Chromatin remodeling in development and differentiation.

abstract：:Embryonic development is key for determining the architecture and shape of multicellular bodies. However, most cells are produced postembryonically in, at least partly, differentiated organs. In this regard, organismal growth faces common challenges in coordinating expansion and function of body structures. Here we co...

journal_title：Current opinion in genetics & development

authors： Shi D,Tavhelidse T,Thumberger T,Wittbrodt J,Greb T

更新日期：2017-08-01 00:00:00

abstract：:The advent of gene targeting in the mouse has led to rapid advances in the identification of factors controlling gene expression that are essential for normal hematopoietic development. Recent work has also uncovered roles for some of these factors in leukemogenesis and in the global regulation of chromatin structure....

journal_title：Current opinion in genetics & development

authors： Engel I,Murre C

更新日期：1999-10-01 00:00:00

abstract：:TGFβ acts as a potent tumor suppressor and tumor promoter in a context dependent manner. Tumor suppressive functions include inhibition of cell proliferation, induction of apoptosis and regulation of autophagy. As tumors develop they switch their response to TGFβ and utilise this factor as a potent promoter of cell mo...

journal_title：Current opinion in genetics & development

authors： Inman GJ

更新日期：2011-02-01 00:00:00

abstract：:Covalent modifications of histone proteins play key roles in transcription, DNA repair, recombination, and other such processes. Over a hundred histone modifications have been described, and a popular idea in the field is that the function of a single histone mark cannot be understood without understanding its combina...

journal_title：Current opinion in genetics & development

authors： Rando OJ

更新日期：2012-04-01 00:00:00

abstract：:Gibberellins (GAs) affect several growth and developmental responses during the plant life cycle. Components essential for GA perception and GA signaling have been identified in rice and Arabidopsis and are conserved among vascular plants but not in Physcomitrella patens. The recent observation that DELLAs bind in nuc...

journal_title：Current opinion in genetics & development

authors： Davière JM,de Lucas M,Prat S

更新日期：2008-08-01 00:00:00

abstract：:Epidemiologic studies of twins indicate that 20-40% of common tumors such as breast, colorectal, and prostate cancers are inherited. However, the effect of high penetrance tumor susceptibility genes such as APC, BRCA1, BRAC2, MSH1, MLH2 and MSH6 only accounts for a small fraction of these cancers. Low to moderate pene...

journal_title：Current opinion in genetics & development

authors： Pasche B,Yi N

更新日期：2010-06-01 00:00:00

abstract：:The nuclear periphery has been implicated in gene regulation and it has been proposed that proximity to the nuclear lamina and inner nuclear membrane (INM) leads to gene repression. More recently, it appears that there is a correlation and interdependence between lamina associated domains (LADs), the epigenome and ove...

journal_title：Current opinion in genetics & development

authors： Luperchio TR,Wong X,Reddy KL

更新日期：2014-04-01 00:00:00

abstract：:Following neurulation, neural crest cells emerge from the neural tube and undergo extensive migrations. At the onset of migration, multipotent stem cells exist within the neural crest population. Eventually, these assume one of a number of possible fates, ranging from neurons and glia of the peripheral nervous system ...

journal_title：Current opinion in genetics & development

authors： Bronner-Fraser M

更新日期：1993-08-01 00:00:00

abstract：:Eukaryotic DNA replication is regulated at least in part by the assembly of initiation proteins onto origins of replication. The origin recognition complex (ORC) is bound to origins throughout most of the cell cycle. Other initiation proteins, such as Cdc6 and the MCM/P1 proteins, are assembled onto ORC-containing chr...

journal_title：Current opinion in genetics & development

authors： Rowles A,Blow JJ

更新日期：1997-04-01 00:00:00

abstract：:For many years, biologists' efforts in achieving gene targeting by homologous recombination in multicellular organisms have been hampered by the difficulty in culturing pluripotent stem cells. Recent advances have eliminated this requirement for several animal species. For large mammals, cloning by nuclear transfer ha...

