Abstract:
:The PML and SP100-containing nuclear bodies (NBs) represent the best-studied example of a defined nuclear substructure the integrity of which is compromised in certain human diseases, including leukemia, neurodegenerative disorders and viral infection. Although recent progress has underscored the unexpectedly broad involvement of NB constituents in the control of cell growth, gene regulation and apoptosis in both pathological and normal contexts, evidence for a specific physiological activity within the NBs remains scant, thus precluding a unifying hypothesis for NB function.
journal_name
Curr Opin Genet Devjournal_title
Current opinion in genetics & developmentauthors
Seeler JS,Dejean Adoi
10.1016/s0959-437x(99)80054-9subject
Has Abstractpub_date
1999-06-01 00:00:00pages
362-7issue
3eissn
0959-437Xissn
1879-0380pii
gd9303journal_volume
9pub_type
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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