Recent advances in assessing gene flow between diverging populations and species.

abstract：:All bovine chromosomes are now represented by a syntenic group, a linkage map and at least one in situ hybridization. Almost 1,000 loci are mapped, about 300 of which are coding sequences useful for comparative mapping and evolutionary inference. Economically important loci are beginning to appear on bovine linkage ma...

journal_title：Current opinion in genetics & development

authors： Womack JE,Kata SR

更新日期：1995-12-01 00:00:00

abstract：:Recent studies in invertebrates have provided important mechanistic insights into several general aspects of muscle development. Two new genes have been identified that are involved in muscle fusion in Drosophila and a novel maternal component was shown to be responsible for myogenic determination in an ascidian. In a...

journal_title：Current opinion in genetics & development

authors： Baylies MK,Michelson AM

更新日期：2001-08-01 00:00:00

abstract：:A rooted phylogenetic tree of the kinetoplastid protozoa has been constructed that, together with a comparative analysis of editing of several genes, leads to the surprising conclusion that extensive or pan-editing with multiple overlapping guide RNAs is more ancient than 5'-editing. The mechanism of editing is still ...

journal_title：Current opinion in genetics & development

authors： Simpson L,Maslov DA

更新日期：1994-12-01 00:00:00

abstract：:The mammalian genome is folded into topological domains, chromosomal units that probably serve to spatially accommodate enhancer-promoter interactions and control gene expression levels across cell populations. Longer-range contacts beyond topological domains are also formed, but only in subpopulations of cells. We pr...

journal_title：Current opinion in genetics & development

authors： Krijger PH,de Laat W

更新日期：2013-04-01 00:00:00

abstract：:Type 1 diabetes is the most common autoimmune disorder in childhood, characterized by the development of autoimmunity through unknown environmental insults in genetically susceptible individuals. There are now over 50 regions of the genome that harbor type 1 diabetes susceptibility genes, with much of the genetic risk...

journal_title：Current opinion in genetics & development

authors： Robertson CC,Rich SS

更新日期：2018-06-01 00:00:00

abstract：:The increasing availability of large-scale autosomal genetic variation data sampled from world-wide geographic areas, coupled with advances in the statistical methodology to analyse these data, is showcasing the power of DNA as a major tool to gain insights into the demographic history of humans and other organisms. H...

journal_title：Current opinion in genetics & development

authors： Wangkumhang P,Hellenthal G

更新日期：2018-12-01 00:00:00

abstract：:Loss of cardiomyocytes from cardiovascular disease is irreversible and current therapeutic strategies do not redress the loss of myocardium after injury. The discovery that endogenous fibroblasts in the heart can be reprogrammed to cardiomyocyte-like cells after myocardial infarction and heart function is improved sub...

journal_title：Current opinion in genetics & development

authors： Srivastava D,Berry EC

更新日期：2013-10-01 00:00:00

abstract：:The mammalian globin gene clusters provide a paradigm for studying the relationship between genome structure and function. As blood stem cells undergo lineage specification and differentiation to form red blood cells, the chromatin structure and expression of the α-globin cluster change. The gradual activation of the ...

journal_title：Current opinion in genetics & development

authors： Oudelaar AM,Beagrie RA,Kassouf MT,Higgs DR

更新日期：2020-11-19 00:00:00

abstract：:The past decade has seen a huge jump in the resolution and scale at which we can interrogate the three-dimensional properties of the genome. This revealed different types of chromatin structures including topologically associating domains, partitioning genes and their enhancers into interacting domains. While the visu...

journal_title：Current opinion in genetics & development

authors： Cavalheiro GR,Pollex T,Furlong EE

更新日期：2021-01-23 00:00:00

abstract：:Mitochondria are highly abundant in and essential to the beat-to-beat contractile performance of hearts. However, relatively few cardiac diseases have been attributed to primary mitochondrial dysfunction. The paucity of evidence for 'primary mitochondrial cardiac diseases' may be because such an entity does not exist....

