Abstract：
:The mammalian globin gene clusters provide a paradigm for studying the relationship between genome structure and function. As blood stem cells undergo lineage specification and differentiation to form red blood cells, the chromatin structure and expression of the α-globin cluster change. The gradual activation of the α-globin genes in well-defined cell populations has enabled investigation of the structural and functional roles of its enhancers, promoters and boundary elements. Recent studies of gene regulatory processes involving these elements at the mouse α-globin cluster have brought new insights into the general principles underlying the three-dimensional structure of the genome and its relationship to gene expression throughout time.
journal_name
Curr Opin Genet Devjournal_title
Current opinion in genetics & developmentauthors
Oudelaar AM,Beagrie RA,Kassouf MT,Higgs DRdoi
10.1016/j.gde.2020.10.003subject
Has Abstractpub_date
2020-11-19 00:00:00pages
18-24eissn
0959-437Xissn
1879-0380pii
S0959-437X(20)30142-8journal_volume
67pub_type
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