abstract：:The past decade has seen a huge jump in the resolution and scale at which we can interrogate the three-dimensional properties of the genome. This revealed different types of chromatin structures including topologically associating domains, partitioning genes and their enhancers into interacting domains. While the visu...

journal_title：Current opinion in genetics & development

authors： Cavalheiro GR,Pollex T,Furlong EE

更新日期：2021-01-23 00:00:00

abstract：:Modelling human colon cancer has long been the ambition of researchers and oncologists with the aim to better replicate disease progression and treatment response. Advances in our understanding of genetics, stem cell biology, tumour microenvironment and immunology have prepared the groundwork for recent major advances...

journal_title：Current opinion in genetics & development

authors： Lannagan TR,Jackstadt R,Leedham SJ,Sansom OJ

更新日期：2021-01-07 00:00:00

abstract：:Allele-specific gene expression can influence disease traits. Non-coding germline genetic variants that alter regulatory elements can cause allele-specific gene expression and contribute to cancer susceptibility. In tumors, both somatic copy number alterations and somatic single nucleotide variants have been shown to ...

journal_title：Current opinion in genetics & development

authors： Robles-Espinoza CD,Mohammadi P,Bonilla X,Gutierrez-Arcelus M

更新日期：2020-12-28 00:00:00

abstract：:Thousands of genes produce polyadenylated mRNAs that still contain one or more introns. These transcripts are known as retained intron RNAs (RI-RNAs). In the past 10 years, RI-RNAs have been linked to post-transcriptional alternative splicing in a variety of developmental contexts, but they can also be dead-end produc...

journal_title：Current opinion in genetics & development

authors： Gordon JM,Phizicky DV,Neugebauer KM

更新日期：2020-12-05 00:00:00

abstract：:Control of protein synthesis (mRNA translation) is essential for proper brain development and function. Perturbations to the mechanisms governing mRNA translation have repeatedly been shown to constitute a neurodegenerative, neuropsychiatric, and neurodevelopmental disorder risk factor. Developing effective therapeuti...

journal_title：Current opinion in genetics & development

authors： Wiebe S,Nagpal A,Sonenberg N

更新日期：2020-12-01 00:00:00

abstract：:In the past ten years, there has been increasing recognition that cells can acquire genetic variants during cortical development that can give rise to brain malformations as well as nonlesional focal epilepsy. These often brain tissue-specific, de novo variants can result in highly variable phenotypes based on the bur...

journal_title：Current opinion in genetics & development

authors： Heinzen EL

更新日期：2020-12-01 00:00:00

abstract：:Molecules and cellular processes important for nervous system development can be repurposed in adulthood for the regulation of adult neurogenesis, synaptic plasticity, and neural regeneration following injury or degeneration. Efforts to recapitulate neural development in order to ameliorate injury or disease are promi...

journal_title：Current opinion in genetics & development

authors： Hunyara JL,Kolodkin AL

更新日期：2020-12-01 00:00:00

abstract：:Non-human primates (NHPs) have been proposed as good models for neurodevelopmental disorders due to close similarities to humans in terms of brain structure and cognitive function. The recent development of genome editing technologies has opened new avenues to generate and investigate genetically modified NHPs as mode...

journal_title：Current opinion in genetics & development

authors： Aida T,Feng G

更新日期：2020-12-01 00:00:00

abstract：:In this review we discuss the importance of genetic somatic mosaicism and its impact on brain diseases. We start from introducing the different types of somatic mutations, their frequencies and abundances across development and lifespan. We then describe how weakness in DNA repair mechanisms influences their prevalenc...

journal_title：Current opinion in genetics & development

authors： Jourdon A,Fasching L,Scuderi S,Abyzov A,Vaccarino FM

更新日期：2020-12-01 00:00:00

abstract：:The mammalian globin gene clusters provide a paradigm for studying the relationship between genome structure and function. As blood stem cells undergo lineage specification and differentiation to form red blood cells, the chromatin structure and expression of the α-globin cluster change. The gradual activation of the ...