journal_title：Current opinion in genetics & development

authors： Gong M,Rong YS

更新日期：2003-04-01 00:00:00

abstract：:The increasing availability of large-scale autosomal genetic variation data sampled from world-wide geographic areas, coupled with advances in the statistical methodology to analyse these data, is showcasing the power of DNA as a major tool to gain insights into the demographic history of humans and other organisms. H...

journal_title：Current opinion in genetics & development

authors： Wangkumhang P,Hellenthal G

更新日期：2018-12-01 00:00:00

abstract：:Pluripotency-associated transcription factors possess a pivotal role to maintain pluripotency in pluripotent stem cells as well as to induce pluripotency in somatic cells. They direct specific pattern of gene expression from the genome by co-operating with the genetic and epigenetic mechanisms. Recent findings reveale...

journal_title：Current opinion in genetics & development

authors： Niwa H

更新日期：2014-10-01 00:00:00

abstract：:Eukaryotic organisms have the remarkable ability to inherit states of gene activity without altering the underlying DNA sequence. This epigenetic inheritance can persist over thousands of years, providing an alternative to genetic mutations as a substrate for natural selection. Epigenetic inheritance might be propagat...

journal_title：Current opinion in genetics & development

authors： Zilberman D,Henikoff S

更新日期：2005-10-01 00:00:00

abstract：:To control changes in shape during development, the molecular regulatory networks have to interact with the mechanical, structural components of the individual cells, in particular the cytoskeleton and the cell wall. A widely accepted hypothesis proposes that molecular regulation interferes with wall synthesis and sti...

journal_title：Current opinion in genetics & development

authors： Zhao F,Chen W,Traas J

更新日期：2018-08-01 00:00:00

abstract：:The combination of complete genome sequence information and estimates of mRNA abundances have begun to reveal causes of both silent and protein sequence evolution. Translational selection appears to explain patterns of synonymous codon usage in many prokaryotes as well as a number of eukaryotic model organisms (with t...

journal_title：Current opinion in genetics & development

authors： Akashi H

更新日期：2001-12-01 00:00:00

abstract：:Retrotransposons are mutagenic units able to move within the genome. Despite many defenses deployed by the host to suppress potentially harmful activities of retrotransposons, these genetic units have found ways to meld with normal cellular functions through processes of exaptation and domestication. The same host mec...

journal_title：Current opinion in genetics & development

authors： Mita P,Boeke JD

更新日期：2016-04-01 00:00:00

abstract：:Recent research has broadened significantly our understanding of how the somite, a specialized mesodermal structure found in vertebrate embryos, gives rise to the cartilage, muscle and tendon cell lineages. The specification of somite derivatives involves the action of patterning signals secreted from adjacent tissue ...

journal_title：Current opinion in genetics & development

authors： Brent AE,Tabin CJ

更新日期：2002-10-01 00:00:00

abstract：:Multicellularity has evolved multiple times independently from a variety of ancestral unicellular lineages. Past research on multicellularity was focused more on explaining why it was repeatedly invented and less so on the molecular foundations associated with each transition. Several recent comparative functional ana...

journal_title：Current opinion in genetics & development

authors： Rokas A

更新日期：2008-12-01 00:00:00

abstract：:The ciliated protozoa undergo an extensive genome reorganization during the course of forming a transcriptionally active macronucleus. The process includes numerous chromosome fragmentation and DNA breakage and rejoining events. Recent work indicates that transposable elements play a role in the process. ...

journal_title：Current opinion in genetics & development

authors： Klobutcher LA,Jahn CL

更新日期：1991-10-01 00:00:00

abstract：:In 2003, a p53-expressing adenovirus was approved as a cancer therapy drug in China. Consequently, there has been a surge in the need to understand the regulation of wild type p53 function in vivo. The majority of the progress made during the past two years has focused on the cellular factors and post-translational mo...

