Getting signals crossed in C. elegans.

abstract：:In metazoans, lineage-specific transcription factors and epigenetic modifiers function to establish and maintain proper gene expression programs during development. Recent landmark studies in both mouse and human have defined a set of transcription factors whose ectopic expression by retroviral transduction is capable...

journal_title：Current opinion in genetics & development

authors： Welstead GG,Schorderet P,Boyer LA

更新日期：2008-04-01 00:00:00

abstract：:The past decade has seen a huge jump in the resolution and scale at which we can interrogate the three-dimensional properties of the genome. This revealed different types of chromatin structures including topologically associating domains, partitioning genes and their enhancers into interacting domains. While the visu...

journal_title：Current opinion in genetics & development

authors： Cavalheiro GR,Pollex T,Furlong EE

更新日期：2021-01-23 00:00:00

abstract：:Type 1 diabetes is the most common autoimmune disorder in childhood, characterized by the development of autoimmunity through unknown environmental insults in genetically susceptible individuals. There are now over 50 regions of the genome that harbor type 1 diabetes susceptibility genes, with much of the genetic risk...

journal_title：Current opinion in genetics & development

authors： Robertson CC,Rich SS

更新日期：2018-06-01 00:00:00

abstract：:Axonal growth cones (GCs) steer in response to extrinsic cues using mechanisms that include local protein synthesis. This adaptive form of gene regulation occurs with spatial precision and depends on subcellular mRNA localisation. Recent genome-wide studies have shown unexpectedly complex and dynamically changing mRNA...

journal_title：Current opinion in genetics & development

authors： Jung H,O'Hare CM,Holt CE

更新日期：2011-08-01 00:00:00

abstract：:After fertilization, mouse embryos go through preimplantation development to give rise to blastocyst. Two key molecular events, zygotic genome activation (ZGA) and the first cell lineage specification, are essential for the process. Recent advances in low-input epigenomics profiling techniques allow the analysis of th...

journal_title：Current opinion in genetics & development

authors： Fu X,Zhang C,Zhang Y

更新日期：2020-10-01 00:00:00

abstract：:The dystrophin-glycoprotein complex (DGC) is a multisubunit complex that connects the cytoskeleton of a muscle fiber to its surrounding extracellular matrix. Mutations in the DGC disrupt the complex and lead to muscular dystrophy. There are a few naturally occurring animal models of DGC-associated muscular dystrophy (...

journal_title：Current opinion in genetics & development

authors： Durbeej M,Campbell KP

更新日期：2002-06-01 00:00:00

abstract：:A newly-identified major histocompatibility Class I-like gene, HFE (originally HLA-H) located approximately 3.5 Mb telomeric to the Class I cluster on chromosome 6p 21.3 harbours mutations in haemochromatosis. Two of these, Cys282Tyr (C282Y) and His63Asp (H63D, a minor determinant) have diagnostic utility as approxima...

journal_title：Current opinion in genetics & development

authors： Cox TM,Kelly AL

更新日期：1998-06-01 00:00:00

abstract：:The nature-nurture argument surrounding the mechanisms of disease causation cannot be resolved, as the roles of genes and environment are inextricably entwined. Environmental fluctuation is clearly a major modifier of phenotype, as well as a promoter of evolutionary change. Both types of variability can be mediated by...

journal_title：Current opinion in genetics & development

authors： Yeyati PL,van Heyningen V

更新日期：2008-06-01 00:00:00

abstract：:Successful cell migration depends on the careful regulation of the timing of movement, the guidance of motile cells, and cytoskeletal and adhesive changes within the cells. This review focuses on genes that act cell-autonomously to promote these aspects of cell migration in Drosophila. We discuss recent advances in un...

journal_title：Current opinion in genetics & development

authors： Starz-Gaiano M,Montell DJ

更新日期：2004-02-01 00:00:00

abstract：:Flowers are central to sexual reproduction in plants. The study of floral development proved tremendously successful in obtaining key insight into processes, such as fate determination, pattern formation, and growth regulation. Recent advances relate to the complex mechanisms underlying the crosstalk between phytohorm...

