Regulation of p21ras by GTPase activating proteins and guanine nucleotide exchange proteins.

abstract：:The fundamental tasks of the root system are, besides anchoring, mediating interactions between plant and soil and providing the plant with water and nutrients. The architecture of the root system is controlled by endogenous mechanisms that constantly integrate environmental signals, such as availability of nutrients ...

journal_title：Current opinion in genetics & development

authors： Ötvös K,Benková E

更新日期：2017-08-01 00:00:00

abstract：:Multiple neural and non-neural cell types arise from the neural crest (NC) in vertebrate embryos. Recent work has provided evidence for multipotent stem cells and intermediate precursors in the early NC cell population as well as in various NC derivatives in embryos and even in adult. Advances have been made towards u...

journal_title：Current opinion in genetics & development

authors： Le Douarin NM,Dupin E

更新日期：2003-10-01 00:00:00

abstract：:Subtelomeres are the regions at chromosome ends, immediately adjacent to the terminal telomeric repeats. The majority of human subtelomeres are CpG-rich in their distal two kilobases, and are methylated during early embryonic development by the de novo DNA methyltransferase DNMT3B. The biological relevance of subtelom...

journal_title：Current opinion in genetics & development

authors： Toubiana S,Selig S

更新日期：2020-02-01 00:00:00

abstract：:Bioinformatics is now an essential tool in many aspects of human molecular genetics research. Methods for the prediction of gene structure are essential components in genomic sequencing projects and provide the key to deriving protein sequence and locating intron/exon junctions. Sequence comparison and database search...

journal_title：Current opinion in genetics & development

authors： Rawlings CJ,Searls DB

更新日期：1997-06-01 00:00:00

abstract：:Recent studies have uncovered a bifunctional role of the diffusible axon guidance molecules netrin-1 and UNC-6 in that they attract some axons and steer others away simultaneously. Homology screens have extended the semaphorin and collapsin family to include at least 20 members, in both secreted and membrane-bound for...

journal_title：Current opinion in genetics & development

authors： Müller BK,Bonhoeffer F,Drescher U

更新日期：1996-08-01 00:00:00

abstract：:Recent advances in cell reprogramming via employing different sets of factors, which allows generation of various cell types that are beyond the downstream developmental lineages from the starting cell type, provide significant opportunities to study fundamental biology and hold enormous promise in regenerative medici...

journal_title：Current opinion in genetics & development

authors： Yu C,Liu K,Tang S,Ding S

更新日期：2014-10-01 00:00:00

abstract：:RET mutations have been identified as the underlying cause of two congenital diseases that predominately affect tissues of neural crest origin: the MEN 2 cancer syndromes and a proportion of cases of dominantly inherited Hirschsprung disease, a disorder of gut development. This review summarizes the disease-causing mu...

journal_title：Current opinion in genetics & development

authors： Mak YF,Ponder BA

更新日期：1996-02-01 00:00:00

abstract：:Does the intron/exon structure of eukaryotic genes belie their ancient assembly by exon-shuffling or have introns been inserted into preformed genes during eukaryotic evolution? These are the central questions in the ongoing 'introns-early' versus 'introns-late' controversy. The phylogenetic distribution of spliceosom...

journal_title：Current opinion in genetics & development

authors： Logsdon JM Jr

更新日期：1998-12-01 00:00:00

abstract：:Family-based next generation sequencing (NGS) has recently pointed to an important role for de novo germline point mutations in both rare and common genetic disorders associated with reduced fitness. In this review we highlight the impact of the mutational target size on the frequency of diseases caused by these de no...

journal_title：Current opinion in genetics & development

authors： de Ligt J,Veltman JA,Vissers LE

更新日期：2013-06-01 00:00:00

abstract：:Flowers are central to sexual reproduction in plants. The study of floral development proved tremendously successful in obtaining key insight into processes, such as fate determination, pattern formation, and growth regulation. Recent advances relate to the complex mechanisms underlying the crosstalk between phytohorm...

