elegans has enabled the identification of points of convergence between signaling pathways and permitted the elucidation of how multiple sig...

journal_title：Current opinion in genetics & development

authors： Hanna-Rose W,Han M

更新日期：2000-10-01 00:00:00

abstract：:Following neurulation, neural crest cells emerge from the neural tube and undergo extensive migrations. At the onset of migration, multipotent stem cells exist within the neural crest population. Eventually, these assume one of a number of possible fates, ranging from neurons and glia of the peripheral nervous system ...

journal_title：Current opinion in genetics & development

authors： Bronner-Fraser M

更新日期：1993-08-01 00:00:00

abstract：:The combination of complete genome sequence information and estimates of mRNA abundances have begun to reveal causes of both silent and protein sequence evolution. Translational selection appears to explain patterns of synonymous codon usage in many prokaryotes as well as a number of eukaryotic model organisms (with t...

journal_title：Current opinion in genetics & development

authors： Akashi H

更新日期：2001-12-01 00:00:00

abstract：:The Prader-Willi and Angelman syndromes are now well established as the paradigm of genomic imprinting in human disease. Over the past year, much has been learnt about the mechanisms by which these syndromes arise and molecular diagnostics for the majority of patients are now available. Mouse models for aspects of the...

journal_title：Current opinion in genetics & development

authors： Nicholls RD

更新日期：1993-06-01 00:00:00

abstract：:What determines phenotype is one of the most fundamental questions in biology. Historically, the search for answers had focused on genetic or environmental variants, but recent studies in epigenetics have revealed a third mechanism that can influence phenotypic outcomes, even in the absence of genetic or environmental...

journal_title：Current opinion in genetics & development

authors： Rakyan VK,Beck S

更新日期：2006-12-01 00:00:00

abstract：:Vertebrate eye formation is a multistep process requiring coordinated inductive interactions between neural and non-neural ectoderm and underlying mesendoderm. The induction and shaping of the eyes involves an elaborate cellular choreography characterized by precise changes in cell shape coupled with complex cellular ...

journal_title：Current opinion in genetics & development

authors： Bazin-Lopez N,Valdivia LE,Wilson SW,Gestri G

更新日期：2015-06-01 00:00:00

abstract：:The formation of new blood vessels through the process of angiogenesis is critical in vascular development and homeostasis. Aberrant angiogenesis leads to a variety of diseases, such as ischemia and cancer. Recent studies have revealed important roles for miRNAs in regulating endothelial cell (EC) function, especially...

journal_title：Current opinion in genetics & development

authors： Wang S,Olson EN

更新日期：2009-06-01 00:00:00

abstract：:Whole-transcriptome analyses have established that the plant circadian clock regulates virtually every plant biological process and most prominently hormonal and stress response pathways. Systems biology efforts have successfully modeled the plant central clock machinery and an iterative process of model refinement an...

journal_title：Current opinion in genetics & development

authors： McClung CR,Gutiérrez RA

更新日期：2010-12-01 00:00:00

abstract：:One of the ways in which higher eukaryotes receive messages from the environment is via cell surface receptor tyrosine kinases. These are transmembrane proteins with an extracellular binding domain that specifies the growth factor with which it will interact, and an intracellular domain that encodes the tyrosine kinas...

journal_title：Current opinion in genetics & development

authors： Kazlauskas A

更新日期：1994-02-01 00:00:00

abstract：:The gene regulatory networks that control sex determination vary between species. Despite these differences, comparative studies in insects have found that alternative splicing is reiteratively used in evolution to control expression of the key sex-determining genes. Sex determination is best understood in Drosophila ...

journal_title：Current opinion in genetics & development

authors： Salz HK

更新日期：2011-08-01 00:00:00

abstract：:Tumor blood vessels have multiple structural and functional abnormalities. They are unusually dynamic, and naturally undergo sprouting, proliferation, remodeling or regression. The vessels are irregularly shaped, tortuous, and lack the normal hierarchical arrangement of arterioles, capillaries and venules. Endothelial...

journal_title：Current opinion in genetics & development

authors： Baluk P,Hashizume H,McDonald DM

更新日期：2005-02-01 00:00:00

abstract：:Rapid progress in identifying the genes underlying autism spectrum disorder (ASD) has provided the substrate for a first wave of analyses into the underlying neurobiology. This review describes the consensus across these diverse analyses, highlighting two distinct sets of genes: 1) Genes that regulate chromatin and tr...

journal_title：Current opinion in genetics & development

authors： Sanders SJ

更新日期：2015-08-01 00:00:00

abstract：:All bovine chromosomes are now represented by a syntenic group, a linkage map and at least one in situ hybridization. Almost 1,000 loci are mapped, about 300 of which are coding sequences useful for comparative mapping and evolutionary inference. Economically important loci are beginning to appear on bovine linkage ma...

journal_title：Current opinion in genetics & development

authors： Womack JE,Kata SR

更新日期：1995-12-01 00:00:00

abstract：:DNA sequence data are generally interpreted as favouring Kimura's neutral theory but not without dissent and often with a great deal of controversy with respect to molecular clocks, DNA polymorphism, adaptive evolution, and gene genealogy. Although the theory serves as a guiding principle, many issues concerning mutat...

journal_title：Current opinion in genetics & development

authors： Takahata N

更新日期：1996-12-01 00:00:00

abstract：:Engineering cancer-associated mutations into the mouse germline is an important tool for biological studies of growth control and tumorigenesis. Tractable models of many human cancers now exist in which the initiating genetic lesions have been elucidated and, in some instances, where the cooperating lesions are also k...

journal_title：Current opinion in genetics & development

authors： Weiss B,Shannon K

更新日期：2003-02-01 00:00:00

abstract：:The genomic perspective aids in integrating the analysis of single resistance (R-) genes into a higher order model of complex plant resistance systems. The majority of R-genes encode a class of proteins with nucleotide binding (NB) and leucine-rich repeat (LRR) domains. Several R-proteins act in multi-protein R-comple...

journal_title：Current opinion in genetics & development

authors： Friedman AR,Baker BJ

更新日期：2007-12-01 00:00:00