journal_title：Current opinion in genetics & development

authors： Oudelaar AM,Beagrie RA,Kassouf MT,Higgs DR

更新日期：2020-11-19 00:00:00

abstract：:After fertilization, mouse embryos go through preimplantation development to give rise to blastocyst. Two key molecular events, zygotic genome activation (ZGA) and the first cell lineage specification, are essential for the process. Recent advances in low-input epigenomics profiling techniques allow the analysis of th...

journal_title：Current opinion in genetics & development

authors： Fu X,Zhang C,Zhang Y

更新日期：2020-10-01 00:00:00

abstract：:Induction of pluripotency in somatic cells via ectopic expression of defined factors demonstrates the reversibility of developmental programming, thus serves as an ideal model to investigate the underlying principles of cell fate determination, which drives the differentiation of various cell types from an identical g...

journal_title：Current opinion in genetics & development

authors： Chen J

更新日期：2020-10-01 00:00:00

abstract：:Folding is an important way by which epithelia are sculpted into three-dimensional shapes during development. Recent studies have integrated quantitative image analysis and physical modeling to uncover contributing mechanisms. It is becoming clear that folding processes often employ multiple mechanisms of force genera...

journal_title：Current opinion in genetics & development

authors： Denk-Lobnig M,Martin AC

更新日期：2020-08-01 00:00:00

abstract：:Eukaryotic genomes encode genetic information in their linear sequence, but appropriate expression of their genes requires chromosomes to fold into complex three-dimensional structures. Fueled by a growing collection of sequencing and imaging-based technologies, studies have uncovered a hierarchy of DNA interactions, ...

journal_title：Current opinion in genetics & development

authors： Luppino JM,Joyce EF

更新日期：2020-04-01 00:00:00

abstract：:Subtelomeres are the regions at chromosome ends, immediately adjacent to the terminal telomeric repeats. The majority of human subtelomeres are CpG-rich in their distal two kilobases, and are methylated during early embryonic development by the de novo DNA methyltransferase DNMT3B. The biological relevance of subtelom...

journal_title：Current opinion in genetics & development

authors： Toubiana S,Selig S

更新日期：2020-02-01 00:00:00

abstract：:Telomerase regulation and telomere shortening act as a strong tumor suppressor mechanism in human somatic cells. Point mutations in the promoter of telomerase reverse transcriptase (TERT) are the most frequent non-coding mutation in cancer. These TERT promoter mutations (TPMs) create de novo ETS factor binding sites u...

journal_title：Current opinion in genetics & development

authors： Lorbeer FK,Hockemeyer D

更新日期：2020-02-01 00:00:00

abstract：:Cancer remains one of the leading causes of death in the developed world and despite impressive advances in therapeutic modalities, only a small subset of patients are currently cured. The underlying genetic heterogeneity of cancers clearly plays a crucial role in determining both the clinical course of individual pat...

journal_title：Current opinion in genetics & development

authors： Pepper C,Norris K,Fegan C

更新日期：2020-02-01 00:00:00

abstract：:The discovery that rare POT1 variants are associated with extremely long telomeres and increased cancer predisposition has provided a framework to revisit the relationship between telomere length and cancer development. Telomere shortening is linked with increased risk for cancer. However, over the past decade, there ...

journal_title：Current opinion in genetics & development

authors： Gong Y,Stock AJ,Liu Y

更新日期：2020-02-01 00:00:00

abstract：:Genetic conflicts arise when the evolutionary interests of two genetic elements are not aligned. Conflicts between genomes (e.g. pathogen versus host) or within the same genome (e.g. internal parasitic DNA sequences versus the rest of the host genome) can both foster 'molecular arms races', in which genes on both side...

journal_title：Current opinion in genetics & development

authors： Daugherty MD,Zanders SE

更新日期：2019-10-01 00:00:00

abstract：:During development, embryos perform a mesmerizing choreography, which is crucial for the correct shaping, positioning and function of all organs. The cellular properties powering animal morphogenesis have been the focus of much attention. In contrast, much less consideration has been given to the invisible engine cons...

