The language of the protein universe.

Abstract:

:Proteins, the main cell machinery which play a major role in nearly every cellular process, have always been a central focus in biology. We live in the post-genomic era, and inferring information from massive data sets is a steadily growing universal challenge. The increasing availability of fully sequenced genomes can be regarded as the 'Rosetta Stone' of the protein universe, allowing the understanding of genomes and their evolution, just as the original Rosetta Stone allowed Champollion to decipher the ancient Egyptian hieroglyphics. In this review, we consider aspects of the protein domain architectures repertoire that are closely related to those of human languages and aim to provide some insights about the language of proteins.

journal_name

Curr Opin Genet Dev

authors

Scaiewicz A,Levitt M

doi

10.1016/j.gde.2015.08.010

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

50-6

eissn

0959-437X

issn

1879-0380

pii

S0959-437X(15)00093-3

journal_volume

35

pub_type

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