Ancient origin of RNA editing in kinetoplastid protozoa.

abstract：:Hox proteins regulate specific sets of target genes to give rise to morphological distinctions along the anterior-posterior body axis of metazoans. Though they have high developmental specificity, Hox proteins have low DNA binding specificity, so how they select the appropriate target genes has remained enigmatic. The...

journal_title：Current opinion in genetics & development

authors： Mahaffey JW

更新日期：2005-08-01 00:00:00

abstract：:Investigations on chromatin assembly in vitro implicate chromatin assembly factor 1 (CAF1) as a chaperone for histones H3/H4 and nucleosome assembly protein 1 (NAP1) as a chaperone for histones H2A/H2B. Deletion analysis of CAF1 in vivo suggests multiple redundant pathways for deposition of the histones. Histone depos...

journal_title：Current opinion in genetics & development

authors： Adams CR,Kamakaka RT

更新日期：1999-04-01 00:00:00

abstract：:Hepatocytes differentiate from the endoderm during embryonic development. Recent studies show, however, that hepatocytes can also be derived from rare cells that reside in the pancreas, bone marrow, and brain. Indeed, the latest discoveries indicate that embryonic hepatocytes normally arise by diversion of an endoderm...

journal_title：Current opinion in genetics & development

authors： Zaret KS

更新日期：2001-10-01 00:00:00

abstract：:The DNA damage response (DDR) orchestrates DNA repair and halts cell cycle. If damage is not resolved, cells can enter into an irreversible state of proliferative arrest called cellular senescence. Organismal ageing in mammals is associated with accumulation of markers of cellular senescence and DDR persistence at tel...

journal_title：Current opinion in genetics & development

authors： Rossiello F,Herbig U,Longhese MP,Fumagalli M,d'Adda di Fagagna F

更新日期：2014-06-01 00:00:00

abstract：:The pattern of expression of homeodomain proteins often exceeds their apparent domain of activity. Tissue-specific proteins that modulate the in vivo activity of homeodomain proteins have been proposed to account for this functional restriction. The first identified example of such an accessory protein is DCoH, which ...

journal_title：Current opinion in genetics & development

authors： Hansen LP,Crabtree GR

更新日期：1993-04-01 00:00:00

abstract：:Our understanding of the mechanism of action of retinoids has been greatly expanded by a series of recent findings. First, the three-dimensional structure of the ligand-binding domain of two retinoid receptors has been solved and suggests that ligand binding induces marked allosteric changes. Second, several co-factor...

journal_title：Current opinion in genetics & development

authors： Minucci S,Ozato K

更新日期：1996-10-01 00:00:00

abstract：:Many acquired and familial renal diseases in man lead to kidney dysfunction and nephrotic syndrome. These diseases share a common pathological fate in the form of glomerular dysfunction and proteinuria. Classification of the disease is difficult because the onset of pathological appearance in congenital nephrotic synd...

journal_title：Current opinion in genetics & development

authors： Khoshnoodi J,Tryggvason K

更新日期：2001-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a large class of small RNAs that function as negative gene regulators in eukaryotes. They regulate diverse biological processes, and bioinformatics data indicate that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. ...

journal_title：Current opinion in genetics & development

authors： Niwa R,Slack FJ

更新日期：2007-04-01 00:00:00

abstract：:The recent flood of information concerning Saccharomyces cerevisiae replication origins and the proteins that interact with them contrasts alarmingly to the trickle of progress in our understanding of metazoan origins. In mammalian cells, origins are complex and heterogeneous, and appear to be selected by features of ...

journal_title：Current opinion in genetics & development

authors： Gilbert DM

更新日期：1998-04-01 00:00:00

abstract：:Tumor blood vessels have multiple structural and functional abnormalities. They are unusually dynamic, and naturally undergo sprouting, proliferation, remodeling or regression. The vessels are irregularly shaped, tortuous, and lack the normal hierarchical arrangement of arterioles, capillaries and venules. Endothelial...

