Transcription factors in hematopoiesis.

abstract：:Autoimmunity is a complex disease process that results from a breakdown in the ability of the immune system to discriminate self from non-self. One approach to unraveling how autoimmunity occurs is to study monogenic diseases, for which a single gene defect is responsible. Recent work on the monogenic autoimmune disea...

journal_title：Current opinion in genetics & development

authors： DeVoss JJ,Anderson MS

更新日期：2007-06-01 00:00:00

abstract：:The effort to map the entire human genome has led recently to the important milestone publication in late 1999 of the complete sequence of chromosome 22. This has been facilitated by increasingly sophisticated tools for genetic analysis and the ensuing wealth of detailed genetic information. The quest for genetic fact...

journal_title：Current opinion in genetics & development

authors： de Silva HR,Khan NL,Wood NW

更新日期：2000-06-01 00:00:00

abstract：:All bovine chromosomes are now represented by a syntenic group, a linkage map and at least one in situ hybridization. Almost 1,000 loci are mapped, about 300 of which are coding sequences useful for comparative mapping and evolutionary inference. Economically important loci are beginning to appear on bovine linkage ma...

journal_title：Current opinion in genetics & development

authors： Womack JE,Kata SR

更新日期：1995-12-01 00:00:00

abstract：:The mammalian globin gene clusters provide a paradigm for studying the relationship between genome structure and function. As blood stem cells undergo lineage specification and differentiation to form red blood cells, the chromatin structure and expression of the α-globin cluster change. The gradual activation of the ...

journal_title：Current opinion in genetics & development

authors： Oudelaar AM,Beagrie RA,Kassouf MT,Higgs DR

更新日期：2020-11-19 00:00:00

abstract：:After fertilization, mouse embryos go through preimplantation development to give rise to blastocyst. Two key molecular events, zygotic genome activation (ZGA) and the first cell lineage specification, are essential for the process. Recent advances in low-input epigenomics profiling techniques allow the analysis of th...

journal_title：Current opinion in genetics & development

authors： Fu X,Zhang C,Zhang Y

更新日期：2020-10-01 00:00:00

abstract：:Flowers are central to sexual reproduction in plants. The study of floral development proved tremendously successful in obtaining key insight into processes, such as fate determination, pattern formation, and growth regulation. Recent advances relate to the complex mechanisms underlying the crosstalk between phytohorm...

journal_title：Current opinion in genetics & development

authors： Vaddepalli P,Scholz S,Schneitz K

更新日期：2015-06-01 00:00:00

abstract：:In eukaryotic cells, transcription and DNA replication occur on DNA templates associated with chromatin proteins, most notably histone octamers. Protein factors that can assemble these units have been isolated from many sources. In particular, one factor from human cells is associated with ongoing DNA synthesis; other...

journal_title：Current opinion in genetics & development

authors： Kaufman PD,Botchan MR

更新日期：1994-04-01 00:00:00

abstract：:Notch signaling has been implicated in a wide variety of processes from cell-fate decisions, tissue patterning and morphogenesis to human diseases and cancer. A model for Notch directly regulating gene expression has been proposed and at least two signaling pathways have been identified; however, the molecular mechani...

journal_title：Current opinion in genetics & development

authors： Weinmaster G

更新日期：1998-08-01 00:00:00

abstract：:Members of the Swi/Snf family of chromatin-remodeling complexes play critical roles in transcriptional control. Recent studies have made significant advances in our understanding of the fundamental aspects of Swi/Snf complexes, including the roles of specific subunits, the repression of transcription, and the mechanis...

journal_title：Current opinion in genetics & development

authors： Martens JA,Winston F

更新日期：2003-04-01 00:00:00

abstract：:The past decade has seen a huge jump in the resolution and scale at which we can interrogate the three-dimensional properties of the genome. This revealed different types of chromatin structures including topologically associating domains, partitioning genes and their enhancers into interacting domains. While the visu...