journal_title：Current opinion in genetics & development

authors： Vaddepalli P,Scholz S,Schneitz K

更新日期：2015-06-01 00:00:00

abstract：:The recent flood of information concerning Saccharomyces cerevisiae replication origins and the proteins that interact with them contrasts alarmingly to the trickle of progress in our understanding of metazoan origins. In mammalian cells, origins are complex and heterogeneous, and appear to be selected by features of ...

journal_title：Current opinion in genetics & development

authors： Gilbert DM

更新日期：1998-04-01 00:00:00

abstract：:The establishment of left-right asymmetries in the vertebrate embryo is carried out by complex genetic interactions that impart left- or right-sided information to the developing organs and structures. The origin of LR information is still unclear, but recent advances have provided new insights as to how it is relayed...

journal_title：Current opinion in genetics & development

authors： Raya A,Izpisúa Belmonte JC

更新日期：2004-10-01 00:00:00

abstract：:Organogenesis depends upon a well-ordered series of inductive events involving coordination of molecular pathways that regulate the generation and patterning of specific cell types. Key questions in organogenesis involve the identification of the molecular mechanisms by which proteins interact to organize distinct pat...

journal_title：Current opinion in genetics & development

authors： Bei M

更新日期：2009-10-01 00:00:00

abstract：:Vertebrate eye formation is a multistep process requiring coordinated inductive interactions between neural and non-neural ectoderm and underlying mesendoderm. The induction and shaping of the eyes involves an elaborate cellular choreography characterized by precise changes in cell shape coupled with complex cellular ...

journal_title：Current opinion in genetics & development

authors： Bazin-Lopez N,Valdivia LE,Wilson SW,Gestri G

更新日期：2015-06-01 00:00:00

abstract：:Differential gene expression gives rise to the many cell types of complex organisms. Enhancers regulate transcription by binding transcription factors (TFs), which in turn recruit cofactors to activate RNA Polymerase II at core promoters. Transcriptional regulation is typically mediated by distinct combinations of TFs...

journal_title：Current opinion in genetics & development

authors： Reiter F,Wienerroither S,Stark A

更新日期：2017-04-01 00:00:00

abstract：:Models in developmental biology continue to yield valuable insights, yet do not play a strong role as guides to experiment. This may be because of the largely unexplored complexity of most developing organisms, and the fact that the most powerful models work at a very abstract level. In Dictyostelium discoideum, howev...

journal_title：Current opinion in genetics & development

authors： Cox EC

更新日期：1992-08-01 00:00:00

abstract：:Thousands of genes produce polyadenylated mRNAs that still contain one or more introns. These transcripts are known as retained intron RNAs (RI-RNAs). In the past 10 years, RI-RNAs have been linked to post-transcriptional alternative splicing in a variety of developmental contexts, but they can also be dead-end produc...

journal_title：Current opinion in genetics & development

authors： Gordon JM,Phizicky DV,Neugebauer KM

更新日期：2020-12-05 00:00:00

abstract：:One of the ways in which higher eukaryotes receive messages from the environment is via cell surface receptor tyrosine kinases. These are transmembrane proteins with an extracellular binding domain that specifies the growth factor with which it will interact, and an intracellular domain that encodes the tyrosine kinas...

journal_title：Current opinion in genetics & development

authors： Kazlauskas A

更新日期：1994-02-01 00:00:00

abstract：:The conversion of one cell type to another is defined as metaplasia (or sometimes it is referred to as transdifferentiation or cellular reprogramming). Metaplasia is important clinically and may predispose to the development of cancer. Barrett's metaplasia is one such example and is the focus of the present review. Ba...

journal_title：Current opinion in genetics & development

authors： Burke ZD,Tosh D

更新日期：2012-10-01 00:00:00

abstract：:In eukaryotes, the genetic material is stored in the nucleus, which is enclosed in a double lipid bilayer, the nuclear envelope (NE). It protects the genome from physical stress and separates it from the rest of the cell. On top of this physical function, growing evidence shows that the nuclear periphery contributes t...