journal_title：Current opinion in genetics & development

authors： Dorn G II

更新日期：2016-06-01 00:00:00

abstract：:Subsets of patients with common cancers belong to families in which the predisposition is inherited in a regular Mendelian fashion. Genes underlying these cancers are now recognized in colorectal cancer (APC, mismatch repair genes, LKB1) and in breast cancer (BRCA1, BRCA2) whereas, in prostate cancer, a locus in chrom...

journal_title：Current opinion in genetics & development

authors： de la Chapelle A,Peltomäki P

更新日期：1998-06-01 00:00:00

abstract：:Loss of the retinoblastoma protein, pRb, appears to have a role in several human tumor types. Mice lacking pRb have been produced as models of human disease, but have a different spectrum of affected tissues. Recent work shows that the tumorigenic effects of pRb may be revealed only after additional genetic alteration...

journal_title：Current opinion in genetics & development

authors： Hinds PW

更新日期：1995-02-01 00:00:00

abstract：:The current state of the gene regulatory network for endomesoderm specification in sea urchin embryos is reviewed. The network was experimentally defined, and is presented as a predictive map of cis-regulatory inputs and functional regulatory gene interconnections (updated versions of the network and most of the under...

journal_title：Current opinion in genetics & development

authors： Oliveri P,Davidson EH

更新日期：2004-08-01 00:00:00

abstract：:Eukaryotic DNA replication is regulated at least in part by the assembly of initiation proteins onto origins of replication. The origin recognition complex (ORC) is bound to origins throughout most of the cell cycle. Other initiation proteins, such as Cdc6 and the MCM/P1 proteins, are assembled onto ORC-containing chr...

journal_title：Current opinion in genetics & development

authors： Rowles A,Blow JJ

更新日期：1997-04-01 00:00:00

abstract：:The induction of apoptosis of virus-infected cells is an important host defense mechanism against invading pathogens. Some viruses express anti-apoptotic proteins that efficiently block apoptosis induced by death receptors or in response to stress signaled through mitochondria. Viral interference with host cell apopto...

journal_title：Current opinion in genetics & development

authors： Tschopp J,Thome M,Hofmann K,Meinl E

更新日期：1998-02-01 00:00:00

abstract：:For many years, biologists' efforts in achieving gene targeting by homologous recombination in multicellular organisms have been hampered by the difficulty in culturing pluripotent stem cells. Recent advances have eliminated this requirement for several animal species. For large mammals, cloning by nuclear transfer ha...

journal_title：Current opinion in genetics & development

authors： Gong M,Rong YS

更新日期：2003-04-01 00:00:00

abstract：:Dorsoventral pattern of Drosophila embryo is specified by the nuclear localization gradient of the transcription factor Dorsal. Genetic and genomic studies of this morphogen gradient provided important insights into spatial control of gene expression in development. Recent live imaging experiments revealed hitherto un...

journal_title：Current opinion in genetics & development

authors： Rushlow CA,Shvartsman SY

更新日期：2012-12-01 00:00:00

abstract：:Cornelia de Lange Syndrome (CdLS) is a rare multiple malformation disorder with characteristic facial features, growth and cognitive retardation, and many other abnormalities. CdLS individuals were recently shown to have heterozygous mutations in a previously uncharacterised gene, NIPBL, which encodes delangin, a homo...

journal_title：Current opinion in genetics & development

authors： Strachan T

更新日期：2005-06-01 00:00:00

abstract：:Colonial ascidians are marine invertebrate chordates that are the closest invertebrate relative to the vertebrates. Colonies of Botryllus schlosseri undergo a continuous asexual reproduction process that involves the regeneration of entire new bodies, which include all somatic and germline tissues. This adult regenera...

journal_title：Current opinion in genetics & development

authors： Kassmer SH,Rodriguez D,De Tomaso AW

更新日期：2016-08-01 00:00:00

abstract：:Expansions of microsatellite DNA repeats contribute to the inheritance of nearly 30 developmental and neurological disorders. Significant progress has been made in elucidating the molecular mechanisms of repeat expansions using various model organisms and mammalian cell culture, and models implicating nearly all DNA t...

