The RNA polymerase II carboxy-terminal domain: links to a bigger and better 'holoenzyme'?

abstract：:Does the intron/exon structure of eukaryotic genes belie their ancient assembly by exon-shuffling or have introns been inserted into preformed genes during eukaryotic evolution? These are the central questions in the ongoing 'introns-early' versus 'introns-late' controversy. The phylogenetic distribution of spliceosom...

journal_title：Current opinion in genetics & development

authors： Logsdon JM Jr

更新日期：1998-12-01 00:00:00

abstract：:The detection of sequence variation with restriction fragment length polymorphisms is advancing our knowledge of plant genetics on several fronts. In the past year, there has been progress in genetic map construction, phylogeny studies, and the dissection of multigenic traits. In addition, new methods that are indepen...

journal_title：Current opinion in genetics & development

authors： Chang C,Meyerowitz EM

更新日期：1991-06-01 00:00:00

abstract：:Peripheral neuropathies are characterized by degeneration of peripheral motor, sensory and/or autonomic axons, leading to progressive distal muscle weakness, sensory deficits and/or autonomic dysfunction. Acquired peripheral neuropathies, e.g., as a side effect of chemotherapy, are distinguished from inherited periphe...

journal_title：Current opinion in genetics & development

authors： Bussmann J,Storkebaum E

更新日期：2017-06-01 00:00:00

abstract：:Mutations in the BRCA1 and BRCA2 genes confer a high risk of breast cancer development. Both genes encode very large proteins of unknown function but recent results suggest that they may have roles in transcriptional regulation and DNA repair. These advances offer the prospect of understanding not only the normal cell...

journal_title：Current opinion in genetics & development

authors： Bertwistle D,Ashworth A

更新日期：1998-02-01 00:00:00

abstract：:Eukaryotic organisms have the remarkable ability to inherit states of gene activity without altering the underlying DNA sequence. This epigenetic inheritance can persist over thousands of years, providing an alternative to genetic mutations as a substrate for natural selection. Epigenetic inheritance might be propagat...

journal_title：Current opinion in genetics & development

authors： Zilberman D,Henikoff S

更新日期：2005-10-01 00:00:00

abstract：:Multicellularity has evolved multiple times independently from a variety of ancestral unicellular lineages. Past research on multicellularity was focused more on explaining why it was repeatedly invented and less so on the molecular foundations associated with each transition. Several recent comparative functional ana...

journal_title：Current opinion in genetics & development

authors： Rokas A

更新日期：2008-12-01 00:00:00

abstract：:Molecules and cellular processes important for nervous system development can be repurposed in adulthood for the regulation of adult neurogenesis, synaptic plasticity, and neural regeneration following injury or degeneration. Efforts to recapitulate neural development in order to ameliorate injury or disease are promi...

journal_title：Current opinion in genetics & development

authors： Hunyara JL,Kolodkin AL

更新日期：2020-12-01 00:00:00

abstract：:Type 1 diabetes is the most common autoimmune disorder in childhood, characterized by the development of autoimmunity through unknown environmental insults in genetically susceptible individuals. There are now over 50 regions of the genome that harbor type 1 diabetes susceptibility genes, with much of the genetic risk...

journal_title：Current opinion in genetics & development

authors： Robertson CC,Rich SS

更新日期：2018-06-01 00:00:00

abstract：:Significant advances in the field of hepatocyte-specific gene expression have been made during the past year. Several new transcription factors have been cloned and partially characterized. Analyses of the promoter regions of several factors have also been initiated and Drosophila homologs for two of these factors hav...

journal_title：Current opinion in genetics & development

authors： Sladek FM,Darnell JE

更新日期：1992-04-01 00:00:00

abstract：:Several advances have been made in our understanding of the control of the growth and patterning of embryonic limbs. Development of the vertebrate limb is dependent on reciprocal interactions between the ectoderm and mesoderm that regulate the structure and function of the apical ectodermal ridge. One key component of...

