Cardiac reprogramming: from mouse toward man.

abstract：:Unexpected patterns of neuroblast, angioblast and myoblast movement and tissue organization have been defined using lineage tracing and transplantation methods. The most novel and enigmatic new data derive from analyses of genes in the Hox- and Pax-gene families. In addition to the characterization of expression patte...

journal_title：Current opinion in genetics & development

authors： Noden DM

更新日期：1992-08-01 00:00:00

abstract：:Covalent modifications of histone proteins play key roles in transcription, DNA repair, recombination, and other such processes. Over a hundred histone modifications have been described, and a popular idea in the field is that the function of a single histone mark cannot be understood without understanding its combina...

journal_title：Current opinion in genetics & development

authors： Rando OJ

更新日期：2012-04-01 00:00:00

abstract：:Multiple histone-modifying enzymes have been identified in the past several years. Much has been learned regarding the biochemistry of these enzymes and their effects on gene expression in cultured cells. However, the functions of these factors during development are still largely unknown. Recent genetic studies indic...

journal_title：Current opinion in genetics & development

authors： Lin W,Dent SY

更新日期：2006-04-01 00:00:00

abstract：:The dystrophin-glycoprotein complex (DGC) is a multisubunit complex that connects the cytoskeleton of a muscle fiber to its surrounding extracellular matrix. Mutations in the DGC disrupt the complex and lead to muscular dystrophy. There are a few naturally occurring animal models of DGC-associated muscular dystrophy (...

journal_title：Current opinion in genetics & development

authors： Durbeej M,Campbell KP

更新日期：2002-06-01 00:00:00

abstract：:Eukaryotic messenger RNA utilization is a tightly controlled process. Control of translation is exerted at several levels, but the predominant step is ribosome binding, which is rate limiting for translation of most mRNAs. There appear to be several alternative modes by which ribosomes bind to the mRNA and initiate tr...

journal_title：Current opinion in genetics & development

authors： Sonenberg N

更新日期：1994-04-01 00:00:00

abstract：:The vertebrate inner ear is a sensory organ of exquisite design and sensitivity. It responds to sound, gravity and movement, serving both auditory (hearing) and vestibular (balance) functions. Almost all cell types of the inner ear, including sensory hair cells, sensory neurons, secretory cells and supporting cells, d...

journal_title：Current opinion in genetics & development

authors： Whitfield TT

更新日期：2015-06-01 00:00:00

abstract：:The advent of gene targeting in the mouse has led to rapid advances in the identification of factors controlling gene expression that are essential for normal hematopoietic development. Recent work has also uncovered roles for some of these factors in leukemogenesis and in the global regulation of chromatin structure....

journal_title：Current opinion in genetics & development

authors： Engel I,Murre C

更新日期：1999-10-01 00:00:00

abstract：:The PML and SP100-containing nuclear bodies (NBs) represent the best-studied example of a defined nuclear substructure the integrity of which is compromised in certain human diseases, including leukemia, neurodegenerative disorders and viral infection. Although recent progress has underscored the unexpectedly broad in...

journal_title：Current opinion in genetics & development

authors： Seeler JS,Dejean A

更新日期：1999-06-01 00:00:00

abstract：:The regulation of synapse formation and plasticity in the developing and adult brain underlies a complex interplay of intrinsic genetic programs and extrinsic factors. Recent research identified microRNAs (miRNAs), a class of small non-coding RNAs, as a new functional layer in this regulatory network. Within only a fe...

journal_title：Current opinion in genetics & development

authors： Siegel G,Saba R,Schratt G

更新日期：2011-08-01 00:00:00

abstract：:The ciliated protozoa undergo an extensive genome reorganization during the course of forming a transcriptionally active macronucleus. The process includes numerous chromosome fragmentation and DNA breakage and rejoining events. Recent work indicates that transposable elements play a role in the process. ...

