Endosperm gene imprinting and seed development.

abstract：:The nuclear periphery has been implicated in gene regulation and it has been proposed that proximity to the nuclear lamina and inner nuclear membrane (INM) leads to gene repression. More recently, it appears that there is a correlation and interdependence between lamina associated domains (LADs), the epigenome and ove...

journal_title：Current opinion in genetics & development

authors： Luperchio TR,Wong X,Reddy KL

更新日期：2014-04-01 00:00:00

abstract：:The pituitary gland functions as a relay between the hypothalamus and peripheral target organs that regulate basic physiological functions, including growth, the stress response, reproduction, metabolism and lactation. The development of the pituitary gland has been studied extensively in mice, and has begun to be exp...

journal_title：Current opinion in genetics & development

authors： Zhu X,Lin CR,Prefontaine GG,Tollkuhn J,Rosenfeld MG

更新日期：2005-06-01 00:00:00

abstract：:Plant genomes exhibit tremendous diversity in both their size and structure, with genome sizes across land plants ranging over two to three orders of magnitude and significant variation in structural organization was observed across species (EA Kellogg, JL Bennetzen, The evolution of nuclear genome structure in seed p...

journal_title：Current opinion in genetics & development

authors： Flowers JM,Purugganan MD

更新日期：2008-12-01 00:00:00

abstract：:The advent of single-cell sequencing has been revolutionary to the field of cancer genomics. Perfectly suited to capture cancer's heterogeneous nature, single-cell analyses provide information bulk sequencing could never hope to uncover. Many mechanisms of cancer have yet to be fully understood, and single-cell approa...

journal_title：Current opinion in genetics & development

authors： Tsoucas D,Yuan GC

更新日期：2017-02-01 00:00:00

abstract：:During embryogenesis, tissues and organs are progressively shaped into their functional morphologies. While the information about tissue and organ shape is encoded genetically, the sculpting of embryonic structures in the 3D space is ultimately a physical process. The control of physical quantities involved in tissue ...

journal_title：Current opinion in genetics & development

authors： Stooke-Vaughan GA,Campàs O

更新日期：2018-08-01 00:00:00

abstract：:Eukaryotic chromatin is a negatively charged long polymer composed of genomic DNA, histones, and various proteins. The charged property causes the chromatin structure to be dynamically changed. These dynamic changes are critical for genome functions such as gene expression because they directly govern the degree of DN...

journal_title：Current opinion in genetics & development

authors： Maeshima K,Ide S,Hibino K,Sasai M

更新日期：2016-04-01 00:00:00

abstract：:The vertebrate inner ear is a sensory organ of exquisite design and sensitivity. It responds to sound, gravity and movement, serving both auditory (hearing) and vestibular (balance) functions. Almost all cell types of the inner ear, including sensory hair cells, sensory neurons, secretory cells and supporting cells, d...

journal_title：Current opinion in genetics & development

authors： Whitfield TT

更新日期：2015-06-01 00:00:00

abstract：:The effort to map the entire human genome has led recently to the important milestone publication in late 1999 of the complete sequence of chromosome 22. This has been facilitated by increasingly sophisticated tools for genetic analysis and the ensuing wealth of detailed genetic information. The quest for genetic fact...

journal_title：Current opinion in genetics & development

authors： de Silva HR,Khan NL,Wood NW

更新日期：2000-06-01 00:00:00

abstract：:All the aspects of transcription are controlled by complexes that modify or remodel chromatin at the level of individual genes, gene clusters, or whole chromosomes. The MSL complex that is responsible for dosage compensation in Drosophila is an example of complexes that operate at the whole-chromosome level on the tra...

journal_title：Current opinion in genetics & development

authors： Lucchesi JC

更新日期：2009-12-01 00:00:00

abstract：:A newly-identified major histocompatibility Class I-like gene, HFE (originally HLA-H) located approximately 3.5 Mb telomeric to the Class I cluster on chromosome 6p 21.3 harbours mutations in haemochromatosis. Two of these, Cys282Tyr (C282Y) and His63Asp (H63D, a minor determinant) have diagnostic utility as approxima...

