Developmental systems of plasticity and trans-generational epigenetic inheritance in nematodes.

abstract：:A casual association has been established between mutations in the fibrillin 1 gene and Marfan syndrome and related phenotypes. Analysis of mutations in these disease types has provided new insights into microfibril assembly and function. These include evidence for a mutation in a fibrillin 1 domain associated with se...

journal_title：Current opinion in genetics & development

authors： Ramirez F

更新日期：1996-06-01 00:00:00

abstract：:Vertebrate neural crest cells are embryonic neuroepithelial cells that undergo an epithelial-mesenchymal transition, migrate throughout the embryo and form a wide variety of derivatives, including peripheral neurons and glia, pigment cells, and craniofacial cartilage, bone and teeth. Neural crest cell evolution and el...

journal_title：Current opinion in genetics & development

authors： Baker CV

更新日期：2008-12-01 00:00:00

abstract：:Trait exaggeration, well known to naturalists and evolutionary biologists, has recently become a prominent research subject in the modern field of Evolutionary Developmental Biology. A large number of traits that can be considered as cases of exaggeration exist in nature. Yet, the field has almost exclusively focused ...

journal_title：Current opinion in genetics & development

authors： Toubiana W,Khila A

更新日期：2016-08-01 00:00:00

abstract：:The recent discovery of self-splicing introns in cyanobacteria has given renewed interest to the question of whether introns may have been present in the ancestor of all living things. The properties of introns in genes of bacteria and bacteriophages are discussed in the context of their possible origin and biological...

journal_title：Current opinion in genetics & development

authors： Shub DA

更新日期：1991-12-01 00:00:00

abstract：:New structural studies of RNA polymerase II (Pol II) complexes mark the beginning of a detailed mechanistic analysis of the eukaryotic mRNA transcription cycle. Crystallographic models of the complete Pol II, together with new biochemical and electron microscopic data, give insights into transcription initiation. The ...

journal_title：Current opinion in genetics & development

authors： Cramer P

更新日期：2004-04-01 00:00:00

abstract：:Embryonic development is key for determining the architecture and shape of multicellular bodies. However, most cells are produced postembryonically in, at least partly, differentiated organs. In this regard, organismal growth faces common challenges in coordinating expansion and function of body structures. Here we co...

journal_title：Current opinion in genetics & development

authors： Shi D,Tavhelidse T,Thumberger T,Wittbrodt J,Greb T

更新日期：2017-08-01 00:00:00

abstract：:Asymmetric cell division during the process of sporulation in the bacterium Bacillus subtilis generates dissimilar progeny that exhibit distinct programs of gene transcription. Recent work reveals a partner switching mechanism that governs the activity of the sporulation regulatory protein sigma F and that may be resp...

journal_title：Current opinion in genetics & development

authors： Duncan L,Alper S,Losick R

更新日期：1994-10-01 00:00:00

abstract：:The pattern of expression of homeodomain proteins often exceeds their apparent domain of activity. Tissue-specific proteins that modulate the in vivo activity of homeodomain proteins have been proposed to account for this functional restriction. The first identified example of such an accessory protein is DCoH, which ...

journal_title：Current opinion in genetics & development

authors： Hansen LP,Crabtree GR

更新日期：1993-04-01 00:00:00

abstract：:Bioinformatics is now an essential tool in many aspects of human molecular genetics research. Methods for the prediction of gene structure are essential components in genomic sequencing projects and provide the key to deriving protein sequence and locating intron/exon junctions. Sequence comparison and database search...

journal_title：Current opinion in genetics & development

authors： Rawlings CJ,Searls DB

更新日期：1997-06-01 00:00:00

abstract：:Recent advances in cell reprogramming via employing different sets of factors, which allows generation of various cell types that are beyond the downstream developmental lineages from the starting cell type, provide significant opportunities to study fundamental biology and hold enormous promise in regenerative medici...

