Abstract:
:Induction of pluripotency in somatic cells via ectopic expression of defined factors demonstrates the reversibility of developmental programming, thus serves as an ideal model to investigate the underlying principles of cell fate determination, which drives the differentiation of various cell types from an identical genome. Over the last decade, our understanding has grown considerably regarding how somatic reprogramming initiates and be regulated. Recent mechanistic investigations on chromatin architecture regulation and cell heterogeneity significantly contribute to the understanding of somatic reprogramming. Specifically, it is found that chromatin dynamics which are regulated by the orchestration of transcriptional factors and epigenetic regulation, play an important role during somatic reprogramming. Moreover, the widespread application of single-cell technologies reveals latent cell fate transition trajectories during the reprogramming process. Here, we highlighted several mechanistic studies on somatic reprogramming, particularly from epigenetic regulation and cell heterogeneity perspectives, and summarized their contribution to our current understanding of cell fate determination.
journal_name
Curr Opin Genet Devjournal_title
Current opinion in genetics & developmentauthors
Chen Jdoi
10.1016/j.gde.2020.05.016subject
Has Abstractpub_date
2020-10-01 00:00:00pages
21-25eissn
0959-437Xissn
1879-0380pii
S0959-437X(20)30067-8journal_volume
64pub_type
杂志文章,评审abstract::The increasing availability of large-scale autosomal genetic variation data sampled from world-wide geographic areas, coupled with advances in the statistical methodology to analyse these data, is showcasing the power of DNA as a major tool to gain insights into the demographic history of humans and other organisms. H...
journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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更新日期:2000-04-01 00:00:00
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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journal_title:Current opinion in genetics & development
pub_type: 杂志文章,评审
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