Baculoviruses: high-level expression in insect cells.

abstract：:The nuclear periphery has been implicated in gene regulation and it has been proposed that proximity to the nuclear lamina and inner nuclear membrane (INM) leads to gene repression. More recently, it appears that there is a correlation and interdependence between lamina associated domains (LADs), the epigenome and ove...

journal_title：Current opinion in genetics & development

authors： Luperchio TR,Wong X,Reddy KL

更新日期：2014-04-01 00:00:00

abstract：:The Selfish Operon Model postulates that the organization of bacterial genes into operons is beneficial to the constituent genes in that proximity allows horizontal cotransfer of all genes required for a selectable phenotype; eukaryotic operons formed for very different reasons. Horizontal transfer of selfish operons ...

journal_title：Current opinion in genetics & development

authors： Lawrence J

更新日期：1999-12-01 00:00:00

abstract：:There are several enzymes, acetylases and deacetylases, that can regulate transcription by modifying the acetylation state of histones or other promoter-bound transcription factors. Some of these enzymes are present in multisubunit complexes. Recent efforts to understand the biological role of these enzymes reveals th...

journal_title：Current opinion in genetics & development

authors： Kouzarides T

更新日期：1999-02-01 00:00:00

abstract：:The ability to reprogram cell lineage specification through the activity of master regulatory transcription factors has transformed disease modeling, drug screening, and cell therapy for regenerative medicine. Recent advances in the engineering of synthetic transcription factors to modulate endogenous gene expression ...

journal_title：Current opinion in genetics & development

authors： Black JB,Gersbach CA

更新日期：2018-10-01 00:00:00

abstract：:The mammalian genome is folded into topological domains, chromosomal units that probably serve to spatially accommodate enhancer-promoter interactions and control gene expression levels across cell populations. Longer-range contacts beyond topological domains are also formed, but only in subpopulations of cells. We pr...

journal_title：Current opinion in genetics & development

authors： Krijger PH,de Laat W

更新日期：2013-04-01 00:00:00

abstract：:Multiple histone-modifying enzymes have been identified in the past several years. Much has been learned regarding the biochemistry of these enzymes and their effects on gene expression in cultured cells. However, the functions of these factors during development are still largely unknown. Recent genetic studies indic...

journal_title：Current opinion in genetics & development

authors： Lin W,Dent SY

更新日期：2006-04-01 00:00:00

abstract：:As immunotherapies to treat malignancy continue to diversify along with the tumor types amenable to treatment, it will become very important to predict which treatment is most likely to benefit a given patient. Tumor neoantigens, novel peptides resulting from somatic tumor mutations and recognized by the immune system...

journal_title：Current opinion in genetics & development

authors： Snyder A,Chan TA

更新日期：2015-02-01 00:00:00

abstract：:The past decade has seen a huge jump in the resolution and scale at which we can interrogate the three-dimensional properties of the genome. This revealed different types of chromatin structures including topologically associating domains, partitioning genes and their enhancers into interacting domains. While the visu...

journal_title：Current opinion in genetics & development

authors： Cavalheiro GR,Pollex T,Furlong EE

更新日期：2021-01-23 00:00:00

abstract：:The sequences of both of the human sex chromosomes and of a substantial part of the chimpanzee Y chromosome have now been determined, and most of the protein-coding genes have been identified. The X chromosome codes for more than 800 proteins but the Y chromosome for only approximately 60, illustrating their very diff...

journal_title：Current opinion in genetics & development

authors： Ross MT,Bentley DR,Tyler-Smith C

更新日期：2006-06-01 00:00:00

abstract：:Pluripotency-associated transcription factors possess a pivotal role to maintain pluripotency in pluripotent stem cells as well as to induce pluripotency in somatic cells. They direct specific pattern of gene expression from the genome by co-operating with the genetic and epigenetic mechanisms. Recent findings reveale...