journal_title：Current opinion in genetics & development

authors： Meister P,Taddei A

更新日期：2013-04-01 00:00:00

abstract：:Transcription and supercoiling of the DNA template are interrelated. This review summarizes recent progress in the study of how template topology affects transcription, and how transcription affects template topology inside wild-type and DNA topoisomerase mutant cells. The interplay between DNA supercoiling and transc...

journal_title：Current opinion in genetics & development

authors： Wang JC,Lynch AS

更新日期：1993-10-01 00:00:00

abstract：:Most of the knowledge we have on the molecular mechanisms of transcription factor mediated reprogramming comes from studies conducted in induced pluripotency. Recently however, a few studies investigated the mechanisms of cellular reprogramming in direct and indirect transdifferentiation, which allows us to explore wh...

journal_title：Current opinion in genetics & development

authors： Firas J,Polo JM

更新日期：2017-10-01 00:00:00

abstract：:Ideas of how a system of interacting enzymes can act as a switch are based on the concept of bistability of a biochemical network. This means that, because of the very structure of a signaling pathway, the system can be in one of two stable steady states: active or inactive. Switching from one state to another may the...

journal_title：Current opinion in genetics & development

authors： Slepchenko BM,Terasaki M

更新日期：2004-08-01 00:00:00

abstract：:The genomic perspective aids in integrating the analysis of single resistance (R-) genes into a higher order model of complex plant resistance systems. The majority of R-genes encode a class of proteins with nucleotide binding (NB) and leucine-rich repeat (LRR) domains. Several R-proteins act in multi-protein R-comple...

journal_title：Current opinion in genetics & development

authors： Friedman AR,Baker BJ

更新日期：2007-12-01 00:00:00

abstract：:The DNA damage response (DDR) orchestrates DNA repair and halts cell cycle. If damage is not resolved, cells can enter into an irreversible state of proliferative arrest called cellular senescence. Organismal ageing in mammals is associated with accumulation of markers of cellular senescence and DDR persistence at tel...

journal_title：Current opinion in genetics & development

authors： Rossiello F,Herbig U,Longhese MP,Fumagalli M,d'Adda di Fagagna F

更新日期：2014-06-01 00:00:00

abstract：:The neocortex represents the brain structure that has been subjected to a major expansion in its relative size during the course of mammalian evolution. An exquisite coordination of appropriate growth of competent territories along multiple axes and their spatial patterning is required for regionalization of the corti...

journal_title：Current opinion in genetics & development

authors： Borello U,Pierani A

更新日期：2010-08-01 00:00:00

abstract：:For many years, biologists' efforts in achieving gene targeting by homologous recombination in multicellular organisms have been hampered by the difficulty in culturing pluripotent stem cells. Recent advances have eliminated this requirement for several animal species. For large mammals, cloning by nuclear transfer ha...

journal_title：Current opinion in genetics & development

authors： Gong M,Rong YS

更新日期：2003-04-01 00:00:00

abstract：:In their development, plants precisely control the patterns of cell size, cell shape and cell division, the position of differentiation of cell types, and the position and number of organs. In the past year, progress has been made in understanding four of these five levels of control of plant pattern formation, includ...

journal_title：Current opinion in genetics & development

authors： Meyerowitz EM

更新日期：1994-08-01 00:00:00

abstract：:Microfluidic devices employ submillimeter length scale control of flow to achieve high-resolution spatial and temporal control over the microenvironment, providing powerful tools to elucidate mechanisms of human pluripotent stem cell (hPSC) regulation and to elicit desired hPSC fates. In addition, microfluidics allow ...

journal_title：Current opinion in genetics & development

authors： Qian T,Shusta EV,Palecek SP

更新日期：2015-10-01 00:00:00

abstract：:Ten years after the initial description of acquired immune deficiency syndrome, its causative agent, the human immunodeficiency virus, remains the subject of intense scientific interest. Recent research has focused on the detailed analysis of the molecular principles governing gene expression and virion formation and ...

journal_title：Current opinion in genetics & development

authors： Kräusslich HG

更新日期：1992-02-01 00:00:00