journal_title：Current opinion in genetics & development

authors： Yu C,Liu K,Tang S,Ding S

更新日期：2014-10-01 00:00:00

abstract：:The recent flood of information concerning Saccharomyces cerevisiae replication origins and the proteins that interact with them contrasts alarmingly to the trickle of progress in our understanding of metazoan origins. In mammalian cells, origins are complex and heterogeneous, and appear to be selected by features of ...

journal_title：Current opinion in genetics & development

authors： Gilbert DM

更新日期：1998-04-01 00:00:00

abstract：:It has been shown recently that some plant transcription factors that regulate cell fate during development can traffic through plasmodesmata-the intercellular channels that connect plant cells. This phenomenon helps explain the non-autonomous effects of many developmental mutations in plants and defines a novel mecha...

journal_title：Current opinion in genetics & development

authors： Jackson D,Hake S

更新日期：1997-08-01 00:00:00

abstract：:The gene regulatory networks that control sex determination vary between species. Despite these differences, comparative studies in insects have found that alternative splicing is reiteratively used in evolution to control expression of the key sex-determining genes. Sex determination is best understood in Drosophila ...

journal_title：Current opinion in genetics & development

authors： Salz HK

更新日期：2011-08-01 00:00:00

abstract：:A plethora of post-transcriptional mechanisms are involved in essential steps in the pathway of genetic information expression in eukaryotes. These processes are specified by cis-acting signals on RNAs and are mediated by specific trans-acting factors, including RNA-binding proteins and small complementary RNAs. Recen...

journal_title：Current opinion in genetics & development

authors： Siomi H,Dreyfuss G

更新日期：1997-06-01 00:00:00

abstract：:The initial human and chimpanzee genome sequences have been published, and additional primate genomes, including those of gorilla and orang-utan, are in progress. With these new resources, we can now address what makes our species unique, by focusing on the underlying genetic differences associated with phenotypes. Co...

journal_title：Current opinion in genetics & development

authors： Stone AC,Verrelli BC

更新日期：2006-12-01 00:00:00

abstract：:Ideas of how a system of interacting enzymes can act as a switch are based on the concept of bistability of a biochemical network. This means that, because of the very structure of a signaling pathway, the system can be in one of two stable steady states: active or inactive. Switching from one state to another may the...

journal_title：Current opinion in genetics & development

authors： Slepchenko BM,Terasaki M

更新日期：2004-08-01 00:00:00

abstract：:The human genome is replete with interspersed repetitive sequences derived from the propagation of mobile DNA elements. Three families of human retrotransposons remain active today: LINE1, Alu, and SVA elements. Since 1988, de novo insertions at previously recognized disease loci have been shown to generate highly pen...

journal_title：Current opinion in genetics & development

authors： Babatz TD,Burns KH

更新日期：2013-06-01 00:00:00

abstract：:A number of prokaryotic and eukaryotic genomes are currently being sequenced. Already, the nucleotide sequences of four yeast chromosomes and of 2.2 Mb from Caenorhabditis elegans have been reported. Human genomic sequences have also been used in comparative studies with both mouse and Fugu rubripes. ...

journal_title：Current opinion in genetics & development

authors： Jones SJ

更新日期：1995-06-01 00:00:00

abstract：:Induction of pluripotency in somatic cells via ectopic expression of defined factors demonstrates the reversibility of developmental programming, thus serves as an ideal model to investigate the underlying principles of cell fate determination, which drives the differentiation of various cell types from an identical g...

journal_title：Current opinion in genetics & development

authors： Chen J

更新日期：2020-10-01 00:00:00

abstract：:Recent studies of beta-globin gene expression have concentrated on the analysis of factor binding and chromatin structure within the endogenous locus. These studies have more precisely defined the extent and nature of the active chromosomal domain and the elements that organize it. Surprisingly, the beta-globin locus ...

