MicroRNAs in the ionizing radiation response and in radiotherapy.

abstract：:The advent of gene targeting in the mouse has led to rapid advances in the identification of factors controlling gene expression that are essential for normal hematopoietic development. Recent work has also uncovered roles for some of these factors in leukemogenesis and in the global regulation of chromatin structure....

journal_title：Current opinion in genetics & development

authors： Engel I,Murre C

更新日期：1999-10-01 00:00:00

abstract：:In eukaryotes, the genetic material is stored in the nucleus, which is enclosed in a double lipid bilayer, the nuclear envelope (NE). It protects the genome from physical stress and separates it from the rest of the cell. On top of this physical function, growing evidence shows that the nuclear periphery contributes t...

journal_title：Current opinion in genetics & development

authors： Meister P,Taddei A

更新日期：2013-04-01 00:00:00

abstract：:Population data suggest that many parasitic protozoa (e.g. Trypanosoma, Leishmania, Entamoeba and Giardia) reproduce clonally, but this hypothesis has been highly controversial for Plasmodium falciparum. Although reproduction is predominantly clonal in the enteric bacteria Escherichia coli and Salmonella, the level of...

journal_title：Current opinion in genetics & development

authors： Hartl DL

更新日期：1992-12-01 00:00:00

abstract：:Transcription and supercoiling of the DNA template are interrelated. This review summarizes recent progress in the study of how template topology affects transcription, and how transcription affects template topology inside wild-type and DNA topoisomerase mutant cells. The interplay between DNA supercoiling and transc...

journal_title：Current opinion in genetics & development

authors： Wang JC,Lynch AS

更新日期：1993-10-01 00:00:00

abstract：:Folding is an important way by which epithelia are sculpted into three-dimensional shapes during development. Recent studies have integrated quantitative image analysis and physical modeling to uncover contributing mechanisms. It is becoming clear that folding processes often employ multiple mechanisms of force genera...

journal_title：Current opinion in genetics & development

authors： Denk-Lobnig M,Martin AC

更新日期：2020-08-01 00:00:00

abstract：:Rapid progress in identifying the genes underlying autism spectrum disorder (ASD) has provided the substrate for a first wave of analyses into the underlying neurobiology. This review describes the consensus across these diverse analyses, highlighting two distinct sets of genes: 1) Genes that regulate chromatin and tr...

journal_title：Current opinion in genetics & development

authors： Sanders SJ

更新日期：2015-08-01 00:00:00

abstract：:There are several enzymes, acetylases and deacetylases, that can regulate transcription by modifying the acetylation state of histones or other promoter-bound transcription factors. Some of these enzymes are present in multisubunit complexes. Recent efforts to understand the biological role of these enzymes reveals th...

journal_title：Current opinion in genetics & development

authors： Kouzarides T

更新日期：1999-02-01 00:00:00

abstract：:The advent of methods for mapping the location of specific proteins across genomes is substantially enlightening our understanding of gene regulation. One recent discovery is that Pol II is concentrated at the 5' end of thousands of genes in mammalian and Drosophila cells. Before this, much research had focused on und...

journal_title：Current opinion in genetics & development

authors： Li J,Gilmour DS

更新日期：2011-04-01 00:00:00

abstract：:In mammalian cells, four protein kinases form the PI3-kinase-related protein kinase (PIK) superfamily. These four enzymes-FRAP, DNA-PK, ATM, and ATR-are distinguished by their large size (all are >2500 amino acids), their common primary sequence relatedness through the carboxy-terminal protein kinase domain, and their...

journal_title：Current opinion in genetics & development

authors： Hoekstra MF

更新日期：1997-04-01 00:00:00

abstract：:Several advances have been made in our understanding of the control of the growth and patterning of embryonic limbs. Development of the vertebrate limb is dependent on reciprocal interactions between the ectoderm and mesoderm that regulate the structure and function of the apical ectodermal ridge. One key component of...

