Abstract：
:Natural selection drives evolving populations up the fitness landscape, the projection from nucleotide sequence space to organismal reproductive success. While it has long been appreciated that topographic complexities on fitness landscapes can arise only as a consequence of epistatic interactions between mutations, evolutionary genetics has mainly focused on epistasis between pairs of mutations. Here we propose a generalization to the classical population genetic treatment of pairwise epistasis that yields expressions for epistasis among arbitrary subsets of mutations of all orders (pairwise, three-way, etc.). Our approach reveals substantial higher-order epistasis in almost every published fitness landscape. Furthermore we demonstrate that higher-order epistasis is critically important in two systems we know best. We conclude that higher-order epistasis deserves empirical and theoretical attention from evolutionary geneticists.
journal_name
Curr Opin Genet Devjournal_title
Current opinion in genetics & developmentauthors
Weinreich DM,Lan Y,Wylie CS,Heckendorn RBdoi
10.1016/j.gde.2013.10.007subject
Has Abstractpub_date
2013-12-01 00:00:00pages
700-7issue
6eissn
0959-437Xissn
1879-0380pii
S0959-437X(13)00142-1journal_volume
23pub_type
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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