journal_title：Current opinion in genetics & development

authors： Vaddepalli P,Scholz S,Schneitz K

更新日期：2015-06-01 00:00:00

abstract：:Studies of primate lentivirus phylogeny over the past decade have established a minimum of five related, but genetically distinct, groups of simian immunodeficiency virus (SIV), each originating from a different African primate species. The hypothesis that HIV-2 (and SIVmac) arose by cross-species transmission from so...

journal_title：Current opinion in genetics & development

authors： Hirsch VM,Dapolito G,Goeken R,Campbell BJ

更新日期：1995-12-01 00:00:00

abstract：:The transcription factor TFIIH is a versatile, multi-functional protein complex with multiple engagements. Apart from its role in basal transcription, TFIIH is intimately implicated in DNA repair and (probably) in cell cycle control (both of which are required to prevent carcinogenesis) as well as having possible role...

journal_title：Current opinion in genetics & development

authors： Hoeijmakers JH,Egly JM,Vermeulen W

更新日期：1996-02-01 00:00:00

abstract：:Atherosclerosis is the major cause of cardiovascular disease. Hypercholesterolaemia, hypertension and cigarette smoking are the common risk factors for atherosclerosis. These risk factors unite behind a convergence of mechanism, involving oxidation and inflammation in the artery wall that, with time, gives rise to cha...

journal_title：Current opinion in genetics & development

authors： Scott J

更新日期：2004-06-01 00:00:00

abstract：:Unexpected relationships among the various aminoacyl-tRNA synthetases continue to be uncovered. The question arises - is this mainly the result of promiscuous exchange, or is the confusion really a reflection of the differential loss of past duplications? Phylogenetic analysis may yet provide the answer. ...

journal_title：Current opinion in genetics & development

authors： Doolittle RF,Handy J

更新日期：1998-12-01 00:00:00

abstract：:Segmentation in Drosophila is a sequential process directed by at least 30 genes that encode various types of proteins, including: many transcription factors; a putative RNA-binding protein; a membrane-associated receptor kinase; several intracellular protein kinases; a number of secreted signaling molecules; and othe...

journal_title：Current opinion in genetics & development

authors： Kornberg TB,Tabata T

更新日期：1993-08-01 00:00:00

abstract：:The advent of the genomics age has greatly facilitated the study of crop evolution. While full-scale genome sequencing projects are underway for just a handful of crop plants, recent years have witnessed a tremendous increase in the availability of DNA sequence data for virtually all major crops. Such resources have b...

journal_title：Current opinion in genetics & development

authors： Burke JM,Burger JC,Chapman MA

更新日期：2007-12-01 00:00:00

abstract：:TGF-beta binding to the cell surface triggers activation of multiple signal transduction pathways that are connected in intricate ways with each other, and with other response networks involved in sensing cellular information input. Recent data indicate that changes in signal intensity and connectivity of these pathwa...

journal_title：Current opinion in genetics & development

authors： Wakefield LM,Roberts AB

更新日期：2002-02-01 00:00:00

abstract：:The advent of gene targeting in the mouse has led to rapid advances in the identification of factors controlling gene expression that are essential for normal hematopoietic development. Recent work has also uncovered roles for some of these factors in leukemogenesis and in the global regulation of chromatin structure....

journal_title：Current opinion in genetics & development

authors： Engel I,Murre C

更新日期：1999-10-01 00:00:00

abstract：:Recent studies have uncovered a bifunctional role of the diffusible axon guidance molecules netrin-1 and UNC-6 in that they attract some axons and steer others away simultaneously. Homology screens have extended the semaphorin and collapsin family to include at least 20 members, in both secreted and membrane-bound for...

journal_title：Current opinion in genetics & development

authors： Müller BK,Bonhoeffer F,Drescher U

更新日期：1996-08-01 00:00:00

abstract：:Multicellularity has evolved multiple times independently from a variety of ancestral unicellular lineages. Past research on multicellularity was focused more on explaining why it was repeatedly invented and less so on the molecular foundations associated with each transition. Several recent comparative functional ana...