journal_title：Current opinion in genetics & development

authors： Dudley AT,Tabin CJ

更新日期：2000-08-01 00:00:00

abstract：:Baculoviruses continue to serve as workhorse vectors for the high-level expression of eukaryotic genes in insect cells; however, numerous researchers are also finding novel uses for these vectors by taking advantage of the unique nature of the viruses and their host cells. Concurrently, the technology involved in cons...

journal_title：Current opinion in genetics & development

authors： Miller LK

更新日期：1993-02-01 00:00:00

abstract：:Hepatocytes differentiate from the endoderm during embryonic development. Recent studies show, however, that hepatocytes can also be derived from rare cells that reside in the pancreas, bone marrow, and brain. Indeed, the latest discoveries indicate that embryonic hepatocytes normally arise by diversion of an endoderm...

journal_title：Current opinion in genetics & development

authors： Zaret KS

更新日期：2001-10-01 00:00:00

abstract：:The conserved homeobox (Hox) gene cluster is neither conserved nor clustered in the nematode Caenorhabditis elegans. Instead, C. elegans has a reduced and dispersed gene complement that is the result the loss of Hox genes in stages throughout its evolutionary history. The roles of Hox genes in patterning the nematode ...

journal_title：Current opinion in genetics & development

authors： Aboobaker A,Blaxter M

更新日期：2003-12-01 00:00:00

abstract：:Covalent modifications of histone proteins play key roles in transcription, DNA repair, recombination, and other such processes. Over a hundred histone modifications have been described, and a popular idea in the field is that the function of a single histone mark cannot be understood without understanding its combina...

journal_title：Current opinion in genetics & development

authors： Rando OJ

更新日期：2012-04-01 00:00:00

abstract：:Recent studies have uncovered a bifunctional role of the diffusible axon guidance molecules netrin-1 and UNC-6 in that they attract some axons and steer others away simultaneously. Homology screens have extended the semaphorin and collapsin family to include at least 20 members, in both secreted and membrane-bound for...

journal_title：Current opinion in genetics & development

authors： Müller BK,Bonhoeffer F,Drescher U

更新日期：1996-08-01 00:00:00

abstract：:Allele-specific gene expression can influence disease traits. Non-coding germline genetic variants that alter regulatory elements can cause allele-specific gene expression and contribute to cancer susceptibility. In tumors, both somatic copy number alterations and somatic single nucleotide variants have been shown to ...

journal_title：Current opinion in genetics & development

authors： Robles-Espinoza CD,Mohammadi P,Bonilla X,Gutierrez-Arcelus M

更新日期：2020-12-28 00:00:00

abstract：:The generation of induced pluripotent stem cells (iPSCs) with Oct4, Sox2, Klf4, c-Myc has been described as 'direct' reprogramming in contrast to reprogramming via nuclear transfer. Interestingly, recent studies have suggested that the conversion process itself includes transient up-regulation and down-regulation of h...

journal_title：Current opinion in genetics & development

authors： Ruetz T,Kaji K

更新日期：2014-10-01 00:00:00

abstract：:Highly repetitive minisatellites' include the most variable human loci described to date. They have proved invaluable in a wide variety of genetic analyses, and despite some controversies surrounding their practical implementation, have been extensively adopted in civil and forensic casework. Molecular analysis of int...

journal_title：Current opinion in genetics & development

authors： Armour JA,Jeffreys AJ

更新日期：1992-12-01 00:00:00

abstract：:The PML and SP100-containing nuclear bodies (NBs) represent the best-studied example of a defined nuclear substructure the integrity of which is compromised in certain human diseases, including leukemia, neurodegenerative disorders and viral infection. Although recent progress has underscored the unexpectedly broad in...

journal_title：Current opinion in genetics & development

authors： Seeler JS,Dejean A

更新日期：1999-06-01 00:00:00

abstract：:Skeletal muscle cells have provided an especially auspicious system in which to dissect the roles of chromatin structure in the control of cell growth, differentiation, and development. The MyoD and MEF2 families of transcription factors act cooperatively to regulate the expression of skeletal muscle-specific genes. R...