journal_title：Current opinion in genetics & development

authors： Bulger M,Sawado T,Schübeler D,Groudine M

更新日期：2002-04-01 00:00:00

abstract：:The nuclear periphery has been implicated in gene regulation and it has been proposed that proximity to the nuclear lamina and inner nuclear membrane (INM) leads to gene repression. More recently, it appears that there is a correlation and interdependence between lamina associated domains (LADs), the epigenome and ove...

journal_title：Current opinion in genetics & development

authors： Luperchio TR,Wong X,Reddy KL

更新日期：2014-04-01 00:00:00

abstract：:The genotype-phenotype map of human evolution is difficult to access since humans cannot be crossed with other species. Most of the ∼20 million genetic changes that occurred since the human and the chimpanzee lineage split, are fixed and hence completely correlated with all phenotypic changes that occurred during huma...

journal_title：Current opinion in genetics & development

authors： Enard W

更新日期：2014-12-01 00:00:00

abstract：:Type 1 diabetes is the most common autoimmune disorder in childhood, characterized by the development of autoimmunity through unknown environmental insults in genetically susceptible individuals. There are now over 50 regions of the genome that harbor type 1 diabetes susceptibility genes, with much of the genetic risk...

journal_title：Current opinion in genetics & development

authors： Robertson CC,Rich SS

更新日期：2018-06-01 00:00:00

abstract：:In their development, plants precisely control the patterns of cell size, cell shape and cell division, the position of differentiation of cell types, and the position and number of organs. In the past year, progress has been made in understanding four of these five levels of control of plant pattern formation, includ...

journal_title：Current opinion in genetics & development

authors： Meyerowitz EM

更新日期：1994-08-01 00:00:00

abstract：:The maternal-to-zygotic transition (MZT) is a universal step in animal development characterized by two major events: activation of zygotic transcription and degradation of maternally provided mRNAs. How zygotic gene products instruct the degradation of maternal messages remains a long-standing question in biology. Mi...

journal_title：Current opinion in genetics & development

authors： Giraldez AJ

更新日期：2010-08-01 00:00:00

abstract：:Notch signaling has been implicated in a wide variety of processes from cell-fate decisions, tissue patterning and morphogenesis to human diseases and cancer. A model for Notch directly regulating gene expression has been proposed and at least two signaling pathways have been identified; however, the molecular mechani...

journal_title：Current opinion in genetics & development

authors： Weinmaster G

更新日期：1998-08-01 00:00:00

abstract：:A wealth of pharmacological data point to the involvement of catecholamine metabolism in a number of psychiatric and behavioral disorders. Furthermore, evidence points to many of these affective disorders having a moderate to large genetic component. These observations have provided the impetus to search for differenc...

journal_title：Current opinion in genetics & development

authors： Mallet J,Meloni R,Laurent C

更新日期：1994-06-01 00:00:00

abstract：:Studies of primate lentivirus phylogeny over the past decade have established a minimum of five related, but genetically distinct, groups of simian immunodeficiency virus (SIV), each originating from a different African primate species. The hypothesis that HIV-2 (and SIVmac) arose by cross-species transmission from so...

journal_title：Current opinion in genetics & development

authors： Hirsch VM,Dapolito G,Goeken R,Campbell BJ

更新日期：1995-12-01 00:00:00

abstract：:Over the past year, interest has focused on identifying signalling molecules--including Wnts, Sonic hedgehog, BMP-4, and noggin--that divert somitic mesodermal cells into the muscle lineage, either by induction or derepression. New mouse mutants have also provided insights into somite formation and differentiation, as...

journal_title：Current opinion in genetics & development

authors： Tajbakhsh S,Cossu G

更新日期：1997-10-01 00:00:00

abstract：:DNA methylation and chromatin modification are two global mechanisms that regulate gene expression. Recent studies provide insight into the mechanism of transcriptional silencing by a methyl-CpG binding protein, MeCP2. MeCP2 is shown to interact with the Sin3/histone deacetylase co-repressor complex. Thus, this intera...

journal_title：Current opinion in genetics & development

authors： Ng HH,Bird A

更新日期：1999-04-01 00:00:00