journal_title：Current opinion in genetics & development

authors： Niwa H

更新日期：2014-10-01 00:00:00

abstract：:Microarray technologies enable genome-scale expression measurements. Already proved to be of value for the functional analysis of individual genes and biological processes, the application of expression profiling to disease gene discovery is now growing in importance and practicality. ...

journal_title：Current opinion in genetics & development

authors： Meltzer PS

更新日期：2001-06-01 00:00:00

abstract：:Ras proteins play a critical role in controlling normal cellular growth and, when activated by mutation, in causing malignant transformation. Regulation of p21ras is achieved by GTPase activating proteins, which control the rate of hydrolysis of GTP to GDP, and also by GDP dissociation stimulators, which catalyze the ...

journal_title：Current opinion in genetics & development

authors： Downward J

更新日期：1992-02-01 00:00:00

abstract：:The regulation of transcription elongation within the context of chromatin is a topic of great interest. Even though chromatin presents a barrier to transcription by the PolII machinery in vitro, this process is rather efficient in vivo. Importantly, the chromatin structure of the actively transcribed genes is altered...

journal_title：Current opinion in genetics & development

authors： Belotserkovskaya R,Reinberg D

更新日期：2004-04-01 00:00:00

abstract：:The regulation of synapse formation and plasticity in the developing and adult brain underlies a complex interplay of intrinsic genetic programs and extrinsic factors. Recent research identified microRNAs (miRNAs), a class of small non-coding RNAs, as a new functional layer in this regulatory network. Within only a fe...

journal_title：Current opinion in genetics & development

authors： Siegel G,Saba R,Schratt G

更新日期：2011-08-01 00:00:00

abstract：:Allele-specific gene expression can influence disease traits. Non-coding germline genetic variants that alter regulatory elements can cause allele-specific gene expression and contribute to cancer susceptibility. In tumors, both somatic copy number alterations and somatic single nucleotide variants have been shown to ...

journal_title：Current opinion in genetics & development

authors： Robles-Espinoza CD,Mohammadi P,Bonilla X,Gutierrez-Arcelus M

更新日期：2020-12-28 00:00:00

abstract：:The impressive diversity of body plans, lifestyles and segmental specializations exhibited by crustaceans (barnacles, copepods, shrimps, crabs, lobsters and their kin) provides great material to address longstanding questions in evolutionary developmental biology. Recent advances in forward and reverse genetics and in...

journal_title：Current opinion in genetics & development

authors： Stamataki E,Pavlopoulos A

更新日期：2016-08-01 00:00:00

abstract：:In this review we discuss the importance of genetic somatic mosaicism and its impact on brain diseases. We start from introducing the different types of somatic mutations, their frequencies and abundances across development and lifespan. We then describe how weakness in DNA repair mechanisms influences their prevalenc...

journal_title：Current opinion in genetics & development

authors： Jourdon A,Fasching L,Scuderi S,Abyzov A,Vaccarino FM

更新日期：2020-12-01 00:00:00

abstract：:The effort to map the entire human genome has led recently to the important milestone publication in late 1999 of the complete sequence of chromosome 22. This has been facilitated by increasingly sophisticated tools for genetic analysis and the ensuing wealth of detailed genetic information. The quest for genetic fact...

journal_title：Current opinion in genetics & development

authors： de Silva HR,Khan NL,Wood NW

更新日期：2000-06-01 00:00:00

abstract：:Filamentous cyanobacteria, the only prokaryotes that form linear patterns of differentiated cells, can be genetically manipulated by the conjugative transfer of plasmids from Escherichia coli. It has become possible to determine the cellular localization of genetic transcription, including transcription of development...

journal_title：Current opinion in genetics & development

authors： Wolk CP

更新日期：1991-10-01 00:00:00

abstract：:Genome-wide data on genetic variation are now available for multiple primate species and populations, facilitating analyses of evolutionary history within and across taxa. One emerging theme from these studies involves the central role of admixture. Genomic data sets indicate that both ancient gene flow following init...