journal_title：Current opinion in genetics & development

authors： Schliffka MF,Maître JL

更新日期：2019-08-01 00:00:00

abstract：:Cardiovascular morphogenesis involves cell behavior and cell identity changes that are activated by mechanical forces associated with heart function. Recently, advances in in vivo imaging, methods to alter blood flow, and computational modelling have greatly advanced our understanding of how forces produced by heart c...

journal_title：Current opinion in genetics & development

authors： Duchemin AL,Vignes H,Vermot J,Chow R

更新日期：2019-08-01 00:00:00

abstract：:Acquired resistance is a major limitation for the successful treatment of cancer patients. Although numerous efficacious cancer therapeutics have been developed in the past decades, resistance arises due to a variety of reasons including tumoral genetic alterations, or modulation of factors in the tumor environment. U...

journal_title：Current opinion in genetics & development

authors： Prahallad A,Jensen MR,Chapeau EA

更新日期：2019-02-01 00:00:00

abstract：:Human genetic studies have long been vastly Eurocentric, raising a key question about the generalizability of these study findings to other populations. Because humans originated in Africa, these populations retain more genetic diversity, and yet individuals of African descent have been tremendously underrepresented i...

journal_title：Current opinion in genetics & development

authors： Martin AR,Teferra S,Möller M,Hoal EG,Daly MJ

更新日期：2018-12-01 00:00:00

abstract：:The genomic variability of Southern African groups is characterized by an exceptional degree of diversity, which is the result of long-term local evolutionary history, migrations and gene-flow. Over the last few years several investigations have identified and described signatures related to these processes, revealing...

journal_title：Current opinion in genetics & development

authors： Montinaro F,Capelli C

更新日期：2018-12-01 00:00:00

abstract：:The increasing availability of large-scale autosomal genetic variation data sampled from world-wide geographic areas, coupled with advances in the statistical methodology to analyse these data, is showcasing the power of DNA as a major tool to gain insights into the demographic history of humans and other organisms. H...

journal_title：Current opinion in genetics & development

authors： Wangkumhang P,Hellenthal G

更新日期：2018-12-01 00:00:00

abstract：:The discovery of induced pluripotent stem cells (iPSCs) has solidified the concept of transcription factors as major players in controlling cell identity and provided a tractable tool to study how somatic cell identity can be dismantled and pluripotency established. A number of landmark studies have established hallma...

journal_title：Current opinion in genetics & development

authors： Apostolou E,Stadtfeld M

更新日期：2018-10-01 00:00:00

abstract：:Understanding the genetic underpinning of early human development is of great interest not only for basic developmental and stem cell biology but also for regenerative medicine, infertility treatments, and better understanding the causes of congenital disease. Our current knowledge has mainly been generated with the u...

journal_title：Current opinion in genetics & development

authors： Ortega NM,Winblad N,Plaza Reyes A,Lanner F

更新日期：2018-10-01 00:00:00

abstract：:Genome editing with engineered nucleases (zinc finger, TAL effector, or CRISPR/Cas9-based) enables `write' access to regulatory programs executed by primary human cells. A decade of its clinical development, along with a reduction of conventional gene therapy to medical and commercial practice, has made cell reprogram...

journal_title：Current opinion in genetics & development

authors： Urnov FD

更新日期：2018-10-01 00:00:00

abstract：:The ability to reprogram cell lineage specification through the activity of master regulatory transcription factors has transformed disease modeling, drug screening, and cell therapy for regenerative medicine. Recent advances in the engineering of synthetic transcription factors to modulate endogenous gene expression ...

journal_title：Current opinion in genetics & development

authors： Black JB,Gersbach CA

更新日期：2018-10-01 00:00:00

abstract：:Cellular fate reprogramming holds great promise to generate functional cell types for replenishing new cells and restoring functional loss. Inspired by transcription factor-induced reprogramming, the field of cellular reprogramming has greatly advanced and developed into divergent streams of reprogramming approaches. ...