journal_title：Current opinion in genetics & development

authors： Dudley AT,Tabin CJ

更新日期：2000-08-01 00:00:00

abstract：:Baculoviruses continue to serve as workhorse vectors for the high-level expression of eukaryotic genes in insect cells; however, numerous researchers are also finding novel uses for these vectors by taking advantage of the unique nature of the viruses and their host cells. Concurrently, the technology involved in cons...

journal_title：Current opinion in genetics & development

authors： Miller LK

更新日期：1993-02-01 00:00:00

abstract：:Hox proteins regulate specific sets of target genes to give rise to morphological distinctions along the anterior-posterior body axis of metazoans. Though they have high developmental specificity, Hox proteins have low DNA binding specificity, so how they select the appropriate target genes has remained enigmatic. The...

journal_title：Current opinion in genetics & development

authors： Mahaffey JW

更新日期：2005-08-01 00:00:00

abstract：:Mutant onco-proteins play a direct, causal role in cancer and are therefore considered attractive drug targets. Clinical experience has supported this view, with some exceptions. However, clinical benefit has often been restricted by rapid emergence of drug-resistant clones through several distinct mechanisms. This pr...

journal_title：Current opinion in genetics & development

authors： McCormick F

更新日期：2011-02-01 00:00:00

abstract：:Studies of primate lentivirus phylogeny over the past decade have established a minimum of five related, but genetically distinct, groups of simian immunodeficiency virus (SIV), each originating from a different African primate species. The hypothesis that HIV-2 (and SIVmac) arose by cross-species transmission from so...

journal_title：Current opinion in genetics & development

authors： Hirsch VM,Dapolito G,Goeken R,Campbell BJ

更新日期：1995-12-01 00:00:00

abstract：:Segmentation in Drosophila is a sequential process directed by at least 30 genes that encode various types of proteins, including: many transcription factors; a putative RNA-binding protein; a membrane-associated receptor kinase; several intracellular protein kinases; a number of secreted signaling molecules; and othe...

journal_title：Current opinion in genetics & development

authors： Kornberg TB,Tabata T

更新日期：1993-08-01 00:00:00

abstract：:Primordial germ cells (PGCs), the embryonic precursors of the gametes of the adult animal, can give rise to two types of pluripotent stem cells. In vivo, PGCs can give rise to embryonal carcinoma cells, the pluripotent stem cells of testicular tumors. Cultured PGCs exposed to a specific cocktail of growth factors give...

journal_title：Current opinion in genetics & development

authors： Donovan PJ,de Miguel MP

更新日期：2003-10-01 00:00:00

abstract：:Eukaryotic DNA replication is regulated at least in part by the assembly of initiation proteins onto origins of replication. The origin recognition complex (ORC) is bound to origins throughout most of the cell cycle. Other initiation proteins, such as Cdc6 and the MCM/P1 proteins, are assembled onto ORC-containing chr...

journal_title：Current opinion in genetics & development

authors： Rowles A,Blow JJ

更新日期：1997-04-01 00:00:00

abstract：:A rooted phylogenetic tree of the kinetoplastid protozoa has been constructed that, together with a comparative analysis of editing of several genes, leads to the surprising conclusion that extensive or pan-editing with multiple overlapping guide RNAs is more ancient than 5'-editing. The mechanism of editing is still ...

journal_title：Current opinion in genetics & development

authors： Simpson L,Maslov DA

更新日期：1994-12-01 00:00:00

abstract：:The discovery of hundreds of plant micro RNAs (miRNAs) has triggered much speculation about their potential roles in plant development. The search for plant genes involved in miRNA processing has revealed common factors such as DICER, and new molecules, including HEN1. Progress is also being made toward identifying mi...

journal_title：Current opinion in genetics & development

authors： Hunter C,Poethig RS

更新日期：2003-08-01 00:00:00

abstract：:Individual susceptibility to cancer in humans is determined by complex interactions between germline genetic variation and levels of exposure to environmental carcinogens or tumour promoters. Only a small fraction of cancer susceptibility is inherited in a Mendelian manner (high-penetrance familial cancer), and most t...

