Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing.

abstract：:Population data suggest that many parasitic protozoa (e.g. Trypanosoma, Leishmania, Entamoeba and Giardia) reproduce clonally, but this hypothesis has been highly controversial for Plasmodium falciparum. Although reproduction is predominantly clonal in the enteric bacteria Escherichia coli and Salmonella, the level of...

journal_title：Current opinion in genetics & development

authors： Hartl DL

更新日期：1992-12-01 00:00:00

abstract：:Axonal growth cones (GCs) steer in response to extrinsic cues using mechanisms that include local protein synthesis. This adaptive form of gene regulation occurs with spatial precision and depends on subcellular mRNA localisation. Recent genome-wide studies have shown unexpectedly complex and dynamically changing mRNA...

journal_title：Current opinion in genetics & development

authors： Jung H,O'Hare CM,Holt CE

更新日期：2011-08-01 00:00:00

abstract：:Premutation alleles (55-200 CGG repeats) of the fragile X mental retardation 1 gene (FMR1) are known to contribute to the fragile X phenotype through genetic instability and transmission of full mutation alleles (>200 repeats). There is now mounting evidence that the premutation alleles themselves contribute to clinic...

journal_title：Current opinion in genetics & development

authors： Hagerman RJ,Hagerman PJ

更新日期：2002-06-01 00:00:00

abstract：:During embryogenesis, tissues and organs are progressively shaped into their functional morphologies. While the information about tissue and organ shape is encoded genetically, the sculpting of embryonic structures in the 3D space is ultimately a physical process. The control of physical quantities involved in tissue ...

journal_title：Current opinion in genetics & development

authors： Stooke-Vaughan GA,Campàs O

更新日期：2018-08-01 00:00:00

abstract：:Recent studies have supported the hypothesis that the high heritability of schizophrenia reflects a combination of relatively common alleles of small effect and some rare alleles with relatively large effects. Genome-wide association studies have identified at least one common allele of small effect at ZNF804a, which ...

journal_title：Current opinion in genetics & development

authors： Owen MJ,Williams HJ,O'Donovan MC

更新日期：2009-06-01 00:00:00

abstract：:Molecular biological techniques have contributed greatly to the study of vertebrate ocular tissues. The specification of ocular tissues has been shown to be closely related to the expression of transcription factors encoded by genes such as Pax6 and microphthalmia. Lens-specific expression of the delta 1-crystallin ge...

journal_title：Current opinion in genetics & development

authors： Kodama R,Eguchi G

更新日期：1994-10-01 00:00:00

abstract：:In the Drosophila eye, photoreceptor clusters are arranged with mirror-image symmetry about the dorso-ventral midline. Recent work indicates critical rôles for Wingless and JAK/STAT signalling in setting up long-range gradients of positional information that determine this symmetry. Furthermore, important functions ha...

journal_title：Current opinion in genetics & development

authors： Strutt H,Strutt D

更新日期：1999-08-01 00:00:00

abstract：:Subtelomeres are the regions at chromosome ends, immediately adjacent to the terminal telomeric repeats. The majority of human subtelomeres are CpG-rich in their distal two kilobases, and are methylated during early embryonic development by the de novo DNA methyltransferase DNMT3B. The biological relevance of subtelom...

journal_title：Current opinion in genetics & development

authors： Toubiana S,Selig S

更新日期：2020-02-01 00:00:00

abstract：:Human pluripotent stem cells derived from embryos (human Embryonic Stem Cells or hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell type...

journal_title：Current opinion in genetics & development

authors： Ortmann D,Vallier L

更新日期：2017-10-01 00:00:00

abstract：:DNA methylation and chromatin modification are two global mechanisms that regulate gene expression. Recent studies provide insight into the mechanism of transcriptional silencing by a methyl-CpG binding protein, MeCP2. MeCP2 is shown to interact with the Sin3/histone deacetylase co-repressor complex. Thus, this intera...