journal_title：Current opinion in genetics & development

authors： Rokas A

更新日期：2008-12-01 00:00:00

abstract：:All the aspects of transcription are controlled by complexes that modify or remodel chromatin at the level of individual genes, gene clusters, or whole chromosomes. The MSL complex that is responsible for dosage compensation in Drosophila is an example of complexes that operate at the whole-chromosome level on the tra...

journal_title：Current opinion in genetics & development

authors： Lucchesi JC

更新日期：2009-12-01 00:00:00

abstract：:Our understanding of how roots develop in soil may be at the eve of significant transformations. The formidable expansion of imaging technologies enables live observations of the rhizosphere micro-pore architecture at unprecedented resolution. Granular matter physics provides ways to understand the microscopic fluctua...

journal_title：Current opinion in genetics & development

authors： Dupuy LX,Mimault M,Patko D,Ladmiral V,Ameduri B,MacDonald MP,Ptashnyk M

更新日期：2018-08-01 00:00:00

abstract：:To understand organ morphogenetic mechanisms, it is essential to clarify how spatiotemporally-regulated molecular/cellular dynamics causes physical tissue deformation. In the case of vertebrate limb development, while some of the genes and oriented cell behaviors underlying morphogenesis have been revealed, tissue def...

journal_title：Current opinion in genetics & development

authors： Suzuki T,Morishita Y

更新日期：2017-08-01 00:00:00

abstract：:Pluripotency-associated transcription factors possess a pivotal role to maintain pluripotency in pluripotent stem cells as well as to induce pluripotency in somatic cells. They direct specific pattern of gene expression from the genome by co-operating with the genetic and epigenetic mechanisms. Recent findings reveale...

journal_title：Current opinion in genetics & development

authors： Niwa H

更新日期：2014-10-01 00:00:00

abstract：:Proliferating cells must increase their mass coordinately with cell division. Recent evidence suggests that coupling of cell growth with cell division might be achieved by making synthesis of activators of cell division particularly sensitive to the capacity of the cell's protein synthesis machinery. ...

journal_title：Current opinion in genetics & development

authors： Polymenis M,Schmidt EV

更新日期：1999-02-01 00:00:00

abstract：:Acquired resistance is a major limitation for the successful treatment of cancer patients. Although numerous efficacious cancer therapeutics have been developed in the past decades, resistance arises due to a variety of reasons including tumoral genetic alterations, or modulation of factors in the tumor environment. U...

journal_title：Current opinion in genetics & development

authors： Prahallad A,Jensen MR,Chapeau EA

更新日期：2019-02-01 00:00:00

abstract：:Ras proteins activate a signaling cascade through direct binding of the serine/threonine kinase Raf. They also activate additional signaling pathways that are essential for full biological activity. Candidate effectors for these pathways include RalGDS and phosphatidyl inositol 3' kinase, as well as several other Ras ...

journal_title：Current opinion in genetics & development

authors： Katz ME,McCormick F

更新日期：1997-02-01 00:00:00

abstract：:Recent studies of beta-globin gene expression have concentrated on the analysis of factor binding and chromatin structure within the endogenous locus. These studies have more precisely defined the extent and nature of the active chromosomal domain and the elements that organize it. Surprisingly, the beta-globin locus ...

journal_title：Current opinion in genetics & development

authors： Bulger M,Sawado T,Schübeler D,Groudine M

更新日期：2002-04-01 00:00:00

abstract：:In the past ten years, there has been increasing recognition that cells can acquire genetic variants during cortical development that can give rise to brain malformations as well as nonlesional focal epilepsy. These often brain tissue-specific, de novo variants can result in highly variable phenotypes based on the bur...

journal_title：Current opinion in genetics & development

authors： Heinzen EL

更新日期：2020-12-01 00:00:00

abstract：:Chromatin-based epigenetic inheritance cooperates with cis-acting DNA sequence information to propagate gene expression states and chromosome architecture across cell division cycles. Histone proteins and their modifications are central components of epigenetic systems but how, and to what extent, they are propagated ...

journal_title：Current opinion in genetics & development

authors： Gómez-Rodríguez M,Jansen LE

更新日期：2013-04-01 00:00:00