journal_title：Current opinion in genetics & development

authors： Li X,Xu J,Deng H

更新日期：2018-10-01 00:00:00

abstract：:During embryogenesis, tissues and organs are progressively shaped into their functional morphologies. While the information about tissue and organ shape is encoded genetically, the sculpting of embryonic structures in the 3D space is ultimately a physical process. The control of physical quantities involved in tissue ...

journal_title：Current opinion in genetics & development

authors： Stooke-Vaughan GA,Campàs O

更新日期：2018-08-01 00:00:00

abstract：:To control changes in shape during development, the molecular regulatory networks have to interact with the mechanical, structural components of the individual cells, in particular the cytoskeleton and the cell wall. A widely accepted hypothesis proposes that molecular regulation interferes with wall synthesis and sti...

journal_title：Current opinion in genetics & development

authors： Zhao F,Chen W,Traas J

更新日期：2018-08-01 00:00:00

abstract：:Our understanding of how roots develop in soil may be at the eve of significant transformations. The formidable expansion of imaging technologies enables live observations of the rhizosphere micro-pore architecture at unprecedented resolution. Granular matter physics provides ways to understand the microscopic fluctua...

journal_title：Current opinion in genetics & development

authors： Dupuy LX,Mimault M,Patko D,Ladmiral V,Ameduri B,MacDonald MP,Ptashnyk M

更新日期：2018-08-01 00:00:00

abstract：:Type 1 diabetes is the most common autoimmune disorder in childhood, characterized by the development of autoimmunity through unknown environmental insults in genetically susceptible individuals. There are now over 50 regions of the genome that harbor type 1 diabetes susceptibility genes, with much of the genetic risk...

journal_title：Current opinion in genetics & development

authors： Robertson CC,Rich SS

更新日期：2018-06-01 00:00:00

abstract：:The processes by which the canonical protein synthesis machinery is modified by environmental stresses to allow healthy cells to respond to external conditions to maintain homeostasis, are frequently hijacked by tumour cells to enhance their survival. Two major stress response pathways that play a major role in this r...

journal_title：Current opinion in genetics & development

authors： Harvey RF,Willis AE

更新日期：2018-02-01 00:00:00

abstract：:Organismal fitness depends on adaptation to complex niches where chemical compounds and pathogens are omnipresent. These stresses can lead to the fixation of alleles in both xenobiotic responses and proliferative signaling pathways that promote survival in these niches. However, both xenobiotic responses and prolifera...

journal_title：Current opinion in genetics & development

authors： Zdraljevic S,Andersen EC

更新日期：2017-12-01 00:00:00

abstract：:Genome-wide data on genetic variation are now available for multiple primate species and populations, facilitating analyses of evolutionary history within and across taxa. One emerging theme from these studies involves the central role of admixture. Genomic data sets indicate that both ancient gene flow following init...

journal_title：Current opinion in genetics & development

authors： Tung J,Barreiro LB

更新日期：2017-12-01 00:00:00

abstract：:Most of the knowledge we have on the molecular mechanisms of transcription factor mediated reprogramming comes from studies conducted in induced pluripotency. Recently however, a few studies investigated the mechanisms of cellular reprogramming in direct and indirect transdifferentiation, which allows us to explore wh...

journal_title：Current opinion in genetics & development

authors： Firas J,Polo JM

更新日期：2017-10-01 00:00:00

abstract：:Human pluripotent stem cells derived from embryos (human Embryonic Stem Cells or hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell type...

journal_title：Current opinion in genetics & development

authors： Ortmann D,Vallier L

更新日期：2017-10-01 00:00:00

abstract：:Embryonic development is key for determining the architecture and shape of multicellular bodies. However, most cells are produced postembryonically in, at least partly, differentiated organs. In this regard, organismal growth faces common challenges in coordinating expansion and function of body structures. Here we co...

journal_title：Current opinion in genetics & development

authors： Shi D,Tavhelidse T,Thumberger T,Wittbrodt J,Greb T

更新日期：2017-08-01 00:00:00