journal_title：Current opinion in genetics & development

authors： Baluk P,Hashizume H,McDonald DM

更新日期：2005-02-01 00:00:00

abstract：:During the past year, significant advances have been made in understanding the functions of the oncoproteins, E6 and E7, of human papillomaviruses that are associated with malignant genital tumors. In addition, important new information is now available on the responses of both the keratinocyte and of the individual f...

journal_title：Current opinion in genetics & development

authors： Gissmann L

更新日期：1992-02-01 00:00:00

abstract：:A newly-identified major histocompatibility Class I-like gene, HFE (originally HLA-H) located approximately 3.5 Mb telomeric to the Class I cluster on chromosome 6p 21.3 harbours mutations in haemochromatosis. Two of these, Cys282Tyr (C282Y) and His63Asp (H63D, a minor determinant) have diagnostic utility as approxima...

journal_title：Current opinion in genetics & development

authors： Cox TM,Kelly AL

更新日期：1998-06-01 00:00:00

abstract：:Organismal fitness depends on adaptation to complex niches where chemical compounds and pathogens are omnipresent. These stresses can lead to the fixation of alleles in both xenobiotic responses and proliferative signaling pathways that promote survival in these niches. However, both xenobiotic responses and prolifera...

journal_title：Current opinion in genetics & development

authors： Zdraljevic S,Andersen EC

更新日期：2017-12-01 00:00:00

abstract：:Recent studies of beta-globin gene expression have concentrated on the analysis of factor binding and chromatin structure within the endogenous locus. These studies have more precisely defined the extent and nature of the active chromosomal domain and the elements that organize it. Surprisingly, the beta-globin locus ...

journal_title：Current opinion in genetics & development

authors： Bulger M,Sawado T,Schübeler D,Groudine M

更新日期：2002-04-01 00:00:00

abstract：:Several advances have been made in our understanding of the control of the growth and patterning of embryonic limbs. Development of the vertebrate limb is dependent on reciprocal interactions between the ectoderm and mesoderm that regulate the structure and function of the apical ectodermal ridge. One key component of...

journal_title：Current opinion in genetics & development

authors： Dudley AT,Tabin CJ

更新日期：2000-08-01 00:00:00

abstract：:Combinatorial regulation of eukaryotic transcription is mediated by proteins that associate in a specific manner to form multiprotein DNA-bound complexes. Substantial progress has recently been made towards the understanding of the molecular determinants of the protein-protein and protein-DNA interactions that govern ...

journal_title：Current opinion in genetics & development

authors： Wolberger C

更新日期：1998-10-01 00:00:00

abstract：:The establishment of left-right asymmetries in the vertebrate embryo is carried out by complex genetic interactions that impart left- or right-sided information to the developing organs and structures. The origin of LR information is still unclear, but recent advances have provided new insights as to how it is relayed...

journal_title：Current opinion in genetics & development

authors： Raya A,Izpisúa Belmonte JC

更新日期：2004-10-01 00:00:00

abstract：:DNA sequence data are generally interpreted as favouring Kimura's neutral theory but not without dissent and often with a great deal of controversy with respect to molecular clocks, DNA polymorphism, adaptive evolution, and gene genealogy. Although the theory serves as a guiding principle, many issues concerning mutat...

journal_title：Current opinion in genetics & development

authors： Takahata N

更新日期：1996-12-01 00:00:00

abstract：:Chromatin-based epigenetic inheritance cooperates with cis-acting DNA sequence information to propagate gene expression states and chromosome architecture across cell division cycles. Histone proteins and their modifications are central components of epigenetic systems but how, and to what extent, they are propagated ...

journal_title：Current opinion in genetics & development

authors： Gómez-Rodríguez M,Jansen LE

更新日期：2013-04-01 00:00:00

abstract：:Members of the Swi/Snf family of chromatin-remodeling complexes play critical roles in transcriptional control. Recent studies have made significant advances in our understanding of the fundamental aspects of Swi/Snf complexes, including the roles of specific subunits, the repression of transcription, and the mechanis...