journal_title：Current opinion in genetics & development

authors： Klobutcher LA,Jahn CL

更新日期：1991-10-01 00:00:00

abstract：:Tissue differentiation and signal transduction involve dramatic changes in gene expression. These changes can be brought about by the expression or activation of sequence-specific transcription factors. In order to regulate their target genes, such factors must navigate the intricate chromatin environment and engage t...

journal_title：Current opinion in genetics & development

authors： Carrera I,Treisman JE

更新日期：2008-10-01 00:00:00

abstract：:Proliferating cells must increase their mass coordinately with cell division. Recent evidence suggests that coupling of cell growth with cell division might be achieved by making synthesis of activators of cell division particularly sensitive to the capacity of the cell's protein synthesis machinery. ...

journal_title：Current opinion in genetics & development

authors： Polymenis M,Schmidt EV

更新日期：1999-02-01 00:00:00

abstract：:Both complex disorders and monogenetic diseases are often modulated in their phenotype by further genetic, epigenetic or extrinsic factors. This gives rise to extensive phenotypic variability and potentially protection from disease manifestations, known as incomplete penetrance. Approaches including whole transcriptom...

journal_title：Current opinion in genetics & development

authors： Wirth B,Garbes L,Riessland M

更新日期：2013-06-01 00:00:00

abstract：:Non-human primates (NHPs) have been proposed as good models for neurodevelopmental disorders due to close similarities to humans in terms of brain structure and cognitive function. The recent development of genome editing technologies has opened new avenues to generate and investigate genetically modified NHPs as mode...

journal_title：Current opinion in genetics & development

authors： Aida T,Feng G

更新日期：2020-12-01 00:00:00

abstract：:The recent identification of Wnt-7a as a signalling molecule in dorsal/ventral patterning means that we now have a known signal for control of each of the three limb axes. Fibroblast growth factors can allow proximal/distal patterning and Sonic hedgehog gene expression signals anterior/posterior patterning. Networks o...

journal_title：Current opinion in genetics & development

authors： Tickle C

更新日期：1995-08-01 00:00:00

abstract：:Cell proliferation is dependent upon the activation of receptor tyrosine kinases and integrins by soluble growth factors and extracellular matrix proteins, respectively. It is now apparent that concerted, rather than individual, signaling by these receptors is the critical feature responsible for cell-cycle progressio...

journal_title：Current opinion in genetics & development

authors： Assoian RK,Schwartz MA

更新日期：2001-02-01 00:00:00

abstract：:The pituitary gland functions as a relay between the hypothalamus and peripheral target organs that regulate basic physiological functions, including growth, the stress response, reproduction, metabolism and lactation. The development of the pituitary gland has been studied extensively in mice, and has begun to be exp...

journal_title：Current opinion in genetics & development

authors： Zhu X,Lin CR,Prefontaine GG,Tollkuhn J,Rosenfeld MG

更新日期：2005-06-01 00:00:00

abstract：:Recent developments in technology have made it possible to create high resolution genome-wide maps of histone marks, DNA binding proteins and physical interactions along genomic regions. Chromatin features are found together in different combinations, dividing the genome up into domains with distinct functional proper...

journal_title：Current opinion in genetics & development

authors： de Graaf CA,van Steensel B

更新日期：2013-04-01 00:00:00

abstract：:The nature-nurture argument surrounding the mechanisms of disease causation cannot be resolved, as the roles of genes and environment are inextricably entwined. Environmental fluctuation is clearly a major modifier of phenotype, as well as a promoter of evolutionary change. Both types of variability can be mediated by...

journal_title：Current opinion in genetics & development

authors： Yeyati PL,van Heyningen V

更新日期：2008-06-01 00:00:00

abstract：:Modelling human colon cancer has long been the ambition of researchers and oncologists with the aim to better replicate disease progression and treatment response. Advances in our understanding of genetics, stem cell biology, tumour microenvironment and immunology have prepared the groundwork for recent major advances...