journal_title：Current opinion in genetics & development

authors： Cox TM,Kelly AL

更新日期：1998-06-01 00:00:00

abstract：:The relationships among in vivo chromatin structures, chromosome organization and genome function must be understood in order to reveal the hidden regulatory information in our genomes. Rather than being stable architectural features, it appears that chromatin and chromosome conformations at all levels are highly dyna...

journal_title：Current opinion in genetics & development

authors： Fraser P

更新日期：2006-10-01 00:00:00

abstract：:Methods to globally survey gene expression provide valuable insights into gene function during development. In particular, comprehensive in situ hybridization studies have demonstrated that gene expression patterns are extraordinarily diverse and new imaging techniques have been introduced to capture these patterns wi...

journal_title：Current opinion in genetics & development

authors： Lécuyer E,Tomancak P

更新日期：2008-12-01 00:00:00

abstract：:Human genetic studies have long been vastly Eurocentric, raising a key question about the generalizability of these study findings to other populations. Because humans originated in Africa, these populations retain more genetic diversity, and yet individuals of African descent have been tremendously underrepresented i...

journal_title：Current opinion in genetics & development

authors： Martin AR,Teferra S,Möller M,Hoal EG,Daly MJ

更新日期：2018-12-01 00:00:00

abstract：:During development and differentiation, early inductive processes that influence cell fate at a later stage leave marks at distinct gene loci that are maintained through several rounds of mitosis. The structure of chromatin is part of this epigenetic memory that restricts or permits differential expression of genes in...

journal_title：Current opinion in genetics & development

authors： Müller C,Leutz A

更新日期：2001-04-01 00:00:00

abstract：:Skeletal muscle cells have provided an especially auspicious system in which to dissect the roles of chromatin structure in the control of cell growth, differentiation, and development. The MyoD and MEF2 families of transcription factors act cooperatively to regulate the expression of skeletal muscle-specific genes. R...

journal_title：Current opinion in genetics & development

authors： McKinsey TA,Zhang CL,Olson EN

更新日期：2001-10-01 00:00:00

abstract：:Proliferating cells must increase their mass coordinately with cell division. Recent evidence suggests that coupling of cell growth with cell division might be achieved by making synthesis of activators of cell division particularly sensitive to the capacity of the cell's protein synthesis machinery. ...

journal_title：Current opinion in genetics & development

authors： Polymenis M,Schmidt EV

更新日期：1999-02-01 00:00:00

abstract：:Recent developments in technology have made it possible to create high resolution genome-wide maps of histone marks, DNA binding proteins and physical interactions along genomic regions. Chromatin features are found together in different combinations, dividing the genome up into domains with distinct functional proper...

journal_title：Current opinion in genetics & development

authors： de Graaf CA,van Steensel B

更新日期：2013-04-01 00:00:00

abstract：:The Prader-Willi and Angelman syndromes are now well established as the paradigm of genomic imprinting in human disease. Over the past year, much has been learnt about the mechanisms by which these syndromes arise and molecular diagnostics for the majority of patients are now available. Mouse models for aspects of the...

journal_title：Current opinion in genetics & development

authors： Nicholls RD

更新日期：1993-06-01 00:00:00

abstract：:The conserved homeobox (Hox) gene cluster is neither conserved nor clustered in the nematode Caenorhabditis elegans. Instead, C. elegans has a reduced and dispersed gene complement that is the result the loss of Hox genes in stages throughout its evolutionary history. The roles of Hox genes in patterning the nematode ...

journal_title：Current opinion in genetics & development

authors： Aboobaker A,Blaxter M

更新日期：2003-12-01 00:00:00

abstract：:Vertebrate eye formation is a multistep process requiring coordinated inductive interactions between neural and non-neural ectoderm and underlying mesendoderm. The induction and shaping of the eyes involves an elaborate cellular choreography characterized by precise changes in cell shape coupled with complex cellular ...