journal_title：Current opinion in genetics & development

authors： McKinsey TA,Zhang CL,Olson EN

更新日期：2001-10-01 00:00:00

abstract：:Microsatellites may soon become the markers of choice for molecular population genetic studies. However, our knowledge of these simple repetitive sequences and how they evolve in natural populations is far from complete. We highlight some recent results of population studies and advances in our ability to interpret so...

journal_title：Current opinion in genetics & development

authors： Bruford MW,Wayne RK

更新日期：1993-12-01 00:00:00

abstract：:Seed development starts at double fertilization when two sperms fuse with a female gamete, the egg and central cell, giving rise to the embryo and endosperm, respectively. Uniting two parental genomes into one, unique, zygotic genome is certainly the first event requiring large-scale chromatin modifications and remode...

journal_title：Current opinion in genetics & development

authors： Baroux C,Pien S,Grossniklaus U

更新日期：2007-12-01 00:00:00

abstract：:An epigenetic imprinting mechanism that is based on a gamete-specific methylation imprint restricts expression of a subset of mammalian genes to one parental chromosome. Recent results suggest that imprints may act only indirectly to induce monoallelic expression of coding genes. Instead, atypical non-coding RNAs appe...

journal_title：Current opinion in genetics & development

authors： Sleutels F,Barlow DP,Lyle R

更新日期：2000-04-01 00:00:00

abstract：:Atherosclerosis is the major cause of cardiovascular disease. Hypercholesterolaemia, hypertension and cigarette smoking are the common risk factors for atherosclerosis. These risk factors unite behind a convergence of mechanism, involving oxidation and inflammation in the artery wall that, with time, gives rise to cha...

journal_title：Current opinion in genetics & development

authors： Scott J

更新日期：2004-06-01 00:00:00

abstract：:The vertebrate inner ear is a sensory organ of exquisite design and sensitivity. It responds to sound, gravity and movement, serving both auditory (hearing) and vestibular (balance) functions. Almost all cell types of the inner ear, including sensory hair cells, sensory neurons, secretory cells and supporting cells, d...

journal_title：Current opinion in genetics & development

authors： Whitfield TT

更新日期：2015-06-01 00:00:00

abstract：:Ras proteins activate a signaling cascade through direct binding of the serine/threonine kinase Raf. They also activate additional signaling pathways that are essential for full biological activity. Candidate effectors for these pathways include RalGDS and phosphatidyl inositol 3' kinase, as well as several other Ras ...

journal_title：Current opinion in genetics & development

authors： Katz ME,McCormick F

更新日期：1997-02-01 00:00:00

abstract：:Ideas of how a system of interacting enzymes can act as a switch are based on the concept of bistability of a biochemical network. This means that, because of the very structure of a signaling pathway, the system can be in one of two stable steady states: active or inactive. Switching from one state to another may the...

journal_title：Current opinion in genetics & development

authors： Slepchenko BM,Terasaki M

更新日期：2004-08-01 00:00:00

abstract：:Trait exaggeration, well known to naturalists and evolutionary biologists, has recently become a prominent research subject in the modern field of Evolutionary Developmental Biology. A large number of traits that can be considered as cases of exaggeration exist in nature. Yet, the field has almost exclusively focused ...

journal_title：Current opinion in genetics & development

authors： Toubiana W,Khila A

更新日期：2016-08-01 00:00:00

abstract：:The past decade has seen a huge jump in the resolution and scale at which we can interrogate the three-dimensional properties of the genome. This revealed different types of chromatin structures including topologically associating domains, partitioning genes and their enhancers into interacting domains. While the visu...

journal_title：Current opinion in genetics & development

authors： Cavalheiro GR,Pollex T,Furlong EE

更新日期：2021-01-23 00:00:00

abstract：:The maternal-to-zygotic transition (MZT) is a universal step in animal development characterized by two major events: activation of zygotic transcription and degradation of maternally provided mRNAs. How zygotic gene products instruct the degradation of maternal messages remains a long-standing question in biology. Mi...

journal_title：Current opinion in genetics & development

authors： Giraldez AJ

更新日期：2010-08-01 00:00:00