journal_title：Current opinion in genetics & development

authors： Lannagan TR,Jackstadt R,Leedham SJ,Sansom OJ

更新日期：2021-01-07 00:00:00

abstract：:An epigenetic imprinting mechanism that is based on a gamete-specific methylation imprint restricts expression of a subset of mammalian genes to one parental chromosome. Recent results suggest that imprints may act only indirectly to induce monoallelic expression of coding genes. Instead, atypical non-coding RNAs appe...

journal_title：Current opinion in genetics & development

authors： Sleutels F,Barlow DP,Lyle R

更新日期：2000-04-01 00:00:00

abstract：:During the past year, significant advances have been made in understanding the functions of the oncoproteins, E6 and E7, of human papillomaviruses that are associated with malignant genital tumors. In addition, important new information is now available on the responses of both the keratinocyte and of the individual f...

journal_title：Current opinion in genetics & development

authors： Gissmann L

更新日期：1992-02-01 00:00:00

abstract：:Members of the Swi/Snf family of chromatin-remodeling complexes play critical roles in transcriptional control. Recent studies have made significant advances in our understanding of the fundamental aspects of Swi/Snf complexes, including the roles of specific subunits, the repression of transcription, and the mechanis...

journal_title：Current opinion in genetics & development

authors： Martens JA,Winston F

更新日期：2003-04-01 00:00:00

abstract：:Expansions of microsatellite DNA repeats contribute to the inheritance of nearly 30 developmental and neurological disorders. Significant progress has been made in elucidating the molecular mechanisms of repeat expansions using various model organisms and mammalian cell culture, and models implicating nearly all DNA t...

journal_title：Current opinion in genetics & development

authors： Kim JC,Mirkin SM

更新日期：2013-06-01 00:00:00

abstract：:Molecular biological techniques have contributed greatly to the study of vertebrate ocular tissues. The specification of ocular tissues has been shown to be closely related to the expression of transcription factors encoded by genes such as Pax6 and microphthalmia. Lens-specific expression of the delta 1-crystallin ge...

journal_title：Current opinion in genetics & development

authors： Kodama R,Eguchi G

更新日期：1994-10-01 00:00:00

abstract：:Several decades of research provided detailed insight into how genes control development and evolution, whereas recent studies have expanded this purely genetic perspective by presenting strong evidence for environmental and epigenetic influences. We summarize examples of phenotypic plasticity and trans-generational e...

journal_title：Current opinion in genetics & development

authors： Serobyan V,Sommer RJ

更新日期：2017-08-01 00:00:00

abstract：:In recent years, the classical approaches of experimental embryology have been used in combination with more modern techniques to investigate aspects of neurogenesis. This combination has advanced our knowledge of several areas of neuronal development, including the lineages of neuronal precursors, the segmentation of...

journal_title：Current opinion in genetics & development

authors： Fraser SE

更新日期：1991-08-01 00:00:00

abstract：:Whole-transcriptome analyses have established that the plant circadian clock regulates virtually every plant biological process and most prominently hormonal and stress response pathways. Systems biology efforts have successfully modeled the plant central clock machinery and an iterative process of model refinement an...

journal_title：Current opinion in genetics & development

authors： McClung CR,Gutiérrez RA

更新日期：2010-12-01 00:00:00

abstract：:Seed development starts at double fertilization when two sperms fuse with a female gamete, the egg and central cell, giving rise to the embryo and endosperm, respectively. Uniting two parental genomes into one, unique, zygotic genome is certainly the first event requiring large-scale chromatin modifications and remode...

journal_title：Current opinion in genetics & development

authors： Baroux C,Pien S,Grossniklaus U

更新日期：2007-12-01 00:00:00

abstract：:Atherosclerosis is the major cause of cardiovascular disease. Hypercholesterolaemia, hypertension and cigarette smoking are the common risk factors for atherosclerosis. These risk factors unite behind a convergence of mechanism, involving oxidation and inflammation in the artery wall that, with time, gives rise to cha...

journal_title：Current opinion in genetics & development

authors： Scott J

更新日期：2004-06-01 00:00:00