journal_title：Current opinion in genetics & development

authors： Cavalheiro GR,Pollex T,Furlong EE

更新日期：2021-01-23 00:00:00

abstract：:Filamentous cyanobacteria, the only prokaryotes that form linear patterns of differentiated cells, can be genetically manipulated by the conjugative transfer of plasmids from Escherichia coli. It has become possible to determine the cellular localization of genetic transcription, including transcription of development...

journal_title：Current opinion in genetics & development

authors： Wolk CP

更新日期：1991-10-01 00:00:00

abstract：:The advent of methods for mapping the location of specific proteins across genomes is substantially enlightening our understanding of gene regulation. One recent discovery is that Pol II is concentrated at the 5' end of thousands of genes in mammalian and Drosophila cells. Before this, much research had focused on und...

journal_title：Current opinion in genetics & development

authors： Li J,Gilmour DS

更新日期：2011-04-01 00:00:00

abstract：:Pluripotency-associated transcription factors possess a pivotal role to maintain pluripotency in pluripotent stem cells as well as to induce pluripotency in somatic cells. They direct specific pattern of gene expression from the genome by co-operating with the genetic and epigenetic mechanisms. Recent findings reveale...

journal_title：Current opinion in genetics & development

authors： Niwa H

更新日期：2014-10-01 00:00:00

abstract：:Individual susceptibility to cancer in humans is determined by complex interactions between germline genetic variation and levels of exposure to environmental carcinogens or tumour promoters. Only a small fraction of cancer susceptibility is inherited in a Mendelian manner (high-penetrance familial cancer), and most t...

journal_title：Current opinion in genetics & development

authors： Mao JH,Balmain A

更新日期：2003-02-01 00:00:00

abstract：:Differential gene expression gives rise to the many cell types of complex organisms. Enhancers regulate transcription by binding transcription factors (TFs), which in turn recruit cofactors to activate RNA Polymerase II at core promoters. Transcriptional regulation is typically mediated by distinct combinations of TFs...

journal_title：Current opinion in genetics & development

authors： Reiter F,Wienerroither S,Stark A

更新日期：2017-04-01 00:00:00

abstract：:Several decades of research provided detailed insight into how genes control development and evolution, whereas recent studies have expanded this purely genetic perspective by presenting strong evidence for environmental and epigenetic influences. We summarize examples of phenotypic plasticity and trans-generational e...

journal_title：Current opinion in genetics & development

authors： Serobyan V,Sommer RJ

更新日期：2017-08-01 00:00:00

abstract：:The maternal-to-zygotic transition (MZT) is a universal step in animal development characterized by two major events: activation of zygotic transcription and degradation of maternally provided mRNAs. How zygotic gene products instruct the degradation of maternal messages remains a long-standing question in biology. Mi...

journal_title：Current opinion in genetics & development

authors： Giraldez AJ

更新日期：2010-08-01 00:00:00

abstract：:Considerable progress has been made in unraveling the mechanistic features of RNA editing processes in a number of genetic systems. Recent highlights include the identification of the catalytic subunit of the mammalian apolipoprotein B mRNA editing enzyme as a zinc-dependent cytidine deaminase that binds to RNA, the d...

journal_title：Current opinion in genetics & development

authors： Benne R

更新日期：1996-04-01 00:00:00

abstract：:In mammalian cells, four protein kinases form the PI3-kinase-related protein kinase (PIK) superfamily. These four enzymes-FRAP, DNA-PK, ATM, and ATR-are distinguished by their large size (all are >2500 amino acids), their common primary sequence relatedness through the carboxy-terminal protein kinase domain, and their...

journal_title：Current opinion in genetics & development

authors： Hoekstra MF

更新日期：1997-04-01 00:00:00

abstract：:Vertebrate neural crest cells are embryonic neuroepithelial cells that undergo an epithelial-mesenchymal transition, migrate throughout the embryo and form a wide variety of derivatives, including peripheral neurons and glia, pigment cells, and craniofacial cartilage, bone and teeth. Neural crest cell evolution and el...