journal_title：Current opinion in genetics & development

authors： Ng HH,Bird A

更新日期：1999-04-01 00:00:00

abstract：:In 2003, a p53-expressing adenovirus was approved as a cancer therapy drug in China. Consequently, there has been a surge in the need to understand the regulation of wild type p53 function in vivo. The majority of the progress made during the past two years has focused on the cellular factors and post-translational mo...

journal_title：Current opinion in genetics & development

authors： Lu X

更新日期：2005-02-01 00:00:00

abstract：:There are several enzymes, acetylases and deacetylases, that can regulate transcription by modifying the acetylation state of histones or other promoter-bound transcription factors. Some of these enzymes are present in multisubunit complexes. Recent efforts to understand the biological role of these enzymes reveals th...

journal_title：Current opinion in genetics & development

authors： Kouzarides T

更新日期：1999-02-01 00:00:00

abstract：:Methods to globally survey gene expression provide valuable insights into gene function during development. In particular, comprehensive in situ hybridization studies have demonstrated that gene expression patterns are extraordinarily diverse and new imaging techniques have been introduced to capture these patterns wi...

journal_title：Current opinion in genetics & development

authors： Lécuyer E,Tomancak P

更新日期：2008-12-01 00:00:00

abstract：:Successful cell migration depends on the careful regulation of the timing of movement, the guidance of motile cells, and cytoskeletal and adhesive changes within the cells. This review focuses on genes that act cell-autonomously to promote these aspects of cell migration in Drosophila. We discuss recent advances in un...

journal_title：Current opinion in genetics & development

authors： Starz-Gaiano M,Montell DJ

更新日期：2004-02-01 00:00:00

abstract：:Many acquired and familial renal diseases in man lead to kidney dysfunction and nephrotic syndrome. These diseases share a common pathological fate in the form of glomerular dysfunction and proteinuria. Classification of the disease is difficult because the onset of pathological appearance in congenital nephrotic synd...

journal_title：Current opinion in genetics & development

authors： Khoshnoodi J,Tryggvason K

更新日期：2001-06-01 00:00:00

abstract：:The generation of induced pluripotent stem cells (iPSCs) with Oct4, Sox2, Klf4, c-Myc has been described as 'direct' reprogramming in contrast to reprogramming via nuclear transfer. Interestingly, recent studies have suggested that the conversion process itself includes transient up-regulation and down-regulation of h...

journal_title：Current opinion in genetics & development

authors： Ruetz T,Kaji K

更新日期：2014-10-01 00:00:00

abstract：:Recognition and pairing of homologous chromosomes are absolutely required for successful segregation during meiosis. We still have no model, however, that adequately explains the mechanism of these processes in a quantitative way. The fact that homologue pairing takes similar times across several orders of magnitude i...

journal_title：Current opinion in genetics & development

authors： Moore G,Shaw P

更新日期：2009-04-01 00:00:00

abstract：:Proteins, the main cell machinery which play a major role in nearly every cellular process, have always been a central focus in biology. We live in the post-genomic era, and inferring information from massive data sets is a steadily growing universal challenge. The increasing availability of fully sequenced genomes ca...

journal_title：Current opinion in genetics & development

authors： Scaiewicz A,Levitt M

更新日期：2015-12-01 00:00:00

abstract：:Seed development starts at double fertilization when two sperms fuse with a female gamete, the egg and central cell, giving rise to the embryo and endosperm, respectively. Uniting two parental genomes into one, unique, zygotic genome is certainly the first event requiring large-scale chromatin modifications and remode...

journal_title：Current opinion in genetics & development

authors： Baroux C,Pien S,Grossniklaus U

更新日期：2007-12-01 00:00:00

abstract：:Modelling human colon cancer has long been the ambition of researchers and oncologists with the aim to better replicate disease progression and treatment response. Advances in our understanding of genetics, stem cell biology, tumour microenvironment and immunology have prepared the groundwork for recent major advances...