journal_title：Current opinion in genetics & development

authors： Mao JH,Balmain A

更新日期：2003-02-01 00:00:00

abstract：:The establishment of left-right asymmetries in the vertebrate embryo is carried out by complex genetic interactions that impart left- or right-sided information to the developing organs and structures. The origin of LR information is still unclear, but recent advances have provided new insights as to how it is relayed...

journal_title：Current opinion in genetics & development

authors： Raya A,Izpisúa Belmonte JC

更新日期：2004-10-01 00:00:00

abstract：:The advent of single-cell sequencing has been revolutionary to the field of cancer genomics. Perfectly suited to capture cancer's heterogeneous nature, single-cell analyses provide information bulk sequencing could never hope to uncover. Many mechanisms of cancer have yet to be fully understood, and single-cell approa...

journal_title：Current opinion in genetics & development

authors： Tsoucas D,Yuan GC

更新日期：2017-02-01 00:00:00

abstract：:In 2003, a p53-expressing adenovirus was approved as a cancer therapy drug in China. Consequently, there has been a surge in the need to understand the regulation of wild type p53 function in vivo. The majority of the progress made during the past two years has focused on the cellular factors and post-translational mo...

journal_title：Current opinion in genetics & development

authors： Lu X

更新日期：2005-02-01 00:00:00

abstract：:Identification of new genes involved in muscle disorders has dramatically changed the traditional clinical classification of the large and heterogeneous group of the muscular dystrophies. Results obtained in recent years by positional candidate cloning have demonstrated the role of the sarcolemma and of the nuclear en...

journal_title：Current opinion in genetics & development

authors： Toniolo D,Minetti C

更新日期：1999-06-01 00:00:00

abstract：:In eukaryotes, the genetic material is stored in the nucleus, which is enclosed in a double lipid bilayer, the nuclear envelope (NE). It protects the genome from physical stress and separates it from the rest of the cell. On top of this physical function, growing evidence shows that the nuclear periphery contributes t...

journal_title：Current opinion in genetics & development

authors： Meister P,Taddei A

更新日期：2013-04-01 00:00:00

abstract：:The mammalian globin gene clusters provide a paradigm for studying the relationship between genome structure and function. As blood stem cells undergo lineage specification and differentiation to form red blood cells, the chromatin structure and expression of the α-globin cluster change. The gradual activation of the ...

journal_title：Current opinion in genetics & development

authors： Oudelaar AM,Beagrie RA,Kassouf MT,Higgs DR

更新日期：2020-11-19 00:00:00

abstract：:Genetic conflicts arise when the evolutionary interests of two genetic elements are not aligned. Conflicts between genomes (e.g. pathogen versus host) or within the same genome (e.g. internal parasitic DNA sequences versus the rest of the host genome) can both foster 'molecular arms races', in which genes on both side...

journal_title：Current opinion in genetics & development

authors： Daugherty MD,Zanders SE

更新日期：2019-10-01 00:00:00

abstract：:In the Drosophila eye, photoreceptor clusters are arranged with mirror-image symmetry about the dorso-ventral midline. Recent work indicates critical rôles for Wingless and JAK/STAT signalling in setting up long-range gradients of positional information that determine this symmetry. Furthermore, important functions ha...

journal_title：Current opinion in genetics & development

authors： Strutt H,Strutt D

更新日期：1999-08-01 00:00:00

abstract：:Loss of cardiomyocytes from cardiovascular disease is irreversible and current therapeutic strategies do not redress the loss of myocardium after injury. The discovery that endogenous fibroblasts in the heart can be reprogrammed to cardiomyocyte-like cells after myocardial infarction and heart function is improved sub...

journal_title：Current opinion in genetics & development

authors： Srivastava D,Berry EC

更新日期：2013-10-01 00:00:00

abstract：:Human genetic studies have long been vastly Eurocentric, raising a key question about the generalizability of these study findings to other populations. Because humans originated in Africa, these populations retain more genetic diversity, and yet individuals of African descent have been tremendously underrepresented i...

journal_title：Current opinion in genetics & development

authors： Martin AR,Teferra S,Möller M,Hoal EG,Daly MJ

更新日期：2018-12-01 00:00:00