journal_title：Current opinion in genetics & development

authors： Tung J,Barreiro LB

更新日期：2017-12-01 00:00:00

abstract：:Whole-transcriptome analyses have established that the plant circadian clock regulates virtually every plant biological process and most prominently hormonal and stress response pathways. Systems biology efforts have successfully modeled the plant central clock machinery and an iterative process of model refinement an...

journal_title：Current opinion in genetics & development

authors： McClung CR,Gutiérrez RA

更新日期：2010-12-01 00:00:00

abstract：:In recent years, the classical approaches of experimental embryology have been used in combination with more modern techniques to investigate aspects of neurogenesis. This combination has advanced our knowledge of several areas of neuronal development, including the lineages of neuronal precursors, the segmentation of...

journal_title：Current opinion in genetics & development

authors： Fraser SE

更新日期：1991-08-01 00:00:00

abstract：:Unexpected patterns of neuroblast, angioblast and myoblast movement and tissue organization have been defined using lineage tracing and transplantation methods. The most novel and enigmatic new data derive from analyses of genes in the Hox- and Pax-gene families. In addition to the characterization of expression patte...

journal_title：Current opinion in genetics & development

authors： Noden DM

更新日期：1992-08-01 00:00:00

abstract：:The establishment of left-right asymmetries in the vertebrate embryo is carried out by complex genetic interactions that impart left- or right-sided information to the developing organs and structures. The origin of LR information is still unclear, but recent advances have provided new insights as to how it is relayed...

journal_title：Current opinion in genetics & development

authors： Raya A,Izpisúa Belmonte JC

更新日期：2004-10-01 00:00:00

abstract：:The eukaryotic nucleus is a highly compartmentalized and dynamic environment. Chromosome territories are arranged nonrandomly within the nucleus and numerous studies have indicated that a gene's position in the nucleus can impact its transcriptional activity. Here, we focus on recent advances in our understanding of t...

journal_title：Current opinion in genetics & development

authors： Zhao R,Bodnar MS,Spector DL

更新日期：2009-04-01 00:00:00

abstract：:Many acquired and familial renal diseases in man lead to kidney dysfunction and nephrotic syndrome. These diseases share a common pathological fate in the form of glomerular dysfunction and proteinuria. Classification of the disease is difficult because the onset of pathological appearance in congenital nephrotic synd...

journal_title：Current opinion in genetics & development

authors： Khoshnoodi J,Tryggvason K

更新日期：2001-06-01 00:00:00

abstract：:The digital reconstruction of the embryogenesis of model organisms from 3D+time data is revolutionizing practices in quantitative and integrative Developmental Biology. A manual and fully supervised image analysis of the massive complex data acquired with new microscopy technologies is no longer an option and automate...

journal_title：Current opinion in genetics & development

authors： Luengo-Oroz MA,Ledesma-Carbayo MJ,Peyriéras N,Santos A

更新日期：2011-10-01 00:00:00

abstract：:Multiple neural and non-neural cell types arise from the neural crest (NC) in vertebrate embryos. Recent work has provided evidence for multipotent stem cells and intermediate precursors in the early NC cell population as well as in various NC derivatives in embryos and even in adult. Advances have been made towards u...

journal_title：Current opinion in genetics & development

authors： Le Douarin NM,Dupin E

更新日期：2003-10-01 00:00:00

abstract：:Family-based next generation sequencing (NGS) has recently pointed to an important role for de novo germline point mutations in both rare and common genetic disorders associated with reduced fitness. In this review we highlight the impact of the mutational target size on the frequency of diseases caused by these de no...

journal_title：Current opinion in genetics & development

authors： de Ligt J,Veltman JA,Vissers LE

更新日期：2013-06-01 00:00:00

abstract：:Asymmetric cell division during the process of sporulation in the bacterium Bacillus subtilis generates dissimilar progeny that exhibit distinct programs of gene transcription. Recent work reveals a partner switching mechanism that governs the activity of the sporulation regulatory protein sigma F and that may be resp...

journal_title：Current opinion in genetics & development

authors： Duncan L,Alper S,Losick R

更新日期：1994-10-01 00:00:00