Abstract:
:Cellular phenotypes can critically rely on mono-allelic gene expression. Recent studies suggest that in mammalian cells inter-chromosomal DNA interactions may mediate the decision which allele to activate and which to silence. Here, these findings are discussed in the context of knowledge on gene competition, chromatin dynamics, and nuclear organization. We argue that data obtained by 4C technology strongly support the idea that chromatin folds according to self-organizing principles. In this concept, the nuclear positioning of a given locus is probabilistic as it also depends on the properties of neighbouring DNA segments and, by extrapolation, the whole chromosome. The linear distribution of repetitive DNA sequences and of active and inactive DNA regions is important for the folding and relative positioning of chromosomes. This stochastic concept of nuclear organization predicts that tissue-specific interactions between two selected loci present on different chromosomes will be rare.
journal_name
Curr Opin Genet Devjournal_title
Current opinion in genetics & developmentauthors
de Laat W,Grosveld Fdoi
10.1016/j.gde.2007.07.009subject
Has Abstractpub_date
2007-10-01 00:00:00pages
456-64issue
5eissn
0959-437Xissn
1879-0380pii
S0959-437X(07)00139-6journal_volume
17pub_type
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journal_title:Current opinion in genetics & development
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journal_title:Current opinion in genetics & development
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