Gene regulation and differentiation in vertebrate ocular tissues.

abstract：:Combinatorial regulation of eukaryotic transcription is mediated by proteins that associate in a specific manner to form multiprotein DNA-bound complexes. Substantial progress has recently been made towards the understanding of the molecular determinants of the protein-protein and protein-DNA interactions that govern ...

journal_title：Current opinion in genetics & development

authors： Wolberger C

更新日期：1998-10-01 00:00:00

abstract：:Imprinting occurs in the endosperm of flowering plants. Endosperm, produced by fertilization of the central cell in the female gametophyte, is essential for embryo and seed development. Several imprinted genes play an important role in endosperm development. The mechanism of gene imprinting involves DNA methylation an...

journal_title：Current opinion in genetics & development

authors： Huh JH,Bauer MJ,Hsieh TF,Fischer R

更新日期：2007-12-01 00:00:00

abstract：:Tumor blood vessels have multiple structural and functional abnormalities. They are unusually dynamic, and naturally undergo sprouting, proliferation, remodeling or regression. The vessels are irregularly shaped, tortuous, and lack the normal hierarchical arrangement of arterioles, capillaries and venules. Endothelial...

journal_title：Current opinion in genetics & development

authors： Baluk P,Hashizume H,McDonald DM

更新日期：2005-02-01 00:00:00

abstract：:Cell proliferation is dependent upon the activation of receptor tyrosine kinases and integrins by soluble growth factors and extracellular matrix proteins, respectively. It is now apparent that concerted, rather than individual, signaling by these receptors is the critical feature responsible for cell-cycle progressio...

journal_title：Current opinion in genetics & development

authors： Assoian RK,Schwartz MA

更新日期：2001-02-01 00:00:00

abstract：:The Myc oncoprotein dimerizes with its partner, Max, to bind DNA, activate transcription, and promote cell proliferation, as well as programmed cell death. Max also forms homodimers or heterodimers with its alternative partners, Mad and Mxi-1. These complexes behave as antagonists of Myc/Max through competition for co...

journal_title：Current opinion in genetics & development

authors： Amati B,Land H

更新日期：1994-02-01 00:00:00

abstract：:Atherosclerosis is the major cause of cardiovascular disease. Hypercholesterolaemia, hypertension and cigarette smoking are the common risk factors for atherosclerosis. These risk factors unite behind a convergence of mechanism, involving oxidation and inflammation in the artery wall that, with time, gives rise to cha...

journal_title：Current opinion in genetics & development

authors： Scott J

更新日期：2004-06-01 00:00:00

abstract：:The combination of complete genome sequence information and estimates of mRNA abundances have begun to reveal causes of both silent and protein sequence evolution. Translational selection appears to explain patterns of synonymous codon usage in many prokaryotes as well as a number of eukaryotic model organisms (with t...

journal_title：Current opinion in genetics & development

authors： Akashi H

更新日期：2001-12-01 00:00:00

abstract：:Over the last decade we have witnessed the convergence of two powerful experimental designs toward a common goal of defining the molecular subtypes that underpin the likelihood of a cancer patient responding to treatment in the clinic. The first of these 'experiments' has been the systematic sequencing of large number...

journal_title：Current opinion in genetics & development

authors： Garnett MJ,McDermott U

更新日期：2014-02-01 00:00:00

abstract：:Significant advances in the field of hepatocyte-specific gene expression have been made during the past year. Several new transcription factors have been cloned and partially characterized. Analyses of the promoter regions of several factors have also been initiated and Drosophila homologs for two of these factors hav...

journal_title：Current opinion in genetics & development

authors： Sladek FM,Darnell JE

更新日期：1992-04-01 00:00:00

abstract：:During the past year, significant advances have been made in understanding the functions of the oncoproteins, E6 and E7, of human papillomaviruses that are associated with malignant genital tumors. In addition, important new information is now available on the responses of both the keratinocyte and of the individual f...