journal_title：Current opinion in genetics & development

authors： Martens JA,Winston F

更新日期：2003-04-01 00:00:00

abstract：:Acquired resistance is a major limitation for the successful treatment of cancer patients. Although numerous efficacious cancer therapeutics have been developed in the past decades, resistance arises due to a variety of reasons including tumoral genetic alterations, or modulation of factors in the tumor environment. U...

journal_title：Current opinion in genetics & development

authors： Prahallad A,Jensen MR,Chapeau EA

更新日期：2019-02-01 00:00:00

abstract：:Both complex disorders and monogenetic diseases are often modulated in their phenotype by further genetic, epigenetic or extrinsic factors. This gives rise to extensive phenotypic variability and potentially protection from disease manifestations, known as incomplete penetrance. Approaches including whole transcriptom...

journal_title：Current opinion in genetics & development

authors： Wirth B,Garbes L,Riessland M

更新日期：2013-06-01 00:00:00

abstract：:We discuss recent work about cellular reprogramming during regeneration of the imaginal discs of Drosophila. These contain various lineage blocks, compartments, which express distinct genetic programmes. It has been found that after massive damage to a compartment cells from a neighbour compartment can transgress the ...

journal_title：Current opinion in genetics & development

authors： Morata G,Herrera SC

更新日期：2016-10-01 00:00:00

abstract：:One of the ways in which higher eukaryotes receive messages from the environment is via cell surface receptor tyrosine kinases. These are transmembrane proteins with an extracellular binding domain that specifies the growth factor with which it will interact, and an intracellular domain that encodes the tyrosine kinas...

journal_title：Current opinion in genetics & development

authors： Kazlauskas A

更新日期：1994-02-01 00:00:00

abstract：:The fundamental tasks of the root system are, besides anchoring, mediating interactions between plant and soil and providing the plant with water and nutrients. The architecture of the root system is controlled by endogenous mechanisms that constantly integrate environmental signals, such as availability of nutrients ...

journal_title：Current opinion in genetics & development

authors： Ötvös K,Benková E

更新日期：2017-08-01 00:00:00

abstract：:Following neurulation, neural crest cells emerge from the neural tube and undergo extensive migrations. At the onset of migration, multipotent stem cells exist within the neural crest population. Eventually, these assume one of a number of possible fates, ranging from neurons and glia of the peripheral nervous system ...

journal_title：Current opinion in genetics & development

authors： Bronner-Fraser M

更新日期：1993-08-01 00:00:00

abstract：:Recent research has broadened significantly our understanding of how the somite, a specialized mesodermal structure found in vertebrate embryos, gives rise to the cartilage, muscle and tendon cell lineages. The specification of somite derivatives involves the action of patterning signals secreted from adjacent tissue ...

journal_title：Current opinion in genetics & development

authors： Brent AE,Tabin CJ

更新日期：2002-10-01 00:00:00

abstract：:Colonial ascidians are marine invertebrate chordates that are the closest invertebrate relative to the vertebrates. Colonies of Botryllus schlosseri undergo a continuous asexual reproduction process that involves the regeneration of entire new bodies, which include all somatic and germline tissues. This adult regenera...

journal_title：Current opinion in genetics & development

authors： Kassmer SH,Rodriguez D,De Tomaso AW

更新日期：2016-08-01 00:00:00

abstract：:The discovery of induced pluripotent stem cells (iPSCs) has solidified the concept of transcription factors as major players in controlling cell identity and provided a tractable tool to study how somatic cell identity can be dismantled and pluripotency established. A number of landmark studies have established hallma...

journal_title：Current opinion in genetics & development

authors： Apostolou E,Stadtfeld M

更新日期：2018-10-01 00:00:00

abstract：:Morphogen gradients regulate the patterning and growth of many tissues, hence a key question is how they are established and maintained during development. Theoretical descriptions have helped to explain how gradient shape is controlled by the rates of morphogen production, spreading and degradation. These effective r...

journal_title：Current opinion in genetics & development

authors： Kicheva A,Bollenbach T,Wartlick O,Jülicher F,Gonzalez-Gaitan M

更新日期：2012-12-01 00:00:00