Abstract:
:The past decade has seen a huge jump in the resolution and scale at which we can interrogate the three-dimensional properties of the genome. This revealed different types of chromatin structures including topologically associating domains, partitioning genes and their enhancers into interacting domains. While the visualisation of these topologies and their dynamics has dramatically improved, our understanding of their underlying mechanisms and functional roles in gene expression has lagged behind. A suite of recent studies have addressed this using genetic manipulations to perturb topological features and loops at different scales. Here we assess the new biological insights gained on the functional relationship between genome topology and gene expression, with a particular focus on enhancer function.
journal_name
Curr Opin Genet Devjournal_title
Current opinion in genetics & developmentauthors
Cavalheiro GR,Pollex T,Furlong EEdoi
10.1016/j.gde.2020.12.015subject
Has Abstractpub_date
2021-01-23 00:00:00pages
119-129eissn
0959-437Xissn
1879-0380pii
S0959-437X(20)30179-9journal_volume
67pub_type
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