journal_title：Current opinion in genetics & development

authors： Gissmann L

更新日期：1992-02-01 00:00:00

abstract：:Radiotherapy is a form of cancer treatment that utilizes the ability of ionizing radiation to induce cell inactivation and cell death, generally via inflicting DNA double-strand breaks. However, different tumors and their normal surrounding tissues are not equally sensitive to radiation, posing a major challenge in th...

journal_title：Current opinion in genetics & development

authors： Metheetrairut C,Slack FJ

更新日期：2013-02-01 00:00:00

abstract：:Unexpected relationships among the various aminoacyl-tRNA synthetases continue to be uncovered. The question arises - is this mainly the result of promiscuous exchange, or is the confusion really a reflection of the differential loss of past duplications? Phylogenetic analysis may yet provide the answer. ...

journal_title：Current opinion in genetics & development

authors： Doolittle RF,Handy J

更新日期：1998-12-01 00:00:00

abstract：:Hepatocytes differentiate from the endoderm during embryonic development. Recent studies show, however, that hepatocytes can also be derived from rare cells that reside in the pancreas, bone marrow, and brain. Indeed, the latest discoveries indicate that embryonic hepatocytes normally arise by diversion of an endoderm...

journal_title：Current opinion in genetics & development

authors： Zaret KS

更新日期：2001-10-01 00:00:00

abstract：:Seed development starts at double fertilization when two sperms fuse with a female gamete, the egg and central cell, giving rise to the embryo and endosperm, respectively. Uniting two parental genomes into one, unique, zygotic genome is certainly the first event requiring large-scale chromatin modifications and remode...

journal_title：Current opinion in genetics & development

authors： Baroux C,Pien S,Grossniklaus U

更新日期：2007-12-01 00:00:00

abstract：:The gene regulatory networks that control sex determination vary between species. Despite these differences, comparative studies in insects have found that alternative splicing is reiteratively used in evolution to control expression of the key sex-determining genes. Sex determination is best understood in Drosophila ...

journal_title：Current opinion in genetics & development

authors： Salz HK

更新日期：2011-08-01 00:00:00

abstract：:Control of protein synthesis (mRNA translation) is essential for proper brain development and function. Perturbations to the mechanisms governing mRNA translation have repeatedly been shown to constitute a neurodegenerative, neuropsychiatric, and neurodevelopmental disorder risk factor. Developing effective therapeuti...

journal_title：Current opinion in genetics & development

authors： Wiebe S,Nagpal A,Sonenberg N

更新日期：2020-12-01 00:00:00

abstract：:Investigations on chromatin assembly in vitro implicate chromatin assembly factor 1 (CAF1) as a chaperone for histones H3/H4 and nucleosome assembly protein 1 (NAP1) as a chaperone for histones H2A/H2B. Deletion analysis of CAF1 in vivo suggests multiple redundant pathways for deposition of the histones. Histone depos...

journal_title：Current opinion in genetics & development

authors： Adams CR,Kamakaka RT

更新日期：1999-04-01 00:00:00

abstract：:The sequences of both of the human sex chromosomes and of a substantial part of the chimpanzee Y chromosome have now been determined, and most of the protein-coding genes have been identified. The X chromosome codes for more than 800 proteins but the Y chromosome for only approximately 60, illustrating their very diff...

journal_title：Current opinion in genetics & development

authors： Ross MT,Bentley DR,Tyler-Smith C

更新日期：2006-06-01 00:00:00

abstract：:Vertebrate eye formation is a multistep process requiring coordinated inductive interactions between neural and non-neural ectoderm and underlying mesendoderm. The induction and shaping of the eyes involves an elaborate cellular choreography characterized by precise changes in cell shape coupled with complex cellular ...

journal_title：Current opinion in genetics & development

authors： Bazin-Lopez N,Valdivia LE,Wilson SW,Gestri G

更新日期：2015-06-01 00:00:00

abstract：:Skeletal muscle cells have provided an especially auspicious system in which to dissect the roles of chromatin structure in the control of cell growth, differentiation, and development. The MyoD and MEF2 families of transcription factors act cooperatively to regulate the expression of skeletal muscle-specific genes. R...