journal_title：Current opinion in genetics & development

authors： Lu X

更新日期：2005-02-01 00:00:00

abstract：:The pattern of expression of homeodomain proteins often exceeds their apparent domain of activity. Tissue-specific proteins that modulate the in vivo activity of homeodomain proteins have been proposed to account for this functional restriction. The first identified example of such an accessory protein is DCoH, which ...

journal_title：Current opinion in genetics & development

authors： Hansen LP,Crabtree GR

更新日期：1993-04-01 00:00:00

abstract：:Recent studies have supported the hypothesis that the high heritability of schizophrenia reflects a combination of relatively common alleles of small effect and some rare alleles with relatively large effects. Genome-wide association studies have identified at least one common allele of small effect at ZNF804a, which ...

journal_title：Current opinion in genetics & development

authors： Owen MJ,Williams HJ,O'Donovan MC

更新日期：2009-06-01 00:00:00

abstract：:The cloning of large DNAs as yeast artificial chromosomes (YACs) holds the promise of greatly expanding the scope of physical genomic mapping. Recent improvements in YAC clone libraries and their screening, as well as in the analysis of YAC-cloned DNA, are beginning to fulfill the potential of this system. ...

journal_title：Current opinion in genetics & development

authors： Burke DT

更新日期：1991-06-01 00:00:00

abstract：:In their development, plants precisely control the patterns of cell size, cell shape and cell division, the position of differentiation of cell types, and the position and number of organs. In the past year, progress has been made in understanding four of these five levels of control of plant pattern formation, includ...

journal_title：Current opinion in genetics & development

authors： Meyerowitz EM

更新日期：1994-08-01 00:00:00

abstract：:The specification of cell fate is integral to embryonic development. Recent research has identified several molecules that are involved in the development of the embryonic vasculature. Their combined actions are required for the specification and development of the arteries, veins and lymphatic vessels; vascular netwo...

journal_title：Current opinion in genetics & development

authors： Harvey NL,Oliver G

更新日期：2004-10-01 00:00:00

abstract：:The past year has been a spectacular one for Drosophila research. The sequencing and annotation of the Drosophila melanogaster genome has allowed a comprehensive analysis of the first three eukaryotes to be sequenced-yeast, worm and fly-including an analysis of the fly's influences as a model for the study of human di...

journal_title：Current opinion in genetics & development

authors： Celniker SE

更新日期：2000-12-01 00:00:00

abstract：:Logical models provide insight about key control elements of biological networks. Based solely on the logical structure, we can determine state transition diagrams that give the allowed possible transitions in a coarse grained phase space. Attracting pathways and stable nodes in the state transition diagram correspond...

journal_title：Current opinion in genetics & development

authors： Glass L,Siegelmann HT

更新日期：2010-12-01 00:00:00

abstract：:Our understanding of the mechanism of action of retinoids has been greatly expanded by a series of recent findings. First, the three-dimensional structure of the ligand-binding domain of two retinoid receptors has been solved and suggests that ligand binding induces marked allosteric changes. Second, several co-factor...

journal_title：Current opinion in genetics & development

authors： Minucci S,Ozato K

更新日期：1996-10-01 00:00:00

abstract：:The detection of sequence variation with restriction fragment length polymorphisms is advancing our knowledge of plant genetics on several fronts. In the past year, there has been progress in genetic map construction, phylogeny studies, and the dissection of multigenic traits. In addition, new methods that are indepen...

journal_title：Current opinion in genetics & development

authors： Chang C,Meyerowitz EM

更新日期：1991-06-01 00:00:00

abstract：:The Caenorhabditis elegans hermaphrodite vulva is one of the best studied models for signal transduction and cell fate determination during organogenesis. Systematic forward genetic screens have identified a complex and highly interconnected signaling network formed by the conserved EGFR, NOTCH, and WNT signaling path...

journal_title：Current opinion in genetics & development

authors： Schmid T,Hajnal A

更新日期：2015-06-01 00:00:00