journal_title：Current opinion in genetics & development

authors： Bazin-Lopez N,Valdivia LE,Wilson SW,Gestri G

更新日期：2015-06-01 00:00:00

abstract：:Studies of primate lentivirus phylogeny over the past decade have established a minimum of five related, but genetically distinct, groups of simian immunodeficiency virus (SIV), each originating from a different African primate species. The hypothesis that HIV-2 (and SIVmac) arose by cross-species transmission from so...

journal_title：Current opinion in genetics & development

authors： Hirsch VM,Dapolito G,Goeken R,Campbell BJ

更新日期：1995-12-01 00:00:00

abstract：:Tissue differentiation and signal transduction involve dramatic changes in gene expression. These changes can be brought about by the expression or activation of sequence-specific transcription factors. In order to regulate their target genes, such factors must navigate the intricate chromatin environment and engage t...

journal_title：Current opinion in genetics & development

authors： Carrera I,Treisman JE

更新日期：2008-10-01 00:00:00

abstract：:Natural selection drives evolving populations up the fitness landscape, the projection from nucleotide sequence space to organismal reproductive success. While it has long been appreciated that topographic complexities on fitness landscapes can arise only as a consequence of epistatic interactions between mutations, e...

journal_title：Current opinion in genetics & development

authors： Weinreich DM,Lan Y,Wylie CS,Heckendorn RB

更新日期：2013-12-01 00:00:00

abstract：:Mitochondria are highly abundant in and essential to the beat-to-beat contractile performance of hearts. However, relatively few cardiac diseases have been attributed to primary mitochondrial dysfunction. The paucity of evidence for 'primary mitochondrial cardiac diseases' may be because such an entity does not exist....

journal_title：Current opinion in genetics & development

authors： Dorn G II

更新日期：2016-06-01 00:00:00

abstract：:Identification of new genes involved in muscle disorders has dramatically changed the traditional clinical classification of the large and heterogeneous group of the muscular dystrophies. Results obtained in recent years by positional candidate cloning have demonstrated the role of the sarcolemma and of the nuclear en...

journal_title：Current opinion in genetics & development

authors： Toniolo D,Minetti C

更新日期：1999-06-01 00:00:00

abstract：:Molecular biological techniques have contributed greatly to the study of vertebrate ocular tissues. The specification of ocular tissues has been shown to be closely related to the expression of transcription factors encoded by genes such as Pax6 and microphthalmia. Lens-specific expression of the delta 1-crystallin ge...

journal_title：Current opinion in genetics & development

authors： Kodama R,Eguchi G

更新日期：1994-10-01 00:00:00

abstract：:Non-human primates (NHPs) have been proposed as good models for neurodevelopmental disorders due to close similarities to humans in terms of brain structure and cognitive function. The recent development of genome editing technologies has opened new avenues to generate and investigate genetically modified NHPs as mode...

journal_title：Current opinion in genetics & development

authors： Aida T,Feng G

更新日期：2020-12-01 00:00:00

abstract：:The regulation of transcription elongation within the context of chromatin is a topic of great interest. Even though chromatin presents a barrier to transcription by the PolII machinery in vitro, this process is rather efficient in vivo. Importantly, the chromatin structure of the actively transcribed genes is altered...

journal_title：Current opinion in genetics & development

authors： Belotserkovskaya R,Reinberg D

更新日期：2004-04-01 00:00:00

abstract：:Flowers are central to sexual reproduction in plants. The study of floral development proved tremendously successful in obtaining key insight into processes, such as fate determination, pattern formation, and growth regulation. Recent advances relate to the complex mechanisms underlying the crosstalk between phytohorm...

journal_title：Current opinion in genetics & development

authors： Vaddepalli P,Scholz S,Schneitz K

更新日期：2015-06-01 00:00:00

abstract：:Our understanding of the mechanism of action of retinoids has been greatly expanded by a series of recent findings. First, the three-dimensional structure of the ligand-binding domain of two retinoid receptors has been solved and suggests that ligand binding induces marked allosteric changes. Second, several co-factor...

journal_title：Current opinion in genetics & development

authors： Minucci S,Ozato K

更新日期：1996-10-01 00:00:00