journal_title：Current opinion in genetics & development

authors： McKinsey TA,Zhang CL,Olson EN

更新日期：2001-10-01 00:00:00

abstract：:As immunotherapies to treat malignancy continue to diversify along with the tumor types amenable to treatment, it will become very important to predict which treatment is most likely to benefit a given patient. Tumor neoantigens, novel peptides resulting from somatic tumor mutations and recognized by the immune system...

journal_title：Current opinion in genetics & development

authors： Snyder A,Chan TA

更新日期：2015-02-01 00:00:00

abstract：:Since the recognition of the uniqueness and coherence of the archaebacteria (sometimes called Archaea), our perception of their role in early evolution has been modified repeatedly. The deluge of sequence data and rapidly improving molecular systematic methods have combined with a better understanding of archaebacteri...

journal_title：Current opinion in genetics & development

authors： Keeling PJ,Charlebois RL,Doolittle WF

更新日期：1994-12-01 00:00:00

abstract：:Organismal fitness depends on adaptation to complex niches where chemical compounds and pathogens are omnipresent. These stresses can lead to the fixation of alleles in both xenobiotic responses and proliferative signaling pathways that promote survival in these niches. However, both xenobiotic responses and prolifera...

journal_title：Current opinion in genetics & development

authors： Zdraljevic S,Andersen EC

更新日期：2017-12-01 00:00:00

abstract：:Modelling human colon cancer has long been the ambition of researchers and oncologists with the aim to better replicate disease progression and treatment response. Advances in our understanding of genetics, stem cell biology, tumour microenvironment and immunology have prepared the groundwork for recent major advances...

journal_title：Current opinion in genetics & development

authors： Lannagan TR,Jackstadt R,Leedham SJ,Sansom OJ

更新日期：2021-01-07 00:00:00

abstract：:In eukaryotes, the genetic material is stored in the nucleus, which is enclosed in a double lipid bilayer, the nuclear envelope (NE). It protects the genome from physical stress and separates it from the rest of the cell. On top of this physical function, growing evidence shows that the nuclear periphery contributes t...

journal_title：Current opinion in genetics & development

authors： Meister P,Taddei A

更新日期：2013-04-01 00:00:00

abstract：:Human genetic studies have long been vastly Eurocentric, raising a key question about the generalizability of these study findings to other populations. Because humans originated in Africa, these populations retain more genetic diversity, and yet individuals of African descent have been tremendously underrepresented i...

journal_title：Current opinion in genetics & development

authors： Martin AR,Teferra S,Möller M,Hoal EG,Daly MJ

更新日期：2018-12-01 00:00:00

abstract：:All bovine chromosomes are now represented by a syntenic group, a linkage map and at least one in situ hybridization. Almost 1,000 loci are mapped, about 300 of which are coding sequences useful for comparative mapping and evolutionary inference. Economically important loci are beginning to appear on bovine linkage ma...

journal_title：Current opinion in genetics & development

authors： Womack JE,Kata SR

更新日期：1995-12-01 00:00:00

abstract：:Recent studies in invertebrates have provided important mechanistic insights into several general aspects of muscle development. Two new genes have been identified that are involved in muscle fusion in Drosophila and a novel maternal component was shown to be responsible for myogenic determination in an ascidian. In a...

journal_title：Current opinion in genetics & development

authors： Baylies MK,Michelson AM

更新日期：2001-08-01 00:00:00

abstract：:Population data suggest that many parasitic protozoa (e.g. Trypanosoma, Leishmania, Entamoeba and Giardia) reproduce clonally, but this hypothesis has been highly controversial for Plasmodium falciparum. Although reproduction is predominantly clonal in the enteric bacteria Escherichia coli and Salmonella, the level of...

journal_title：Current opinion in genetics & development

authors： Hartl DL

更新日期：1992-12-01 00:00:00

abstract：:The nuclear periphery has been implicated in gene regulation and it has been proposed that proximity to the nuclear lamina and inner nuclear membrane (INM) leads to gene repression. More recently, it appears that there is a correlation and interdependence between lamina associated domains (LADs), the epigenome and ove...

journal_title：Current opinion in genetics & development

authors： Luperchio TR,Wong X,Reddy KL

更新日期：2014-04-01 00:00:00