journal_title：Current opinion in genetics & development

authors： Kim JC,Mirkin SM

更新日期：2013-06-01 00:00:00

abstract：:Identification of new genes involved in muscle disorders has dramatically changed the traditional clinical classification of the large and heterogeneous group of the muscular dystrophies. Results obtained in recent years by positional candidate cloning have demonstrated the role of the sarcolemma and of the nuclear en...

journal_title：Current opinion in genetics & development

authors： Toniolo D,Minetti C

更新日期：1999-06-01 00:00:00

abstract：:The past year has been a spectacular one for Drosophila research. The sequencing and annotation of the Drosophila melanogaster genome has allowed a comprehensive analysis of the first three eukaryotes to be sequenced-yeast, worm and fly-including an analysis of the fly's influences as a model for the study of human di...

journal_title：Current opinion in genetics & development

authors： Celniker SE

更新日期：2000-12-01 00:00:00

abstract：:Molecular biological techniques have contributed greatly to the study of vertebrate ocular tissues. The specification of ocular tissues has been shown to be closely related to the expression of transcription factors encoded by genes such as Pax6 and microphthalmia. Lens-specific expression of the delta 1-crystallin ge...

journal_title：Current opinion in genetics & development

authors： Kodama R,Eguchi G

更新日期：1994-10-01 00:00:00

abstract：:Understanding the past is to understand the present. Mammalian life, with all its complexity comes from a humble beginning of a single fertilized egg cell. Achieving this requires an enormous diversification of cellular function, the majority of which is generated through a series of cellular decisions during embryoge...

journal_title：Current opinion in genetics & development

authors： Leung CY,Zernicka-Goetz M

更新日期：2015-10-01 00:00:00

abstract：:Imprinting occurs in the endosperm of flowering plants. Endosperm, produced by fertilization of the central cell in the female gametophyte, is essential for embryo and seed development. Several imprinted genes play an important role in endosperm development. The mechanism of gene imprinting involves DNA methylation an...

journal_title：Current opinion in genetics & development

authors： Huh JH,Bauer MJ,Hsieh TF,Fischer R

更新日期：2007-12-01 00:00:00

abstract：:Tissue differentiation and signal transduction involve dramatic changes in gene expression. These changes can be brought about by the expression or activation of sequence-specific transcription factors. In order to regulate their target genes, such factors must navigate the intricate chromatin environment and engage t...

journal_title：Current opinion in genetics & development

authors： Carrera I,Treisman JE

更新日期：2008-10-01 00:00:00

abstract：:Evolutionary studies suggest that the limbs of vertebrates and the appendages of arthropods do not share a common origin. However, recent genetic studies show new similarities in their developmental programmes. These similarities might be caused by the independent recruitment of homologous genes for similar functions ...

journal_title：Current opinion in genetics & development

authors： Pueyo JI,Couso JP

更新日期：2005-08-01 00:00:00

abstract：:The definitive endoderm (DE) was first defined as the innermost germ layer found in all metazoan embryos. During development, it gives rise to a vast array of specialized epithelial cell types lining the respiratory and digestive systems, and contributes to associated organs such as thyroid, thymus, lungs, liver, and ...

journal_title：Current opinion in genetics & development

authors： Kraus MR,Grapin-Botton A

更新日期：2012-08-01 00:00:00

abstract：:Significant advances in the field of hepatocyte-specific gene expression have been made during the past year. Several new transcription factors have been cloned and partially characterized. Analyses of the promoter regions of several factors have also been initiated and Drosophila homologs for two of these factors hav...

journal_title：Current opinion in genetics & development

authors： Sladek FM,Darnell JE

更新日期：1992-04-01 00:00:00

abstract：:Numerous roles have been identified for extracellular signals such as Fibroblast Growth Factors (FGFs), Transforming Growth Factor-βs (TGFβs), Wingless-Int proteins (WNTs), and Sonic Hedgehog (SHH) in assigning fates to cells during development of the cerebrum. However, several fundamental questions remain largely une...

journal_title：Current opinion in genetics & development

authors： Hébert JM

更新日期：2013-08-01 00:00:00