journal_title：Current opinion in genetics & development

authors： Baker CV

更新日期：2008-12-01 00:00:00

abstract：:There has been much recent progress in our understanding of the role played by the RAS-RAF-MEK-ERK cascade in human cancer. RAS is an oncogene and this pathway is known to promote proliferation and malignant transformation. More recently, however, RAF has become the focus of attention, particularly in melanoma, where ...

journal_title：Current opinion in genetics & development

authors： Dhomen N,Marais R

更新日期：2007-02-01 00:00:00

abstract：:We discuss recent work about cellular reprogramming during regeneration of the imaginal discs of Drosophila. These contain various lineage blocks, compartments, which express distinct genetic programmes. It has been found that after massive damage to a compartment cells from a neighbour compartment can transgress the ...

journal_title：Current opinion in genetics & development

authors： Morata G,Herrera SC

更新日期：2016-10-01 00:00:00

abstract：:Dorsoventral pattern of Drosophila embryo is specified by the nuclear localization gradient of the transcription factor Dorsal. Genetic and genomic studies of this morphogen gradient provided important insights into spatial control of gene expression in development. Recent live imaging experiments revealed hitherto un...

journal_title：Current opinion in genetics & development

authors： Rushlow CA,Shvartsman SY

更新日期：2012-12-01 00:00:00

abstract：:The impressive diversity of body plans, lifestyles and segmental specializations exhibited by crustaceans (barnacles, copepods, shrimps, crabs, lobsters and their kin) provides great material to address longstanding questions in evolutionary developmental biology. Recent advances in forward and reverse genetics and in...

journal_title：Current opinion in genetics & development

authors： Stamataki E,Pavlopoulos A

更新日期：2016-08-01 00:00:00

abstract：:Understanding the genetic underpinning of early human development is of great interest not only for basic developmental and stem cell biology but also for regenerative medicine, infertility treatments, and better understanding the causes of congenital disease. Our current knowledge has mainly been generated with the u...

journal_title：Current opinion in genetics & development

authors： Ortega NM,Winblad N,Plaza Reyes A,Lanner F

更新日期：2018-10-01 00:00:00

abstract：:Much progress has been made in the past few years in understanding the mechanism and regulation of mRNA synthesis. This rapid progress has largely been due to the availability of cloned genes encoding components of the transcription machinery. Structural and biochemical studies are rapidly defining the architecture of...

journal_title：Current opinion in genetics & development

authors： Ranish JA,Hahn S

更新日期：1996-04-01 00:00:00

abstract：:In the past few years, the area of comparative genomics of malaria parasites has begun to come of age, with the completion of genome sequencing projects of four Plasmodium species, and several functional genomics studies. A picture is emerging of a parasite genome that is highly adapted to its mammalian and vector hos...

journal_title：Current opinion in genetics & development

authors： Hall N,Carlton J

更新日期：2005-12-01 00:00:00

abstract：:Eukaryotic messenger RNA utilization is a tightly controlled process. Control of translation is exerted at several levels, but the predominant step is ribosome binding, which is rate limiting for translation of most mRNAs. There appear to be several alternative modes by which ribosomes bind to the mRNA and initiate tr...

journal_title：Current opinion in genetics & development

authors： Sonenberg N

更新日期：1994-04-01 00:00:00

abstract：:Kinase inhibitors have already established a foothold in the current armament for the treatment of malignancies. Indeed, the future of cancer therapy is likely to rely heavily on an ever-growing number of kinase inhibitors, either as single-agents or in combination with other targeted drugs or even chemotherapies. The...

journal_title：Current opinion in genetics & development

authors： Zhang C,Bollag G

更新日期：2010-02-01 00:00:00

abstract：:The genetic study of rats and mice using natural variants, natural mutations, chemical or radiation induced mutations, engineered mutations and conditional engineered mutations has provided the tools for investigating the genetics of disease. The completion of the mouse genomic sequence and progress towards sequencing...

journal_title：Current opinion in genetics & development

authors： Cox RD,Brown SD

更新日期：2003-06-01 00:00:00