journal_title：Current opinion in genetics & development

authors： Lannagan TR,Jackstadt R,Leedham SJ,Sansom OJ

更新日期：2021-01-07 00:00:00

abstract：:The initial human and chimpanzee genome sequences have been published, and additional primate genomes, including those of gorilla and orang-utan, are in progress. With these new resources, we can now address what makes our species unique, by focusing on the underlying genetic differences associated with phenotypes. Co...

journal_title：Current opinion in genetics & development

authors： Stone AC,Verrelli BC

更新日期：2006-12-01 00:00:00

abstract：:Since the recognition of the uniqueness and coherence of the archaebacteria (sometimes called Archaea), our perception of their role in early evolution has been modified repeatedly. The deluge of sequence data and rapidly improving molecular systematic methods have combined with a better understanding of archaebacteri...

journal_title：Current opinion in genetics & development

authors： Keeling PJ,Charlebois RL,Doolittle WF

更新日期：1994-12-01 00:00:00

abstract：:Gibberellins (GAs) affect several growth and developmental responses during the plant life cycle. Components essential for GA perception and GA signaling have been identified in rice and Arabidopsis and are conserved among vascular plants but not in Physcomitrella patens. The recent observation that DELLAs bind in nuc...

journal_title：Current opinion in genetics & development

authors： Davière JM,de Lucas M,Prat S

更新日期：2008-08-01 00:00:00

abstract：:The combination of complete genome sequence information and estimates of mRNA abundances have begun to reveal causes of both silent and protein sequence evolution. Translational selection appears to explain patterns of synonymous codon usage in many prokaryotes as well as a number of eukaryotic model organisms (with t...

journal_title：Current opinion in genetics & development

authors： Akashi H

更新日期：2001-12-01 00:00:00

abstract：:TGF-beta binding to the cell surface triggers activation of multiple signal transduction pathways that are connected in intricate ways with each other, and with other response networks involved in sensing cellular information input. Recent data indicate that changes in signal intensity and connectivity of these pathwa...

journal_title：Current opinion in genetics & development

authors： Wakefield LM,Roberts AB

更新日期：2002-02-01 00:00:00

abstract：:This is the year of the chimpanzee genome. Chimpanzee chromosome 22 has been sequenced and soon will be followed by the whole genome, and thousands of chimpanzee cDNA sequences are available for comparative analysis. Not only does this genomic information allow us to identify human-specific changes in particular genes...

journal_title：Current opinion in genetics & development

authors： Ruvolo M

更新日期：2004-12-01 00:00:00

abstract：:Pluripotency-associated transcription factors possess a pivotal role to maintain pluripotency in pluripotent stem cells as well as to induce pluripotency in somatic cells. They direct specific pattern of gene expression from the genome by co-operating with the genetic and epigenetic mechanisms. Recent findings reveale...

journal_title：Current opinion in genetics & development

authors： Niwa H

更新日期：2014-10-01 00:00:00

abstract：:Ideas of how a system of interacting enzymes can act as a switch are based on the concept of bistability of a biochemical network. This means that, because of the very structure of a signaling pathway, the system can be in one of two stable steady states: active or inactive. Switching from one state to another may the...

journal_title：Current opinion in genetics & development

authors： Slepchenko BM,Terasaki M

更新日期：2004-08-01 00:00:00

abstract：:Hepatocytes differentiate from the endoderm during embryonic development. Recent studies show, however, that hepatocytes can also be derived from rare cells that reside in the pancreas, bone marrow, and brain. Indeed, the latest discoveries indicate that embryonic hepatocytes normally arise by diversion of an endoderm...

journal_title：Current opinion in genetics & development

authors： Zaret KS

更新日期：2001-10-01 00:00:00

abstract：:During development and differentiation, early inductive processes that influence cell fate at a later stage leave marks at distinct gene loci that are maintained through several rounds of mitosis. The structure of chromatin is part of this epigenetic memory that restricts or permits differential expression of genes in...

journal_title：Current opinion in genetics & development

authors： Müller C,Leutz A

更新日期：2001-04-01 00:00:00